Article
Endocrinology & Metabolism
Giulia Zerbini, Eva C. Winnebeck, Martha Merrow
Summary: The study reveals that both season and weekly schedule impact the phase of entrainment and sleep in humans. In summer, the phase of entrainment is about 1 hour earlier compared to winter, with shorter sleep duration, particularly affecting individuals with later chronotypes. These findings suggest that the phase of entrainment is linked to midday or midnight rather than sunrise or sunset.
JOURNAL OF PINEAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yulin Gai, Ran Tian, Fangnan Liu, Yuan Mu, Lei Shan, David M. Irwin, Yang Liu, Shixia Xu, Guang Yang
Summary: Photic niche shifts of mammals are associated with changes in visual capabilities, mediated by three visual pigments: SWS1, M/LWS, and RH1. Evolutionary analyses and in vitro assays revealed accelerated evolution of SWS1 pigment in species living in bright-light environments, and a similar pattern was observed for RH1 in aquatic cetaceans, indicating potential ecological adaptations. Further studies using site-directed mutagenesis identified critical sites responsible for violet and ultraviolet sensitivities in SWS1 and a substitution at site 195 critical for dim-light sensation in RH1.
MOLECULAR BIOLOGY AND EVOLUTION
(2023)
Article
Clinical Neurology
David J. Kennaway
Summary: This study analyzed the saliva DLMO from 3579 participants and the plasma DLMO from 818 healthy controls. A reference range was established and the saliva DLMO was found to be earliest in children and latest around 20 years of age. Saliva DLMO was correlated with the MEQ score and showed a tendency toward morningness with age. Peak plasma melatonin levels varied within studies and age groups, with a small decline between 20 and 50 years and lowest levels after 70 years.
Article
Biology
Michal Mateusz Dermanowski, Arkadiusz Hejduk, Julita Kuczynska, Adam Wichniak, Agnieszka Urbanska, Pawel Mierzejewski
Summary: The study established a method for determining the concentration of melatonin (MELA) in plasma and saliva using liquid chromatography with tandem mass spectrometry (LC-MS/MS). The correlation between plasma and salivary MELA concentration was analyzed, and the dim light melatonin onset (DLMO) was evaluated using both matrices. The results showed a strong correlation between plasma and salivary MELA concentration, and the DLMO calculated based on both plasma and saliva profiles were also correlated.
CHRONOBIOLOGY INTERNATIONAL
(2022)
Article
Clinical Neurology
Linske de Bruijn, Danielle E. J. Starreveld, Michael Schaapveld, Flora E. van Leeuwen, Eveline M. A. Bleiker, Nina E. Berentzen
Summary: This study investigates the association between single-item chronotype and dim light melatonin onset, and finds a correlation between the two. The single-item chronotype questionnaire can serve as an effective alternative for assessing chronotype.
JOURNAL OF SLEEP RESEARCH
(2022)
Article
Endocrinology & Metabolism
Jan-Frieder Harmsen, Jakob Wefers, Daniel Doligkeit, Luc Schlangen, Bas Dautzenberg, Pascal Rense, Dirk van Moorsel, Joris Hoeks, Esther Moonen-Kornips, Marijke C. M. Gordijn, Wouter D. van Marken Lichtenbelt, Patrick Schrauwen
Summary: The study found that bright lighting during the day and dim lighting at night can alter postprandial substrate handling, energy expenditure, and thermoregulation of overweight insulin-resistant individuals. Differences in light intensity have effects on various metabolic parameters and body temperature, indicating the importance of the indoor light environment for metabolic health in at-risk populations.
Article
Biology
Raphaelle Glacet, Eve Reynaud, Ludivine Robin-Choteau, Nathalie Reix, Laurence Hugueny, Elisabeth Ruppert, Pierre A. Geoffroy, Ulker Kilic-Huck, Henri Comtet, Patrice Bourgin
Summary: Dim light melatonin onset (DLMO) is an important circadian phase marker, but the methods to calculate it vary. Establishing clear and validated guidelines on DLMO assessment methodology is crucial for diagnosing circadian rhythm sleep-wake disorders and determining the optimal timing of treatments. Our study found that the hockey stick method showed the most reliable estimate of DLMO in healthy individuals and should be considered for future studies.
CHRONOBIOLOGY INTERNATIONAL
(2023)
Article
Pharmacology & Pharmacy
Haresh T. More, Dilbir S. Bindra, Alexandra Zumba, Kaimeng Zhou, Thiago Carvalho, Rao Mantri
Summary: In this study, it was found that therapeutic proteins, such as monoclonal antibodies (mAbs), are exposed to ambient light conditions during manufacturing and handling processes. The RT/RL stability studies are generally conducted to determine the allowable exposure time. However, an unexpected increase in protein aggregation was observed during a formal RT/RL study due to differences in the setup of the stability chamber. This study emphasizes the importance of understanding UV levels and using representative light conditions for accurate stability assessment of biologic drug products.
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
(2023)
Article
Biology
Yang Xie, Xiaoyan Wu, Xingyue Mou, Meng Wang, Shuman Tao, Yuhui Wan, Fangbiao Tao
Summary: Understanding the influence of biological rhythms on young adult health is crucial due to the risk of circadian misalignment caused by biological changes and circadian phase delay. The effectiveness of a self-rating of biological rhythm disorder for adolescents (SBRDA) was evaluated against objective measures of biological rhythms, such as dim light melatonin onset (DLMO). The findings showed that SBRDA, in line with MEQ and MCTQ, can be used to identify endogenous circadian rhythm disorders in young adults.
JOURNAL OF BIOLOGICAL RHYTHMS
(2023)
Article
Biochemistry & Molecular Biology
Zuzana Dzirbikova, Katarina Stebelova, Katarina Kovacova, Monika Okuliarova, Lucia Olexova, Michal Zeman
Summary: Artificial light at night (ALAN) during pregnancy can disrupt hormonal and biochemical rhythms and interfere with the normal development of offspring.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Environmental Sciences
Valentina J. Alaasam, Xu Liu, Ye Niu, Justine S. Habibian, Simon Pieraut, Brad S. Ferguson, Yong Zhang, Jenny Q. Ouyang
Summary: Artificial light at night (ALAN) disrupts natural circadian rhythms, impacting behavior and physiology in both humans and wildlife. Studies have shown that even low levels of ALAN can lead to changes in nighttime activity and cardiovascular health, emphasizing the need for research into the ecological impacts of light pollution.
ENVIRONMENTAL POLLUTION
(2021)
Article
Clinical Neurology
Taisuke Eto, Shingo Kitamura, Akiko Shikano, Kosuke Tanabe, Shigekazu Higuchi, Shingo Noi
Summary: This study aimed to establish a method for estimating dim light melatonin onset (DLMO) in children using mathematical slopes calculated from melatonin concentrations at three sampling points before and after sleep. The results showed that DLMO could be accurately estimated from salivary melatonin levels at three time points before and after sleep in children.
SLEEP AND BIOLOGICAL RHYTHMS
(2023)
Article
Clinical Neurology
Hongliang Feng, Amy Wing -Yin Ho, Binbin Lei, Joey Wing Yan Chan, Jing Wang, Yaping Liu, Jessie Chi Ching Tsang, Ngan Yin Chan, Siu Ping Lam, Kathleen Ries Merikangas, Chung Shun Ho, Jihui Zhang, Yun Kwok Wing
Summary: This study found that unaffected offspring of parents with bipolar disorder already exhibited circadian rhythm dysregulation, with lower nocturnal melatonin levels, smaller melatonin AUC within two hours after DLMO, and larger phase angle between DLMO and sleep onset compared to offspring of control parents.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Multidisciplinary Sciences
K. M. Zielinska-Dabkowska, E. S. Schernhammer, J. P. Hanifin, G. C. Brainard
Summary: Nocturnal light pollution can have significant effects on humans and other organisms, including strain on the visual system, disruption of circadian rhythms, suppression of melatonin secretion, and impaired sleep. There is increasing evidence pointing to adverse health effects, such as chronic diseases, due to outdoor lighting. This Review synthesizes recent research on the impact of nocturnal light exposure on human health and identifies critical areas for future research, while also highlighting policy steps and recommendations for mitigating light pollution in urban environments.
Article
Public, Environmental & Occupational Health
Heidi M. Lammers-van der Holst, James K. Wyatt, Todd S. Horowitz, John C. Wise, Wei Wang, Joseph M. Ronda, Jeanne F. Duffy, Charles A. Czeisler
Summary: The study found that using intermittent bright light during work hours can enhance adaptation to night shift work and reduce cognitive deficits on evening and day shifts. For workers who need to work night shifts and frequently rotate shifts, this light therapy may be an effective workplace intervention.
SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH
(2021)
Article
Surgery
Makoto Odaka, Takamasa Shibasaki, Daiki Kato, Shohei Mori, Hisatoshi Asano, Makoto Yamashita, Toshiaki Morikawa
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2017)
Article
Biochemistry & Molecular Biology
Asami Makino, Mitsuhiro Abe, Reiko Ishitsuka, Motohide Murate, Takuma Kishimoto, Shota Sakai, Francoise Hullin-Matsuda, Yukiko Shimada, Takehiko Inaba, Hideyuki Miyatake, Hideko Tanaka, Atsushi Kurahashi, Chan-Gi Pack, Rinshi S. Kasai, Shuku Kubo, Nicole L. Schieber, Naoshi Dohmae, Naoya Tochio, Kyoji Hagiwara, Yutaka Sasaki, Yoko Aida, Fumihiro Fujimori, Takanori Kigawa, Kozo Nishibori, Robert G. Parton, Akihiro Kusumi, Yasushi Sako, Gregor Anderluh, Makoto Yamashita, Tetsuyuki Kobayashi, Peter Greimel, Toshihide Kobayashi
Article
Operations Research & Management Science
Yaguang Yang, Makoto Yamashita
OPTIMIZATION LETTERS
(2018)
Article
Peripheral Vascular Disease
Yasuharu Tabara, Takeshi Matsumoto, Kimihiko Murase, Shunsuke Nagashima, Toyohiro Hirai, Shinji Kosugi, Takeo Nakayama, Tomoko Wakamura, Kazuo Chin, Fumihiko Matsuda
HYPERTENSION RESEARCH
(2018)
Article
Clinical Neurology
Takeshi Matsumoto, Kimihiko Murase, Yasuharu Tabara, David Gozal, Dale Smith, Takuma Minami, Ryo Tachikawa, Kiminobu Tanizawa, Toru Oga, Shunsuke Nagashima, Tomoko Wakamura, Naoko Komenami, Kazuya Setoh, Takahisa Kawaguchi, Takanobu Tsutsumi, Yoshimitsu Takahashi, Takeo Nakayama, Toyohiro Hirai, Fumihiko Matsuda, Kazuo Chin
Article
Clinical Neurology
Takeshi Matsumoto, Kimihiko Murase, Yasuharu Tabara, David Gozal, Dale Smith, Takuma Minami, Ryo Tachikawa, Kiminobu Tanizawa, Toru Oga, Shunsuke Nagashima, Tomoko Wakamura, Naoko Komenami, Kazuya Setoh, Takahisa Kawaguchi, Takanobu Tsutsumi, Yoshimitsu Takahashi, Takeo Nakayama, Toyohiro Hirai, Fumihiko Matsuda, Kazuo Chin
Article
Peripheral Vascular Disease
Yasuharu Tabara, Takeshi Matsumoto, Kimihiko Murase, Kazuya Setoh, Takahisa Kawaguchi, Shunsuke Nagashima, Shinji Kosugi, Takeo Nakayama, Tomoko Wakamura, Toyohiro Hirai, Kazuo Chin, Fumihiko Matsuda
AMERICAN JOURNAL OF HYPERTENSION
(2018)
Article
Peripheral Vascular Disease
Makoto Yamashita, Yasuharu Tabara, Yukiko Higo, Kazuya Setoh, Takahisa Kawaguchi, Yoshimitsu Takahashi, Shinji Kosugi, Takeo Nakayama, Fumihiko Matsuda, Tomoko Wakamura
HYPERTENSION RESEARCH
(2018)
Article
Operations Research & Management Science
Takashi Nakagaki, Mituhiro Fukuda, Sunyoung Kim, Makoto Yamashita
COMPUTATIONAL OPTIMIZATION AND APPLICATIONS
(2020)
Article
Computer Science, Software Engineering
Heejune Sheen, Makoto Yamashita
Summary: This research explores the computational efficiency of exploiting the aggregate sparsity in the second-order cone programming (SOCP) relaxation for nonconvex quadratic constrained quadratic programming problems (QCQPs). The study shows that by reducing the number of second-order cones and simplifying the matrix completion procedure, the efficiency of the SOCP relaxation can be improved without losing the max-determinant property. Numerical experiments demonstrate that exploiting the aggregate sparsity allows for handling larger problems compared to the SDP relaxation.
OPTIMIZATION METHODS & SOFTWARE
(2022)
Article
Mathematics, Applied
Makoto Yamashita, Einosuke Iida, Yaguang Yang
Summary: This paper introduces an infeasible arc-search interior-point algorithm for solving nonlinear programming problems. Compared to traditional line-search methods, the proposed algorithm can reach the optimal solution faster. Numerical experiments demonstrate that the algorithm achieves the optimal solution with fewer iterations but longer computational times.
NUMERICAL ALGORITHMS
(2022)
Article
Multidisciplinary Sciences
Shugo Miyamoto, Makoto Yamashita
Summary: The paper proposes a novel method for solving linear complementarity problems in interactive rigid-body simulations, based on the accelerated modulus-based Gauss-Seidel (AMGS) method. A new sufficient condition for convergence is given under a milder matrix splitting condition, providing flexibility in choice and potentially better convergence rates. Numerical experiments demonstrate the method's efficiency and superior accuracy compared to existing methods.
SN APPLIED SCIENCES
(2021)
Article
Health Care Sciences & Services
Shogo Kishimoto, Makoto Yamashita
OPERATIONS RESEARCH FOR HEALTH CARE
(2018)
Article
Biology
Shunsuke Nagashima, Madoka Osawa, Hiroto Matsuyama, Wataru Ohoka, Aemi Ahn, Tomoko Wakamura
CHRONOBIOLOGY INTERNATIONAL
(2018)
Article
Respiratory System
Yusuke Kurita, Jun Araya, Shunsuke Minagawa, Hiromichi Hara, Akihiro Ichikawa, Nayuta Saito, Tsukasa Kadota, Kazuya Tsubouchi, Nahoko Sato, Masahiro Yoshida, Kenji Kobayashi, Saburo Ito, Yu Fujita, Hirofumi Utsumi, Haruhiko Yanagisawa, Mitsuo Hashimoto, Hiroshi Wakui, Yutaka Yoshii, Takeo Ishikawa, Takanori Numata, Yumi Kaneko, Hisatoshi Asano, Makoto Yamashita, Makoto Odaka, Toshiaki Morikawa, Katsutoshi Nakayama, Kazuyoshi Kuwano
RESPIRATORY RESEARCH
(2017)