Article
Surgery
Faisal Aziz
Summary: In an era of diversity, it is important for vascular surgeons to recognize the increasingly diverse population and strive to provide equal quality care that meets patients' expectations.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2023)
Review
Cardiac & Cardiovascular Systems
Tiphaine Raia-Barjat, Osasere Edebiri, Fionnuala Ni Ainle
Summary: Preeclampsia is a common complication that increases the risk of maternal and fetal mortality, requiring early detection and effective intervention. For pregnant women with risk factors, low-dose aspirin is recommended in early pregnancy, and the risk of venous thromboembolism should be assessed based on individual circumstances to ensure timely treatment.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Dermatology
Olga Krizanova, Adela Penesova, Alica Hokynkova, Andrea Pokorna, Amir Samadian, Petr Babula
Summary: Chronic venous disease is a condition that affects the veins in the lower extremities, characterized by impaired blood return. This review discusses the etiology, risk factors, and pathophysiology of venous leg ulcers (VLU), and compares the treatment options.
INTERNATIONAL WOUND JOURNAL
(2023)
Review
Biochemistry & Molecular Biology
Malgorzata Dybowska, Dorota Wyrostkiewicz, Lucyna Opoka, Katarzyna Lewandowska, Malgorzata Sobiecka, Witold Tomkowski, Monika Szturmowicz
Summary: For over two years, the world has been grappling with the COVID-19 pandemic caused by SARS-CoV-2 infection. Post and long-COVID syndromes pose a challenge for the medical and scientific communities. SARS-CoV-2 infection increases the risk of cardiovascular complications, particularly thromboembolic complications, which can be prevented and treated with LMHW. However, there is still controversy surrounding the prevention and treatment of thromboembolic complications.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Surgery
Safa Salim, Matthew Machin, Benjamin O. Patterson, Sarah Onida, Alun H. Davies
Summary: CVD has a significant impact on the global population, with existing epidemiological studies showing significant heterogeneity. Understanding the disease burden and associated risk factors is crucial for optimizing service provision and patient care planning.
Article
Peripheral Vascular Disease
Zhenyu Guo, Xu Li, Tao Wang, Xiaohu Yang, Longhua Fan
Summary: This study found a close correlation between hyperhomocysteinemia (HHcy) and the formation of venous ulcers in patients with primary varicose veins. HHcy may induce endothelial dysfunction and phenotypic switching of vascular smooth muscle cells, leading to the development of venous ulcers.
Article
Surgery
Richmond T. Bergner, Sarah Onida, Rahul Velineni, Konstantina Spagou, Manjit S. Gohel, Marielle Bouschbacher, Serge Bohbot, Joseph Shalhoub, Elaine Holmes, Alun H. Davies
Summary: The study aimed to identify potential biomarkers predictive of healing or failure to heal in venous leg ulceration. It found that serum biofluids could differentiate between healing and nonhealing patients, and the ratio of carnitine to ceramide could differentiate between healing phenotypes with 100% sensitivity, 79% specificity, and 91% accuracy. This metabolic signature has potential applications for disease prognostication and development of targeted therapies for venous leg ulceration.
Review
Biochemistry & Molecular Biology
Mario Enrico Canonico, Ciro Santoro, Marisa Avvedimento, Giuseppe Giugliano, Giulia Elena Mandoli, Maria Prastaro, Anna Franzone, Raffaele Piccolo, Federica Ilardi, Matteo Cameli, Giovanni Esposito
Summary: Acute thrombotic events can reveal occult cancer in a significant number of cases. Malignancy interacts with the hemostatic system, leading to both thrombosis and bleeding. Cancer-related thrombotic events primarily affect the venous side and present in various conditions, including unusual sites of venous thrombosis. The selection of patients for anticoagulation management is complex, taking into account individual patient goals and preferences, prognosis of specific cancers, comorbidities, drug interactions, underweight states, and competing risks of morbidity and mortality. Anticoagulant treatment in cancer is widely debated, with direct oral anticoagulants showing efficacy and safety compared to traditional treatment.
Article
Surgery
Joe L. Pantoja, Rhusheet P. Patel, Jesus G. Ulloa, Steven M. Farley
Summary: This study examined the outcomes of deep venous stenting for central venous obstruction in patients with recalcitrant venous ulcers. The results showed that deep venous stenting resulted in a high rate of ulcer healing, although the healing time was extended and there was a high recurrence rate.
ANNALS OF VASCULAR SURGERY
(2022)
Review
Biochemistry & Molecular Biology
Daniele Pastori, Vito Maria Cormaci, Silvia Marucci, Giovanni Franchino, Francesco Del Sole, Alessandro Capozza, Alessia Fallarino, Chiara Corso, Emanuele Valeriani, Danilo Menichelli, Pasquale Pignatelli
Summary: Venous thromboembolism (VTE) is a common cause of death worldwide. The incidence varies between Western and Eastern countries, with Western countries having a higher incidence. Several risk factors have been identified, including male sex, diabetes, obesity, smoking, genetic mutations, oral contraceptives, long-haul flights, and medical conditions like cancer. This review provides a comprehensive summary of these risk factors and the potential mechanisms leading to VTE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Dermatology
Piyush Kumar, Ismat Ara Khan, Anupam Das, Hiral Shah
Summary: Chronic venous disease (CVD), a common condition in dermatology outpatient department, can progress to chronic leg ulcer if left untreated. It affects patients' quality of life and work productivity. The clinical manifestations range from asymptomatic varicose veins to ulceration and scarring. Increased venous hypertension and chronic inflammation play key roles in the development of CVD.
CLINICAL AND EXPERIMENTAL DERMATOLOGY
(2022)
Review
Surgery
Ioannis Tsouknidas, Nektarios Charisis, Bo Eklof, Nicos Labropoulos
Summary: This scoping review provides a historical perspective of venous claudication (VC) and analyzes its prevalence, pathophysiological aspects, and clinical implications. The findings suggest that VC is almost exclusively found in patients with iliofemoral obstruction and is characterized by increased venous volume and pressure. The time required for venous pressure to return to pre-exercise levels is prolonged compared to normal. VC is an important symptom of venous outflow obstruction that is under studied and merits further recognition.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2022)
Review
Medicine, General & Internal
Miguel A. Ortega, Oscar Fraile-Martinez, Cielo Garcia-Montero, Miguel A. Alvarez-Mon, Chen Chaowen, Fernando Ruiz-Grande, Leonel Pekarek, Jorge Monserrat, Angel Asunsolo, Natalio Garcia-Honduvilla, Melchor Alvarez-Mon, Julia Bujan
Summary: Chronic venous disease (CVD) is a multifactorial condition that affects a significant percentage of the global population, ranging from mild clinical signs to severe manifestations, with varicose veins being the most common form. Genetics and environmental factors play important roles in the development of CVD.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Hematology
Philippe Debourdeau, Anne Lamblin, Theodore Debourdeau, Pierre Yves Marcy, Lea Vazquez
Summary: Symptomatic catheter related thrombosis (CRT) occurs in 4%-8% of cancer patients, with a mean incidence of 12-14% detected by echography or Doppler. No validated thromboprophylaxis has been identified, but pharmacological prophylaxis with vitamin K antagonists or low molecular weight heparins can reduce CRT incidence by 55%-60% without increasing major bleeding risk. This prophylaxis should be started before catheter insertion at prophylactic doses and continued thereafter at subtherapeutic doses.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Review
Surgery
Benedict R. H. Turner, Sara Jasionowska, Matthew Machin, Azfar Javed, Adam M. Gwozdz, Joseph Shalhoub, Sarah Onida, Alun H. Davies
Summary: There is limited data on the effects of exercise on venous ulcer healing and recurrence. The evidence for exercise as an adjunct to venous leg ulceration healing is of low quality and the trials have significant methodologic flaws. Future studies should implement activity monitoring and standardize reporting to determine the role of exercise in venous leg ulceration healing.
JOURNAL OF VASCULAR SURGERY-VENOUS AND LYMPHATIC DISORDERS
(2023)