Article
Oncology
Qing Chen, Jiahong Lei, Jinzhe Zhou, Shaoze Ma, Qi Huang, Bujun Ge
Summary: The study demonstrated that 4'-hydroxychalcone (4-HC) had a significant chemopreventive effect against intestinal tumorigenesis in a transgenic mouse model, reducing the number and size of adenomas and inhibiting proliferation while promoting apoptosis in colon adenomas. Additionally, 4-HC treatment downregulated the expression of beta-catenin target genes, implicating the Wnt/beta-catenin signaling pathway in the development of colon neoplasms. Further research is needed to evaluate the clinical potential of 4-HC as a chemopreventive agent.
Article
Gastroenterology & Hepatology
Marianne Lahde, Sarika Heino, Jenny Hogstrom, Seppo Kaijalainen, Andrey Anisimov, Dustin Flanagan, Pauliina Kallio, Veli-Matti Leppanen, Ari Ristimaki, Olli Ritvos, Katherine Wu, Tuomas Tammela, Michael Hodder, Owen J. Sansom, Kari Alitalo
Summary: Expression of RSPO1 in ApcMin/thorn mice increases apoptosis and reduces proliferation and Wnt signaling in adenoma cells, resulting in development of fewer and smaller intestinal tumors and longer mouse survival.
Article
Biochemistry & Molecular Biology
Haruki Horiguchi, Tsuyoshi Kadomatsu, Shinsei Yumoto, Takeshi Masuda, Keishi Miyata, Shuji Yamamura, Michio Sato, Jun Morinaga, Sumio Ohtsuki, Hideo Baba, Toshiro Moroishi, Yuichi Oike
Summary: Tumor cell-derived ANGPTL2 promotes beta-catenin-driven intestinal tumorigenesis by upregulating OB-cadherin expression and blocking destruction complex-independent proteasomal degradation of beta-catenin proteins. It also leads to decreased cell surface integrin alpha 5 beta 1 expression.
Article
Oncology
Qun Zhao, Jian Guo, Guizhen Wang, Yun Bi, Xinran Cheng, Yingying Liao, Shu Jin, Lian Li, Yang Guo, Longrui Pan, Xudong Zhang, Yan Tan, Guangbiao Zhou, Xianjun Yu
Summary: This study revealed that the inhibition of CXCL13 in colorectal cancer has a mitigating effect on disease progression by promoting intestinal tumorigenesis through the activation of the AKT signaling pathway. Intestinal microbiota translocation drives CXCL13 production in dendritic cells through the activation of NF-kappa B signaling. Inhibition of microbiota translocation reduces CXCL13 production and ameliorates intestinal tumorigenesis.
Article
Endocrinology & Metabolism
Hongyun Zhao, Da Teng, Lifeng Yang, Xincheng Xu, Jiajia Chen, Tengjia Jiang, Austin Y. Feng, Yaqing Zhang, Dennie T. Frederick, Lei Gu, Li Cai, John M. Asara, Marina Pasca di Magliano, Genevieve M. Boland, Keith T. Flaherty, Kenneth D. Swanson, David Liu, Joshua D. Rabinowitz, Bin Zheng
Summary: This study reveals that itaconate, produced by myeloid-derived suppressor cells (MDSCs), acts as an immune checkpoint metabolite to suppress CD8(+) T cells. Inhibition of IRG1 may enhance anti-tumour immunity and improve the efficacy of immune checkpoint blockade. These findings have implications for understanding immune surveillance and developing new strategies for cancer treatment.
Review
Medicine, General & Internal
Jun Sun
Summary: Intestinal bacteria play an important role in the development of colorectal cancer, but identifying the specific causative microorganisms remains challenging. This review focuses on the progress of bacterial infection and colorectal cancer, as well as the microbial contribution to cancer characteristics.
CHINESE MEDICAL JOURNAL
(2022)
Article
Multidisciplinary Sciences
Bogang Wu, Xiaowen Zhang, Huai-Chin Chiang, Haihui Pan, Bin Yuan, Payal Mitra, Leilei Qi, Hayk Simonyan, Colin N. Young, Eric Yvon, Yanfen Hu, Nu Zhang, Rong Li
Summary: Negative elongation factor B (NELFB) associates with T cell transcription factor TCF1 to regulate CD8 + T cell memory and anti-tumor immune responses. NELF cooperates with TCF1 in T cell responses to cancer by controlling RNA polymerase II pausing and chromatin accessibility at TCF1 target gene loci.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Helena Rannikmae, Samantha Peel, Simon Barry, Takao Senda, Marc de la Roche
Summary: The Apc protein regulates key effector pathways for tissue homeostasis, with truncating mutations leading to intestinal epithelial tumorigenesis by affecting Wnt pathway and microtubule dynamics. While Wnt pathway plays a role in cell proliferation, Apc also controls epithelial morphology independently of Wnt-responsive Myc-335 element, and disrupts microtubule cytoskeleton without affecting actin cytoskeleton distribution. This study identifies three independent Apc effector pathways in intestinal epithelial regulation: proliferation, microtubule dynamics, and epithelial morphology.
JOURNAL OF CELL SCIENCE
(2021)
Article
Cell Biology
Qiang Zhang, Xiaoya Yang, Jinjie Wu, Shubiao Ye, Junli Gong, Wai Ming Cheng, Zhanhao Luo, Jing Yu, Yugeng Liu, Wanyi Zeng, Chen Liu, Zhizhong Xiong, Yuan Chen, Zhen He, Ping Lan
Summary: Metabolic enzyme ACOX1 suppresses colorectal cancer progression by regulating palmitic acid reprogramming. ACOX1 is highly downregulated in CRC, and its depletion promotes cell proliferation and tumor growth while overexpression inhibits tumor growth. DUSP14 dephosphorylates ACOX1, leading to increased levels of ACOX1 substrate palmitic acid.
Article
Oncology
Carmen R. Ferrara, Ji Dong K. Bai, Erin M. McNally, Gregory G. Putzel, Xi Kathy Zhou, Hanhan Wang, Alan Lang, Deborah Nagle, Paula Denoya, Jan Krumsiek, Andrew J. Dannenberg, David C. Montrose
Summary: Bacteria and metabolites are important in intestinal tumorigenesis, and celecoxib can suppress intestinal tumor development by altering gut bacteria and metabolites. The use of broad-spectrum antibiotics reduced gut bacteria abundance and attenuated the inhibitory effects of celecoxib on intestinal tumorigenesis. Antibiotics also affected microbial populations and gut luminal and circulating metabolites. Patients with colon cancer treated with antibiotics also showed alterations in blood metabolites. These findings suggest the potential role of bacterial metabolites in mediating the chemopreventive effects of celecoxib and intestinal tumor growth.
CANCER PREVENTION RESEARCH
(2022)
Article
Medicine, Research & Experimental
Keigo Kawashima, Masanori Isogawa, Masaya Onishi, Ian Baudi, Satoru Saito, Atsushi Nakajima, Takashi Fujita, Yasuhito Tanaka
Summary: The study found that interferon-stimulated gene expression was selectively suppressed in intrahepatically primed HBV-specific CD8(+) T cells, leading to dysfunction, possibly due to impaired IFN-1 signaling. Strong induction of type I interferons in the liver facilitated functional differentiation of these T cells by restoring ISGs expression. This suggests a potential therapeutic value of inducing intrahepatic IFN-ls for chronic HBV infection treatment.
Article
Cell Biology
Yu-Jung Lu, Palmira Barreira-Silva, Shayla Boyce, Jennifer Powers, Kelly Cavallo, Samuel M. Behar
Summary: CD4 T cells play a crucial role in immunity to tuberculosis by enhancing CD8 effector functions and preventing exhaustion, promoting the survival of infected mice. Vaccines that elicit both CD4 and CD8 T cells are more likely to be successful in generating protective responses against M. tuberculosis infection.
Article
Biochemistry & Molecular Biology
Joohyeong Lee, Eunmi Kim, Min-Kyung Kang, Jihye Ryu, Ji Eon Kim, Eun-Ae Shin, Yangie Pinanga, Kyung-hee Pyo, Haesong Lee, Eun Hae Lee, Heejin Cho, Jayeon Cheon, Wonsik Kim, Eek-Hoon Jho, Semi Kim, Jung Weon Lee
Summary: Overexpression of TM4SF5 exacerbates pathological abnormalities in both the colon and liver, including intestinal adenomas, carcinomas, sinusoidal dilatation, and fibrosis.
Article
Chemistry, Multidisciplinary
Liansheng Liu, Yalong Wang, Shicheng Yu, Huidong Liu, Yehua Li, Shan Hua, Ye-Guang Chen
Summary: In the absence of Smad4, TGF-beta promotes colonic inflammation and tumorigenesis. TGF-beta 1 stimulates spheroid formation and impairs intestinal stem cell proliferation and lineage specification. YAP mediates the effect of TGF-beta 1 by interacting with Smad2/3.
Article
Chemistry, Multidisciplinary
Rui Li, Walida Ali, Chao Ma, Apratim Bajpai, Ngoc Luu, Aarushi Varshney, Camden Riley Rowe, Weiqiang Chen
Summary: The strategic functionalization of the Wnt5a mimetic peptide ligand Foxy5 on a polydimethylsiloxane elastomer substrate enhances mechanotransduction and activation of cytotoxic CD8(+) T cells by triggering noncanonical Wnt signaling. This innovative mechanoregulatory ligand platform has broad applications in fundamental mechano-immunology research and the development of novel immunotherapies.
CHEMICAL COMMUNICATIONS
(2021)