Article
Immunology
Zhicheng Hu, Shanqiang Qu
Summary: This study identifies the overexpression of EVA1C in glioma, which is closely associated with high infiltration levels of multiple immune cells and poor prognosis. EVA1C may serve as a potential biomarker for predicting high immune infiltration in WHO grade II/III gliomas.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Genetics & Heredity
Jiacheng Zhong, Shuang Shi, Wen Peng, Bei Liu, Biao Yang, Wenyong Niu, Biao Zhang, Chuan Qin, Dong Zhong, Hongjuan Cui, Zhengbao Zhang, Xiaochuan Sun
Summary: Using different data sets for cell and gene analysis, we found that CD138 is associated with immune infiltration in glioma, particularly activated CD4+T cells and CD8+T cells. Through gene expression analysis and survival analysis, we identified key pathways and genes associated with CD138 that are related to poor prognosis in glioma.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Stefan Koeck, Arno Amann, Johan Kern, Marit Zwierzina, Edith Lorenz, Sieghart Sopper, Heinz Zwierzina, Finn Mildner, Martina Sykora, Susanne Sprung, Hubert Hackl, Florian Augustin, Hubert T. Maier, Andreas Pircher, Georg Pall, Dominik Wolf, Gabriele Gamerith
Summary: This study investigates the impact of a whole stromal fibroblast signature on lung adenocarcinoma and finds that it is associated with improved clinical outcome. In vitro and in vivo experiments suggest that this signature increases the recruitment of B and T cells through the induction of chemokines.
Article
Oncology
Ran Ning, Shuaikang Pan, Dashu Xiao, Yan Zheng, Jinguo Zhang
Summary: The function of ANO10 in breast cancer is still unclear, but its low expression level is associated with malignant breast tumors compared to benign breast lesions. Low ANO10 expression is correlated with favorable survival outcomes and negatively correlated with infiltration of memory CD4 T cells, naive B cells, CD8 T cells, chemokines, and chemokine receptors. Additionally, the ANO10 low expression group is more sensitive to certain chemotherapy drugs. Overall, ANO10 is a potential biomarker that can effectively predict the prognosis of breast cancer and a promising prognostic indicator and therapeutic target in breast cancer treatment.
AMERICAN JOURNAL OF CANCER RESEARCH
(2023)
Article
Neurosciences
Peng Li, Fanfan Chen, Chen Yao, Kezhou Zhu, Bei Zhang, Zelong Zheng
Summary: PTPRN is a potential biomarker and correlates with tumor immune infiltration in LGG.
Article
Cell Biology
Yinfang Li, Ling Zou, Xuejun Liu, Judong Luo, Hui Liu
Summary: A novel immune-related prognostic index (IRGPI) was developed based on transcriptomic profiles to predict immune infiltration level, response to ICI treatment, and overall survival in HCC patients. Low-risk patients had better survival compared to high-risk patients, with the latter being associated with higher TP53 mutation rates and immune-suppressing tumor microenvironment.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Oncology
De Luo, Fei Kuang, Juan Du, Mengjia Zhou, Fangyi Peng, Yu Gan, Cheng Fang, Xiaoli Yang, Bo Li, Song Su
Summary: The study reveals a close association between immune cell infiltration patterns and prognosis in pancreatic carcinoma patients, with those having low ICI scores showing better outcomes. Furthermore, low tumor mutation burden is linked to improved overall survival. A high ICI score is characterized by reduced expression of immune-related genes, suppression of metabolic pathways, and poor prognosis.
FRONTIERS IN ONCOLOGY
(2021)
Article
Oncology
Carlo Sorrentino, Stefania Livia Ciummo, Luigi D'Antonio, Cristiano Fieni, Paola Lanuti, Alice Turdo, Matilde Todaro, Emma Di Carlo
Summary: IL30 plays a crucial role in regulating the viability and growth of breast cancer stem cells (BCSC) through juxtacrine signals and mediators such as CXCL10 and IL23. Targeting IL30 could potentially restrain the BCSC compartment and counteract breast cancer progression by disrupting its autocrine loops and immune subversion pathways.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Oncology
Xingkui Tang, Minling Liu, Xijun Luo, Mengyuan Zhu, Shan Huang, Xiaofen Pan
Summary: In this study, a prognostic predictive model based on tumor microenvironment was constructed, revealing a correlation between immune cell infiltration landscape and survival in colon cancer patients. The high ICI score group showed enrichment in specific pathways and better survival, with the prognostic value of ICI score being independent of tumor mutational burden.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Jianwei Zhang, Silu Meng, Xiuqing Zhang, Kang Shao, Cong Lin
Summary: This study provides a comprehensive overview of the infiltration patterns of microenvironment cells throughout cervical cancer progression, revealing changes in abundance and activation status of immune cells, which contributes to a better understanding of the mechanisms involved in cervical cancer.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Qian Long, Chunyu Huang, Jinsheng Huang, Qi Meng, Yanjun Cheng, Yilin Li, Liru He, Miao Chen, Changlin Zhang, Xiaonan Wang, Wancui Zhu, Jin Peng, Dingbo Shi, Fufu Zheng, Pei Dong, Wuguo Deng
Summary: This study investigates the biological and clinical significance of JAK3 promoter methylation in clear cell renal cell carcinoma (ccRCC). The results show that JAK3 promoter is significantly hypomethylated in ccRCC tumor tissues and is strongly correlated with high JAK3 mRNA expression. JAK3 promoter hypomethylation predicts advanced clinicopathological characteristics and shorter overall survival. Furthermore, JAK3 promoter methylation is associated with immune cell infiltration and expression of immune checkpoint molecules. The findings suggest that JAK3 promoter methylation may serve as a molecular biomarker for predicting responses to immune checkpoint inhibitors in ccRCC.
JOURNAL OF ADVANCED RESEARCH
(2022)
Review
Oncology
Yan Tie, Fan Tang, Yu-quan Wei, Xia-wei Wei
Summary: Immunotherapies are effective for treating advanced cancers, but some patients are resistant to these therapies. Targeting immunosuppressive cells and related signals is a promising strategy to enhance the efficacy of immunotherapies.
JOURNAL OF HEMATOLOGY & ONCOLOGY
(2022)
Article
Engineering, Multidisciplinary
Cuidi Li, Zhenjiang Ma, Wentao Li, Tianyang Jie, Liping Zhong, Hongfang Chen, Wenhao Wang, Jinwu Wang, Wenguo Cui, Yongxiang Zhao
Summary: The study combines self-assembled vaccines with 3D-printed scaffolds to activate local antigen-specific immune responses. The results show that this method effectively recruits and activates immune cells, promoting angiogenesis and bone regeneration.
Review
Immunology
Ellen N. Scott, Angela M. Gocher, Creg J. Workman, Dario A. A. Vignali
Summary: Regulatory T cells utilize multiple suppressive mechanisms to hinder effector immune responses within the tumor microenvironment, creating a physical and biological barrier that results in immune exclusion or limitation within the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Jingjia Chang, Hao Wu, Jin Wu, Ming Liu, Wentao Zhang, Yanfen Hu, Xintong Zhang, Jing Xu, Li Li, Pengfei Yu, Jianjun Zhu
Summary: This study systematically analyzed the expression and prognostic value of mitochondrial-related genes in stomach adenocarcinoma patients. A mitochondrial-related risk model was established based on available databases and was validated for its predictive power. The results showed that the risk model was associated with immune cell infiltration, tumor microenvironment, and immune checkpoint molecules. Additionally, certain drugs were found to be more effective for patients in different risk groups.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Daniel Reimer, Maximilian Boesch, Dominik Wolf, Christian Marth, Sieghart Sopper, Jiri Hatina, Peter Altevogt, Walther Parson, Hubert Hackl, Alain G. Zeimet
INTERNATIONAL JOURNAL OF CANCER
(2018)
Meeting Abstract
Oncology
G. Gamerith, H. Hackl, P. Wallinger, L. Fandel, J. Kern, F. Augustin, E. Lorenz, E. Hoflehner, F. Mildner, P. Moser, S. Sprung, B. Zelger, S. Koeck, A. Amann, G. Schaefer, D. Oefner, H. Maier, Z. Trajanoski, H. Zwierzina, S. Sopper
EUROPEAN JOURNAL OF CANCER
(2018)
Correction
Immunology
Aimin Wu, Piotr Tymoszuk, David Haschka, Simon Heeke, Stefanie Dichtl, Verena Petzer, Markus Seifert, Richard Hilbe, Sieghart Sopper, Heribert Talasz, Dirk Bumann, Cornelia Lass-Floerl, Igor Theurl, Keying Zhang, Guenter Weiss
INFECTION AND IMMUNITY
(2018)
Review
Biochemistry & Molecular Biology
Maximilian Boesch, Florent Baty, Holger Rumpold, Sieghart Sopper, Dominik Wolf, Martin H. Brutsche
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2019)
Article
Oncology
Dominik Wolf, Heidi Fiegl, Alain G. Zeimet, Verena Wieser, Christian Marth, Susanne Sprung, Sieghart Sopper, Gunther Hartmann, Daniel Reimer, Maximilian Boesch
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Hematology
Verena Petzer, Piotr Tymoszuk, Malte Asshoff, Joana Carvalho, Jonathan Papworth, Cecilia Deantonio, Luke Bayliss, Matthew Stephen Wake, Markus Seifert, Natascha Brigo, Lara Valente de Souza, Richard Hilbe, Philipp Grubwieser, Egon Demetz, Stefanie Dichtl, Chiara Volani, Sylvia Berger, Felix Boehm, Alexander Hoffmann, Christa Pfeifhofer-Obermair, Laura von Raffay, Sieghart Sopper, Stephanie Arndt, Anja Bosserhoff, Leon Kautz, Prunelle Perrier, Manfred Nairz, Dominik Wolf, Guenter Weiss, Volker Germaschewski, Igor Theurl
Review
Oncology
Finn Mildner, Sieghart Sopper, Arno Amann, Andreas Pircher, Georg Pall, Stefan Koeck, Erin Naismith, Dominik Wolf, Gabriele Gamerith
CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY
(2020)
Article
Cardiac & Cardiovascular Systems
Egon Demetz, Piotr Tymoszuk, Richard Hilbe, Chiara Volani, David Haschka, Christiane Heim, Kristina Auer, Daniela Lener, Lucas B. Zeiger, Christa Pfeifhofer-Obermair, Anna Boehm, Gerald J. Obermair, Cornelia Ablinger, Stefan Coassin, Claudia Lamina, Juliane Kager, Verena Petzer, Malte Asshoff, Andrea Schroll, Manfred Nairz, Stefanie Dichtl, Markus Seifert, Laura von Raffay, Christine Fischer, Marina Barros-Pinkelnig, Natascha Brigo, Lara Valente de Souza, Sieghart Sopper, Jakob Hirsch, Michael Graber, Can Gollmann-Tepekoeylue, Johannes Holfeld, Julia Halper, Sophie Macheiner, Johanna Gostner, Georg F. Vogel, Raimund Pechlaner, Patrizia Moser, Medea Imboden, Pedro Marques-Vidal, Nicole M. Probst-Hensch, Heike Meiselbach, Konstantin Strauch, Annette Peters, Bernhard Paulweber, Johann Willeit, Stefan Kiechl, Florian Kronenberg, Igor Theurl, Ivan Tancevski, Guenter Weiss
EUROPEAN HEART JOURNAL
(2020)
Article
Neurosciences
Pia Koudouovoh-Tripp, Katharina Huefner, Jonas Egeter, Christina Kandler, Johannes M. Giesinger, Sieghart Sopper, Christian Humpel, Barbara Sperner-Unterweger
Summary: Chronic mental stress is associated with increased state anxiety, depressive symptoms, and perceived stress, as well as enhanced proinflammatory platelet activity. Acute mental stress can alter platelet bioactivity and aggregation. Both chronic and acute mental stress have significant impacts on platelets, potentially linking mental and somatic disorders.
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2021)
Article
Surgery
S. Gasteiger, F. Primavesi, G. Goebel, E. Braunwarth, B. Cardini, M. Maglione, S. Sopper, D. Oefner, S. Staettner
WORLD JOURNAL OF SURGERY
(2020)
Article
Multidisciplinary Sciences
Silvia Gasteiger, Florian Primavesi, Peter Werkl, Lucie Dostal, Philipp Gehwolf, Eva Braunwarth, Manuel Maglione, Sieghart Sopper, Dietmar Oefner, Stefan Staettner
Article
Biochemical Research Methods
Maximilian Boesch, Martina Sykora, Silvia Gasteiger, Florent Baty, Martin H. Brutsche, Sieghart Sopper
Summary: This optimized multicolor immunofluorescence panel is designed to efficiently identify and quantify various leukocyte populations in human blood with minimal markers. It offers high performance, is suitable for whole blood, and widely applicable for immune cell identification, quantification, and characterization.
Review
Oncology
Erin Naismith, Janine Steichen, Sieghart Sopper, Dominik Wolf
Summary: NK cells play a crucial role in managing Ph+ and Ph- MPNs, contributing significantly to tumor control. However, their functionality may be altered during MPN treatment, highlighting the importance of further research on their role and associated changes in therapy.
Editorial Material
Immunology
Florian Hornsteiner, Martina M. Sykora, Christoph H. Tripp, Sieghart Sopper, Patrizia Stoitzner
EUROPEAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
David Haschka, Verena Petzer, Florian Kocher, Christoph Tschurtschenthaler, Benedikt Schaefer, Markus Seifert, Sieghart Sopper, Thomas Sonnweber, Clemens Feistritzer, Tara L. Arvedson, Heinz Zoller, Reinhard Stauder, Igor Theurl, Guenter Weiss, Piotr Tymoszuk