期刊
MOLECULAR METABOLISM
卷 6, 期 9, 页码 1052-1065出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.molmet.2017.04.011
关键词
Leptin; Diabetes; Glucose metabolism
资金
- Canadian Institutes of Health Research
- Natural Sciences and Engineering Research Council of Canada
Background: The hormone leptin is an important regulator of metabolic homeostasis, able to inhibit food intake and increase energy expenditure. Leptin can also independently lower blood glucose levels, particularly in hyperglycemic models of leptin or insulin deficiency. Despite significant efforts and relevance to diabetes, the mechanisms by which leptin acts to regulate blood glucose levels are not fully understood. Scope of review: Here we assess literature relevant to the glucose lowering effects of leptin. Leptin receptors are widely expressed in multiple cell types, and we describe both peripheral and central effects of leptin that may be involved in lowering blood glucose. In addition, we summarize the potential clinical application of leptin in regulating glucose homeostasis. Major conclusions: Leptin exerts a plethora of metabolic effects on various tissues including suppressing production of glucagon and corticosterone, increasing glucose uptake, and inhibiting hepatic glucose output. A more in-depth understanding of the mechanisms of the glucose lowering actions of leptin may reveal new strategies to treat metabolic disorders. (C) 2017 The Authors. Published by Elsevier GmbH.
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