Article
Endocrinology & Metabolism
Shaobo Li, Haoyong Yu, Pin Zhang, Yinfang Tu, Yunfeng Xiao, Di Yang, Yuqian Bao, Junfeng Han, Weiping Jia
Summary: This study found a nonlinear relationship between muscle mass and BMI, and suggested that baseline muscle mass and eFFMI are more reliable predictors of diabetes remission than BMI.
Article
Endocrinology & Metabolism
Shaobo Li, Haoyong Yu, Pin Zhang, Yinfang Tu, Yunfeng Xiao, Di Yang, Yuqian Bao, Junfeng Han, Weiping Jia
Summary: The study found a non-linear relationship between muscle mass and BMI, with psoas muscle mass and eFFMI being better predictors of diabetes remission after Roux-en-Y gastric bypass surgery compared to BMI.
Review
Geriatrics & Gerontology
Rongqiang Liu, Zhendong Qiu, Lilong Zhang, Wangbin Ma, Liuliu Zi, Kunpeng Wang, Tainrui Kuang, Kailiang Zhao, Weixing Wang
Summary: In cancer patients, high intramuscular adipose tissue content (IMAC) is associated with unfavorable overall survival, relapse-free survival, and disease-specific survival. It also has better predictive value for specific cancer types and is identified as a significant risk factor for postoperative complications.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Review
Agriculture, Dairy & Animal Science
Dong Qiao Peng, Stephen B. Smith, Hong Gu Lee
Summary: The development of intramuscular adipose tissue and muscle in cattle is dependent on cell hyperplasia and hypertrophy, with Vitamin A playing a regulatory role in both processes. Vitamin A supplementation and restriction have opposite effects on adipose tissue development and muscle growth in beef cattle. The timing and level of Vitamin A restriction can interact with the alcohol dehydrogenase-1C (ADH1C) genotype to impact marbling and intramuscular adipose tissue development in cattle, ultimately affecting beef quality.
JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY
(2021)
Review
Geriatrics & Gerontology
Ashish Ranjan Sharma, Srijan Chatterjee, Yeon-Hee Lee, Sang-Soo Lee
Summary: This article discusses the relationship between muscle degeneration and the aging process, as well as the molecular crosstalk between muscles, bones, and fatty tissues. Muscle degeneration is a serious health issue that requires further research and treatment.
Article
Geriatrics & Gerontology
Yuya Takahashi, Hiroki Fujita, Yusuke Seino, Satoko Hattori, Shihomi Hidaka, Tsuyoshi Miyakawa, Atsushi Suzuki, Hironori Waki, Daisuke Yabe, Yutaka Seino, Yuichiro Yamada
Summary: GIP receptor antagonism can suppress IMAT accumulation and promote muscle regeneration, showing potential as a therapeutic approach for sarcopenia.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2023)
Article
Multidisciplinary Sciences
Franziska Alexandra Meister, Jan Bednarsch, Iakovos Amygdalos, Joerg Boecker, Pavel Strnad, Philipp Bruners, Sven Arke Lang, Tom Florian Ulmer, Lara Heij, Daniel Antonio Morales Santana, Wen-Jia Liu, Georg Lurje, Ulf Peter Neumann, Zoltan Czigany
Summary: This study aimed to compare the value and limitations of various selection criteria for defining pre-transplant myosteatosis in assessing short- and long-term outcomes following orthotopic liver transplantation (OLT). The results showed that muscle radiation attenuation values had a superior association with perioperative outcomes in comparison to intramuscular adipose tissue content. Further studies are needed to validate these findings and determine the most suitable selection criterion for assessing myosteatosis.
SCIENTIFIC REPORTS
(2021)
Article
Oncology
Baizhu Xiong, Baoyue Fu, Yulin Wu, Fei Gao, Changlong Hou
Summary: This study found that subcutaneous adipose tissue and sarcopenia are important prognostic factors for patients with hepatocellular carcinoma (HCC) treated with immune checkpoint inhibitors (ICIs). A nomogram based on body composition parameters was established to predict patient survival.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Medicine, General & Internal
Otto Jarvinen, Juho T. Tynkkynen, Marko Virtanen, Pasi Maaranen, Iisa Lindstrom, Damir Vakhitov, Jari Laurikka, Niku K. Oksala, Jussi A. Hernesniemi
Summary: Psoas muscle measurements are significantly associated with mortality in men but not in women. Combining PMA and PMD seems to be a slightly stronger estimate and should be considered in further studies.
ANNALS OF MEDICINE
(2023)
Article
Oncology
Hadass Rom, Shlomit Tamir, Jeroen L. A. Van Vugt, Yael Berger, Gali Perl, Sara Morgenstern, Ana Tovar, Baruch Brenner, Daniel Benchimol, Hanoch Kashtan, Eran Sadot
Summary: The study found that low skeletal muscle index and high intramuscular adipose tissue content are independently associated with impaired survival in patients with resectable pancreatic ductal adenocarcinoma. However, the visceral-to-subcutaneous adipose tissue area ratio is not associated with survival outcomes.
ANNALS OF SURGICAL ONCOLOGY
(2022)
Article
Oncology
Chongming Zheng, Xiaotian Chen, Zhewei Zhang, Anlvna Li, Junwei Wang, Tingting Cai, Yanping Tang, Xuewen An, Fei Lu, Gang Chen, Youqun Xiang
Summary: This study found that intramuscular adipose tissue content is a valid predictor for the prognosis of gallbladder cancer patients and developed a nomogram to predict the prognosis of these patients.
TRANSLATIONAL CANCER RESEARCH
(2022)
Article
Medicine, General & Internal
Takao Miwa, Tatsunori Hanai, Kayoko Nishimura, Satoko Tajirika, Yuki Nakahata, Kenji Imai, Atsushi Suetsugu, Koji Takai, Mayumi Yamamoto, Masahito Shimizu
Summary: The aim of this study was to investigate the impact of body composition on the risk of portopulmonary hypertension in patients with liver cirrhosis using computed tomography (CT). A retrospective analysis of 148 cirrhosis patients treated at a hospital between March 2012 and December 2020 was conducted. Body composition and factors associated with high-risk portopulmonary hypertension were evaluated using logistic regression and decision tree analyses. The study found that BMI, subcutaneous adipose tissue index, and visceral adipose tissue index were associated with high-risk portopulmonary hypertension in cirrhosis patients.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cell Biology
Helaina Von Bank, Charlie Kirsh, Judith Simcox
Summary: Adipose tissue plays diverse roles in maintaining energy balance, including storing lipids in excess energy states and releasing fatty acids in energy-depleted conditions. Aging of adipose tissue leads to changes in cellular composition and function, increasing the risk of metabolic diseases in aged populations.
AGEING RESEARCH REVIEWS
(2021)
Article
Endocrinology & Metabolism
Ji-Hoon Sim, Kyung-Won Kim, Yousun Ko, Young-Jin Moon, Hye-Mee Kwon, In-Gu Jun, Sung-Hoon Kim, Kyoung-Sun Kim, Jun-Gol Song, Gyu-Sam Hwang
Summary: This study found that the visceral-to-subcutaneous fat area ratio (VSR) of both donors and recipients in LDLT is associated with HCC recurrence and mortality. High VSR in donors and recipients is significantly correlated with overall HCC recurrence and mortality.
INTERNATIONAL JOURNAL OF OBESITY
(2023)
Article
Medicine, General & Internal
Stefano Borghi, Matteo Bonato, Antonio La Torre, Giuseppe Banfi, Jacopo Antonino Vitale
Summary: This study investigated the association between lower limb strength, muscle mass and composition, and balance ability in elders. The results showed positive correlations between lower limb strength and appendicular muscle mass, as well as negative correlations between knee extensor strength and thigh intermuscular adipose tissue. Dynamic balance ability did not correlate with any morphological variables of the muscle.
Article
Nutrition & Dietetics
Mahmoud Macshut, Toshimi Kaido, Siyuan Yao, Yosuke Miyachi, Mohamed Sharshar, Sena Iwamura, Masaaki Hirata, Hisaya Shirai, Naoko Kamo, Shintaro Yagi, Shinji Uemoto
Summary: Increased visceral adiposity was identified as an independent risk factor for high intraoperative blood loss during ALDLT recipient operation. The introduction of APRNT was associated with a significant reduction in blood loss and mitigated the risk of high blood loss related to high visceral adiposity.
CLINICAL NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Yusuke Kimura, Kojiro Taura, Nguyen Hai Nam, Yusuke Uemoto, Kenji Yoshino, Yoshinobu Ikeno, Yukihiro Okuda, Takahiro Nishio, Gen Yamamoto, Kazutaka Tanabe, Yukinori Koyama, Takayuki Anazawa, Ken Fukumitsu, Takashi Ito, Shintaro Yagi, Naoko Kamo, Satoru Seo, Keiko Iwaisako, Koichiro Hata, Takumi Imai, Shinji Uemoto
Summary: The study demonstrated that M2BPGi values are strongly influenced by necroinflammatory activity in liver transplantation recipients, and revealed M2BPGi as a disease activity marker rather than just a fibrosis marker. M2BPGi measurement may be useful in detecting early-stage liver inflammation in LT recipients.
LIVER TRANSPLANTATION
(2021)
Article
Gastroenterology & Hepatology
Masaaki Hirata, Shintaro Yagi, Takero Shindo, Atsushi Yoshizawa, Gozo Kiguchi, Masakatsu Kaneshiro, Kimiko Yurugi, Yosuke Miyachi, Sena Iwamura, Siyuan Yao, Shinji Uemoto
Summary: Graft-versus-host disease (GVHD) following liver transplantation is rare but fatal. Donor-dominant one-way HLA matching at three HLA-A/B/DR loci should be avoided to prevent GVHD, while HLA-C/DQ/DP does not have a significant impact on GVHD in this study. It is important to determine HLA genotypes at the allele level for liver transplantation.
HEPATOLOGY RESEARCH
(2021)
Article
Immunology
Jiro Kusakabe, Shintaro Yagi, Kazunari Sasaki, Ryuji Uozumi, Hiroyasu Abe, Yusuke Okamura, Kojiro Taura, Toshimi Kaido, Shinji Uemoto
Summary: The study found that small-for-size grafts and large grafts in living-donor liver transplantation have similar outcomes, with a GRWR of 0.6% being a reasonable minimum requirement for graft volume. However, small grafts should be carefully indicated for high-risk cases.
Article
Gastroenterology & Hepatology
Rosanna Asselta, Elvezia M. Paraboschi, Alessio Gerussi, Heather J. Cordell, George F. Mells, Richard N. Sandford, David E. Jones, Minoru Nakamura, Kazuko Ueno, Yuki Hitomi, Minae Kawashima, Nao Nishida, Katsushi Tokunaga, Masao Nagasaki, Atsushi Tanaka, Ruqi Tang, Zhiqiang Li, Yongyong Shi, Xiangdong Liu, Ma Xiong, Gideon Hirschfield, Katherine A. Siminovitch, Marco Carbone, Giulia Cardamone, Stefano Duga, M. Eric Gershwin, Michael F. Seldin, Pietro Invernizzi
Summary: This study is the first comprehensive investigation of the chrX contribution to the genetics of an autoimmune liver disease, revealing a novel genome-wide significant locus related to PBC.
Editorial Material
Surgery
Mihai Oltean, Alexandru Nistor, Mats Hellstrom, Michael Axelsson, Shintaro Yagi, Eiji Kobayashi, Alberto Ballestin, Yelena Akelina, Norbert Nemeth
Correction
Oncology
Ryohei Takei, Tomoharu Miyashita, Satoshi Takada, Hidehiro Tajima, Itasu Ninomiya, Hiroyuki Takamura, Sachio Fushida, Ai Harashima, Seiichi Munesue, Shintaro Yagi, Noriyuki Inaki, Tetsuo Ohta, Yasuhiko Yamamoto
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Oncology
Ryohei Takei, Tomoharu Miyashita, Satoshi Takada, Hidehiro Tajima, Itasu Ninomiya, Hiroyuki Takamura, Sachio Fushida, Ai Harashima, Seiichi Munesue, Shintaro Yagi, Noriyuki Inaki, Tetsuo Ohta, Yasuhiko Yamamoto
Summary: Chronic inflammation plays a role in tumor development, including esophageal cancer. The study found that metformin could potentially suppress esophageal cancer by improving the immunosuppressive tumor microenvironment and immune evasion.
CANCER IMMUNOLOGY IMMUNOTHERAPY
(2022)
Article
Transplantation
Hiroyuki Takamura, Yoshinao Ohbatake, Sinichi Nakanuma, Hironori Hayashi, Ryousuke Gabata, Isamu Makino, Tomoharu Miyashita, Hidehiro Tajima, Shintaro Yagi, Tetsuo Ohta
Summary: The preemptive bundle therapy was effective in reducing subclinical pulmonary hypertension and extrasinusoidal platelet aggregation after liver transplant, leading to better posttransplant recovery.
EXPERIMENTAL AND CLINICAL TRANSPLANTATION
(2021)
Article
Gastroenterology & Hepatology
Tadahiro Takada, Shuji Isaji, Masahiro Yoshida, Akihiko Horiguchi, Hisami Ando, Shuichi Miyakawa, Seiki Kiriyama, Harumi Gomi, Shuntaro Mukai, Ryota Higuchi, Yuta Abe, Kohji Okamoto, Kenji Suzuki, Naoyuki Toyota, Shutaro Hori, Yuki Homma, Hiroyuki Kato, Akiko Umezawa, Jiro Hata, Dai Inoue, Motoyuki Kobayashi, Toshio Tsuyuguchi, Hirotoshi Maruo, Yusuke Kumamoto, Yukio Asano, Yuka Kondo, Satoshi Arakawa, Koji Asai, Yasuhisa Mori, Yukiko Nagamachi, Shugo Mizuno, Shintaro Yagi, Tetsuji Ohyama, Takeyuki Misawa, Keiji Sano, Takao Itoi, Nobuhiko Taniai, Michiaki Unno, Masakazu Yamamoto, Toshihiko Mayumi
Summary: This study introduced a modified Socratic method for educational seminars, focusing on a clinical scenario of moderate acute cholecystitis. By using lectures, videos, and interactive tools, participants engaged in repeated questioning and discussions, leading to a significant increase in the recognition rate of the topic. The method received high praise and is likely to be adopted by other academic societies in the future.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2022)
Correction
Gastroenterology & Hepatology
Heather J. Cordell, James J. Fryett, Kazuko Ueno, Rebecca Darlay, Yoshihiro Aiba, Yuki Hitomi, Minae Kawashima, Nao Nishida, Seik-Soon Khor, Olivier Gervais, Yosuke Kawai, Masao Nagasaki, Katsushi Tokunaga, Ruqi Tang, Yongyong Shi, Zhiqiang Li, Brian D. Juran, Elizabeth J. Atkinson, Alessio Gerussi, Marco Carbone, Rosanna Asselta, Angela Cheung, Mariza de Andrade, Aris Baras, Julie Horowitz, Manuel A. R. Ferreira, Dylan Sun, David E. Jones, Steven Flack, Ann Spicer, Victoria L. Mulcahy, Jinyoung Byun, Younghun Han, Richard N. Sandford, Konstantinos N. Lazaridis, Christopher I. Amos, Gideon M. Hirsch, Michael F. Seldin, Pietro Invernizzi, Katherine A. Siminovitch, Xiong Ma, Minoru Nakamura, George F. Mells
JOURNAL OF HEPATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Nadja Kroeger, Zoltan Czigany, Jipin Jiang, Mamdouh Afify, Pascal Paschenda, Kazuyuki Nagai, Shintaro Yagi, Rene H. Tolba
Summary: This study investigated the effects of fibrinolysis combined with Venous Systemic Oxygen Persufflation (VSOP) on the preservation of livers retrieved from donors after circulatory death (DCD). The results showed that the combination treatment improved microvascular flow, microperfusion velocity, and portal venous flow. It also reduced enzyme release and lactate dehydrogenase levels, indicating improved organ integrity and viability. The findings suggest that SK + VSOP combination treatment may be a potential therapeutic approach for DCD in the clinical setting.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Gastroenterology & Hepatology
Siyuan Yao, Shintaro Yagi, Masaaki Hirata, Yosuke Miyachi, Eri Ogawa, Ryuji Uozumi, Takuya Sugimoto, Takashi Asahara, Shinji Uemoto, Etsuro Hatano
Summary: This prospective study investigated the changes in gut microbiota and associated intestinal environment during the early period after liver transplantation. The recipients showed dysbiosis and depletion of organic acid before transplantation, which were related to the severity of liver disease. The transplantation procedure caused minimal changes in gut microbiota and organic acid concentrations in the donors, while the recipients exhibited delayed recovery in these factors.
JOURNAL OF HEPATO-BILIARY-PANCREATIC SCIENCES
(2023)
Article
Surgery
Masaaki Hirata, Shintaro Yagi, Takashi Ito, Yuki Masano, Shinya Okumura, Siyuan Yao, Yosuke Miyachi, Hikaru Aoki, Kaoru Katano, Etsuro Hatano
Summary: The present study describes an efficient five-step training protocol for rat liver transplantation (LT), which can be mastered within 3 months through continuous training. The training includes watching videos, performing actual operations, and achieving specific goals. Systematizing the training increases its efficiency, and determining the specific number of operations in advance helps maintain motivation.
EUROPEAN SURGICAL RESEARCH
(2023)
Letter
Surgery
Siyuan Yao, Shintaro Yagi
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2021)
