Evaluation of cebranopadol, a dually acting nociceptin/orphanin FQ and opioid receptor agonist in mouse models of acute, tonic, and chemotherapy-induced neuropathic pain

Systemic and local anti-nociceptive effects of simvastatin in the rat formalin assay: Role of peroxisome proliferator-activated receptor γ and nitric oxide

(2017) Mohammad Taghi Mansouri et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Effects of [Nphe1, Arg14, Lys15] N/OFQ-NH2 (UFP-101), a potent NOP receptor antagonist, on molecular, cellular and behavioural alterations associated with chronic mild stress

(2017) Giovanni Vitale et al.   JOURNAL OF PSYCHOPHARMACOLOGY

Antihyperalgesic, Antiallodynic, and Antinociceptive Effects of Cebranopadol, a Novel Potent Nociceptin/Orphanin FQ and Opioid Receptor Agonist, after Peripheral and Central Administration in Rodent Models of Neuropathic Pain

(2017) Thomas M. Tzschentke et al.   Pain Practice

Nociceptin/orphanin FQ (N/OFQ) modulates immunopathology and airway hyperresponsiveness representing a novel target for the treatment of asthma

(2016) Shailendra R Singh et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cebranopadol: novel dual opioid/NOP receptor agonist analgesic

(2016) R. B. Raffa et al.   JOURNAL OF CLINICAL PHARMACY AND THERAPEUTICS

Involvement of inhibition of RhoA/Rho kinase signaling in simvastatin-induced amelioration of neuropathic pain

(2016) Masahiro Ohsawa et al.   NEUROSCIENCE

Antinociceptive activity of novel amide derivatives of imidazolidine-2,4-dione in a mouse model of acute pain

(2016) Anna Czopek et al.   Pharmacological Reports

TRP channels: potential drug target for neuropathic pain

(2016) Lovish Marwaha et al.   INFLAMMOPHARMACOLOGY

Cebranopadol: a first in-class example of a nociceptin/orphanin FQ receptor and opioid receptor agonist

(2015) D.G. Lambert et al.   BRITISH JOURNAL OF ANAESTHESIA

The TRPA1 channel mediates the analgesic action of dipyrone and pyrazolone derivatives

(2015) Romina Nassini et al.   BRITISH JOURNAL OF PHARMACOLOGY

Intrathecal administration of nociceptin/orphanin FQ receptor agonists in rats: A strategy to relieve chemotherapy-induced neuropathic hypersensitivity

(2015) Laura Micheli et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cebranopadol: a first-in-class potent analgesic agent with agonistic activity at nociceptin/orphanin FQ and opioid receptors

(2015) Kinga Sałat et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Dose-related neuropathic and anti-neuropathic effects of simvastatin in vincristine-induced neuropathic pain in rats

(2015) Shrutya Bhalla et al.   FOOD AND CHEMICAL TOXICOLOGY

Antinociceptive activity of transient receptor potential channel TRPV1, TRPA1, and TRPM8 antagonists in neurogenic and neuropathic pain models in mice

(2015) Kinga Sałat et al.   Journal of Zhejiang University-SCIENCE B

Pharmacotherapy for neuropathic pain in adults: a systematic review and meta-analysis

(2015) Nanna B Finnerup et al.   LANCET NEUROLOGY

Migraine and neuropeptides

(2015) János Tajti et al.   NEUROPEPTIDES

Simvastatin protects Sertoli cells against cisplatin cytotoxicity through enhanced gap junction intercellular communication

(2015) LINGZHI WANG et al.   ONCOLOGY REPORTS

Anticonvulsant active inhibitor of GABA transporter subtype 1, tiagabine, with activity in mouse models of anxiety, pain and depression

(2015) Kinga Sałat et al.   Pharmacological Reports

Modulation of morphine antinociceptive tolerance and physical dependence by co-administration of simvastatin

(2015) Mohammad Taghi Mansouri et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Neuroprotective activities of curcumin and quercetin with potential relevance to mitochondrial dysfunction induced by oxaliplatin

(2015) Mohammad Waseem et al.   PROTOPLASMA

Simultaneous targeting of multiple opioid receptor types

(2015) Mark F. Bird et al.   Current Opinion in Supportive and Palliative Care

Nociceptin/orphanin FQ peptide receptor antagonist JTC-801 reverses pain and anxiety symptoms in a rat model of post-traumatic stress disorder

(2014) Y Zhang et al.   BRITISH JOURNAL OF PHARMACOLOGY

Functional plasticity of the N/OFQ-NOP receptor system determines analgesic properties of NOP receptor agonists

(2014) W Schröder et al.   BRITISH JOURNAL OF PHARMACOLOGY

Activation of Cold-Sensing Transient Receptor Potential Melastatin Subtype 8 Antagonizes Vasoconstriction and Hypertension Through Attenuating RhoA/Rho Kinase Pathway

(2014) Jing Sun et al.   HYPERTENSION

Anti-inflammatory and antinociceptive action of the dimeric enkephalin peptide biphalin in the mouse model of colitis: New potential treatment of abdominal pain associated with inflammatory bowel diseases

(2014) Marta Sobczak et al.   PEPTIDES

Analgesic activity of 3-mono-substituted derivatives of dihydrofuran-2-one in experimental rodent models of pain

(2014) Kinga Sałat et al.   Pharmacological Reports

Antiallodynic and antihyperalgesic activity of 3-[4-(3-trifluoromethyl-phenyl)-piperazin-1-yl]-dihydrofuran-2-one compared to pregabalin in chemotherapy-induced neuropathic pain in mice

(2014) Kinga Sałat et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

Nociceptin / Orphanin FQ (NOP) Receptors as Novel Potential Target in the Treatment of Gastrointestinal Diseases

(2013) Marta Sobczak et al.   CURRENT DRUG TARGETS

Transient Receptor Potential Channels - Emerging Novel Drug Targets for the Treatment of Pain

(2013) Kinga Salat et al.   CURRENT MEDICINAL CHEMISTRY

Simvastatin Attenuates Formalin-Induced Nociceptive Behaviors by Inhibiting Microglial RhoA and p38 MAPK Activation

(2013) Xin-Yi Chen et al.   JOURNAL OF PAIN

Role of spinal opioid receptor on the antiallodynic effect of intrathecal nociceptin in neuropathic rat

(2013) Jin Ju et al.   NEUROSCIENCE LETTERS

Neuropathic pain in the community: More under-treated than refractory?

(2013) Nicola Torrance et al.   PAIN

The biology of Nociceptin/Orphanin FQ (N/OFQ) related to obesity, stress, anxiety, mood, and drug dependence

(2013) Jeffrey M. Witkin et al.   PHARMACOLOGY & THERAPEUTICS

Evaluation of anxiolytic-like, anticonvulsant, antidepressant-like and antinociceptive properties of new 2-substituted 4-hydroxybutanamides with affinity for GABA transporters in mice

(2013) Kinga Sałat et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

P2X7 Cell Death Receptor Activation and Mitochondrial Impairment in Oxaliplatin-Induced Apoptosis and Neuronal Injury: Cellular Mechanisms and In Vivo Approach

(2013) France Massicot et al.   PLoS One

Oxaliplatin-induced neurotoxicity involves TRPM8 in the mechanism of acute hypersensitivity to cold sensation

(2013) Toru Kono et al.   Brain and Behavior

Analgesic, antioedematous and antioxidant activity of γ-butyrolactone derivatives in rodents

(2012) Kinga Salat et al.   BEHAVIOURAL PHARMACOLOGY

Experimental evaluation of analgesic and anti-inflammatory activity of simvastatin and atorvastatin

(2012) SmitaD Sontakke et al.   INDIAN JOURNAL OF PHARMACOLOGY

Role of Nociceptin/Orphanin FQ and NOP Receptors in the Response to Acute and Repeated Restraint Stress in Rats

(2012) G. Delaney et al.   JOURNAL OF NEUROENDOCRINOLOGY

Acute Cold Hypersensitivity Characteristically Induced by Oxaliplatin is Caused by the Enhanced Responsiveness of TRPA1 in Mice

(2012) Meng Zhao et al.   Molecular Pain

Antinociception and Anti-Inflammation Induced by Simvastatin in Algesiometric Assays in Mice

(2011) Hugo F. Miranda et al.   BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY

Mechanisms of pain transmission and pharmacologic management

(2011) Charles Argoff   CURRENT MEDICAL RESEARCH AND OPINION

Statins alleviate experimental nerve injury-induced neuropathic pain

(2011) Xiang Qun Shi et al.   PAIN

Oxaliplatin elicits mechanical and cold allodynia in rodents via TRPA1 receptor stimulation

(2011) Romina Nassini et al.   PAIN

Pharmacological Blockade of TRPM8 Ion Channels Alters Cold and Cold Pain Responses in Mice

(2011) Wendy M. Knowlton et al.   PLoS One

Nociceptin Modulates Bronchoconstriction Induced by Sensory Nerve Activation in Mouse Lung

(2009) Bruno D'Agostino et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY