Article
Cardiac & Cardiovascular Systems
Mingming Yang, Toru Kondo, Jawad H. Butt, William T. Abraham, Inder S. Anand, Akshay S. Desai, Lars Kober, Milton Packer, Marc A. Pfeffer, Jean L. Rouleau, Marc S. Sabatine, Scott D. Solomon, Karl Swedberg, Michael R. Zile, Pardeep S. Jhund, John J. McMurray
Summary: Patients with heart failure who have a history of stroke are at a high risk of subsequent cardiovascular events, regardless of ejection fraction. This study investigated the prevalence of stroke history in patients with heart failure and found that they had more vascular comorbidity and worse heart failure compared to those without stroke history. Targeting underutilization of guideline-recommended treatments might improve outcomes in this high-risk population.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Yogesh N. Reddy, Barry A. Borlaug, Bernard J. Gersh
Summary: Atrial fibrillation is the most common arrhythmia in heart failure patients and can be both the cause and consequence of clinical heart failure. Some patients may benefit from maintaining sinus rhythm with catheter ablation. There is a close relationship between atrial fibrillation, left atrial myopathy, mitral regurgitation, and heart failure with preserved ejection fraction, with potential clinical benefits to catheter ablation therapy. Treatment of atrial fibrillation also requires consideration of the degree of atrial myopathy and chronicity of atrial fibrillation.
Article
Cardiac & Cardiovascular Systems
Ning Ding, Amil M. Shah, Michael J. Blaha, Patricia P. Chang, Wayne D. Rosamond, Kunihiro Matsushita
Summary: This study aimed to evaluate the association between smoking and different phenotypes of heart failure. The results showed a significant association between smoking and the incidence of HFpEF and HFrEF, and smoking cessation significantly reduced the risk of HF.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Letter
Medicine, General & Internal
Elric Zweck, Ralf Westenfeld, Bjorn Redfors, Elmir Omerovic, Robin A. P. Weir, Domenico Gabrielli, Fabrizio Oliva, Giuseppe Zuccala, Scott D. Solomon, Muthiah Vaduganathan, John J. V. McMurray
Summary: Solomon et al. report on the DELIVER trial, which showed that dapagliflozin reduced risks of heart failure-related outcomes in patients with a mildly reduced or preserved left ventricular ejection fraction. These findings are expected to influence guidelines and clinical practice. The trial also confirmed dapagliflozin's efficacy in patients with a left ventricular ejection fraction of 60% or above.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Letter
Medicine, General & Internal
Debdatta Bhattacharyya, Ayan Kar, Saurabh Dhumale, Filippos K. Triposkiadis, Andrew Xanthopoulos, Efstathios K. Iliodromitis, James Amato, Hiddo J. L. Heerspink, Lesley Inker, Tom Greene, Stefan D. Anker, Javed Butler, Milton Packer
Summary: In patients with heart failure and preserved ejection fraction, Empagliflozin reduced the incidence of primary outcome events compared to other drugs, but had higher rates of cardiovascular death, death from any cause, and hospitalization for heart failure compared to spironolactone.
NEW ENGLAND JOURNAL OF MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Li Shen, Pardeep Singh Jhund, Kieran Francis Docherty, Muthiah Vaduganathan, Mark Colquhoun Petrie, Akshay Suvas Desai, Lars Kober, Morten Schou, Milton Packer, Scott David Solomon, Xingwei Zhang, John Joseph Valentine McMurray
Summary: Previous guidelines for treating heart failure with reduced ejection fraction recommended initiating therapy in a chronological order based on trial history. However, this study suggests that accelerating treatment titration and optimizing treatment ordering may improve patient outcomes.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Mikhail N. Kosiborod, Ankeet S. Bhatt, Brian L. Claggett, Muthiah Vaduganathan, Ian J. Kulac, Carolyn S. P. Lam, Adrian F. Hernandez, Felipe A. Martinez, Silvio E. Inzucchi, Sanjiv J. Shah, Rudolf A. de Boer, Pardeep S. Jhund, Akshay S. Desai, James C. Fang, Yaling Han, Josep Comin-Colet, Orly Vardeny, Daniel Lindholm, Ulrica Wilderaeng, Olof Bengtsson, John J. V. McMurray, Scott D. Solomon
Summary: In the DELIVER trial, dapagliflozin was found to significantly improve the health status of heart failure patients, as assessed by the Kansas City Cardiomyopathy Questionnaire. The effects were particularly pronounced in patients with higher baseline symptom burden.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Sebastian Rosch, Karl-Patrik Kresoja, Christian Besler, Karl Fengler, Anne Rebecca Schoeber, Maximilian von Roeder, Christian Luecke, Matthias Gutberlet, Karin Klingel, Holger Thiele, Karl-Philipp Rommel, Philipp Lurz
Summary: In this study, patients with heart failure with preserved ejection fraction (HFpEF) were stratified based on left ventricular ejection fraction (LVEF), resulting in distinct morphologic and pathophysiologic subphenotypes. Patients with LVEF ranging from 50% to 60% demonstrated reduced contractility, impaired ventriculo-arterial coupling, and higher extracellular volume fraction, while patients with LVEF >60% exhibited a hypercontractile state with excessive left ventricular afterload and diminished preload reserve.
Article
Cardiac & Cardiovascular Systems
Bharathi Upadhya, James J. Willard, Laura C. Lovato, Michael V. Rocco, Cora E. Lewis, Suzanne Oparil, William C. Cushman, Jeffrey T. Bates, Natalie A. Bello, Gerard Aurigemma, Karen C. Johnson, Carlos J. Rodriguez, Dominic S. Raj, Anjay Rastogi, Leonardo Tamariz, Alan Wiggers, Dalane W. Kitzman
Summary: In the SPRINT study, intensive blood pressure treatment reduced acute decompensated HFpEF and HFrEF events. After initial incident ADHF, subsequent hospital admission and mortality rates were high and similar for patients who developed HFpEF or HFrEF. Randomization to the intensive arm did not change the risks for subsequent all-cause or HF events in either HFpEF or HFrEF, with age and Black race being independent predictors of clinical outcomes for those who developed HFpEF.
CIRCULATION-HEART FAILURE
(2021)
Article
Cardiac & Cardiovascular Systems
Safia Chatur, Muthiah Vaduganathan, Brian Claggett, Orly Vardeny, Akshay S. Desai, Pardeep S. Jhund, Rudolf A. de Boer, Carolyn S. P. Lam, Mikhail N. Kosiborod, Sanjiv J. Shah, Felipe Martinez, Silvio E. Inzucchi, Adrian F. Hernandez, Tariq Haddad, Sumeet S. Mitter, Zi Michael Miao, Magnus Petersson, Anna Maria Langkilde, John J. McMurray, Scott D. Solomon
Summary: In this study, the safety and efficacy of dapagliflozin were evaluated according to different diuretic therapies and its influence on diuretic use. The results showed that dapagliflozin had consistent clinical benefits in terms of reducing heart failure worsening and cardiovascular death across different diuretic categories and doses, with a similar safety profile. Dapagliflozin also significantly reduced the need for loop diuretics over time.
EUROPEAN HEART JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Jawad H. Butt, Toru Kondo, Pardeep S. Jhund, Josep Comin-Colet, Rudolf A. de Boer, Akshai S. Desai, Adrian F. Hernandez, Silvio E. Inzucchi, Stefan P. Janssens, Mikhail N. Kosiborod, Carolyn S. P. Lam, Anna Maria Langkilde, Daniel Lindholm, Felipe Martinez, Magnus Petersson, Sanjiv J. Shah, Jorge Thierer, Muthiah Vaduganathan, Subodh Verma, Ulrica Wilderang, Brian C. Claggett, Scott D. Solomon, John J. V. McMurray
Summary: This study examined the effects of dapagliflozin in patients with atrial fibrillation (AF) and found that its benefits were consistent across different types of AF.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2022)
Article
Medicine, General & Internal
Anita Pinter, Anett Behon, Boglarka Veres, Eperke Dora Merkel, Walter Richard Schwertner, Luca Katalin Kuthi, Richard Masszi, Balint Karoly Lakatos, Attila Kovacs, David Becker, Bela Merkely, Annamaria Kosztin
Summary: Data on the relevance of anemia in heart failure patients with an ejection fraction > 40% is scarce. This study found that anemia is an important predictor of mortality in HFpEF-HFmrEF and HFrecEF patients.
Article
Cardiac & Cardiovascular Systems
Barry A. Borlaug, Kavita Sharma, Sanjiv J. Shah, Jennifer E. Ho
Summary: The incidence and prevalence of heart failure with preserved ejection fraction (HFpEF) is increasing due to aging, obesity, sedentariness, and cardiometabolic disorders. Despite recent advances in understanding its pathophysiological effects and introduction of new diagnosis approaches, HFpEF remains under-recognized. This is concerning as effective treatments have been identified. This article provides an in-depth examination of the epidemiology, pathophysiology, diagnosis, and treatment of HFpEF. (J Am Coll Cardiol 2023;81:1810-1834) (c) 2023 by the American College of Cardiology Foundation.
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Yi Tang, Haiqiang Sang
Summary: This study aimed to evaluate the economics and effectiveness of adding empagliflozin to standard therapy for heart failure in China. The results showed that adding empagliflozin was slightly more cost-effective in the treatment of heart failure.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Takahiro Jimba, Shun Kohsaka, Masao Yamasaki, Toshiaki Otsuka, Kazumasa Harada, Yasuyuki Shiraishi, Shinji Koba, Makoto Takei, Takashi Kohno, Kenichi Matsushita, Tetsuro Miyazaki, Satoshi Kodera, Shigeto Tsukamoto, Kiyoshi Iida, Akito Shindo, Daisuke Kitano, Takeshi Yamamoto, Ken Nagao, Morimasa Takayama
Summary: This study found a correlation between lower ambient temperature and a higher frequency of admissions for acute heart failure (AHF), with a more pronounced effect in patients with preserved and mildly reduced ejection fraction (HFpEF and HFmrEF) compared to those with reduced ejection fraction (HFrEF).
Article
Cardiac & Cardiovascular Systems
Youngjin Cho, Il-Young Oh, Jin Joo Park, Byung-Hee Oh, Eun-Seok Jeon, Jae-Joong Kim, Kyung-Kuk Hwang, Myeong-Chan Cho, Shung Chull Chae, Sang Hong Baek, Seok-Min Kang, Byung-Su Yoo, Youngkeun Ahn, Dong-Ju Choi
Summary: This study shows that successful restoration of sinus rhythm is associated with lower mortality and heart failure rehospitalization in patients with acute heart failure.
CARDIOLOGY JOURNAL
(2022)
Correction
Cardiac & Cardiovascular Systems
Wonse Kim, Jin Joo Park, Hae-Young Lee, Kye Hun Kim, Byung-Su Yoo, Seok-Min Kang, Sang Hong Baek, Eun-Seok Jeon, Jae-Joong Kim, Myeong-Chan Cho, Shung Chull Chae, Byung-Hee Oh, Woong Kook, Dong-Ju Choi
CLINICAL RESEARCH IN CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Kyung An Kim, Eui-Soon Kim, Jong-Chan Youn, Hye Sun Lee, Soyoung Jeon, Hae-Young Lee, Hyun-Jai Cho, Jin-Oh Choi, Eun-Seok Jeon, Sang Eun Lee, Min-Seok Kim, Jae-Joong Kim, Kyung-Kuk Hwang, Myeong-Chan Cho, Shung Chull Chae, Seok-Min Kang, Dong-Ju Choi, Byung-Su Yoo, Kye Hun Kim, Byung-Hee Oh, Sang Hong Baek
Summary: This study evaluated the dose-response relationship between renin-angiotensin system blockers (RASBs) or beta-blockers (BBs) and survival in patients with acute heart failure syndrome (AHFS). The results showed that the use of RASBs at discharge was associated with a significant reduction in all-cause mortality risk in AHFS patients with reduced ejection fraction, while BBs did not have a significant impact. This highlights the importance of initiating and increasing the dose of RASBs to the maximally tolerated dose in AHFS patients during the transition period.
EUROPEAN HEART JOURNAL-CARDIOVASCULAR PHARMACOTHERAPY
(2022)
Article
Medicine, General & Internal
Nuri Lee, Jae Yeong Cho, Kye Hun Kim, Hyung Yoon Kim, Hyun-Jai Cho, Hae-Young Lee, Eun-Seok Jeon, Jae-Joong Kim, Myeong-Chan Cho, Shung Chull Chae, Sang Hong Baek, Seok-Min Kang, Dong-Ju Choi, Byung-Su Yoo, Byung-Hee Oh
Summary: This study aimed to evaluate the impact of cardiac troponin (TnI) on mortality in patients with acute heart failure and compare between ischemic and non-ischemic heart failure. The results showed that elevated TnI was associated with increased all-cause mortality regardless of the etiology of heart failure.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Oncology
Seon-Hwa Lee, Iksung Cho, Seng-Chan You, Min-Jae Cha, Jee-Suk Chang, William D. Kim, Kyu-yong Go, Dae-Young Kim, Jiwon Seo, Chi-Young Shim, Geu-Ru Hong, Seok-Min Kang, Jong-Won Ha, Sun-Young Rha, Hyo-Song Kim
Summary: Immune checkpoint inhibitors (ICIs), when used in conjunction with cardiotoxic agents, may increase the risk of cancer therapy-related cardiac dysfunction (CTRCD). Monitoring for CTRCD using cardiac biomarkers and echocardiography is recommended for patients receiving ICIs.
Article
Biology
Hyo-In Choi, Sang Eun Lee, Min-Seok Kim, Hae-Young Lee, Hyun-Jai Cho, Jin Oh Choi, Eun-Seok Jeon, Kyung-Kuk Hwang, Shung Chull Chae, Sang Hong Baek, Seok-Min Kang, Dong-Ju Choi, Byung-Su Yoo, Kye Hun Kim, Myeong-Chan Cho, Byung-Hee Oh, Jae-Joong Kim
Summary: This study investigated the prognostic impact and predictors of new-onset atrial fibrillation (NOAF) in acute heart failure (HF) patients. NOAF was associated with decreased survival in acute HF patients with sinus rhythm. Age, worsening HF, valvular heart disease (VHD), loop diuretics, lower heart rate, larger left atrium (LA) diameter, and elevated creatinine could independently predict NOAF.
Article
Peripheral Vascular Disease
Kyeong-Hyeon Chun, Jung Mi Park, Chan Joo Lee, Jaewon Oh, Sungha Park, Seok-Min Kang, Sang-Hak Lee
Summary: Statin use was not associated with cardiovascular risk reduction in high-risk individuals with normal or near normal coronary arteries.
JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS
(2022)
Review
Endocrinology & Metabolism
Kyu-Sun Lee, Junghyun Noh, Seong-Mi Park, Kyung Mook Choi, Seok-Min Kang, Kyu-Chang Won, Hyun-Jai Cho, Min Kyong Moon
Summary: Diabetes mellitus is a significant risk factor for heart failure, with worse prognosis in diabetic patients. Early diagnosis and proper management of heart failure in diabetic patients are crucial. This review discusses the diagnosis criteria, screening tools, recommended pharmacological therapies, and effects of anti-diabetic medications on heart failure.
DIABETES & METABOLISM JOURNAL
(2023)
Article
Cardiac & Cardiovascular Systems
Minkwan Kim, Chan Joo Lee, Hye-Jin Kang, Nak-Hoon Son, SungA Bae, Jiwon Seo, Jaewon Oh, Se-Joong Rim, In Hyun Jung, Eui-Young Choi, Seok-Min Kang
Summary: This study aimed to evaluate the impact of red cell distribution width (RDW) on the prognosis of patients with heart failure. The results showed that elevated RDW at the time of diagnosis was associated with poor prognosis in patients with heart failure, independent of clinical risk factors and echocardiographic parameters. RDW may have important implications in the management of patients with heart failure.
Article
Cell & Tissue Engineering
Sae-Bom Jeon, Hyoeun Kim, Kyeong-Hyeon Chun, Jaewon Oh, Chulan Kwon, Hyo-Kyoung Choi, Sangwoo Kim, Hyoung-Pyo Kim, In-Cheol Kim, Jung-Yoon Yoo, Sahng Wook Park, Seok-Min Kang, Seung-Hyun Lee
Summary: TNNT2 gene with p. Arg205Trp mutation is strongly linked to dilated cardiomyopathy (DCM). A human induced pluripotent stem cell (hiPSC) line, YCMi007-A, was generated from a DCM patient and showed high expression of pluripotent markers, normal karyotype, and differentiation into three germ layers. Therefore, YCMi007-A could be a valuable tool for investigating DCM.
STEM CELL RESEARCH
(2023)
Article
Cardiac & Cardiovascular Systems
Uram Jin, Minjae Yoon, Jaehyung Ha, Seung-Hyun Lee, Doeun Yun, Ji-Su Kim, Jaewon Oh, Sungha Park, Sang-Hak Lee, Seok-Min Kang, Chan Joo Lee
Summary: This study aimed to analyze the relationship between the Korean version of the frailty scale (K-FRAIL) and physical performance in patients with heart failure (HF). The results showed that both peak VO2 and 6MWT scores decreased significantly as frailty worsened in older patients with HF. The K-FRAIL scale was found to be correlated with peak VO2 and 6MWT, and their cut-off values were identified as independent predictors of frailty.
CLINICAL CARDIOLOGY
(2023)
Review
Medicine, General & Internal
Kyeong-Hyeon Chun, Seok-Min Kang
Summary: Advanced heart failure refers to severe symptoms despite optimized therapies, and may require heart transplantation or long-term mechanical circulatory support. Inotropic agents and renal replacement therapy can be used to reduce congestion and increase cardiac output. Cardiac resynchronization therapy is beneficial for patients with reduced ejection fraction, particularly those with left bundle branch block.
KOREAN JOURNAL OF INTERNAL MEDICINE
(2023)
Article
Endocrinology & Metabolism
Seokmin Kang, Eunjin Kim, Sunmin Lee, Jin Kyong Kim, Cho Rok Lee, Sang-Wook Kang, Jandee Lee, Jong Ju Jeong, Kee-Hyun Nam, Woong Youn Chung
Summary: This study retrospectively analyzed 453 patients who underwent preoperative FNAB for thyroid nodules larger than 4 cm in a hospital in Seoul, Korea. The results showed that preoperative FNAB had a high false-negative rate and low diagnostic accuracy in nodules without suspicious cytologic features, leading to the consideration of diagnostic surgery as a treatment option.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Minjae Yoon, Jaewon Oh, Kyeong-Hyeon Chun, Hee Tae Yu, Chan Joo Lee, Tae-Hoon Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung, Seok-Min Kang
Summary: This study retrospectively analyzed clinical data of 174 patients with heart failure and found that device-detected atrial fibrillation (AF) was associated with decreased biventricular pacing and worse clinical outcomes. This suggests that early detection and intervention of AF are important for patients undergoing cardiac resynchronization therapy (CRT) treatment.
KOREAN CIRCULATION JOURNAL
(2023)
Article
Medicine, General & Internal
Jin Joo Park, Minjae Yoon, Hyoung-Won Cho, Sang-Eun Lee, Jin-Oh Choi, Byung-Su Yoo, Seok-Min Kang, Dong-Ju Choi
Summary: This study conducted in Korean patients with heart failure revealed a high prevalence of iron deficiency, especially in women. Clinical parameters are not sufficient to diagnose iron deficiency, and routine laboratory examinations are necessary to identify affected patients.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2023)