Article
Oncology
Pierre Kubicek, Axel Le Cesne, Cyril Lervat, Maud Toulmonde, Christine Chevreau, Florence Duffaud, Louis-Romee Le Nail, Magali Morelle, Nathalie Gaspar, Cecile Verite, Marie-Pierre Castex, Nicolas Penel, Esma Saada, Sylvain Causeret, Francois Bertucci, Christophe Perrin, Emmanuelle Bompas, Daniel Orbach, Valerie Laurence, Sophie Piperno-Neumann, Philippe Anract, Maria Rios, Jean-Claude Gentet, Eric Mascard, Stephanie Pannier, Pascale Blouin, Sebastien Carrere, Loic Chaigneau, Pauline Soibinet-Oudot, Nadege Corradini, Pascaline Boudou-Rouquette, Jean-Christophe Ruzic, Valerie Lebrun-Ly, Pascale Dubray-Longeras, Sharmini Varatharajah, Celeste Lebbe, Mickael Ropars, Jean-Emmanuel Kurtz, Cecile Guillemet, Jean-Pierre Lotz, Juliane Berchoud, Gregory Cherrier, Francoise Ducimetiere, Claire Chemin, Antoine Italiano, Charles Honore, Emmanuel Desandes, Jean-Yves Blay, Francois Gouin, Perrine Marec-Berard
Summary: This study used the NETSARC database to report the management and oncologic outcomes in adolescents and young adults (AYAs) patients with sarcoma in France. The study found that AYAs treated in reference sarcoma centers had improved locoregional recurrence-free survival and progression-free survival compared to those treated in non-reference centers. Therefore, referring AYAs patients with sarcoma to national sarcoma reference centers for comprehensive treatment is crucial.
Article
Pediatrics
Nathan Cantor, Mila Kingsbury, Emily Warner, Hannah Landry, Zahra Clayborne, Raidah Islam, Ian Colman
Summary: This study systematically assessed the relationship between adolescent suicidal ideation and suicide attempts with young adult psychopathological outcomes. The findings showed that adolescent suicidal ideation was associated with young adult suicide attempt, depressive disorders, and anxiety disorders, while adolescent suicide attempts were associated with young adult suicide attempt and anxiety disorders.
Article
Oncology
Cas Drabbe, Elena S. Coenraadts, Winan J. van Houdt, Michiel A. J. van de Sande, Johannes J. Bonenkamp, Jacco J. de Haan, Johanna W. M. Nin, Cornelis Verhoef, Winette T. A. van der Graaf, Olga Husson
Summary: This study aims to identify AYA sarcoma survivors with impaired social functioning (ISF) and determine the clinical and psychosocial factors associated with ISF. The study found that more than one-quarter of AYA sarcoma survivors experience ISF long after diagnosis. Unemployment and having to make lifestyle changes due to financial problems caused by physical conditions or medical treatment were associated with ISF, while better social support was associated with non-ISF. These results emphasize the importance of follow-up care that focuses not only on the disease but also on the psychological and social domains.
Review
Oncology
Katrina M. Ingley, Alessandra Maleddu, Franel Le Grange, Craig Gerrand, Archie Bleyer, Ephia Yasmin, Jeremy Whelan, Sandra J. Strauss
Summary: Bone tumors, including osteosarcoma and Ewing sarcoma, are histologically diverse diseases that mainly affect adolescents and young adults. While some patients can be cured, high rates of treatment failure and morbidity are associated with these cancers. The slow introduction of effective new therapeutics is hindered by the insufficiently characterized complex biology of the diseases.
PEDIATRIC BLOOD & CANCER
(2022)
Review
Oncology
Mary Jane Lim-Fat, Maria Macdonald, Sarah Lapointe, Seth Andrew Climans, Chantel Cacciotti, Manik Chahal, Sebastien Perreault, Derek S. Tsang, Andrew Gao, Stephen Yip, Julia Keith, Julie Bennett, Vijay Ramaswamy, Jay Detsky, Uri Tabori, Sunit Das, Cynthia Hawkins
Summary: The 2021 World Health Organization classification of CNS tumors includes molecular signatures with histology and emphasizes the differences between pediatric and adult-type CNS tumors. This study aims to propose a comprehensive approach to molecular testing for adolescent and young adult (AYA) patients across this spectrum, in order to improve their diagnosis and care.
FRONTIERS IN ONCOLOGY
(2022)
Review
Oncology
Brooke Cherven, Amani Sampson, Sharon L. Bober, Kristin Bingen, Natasha Frederick, David R. Freyer, Gwendolyn P. Quinn
Summary: This study summarizes the literature on sexual function among adolescent and young adult cancer survivors, finding that they experience a burden of sexual dysfunction and interventions are needed to support sexual health and psychosexual adjustment. Collaboration between organizations is necessary to advance assessment of sexual dysfunction and test interventions to improve sexual health among this population.
CA-A CANCER JOURNAL FOR CLINICIANS
(2021)
Article
Medicine, General & Internal
Carol A. Ford, Andrew C. Pool, Nicole F. Kahn, James Jaccard, Carolyn T. Halpern
Summary: This cohort study suggests that positive parent-adolescent relationships are associated with favorable outcomes in young adulthood. Investments in improving these relationships may have long-term benefits for young adult health.
Article
Oncology
Yin Ting Cheung, Chung Tin Ma, Michael Can Heng Li, Keary Rui Zhou, Herbert Ho Fung Loong, Agnes Sui Yin Chan, Kwok Chuen Wong, Chi Kong Li
Summary: Young survivors of bone tumors and soft-tissue sarcoma are at risk of cognitive impairment. Physical inactivity, smoking, and long working hours are associated with worse attention and executive function among survivors. Chronic health conditions coupled with continued physical inactivity may exacerbate cognitive dysfunction.
Article
Hematology
Lori Muffly, Jun Yin, Sawyer Jacobson, Anna Wall, Elisa Quiroz, Anjali S. Advani, Selina M. Luger, Martin S. Tallman, Mark R. Litzow, Matthew C. Foster, Harry P. Erba, Frederick R. Appelbaum, Richard A. Larson, Theresa H. M. Keegan, Wendy Stock
Summary: Hispanic patients treated on CALGB 10403 performed similarly to NHWs and better than population estimates, with higher rates of protocol completion. However, there was a geographical misalignment between trial sites and disease epidemiology, possibly explaining the lower-than-expected enrollment of Hispanic AYA ALL patients.
Review
Oncology
Niki Oveisi, Vicki Cheng, Ursula Ellis, Stuart Peacock, Helen McTaggart-Cowan, Lori A. Brotto, Jonathan Loree, Gillian E. Hanley, Sharlene Gill, Meera Rayar, Amirrtha Srikanthan, Mary A. De Vera
Summary: This systematic review and meta-analysis examined the impacts of cancer on reproductive health outcomes in adolescents and young adults (AYAs) aged 15-39 years. The analysis included 21 studies and assessed 62 reproductive outcomes. The results showed that AYA cancer patients have a higher risk of preterm birth, gestational diabetes, and use of fertility treatment compared to controls, especially among those who received radiation.
Article
Multidisciplinary Sciences
Xiaojing Wang, Anne-Marie Langevin, Peter J. Houghton, Siyuan Zheng
Summary: This study investigates the clinical and genomic disparities between adolescents and young adults (AYA) and older adults in cancer patients. It reveals significant differences in clinical presentation and genetic characteristics between AYA and older adult tumors. AYA tumors tend to have lower mutation burden and less genomic instability, but show overrepresentation of certain mutations across multiple cancer types.
NATURE COMMUNICATIONS
(2022)
Article
Obstetrics & Gynecology
Chelsea Anderson, Victoria Fitz, Allison Deal, Darios Getahun, Marilyn L. Kwan, Jennifer E. Mersereau, Lawrence H. Kushi, Chun R. Chao, Hazel B. Nichols
Summary: This study examines the association between demographic and cancer-related characteristics and factors such as fertility discussion and fertility preservation use with attempting pregnancy after adolescent and young adult cancer. The use of fertility preservation strategies was found to be significantly associated with attempting pregnancy after cancer.
FERTILITY AND STERILITY
(2023)
Review
Oncology
Fumiyuki Yamasaki
Summary: The management of brain tumors developed in adolescents and young adults (AYAs) is challenging. Specific support is necessary to maintain the quality of life (QOL) of AYA brain tumor patients, who may experience negative effects on neurological, neurocognitive, and endocrinological function, as well as on education, employment, and marriage opportunities. The biology underlying the distribution of tumors in AYAs may influence future clinical studies and molecular targeted therapy selection.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2022)
Article
Oncology
Shireen Parsai, Geoffrey Sedor, Timothy D. Smile, Jacob Scott, Allison Ochocki, Nicole Vassil, Stacey Zahler, Lilyana Angelov, Samuel T. Chao, Peng Qi, Peter Anderson, Erin S. Murphy
Summary: This study reported intermediate outcomes and toxicity for pediatric, adolescent, and young adult patients treated with SBRT for recurrent and/or metastatic sarcoma. The results showed that SBRT was well tolerated with favorable local control outcomes in the majority of patients, but further studies are needed to determine the optimal treatment regimen.
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2021)
Article
Oncology
Clare Meernik, Stephanie M. Engel, Christopher D. Baggett, Ally Wardell, Xi Zhou, Kathryn J. Ruddy, Ethan Wantman, Valerie L. Baker, Barbara Luke, Jennifer E. Mersereau, Jianwen Cai, Andrew F. Olshan, Andrew B. Smitherman, Hazel B. Nichols
Summary: Fertility preservation may be underused after cancer diagnosis due to concerns about delaying cancer treatment. However, this study found that fertility preservation can delay gonadotoxic cancer treatment without significantly impacting prognosis for most women.
Article
Oncology
Yuhua Wang, Ram Naresh Pandey, Kaushik Roychoudhury, David Milewski, Tanya Kalin, Sara Szabo, Joseph G. Pressey, Rashmi S. Hegde
Summary: Loss of EYA3 or pharmacologic inhibition of the EYA3 tyrosine phosphatase activity inhibits tumor growth and angiogenesis in Ewing sarcoma. EYA3 regulates VEGFA levels in Ewing tumors, promotes DNA damage repair and survival of Ewing sarcoma tumor cells. Target engagement is demonstrated in tumor tissue through elevated levels of the EYA3 substrate H2AX-pY142 upon loss of EYA3 or with Benzarone treatment.
MOLECULAR CANCER THERAPEUTICS
(2021)
Article
Biochemistry & Molecular Biology
David Milewski, Samriddhi Shukla, Berkley E. Gryder, Arun Pradhan, Johnny Donovan, Parvathi Sudha, Sushmitha Vallabh, Athena Pyros, Yan Xu, Artem Barski, Sara Szabo, Brian Turpin, Joseph G. Pressey, Douglas P. Millay, Javed Khan, Vladimir V. Kalinichenko, Tanya Kalin
Summary: The FOXF1 transcription factor plays a crucial role in FP-RMS tumorigenesis by regulating gene expression associated with FP-RMS gene signature. By cooperating with PAX3-FOXO1 and E-box transcription factors, FOXF1 functions downstream of PAX3-FOXO1 to promote the development of FP-RMS.
Article
Radiology, Nuclear Medicine & Medical Imaging
Samjhana Thapaliya, Leah A. Gilligan, Samuel L. Brady, Christopher G. Anton, Eric J. Crotty, Michael P. Nasser, James Geller, Joseph G. Pressey, Bin Zhang, Jonathan R. Dillman, Andrew T. Trout
Summary: Reduced-dose CT demonstrates over 90% of lung nodules in children and young adults with cancer, with moderate sensitivity and high specificity in nodule detection. The study suggests that CT performed at a 0.3-mSv mean effective dose has acceptable diagnostic performance and potential to reduce patient dose or expand CT utilization in this population.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Article
Oncology
Alina Sadaf, Sara Szabo, Katelyn Ferguson, Joel Sorger, Janos Sumegi, Julia A. Bridge, Joseph G. Pressey
Summary: A novel ARHGAP23-FER fusion was identified in a metastatic spindle-cell soft-tissue neoplasm, which exhibited a rapid and sustained metabolic response to the tyrosine kinase inhibitor lorlatinib.
Article
Oncology
Nawal Merjaneh, Jennifer Young, Avani Mangoli, Mallery Olsen, Bhuvana Setty, Adam Lane, Rajaram Nagarajan, Joseph G. Pressey, Brian Turpin
Summary: The study found that romiplostim may be beneficial in treating chemotherapy-induced thrombocytopenia in patients with Ewing sarcoma, with efficacy associated with higher drug doses. Radiation therapy had some impact on the occurrence of CIT, but other risk factors were not identified. Concurrent use of romiplostim with chemotherapy was found to be safe and feasible.
PEDIATRIC BLOOD & CANCER
(2022)
Article
Medicine, General & Internal
Eman Al Atrash, Mohammad Fahed Abdullah, Joseph Pressey, Shyam Mohan
Summary: This case emphasizes the importance of proper examination of the stomach, as even in children with a normal appearance, serious medical conditions may be present.
Article
Oncology
Margot A. Lazow, Ralph Salloum, Joseph G. Pressey
Summary: This study found that adolescent and young adult patients with central nervous system tumors or sarcomas have a high burden of baseline comorbidities, which increase with age. These comorbidities contribute to treatment-related toxicity and mortality, highlighting the need for tailored therapeutic and supportive care based on individual comorbidities.
JOURNAL OF ADOLESCENT AND YOUNG ADULT ONCOLOGY
(2023)
Article
Oncology
Jo Cooke-Barber, Joseph G. Brungardt, Michael Sorger, Joseph G. Pressey, Brian Turpin, Rajaram Nagarajan, Sara Szabo, Joel Sorger, Neil Johnson, Roshni Dasgupta
Summary: This study aimed to evaluate the efficacy of image-guided percutaneous biopsy for pediatric patients with soft tissue and bony masses, and the role of intraoperative image guidance and diagnostic accuracy. The results showed that image-guided percutaneous biopsy is a safe and effective method for obtaining accurate tissue samples in children with soft tissue or bone tumors.
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Upendra Kumar Soni, Yuhua Wang, Ram Naresh Pandey, Ryan Roberts, Joseph G. Pressey, Rashmi S. Hegde
Summary: This study analyzed the activation of receptor tyrosine kinase (RTK) pathway in Ewing sarcoma tumors and found that the tumors could be divided into two groups, one insensitive to IGF1R inhibition and the other sensitive to IGF1R or WEE1-targeted inhibitors. Primary and metastatic tumors also exhibited differences in IGF1R localization, replication stress levels, and inhibitor sensitivity. Combined inhibition of IGF1R and WEE1 led to tumor regression. These findings highlight the importance of using biopsy-derived predictive biomarkers at multiple stages of Ewing sarcoma disease management.
CLINICAL CANCER RESEARCH
(2023)
Review
Obstetrics & Gynecology
Brooke E. Sanders, Rebecca Wolsky, Elizabeth S. Doughty, Kristen L. Wells, Debashis Ghosh, Lisa Ku, Joseph G. Pressey, Benjamin B. Bitler, Lindsay W. Brubaker
Summary: This article reports a case of small cell carcinoma of the ovary hypercalcemic type (SCCOHT) with both SMARCA4 and BRCA2 germline mutations. The clinical presentation, histopathology, and treatment process are described, along with spatial transcriptomics analysis of the original tumor.
GYNECOLOGIC ONCOLOGY REPORTS
(2022)
Editorial Material
Oncology
Jo Cooke-Barber, Joseph G. Brungardt, Michael Sorger, Joseph G. Pressey, Brian Turpin, Rajaram Nagarajan, Sara Szabo, Joel Sorger, Neil Johnson, Roshni Dasgupta
ANNALS OF SURGICAL ONCOLOGY
(2023)
Editorial Material
Oncology
Jo Cooke-Barber, Joseph G. Brungardt, Michael Sorger, Joseph G. Pressey, Brian Turpin, Rajaram Nagarajan, Sara Szabo, Joel Sorger, Neil Johnson, Roshni Dasgupta
ANNALS OF SURGICAL ONCOLOGY
(2023)
Article
Oncology
Michael E. Johnston, Zishaan A. Farooqui, Rajaram Nagarajan, Joseph G. Pressey, Brian Turpin, Roshni Dasgupta
Summary: This study aimed to investigate the efficacy of ICG as an adjunct to SLNB in the pediatric and young adult population. The results showed that ICG was safer and more effective than blue dye, with a sensitivity of 87% and a PPV of 83% for detection of Tc-99m-hot lymph nodes, and a sensitivity of 84% and a PPV of 91% for detection of pathologically confirmed lymph nodes.
Meeting Abstract
Oncology
M. Macy, T. Cash, N. Pinto, J. G. Pressey, L. Szalontay, W. L. Furman, A. Bukowinski, J. H. Foster, G. K. Friedman, J. HaDuong, E. Fox, B. J. Weigel, J. Grevel, F. Huang, C. Phelps, B. H. Childs, J. Chung, S. Chaturvedi, A. Schulz, S. G. DuBois
EUROPEAN JOURNAL OF CANCER
(2022)
Meeting Abstract
Oncology
Viswatej Avutu, Emily K. Slotkin, J. Andrew Andrew Livingston, Sant P. Chawla, Joseph Gerald Pressey, Preeya Nandkumar, Cheng Zheng, Soamnauth Misir, Philippe Pultar, Dimitris Voliotis, Katherine Anne Thornton, Noah Federman
JOURNAL OF CLINICAL ONCOLOGY
(2022)
