Article
Clinical Neurology
Zohar Elyoseph, Dario Geisinger, Roy Zaltzman, Tamar G. Hartman, Carlos R. Gordon, Matti Mintz
Summary: This study found that peripheral vestibular hypofunction is associated with the Triad of dysfunctions, namely imbalance, anxiety, and spatial disorientation. The combination of SCCs and saccular hypofunction seems to contribute to the emergence of the Triad of symptoms.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Geriatrics & Gerontology
Andrew R. Wagner, Megan J. Kobel, Daniel M. Merfeld
Summary: This study aimed to determine the associations between specific sources of vestibular noise and quantitative measures of quiet stance postural control. The results showed a strong positive association between roll tilt vestibular thresholds and the root mean square distance of the center of pressure captured during eyes closed stance on a sway referenced support surface.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Article
Clinical Neurology
Max Wuehr, Josefine Eder, Aram Keywan, Klaus Jahn
Summary: In patients with bilateral vestibulopathy, imperceptible noisy galvanic vestibular stimulation (nGVS) has been found to improve impaired vestibular motion perception, especially in patients with poor baseline perceptual performance. This non-invasive vestibular noise stimulation offers a potential approach to target spatial memory, orientation, and navigation impairments associated with bilateral vestibulopathy.
JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Sinem Balta Beylergil, Mikkel Petersen, Palak Gupta, Mohamed Elkasaby, Camilla Kilbane, Aasef G. Shaikh
Summary: The study found that Parkinson's disease affects motion perception in both the visual and vestibular domains, with a more severe impact on vestibular perception compared to visual perception, depending on the severity of the disease.
MOVEMENT DISORDERS
(2021)
Article
Neurosciences
Faisal Karmali, Csilla Haburcakova, Wangsong Gong, Charles C. Della Santina, Daniel M. Merfeld, Richard F. Lewis
Summary: Patients with vestibular damage may experience impaired vision, spatial perception, and balance, but using a vestibular implant could potentially help improve these symptoms.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Behavioral Sciences
Anna-Lena Stroh, Frank Roesler, Brigitte Roeder
Summary: Research has shown that deaf signers demonstrate superior mental rotation abilities but impaired balance performance compared to hearing nonsigners. Additionally, while balance skills correlate with mental rotation abilities in hearing nonsigners, no such relationship was observed in deaf signers. This suggests that the link between vestibular and visuo-spatial functions may be altered or even cancelled out by certain sensory or cognitive experiences.
Article
Physiology
Vivekanand Pandey Vimal, Alexander Sacha Panic, James R. Lackner, Paul DiZio
Summary: Spaceflight can cause spatial disorientation for astronauts, leading to fatal aircraft accidents. In this study, blindfolded participants were tested inside a multi-axis rotation device to simulate vertical and horizontal roll plane conditions. It was found that providing orientation-dependent vibrotactile feedback improved performance in the spaceflight analog condition, while specialized vibrotactile training resulted in better learning and performance. The study concludes that vibrotactile orientation feedback can enhance dynamic spatial orientation without negative dependence.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Neurosciences
Vivekanand Pandey Vimal, Paul DiZio, James R. Lackner
Summary: This study explores the role of spatial acuity in active balancing, finding that spatial acuity does not predict active balance control in the horizontal roll plane but is correlated with early active balancing in the vertical roll plane. Additionally, vestibular stimulation may be a valuable tool for assessing individual differences in performance in disorienting spaceflight conditions without reliable gravity-dependent positional cues.
EXPERIMENTAL BRAIN RESEARCH
(2022)
Article
Neurosciences
Aaron R. Allred, Torin K. Clark
Summary: Predicting the time course of motion sickness symptoms is important for evaluating stimuli and developing countermeasures. This study presents an observer-driven model that predicts motion sickness symptoms for passive motions in the dark. The model accurately predicts the development of symptoms and can be applied to various stimuli.
EXPERIMENTAL BRAIN RESEARCH
(2023)
Article
Clinical Neurology
Zohar Elyoseph, Dario Geisinger, Roy Zaltzman, Carlos R. Gordon, Matti Mintz
Summary: The study investigated the relationship between depersonalization/derealization (DPDR) symptoms and vestibular dysfunction in patients with peripheral and central vestibular disorders. The results showed that DPDR symptoms were associated with both semicircular canals and otolith dysfunction. Spatial disorientation and anxiety were found to mediate the development of DPDR symptoms in vestibular patients. However, DPDR did not develop in patients with central vestibular dysfunction but normal otolith response.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2023)
Article
Clinical Neurology
Birgul Balci, Gulden Akdal
Summary: This study investigated the effects of an individualized vestibular rehabilitation program on balance, gait performance, and self-perceived handicap in vestibular migraine patients with associated anxiety. The findings showed that vestibular exercises improved balance and gait performance and reduced self-perceived handicap, even in patients with anxiety complaints. Therefore, vestibular rehabilitation should be included in the treatment of vestibular migraine patients with both high and low anxiety levels to improve vestibular function.
JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Richard T. Ibitoye, Emma-Jane Mallas, Niall J. Bourke, Diego Kaski, Adolfo M. Bronstein, David J. Sharp
Summary: The study investigates the functional anatomy of OP2 and adjacent areas in the posterior peri-sylvian cortex, which is proposed to be the core human vestibular cortex. The results show that different functional subregions of OP2 exhibit strong connectivity to other vestibular areas and distinct responses to visual and caloric stimulation, suggesting a central role for vestibular function in health and disease.
Article
Pediatrics
Swetha Pinninti, Jennifer Christy, Anwar Almutairi, Graham Cochrane, Karen B. Fowler, Suresh Boppana
Summary: In children with asymptomatic cCMV, vestibular, gaze, and balance disorders are highly prevalent. This study found abnormalities in semicircular canals, the inner ear, and vestibulo-visual tracts, along with difficulties in maintaining gaze during head movement and balance. Screening and intervention for these disorders are needed in this population.
Review
Biology
Zhao Zeng, Ce Zhang, Yong Gu
Summary: Multi-sensory decision making (MSDM) is crucial for making accurate decisions in complex environments. Recent research in computational theory, psychophysical behavior, and neurophysiology has made significant progress in understanding MSDM. By studying a visuo-vestibular heading model system, researchers have uncovered the complex temporal dynamics of vestibular signals in various brain regions, challenging the brain's ability to integrate cues across time and sensory modalities. Moreover, new evidence from higher-level decision-related areas has revised our understanding of how signals from different sensory modalities are processed and accumulated to form a unified perceptual decision.
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2023)
Article
Behavioral Sciences
Annemarie van den Hoed, Annemarie Landman, Dirk Van Baelen, Olaf Stroosma, M. M. (Rene) van Paassen, Eric L. Groen, Max Mulder
Summary: This study aimed to test whether a procedure in a hexapod simulator could cause incorrect assumptions of the bank angle and improper interpretations of the attitude indicator in airline pilots. The results indicated that pilots made significantly more errors in the leans-opposite condition compared to the baseline or leans-level condition. Experience (flight hours) did not have a significant effect on the results. The study highlights the importance of clear and unambiguous displays in quickly correcting incorrect assumptions due to spatial disorientation.
Article
Anatomy & Morphology
R. E. Roberts, H. Ahmad, Q. Arshad, M. Patel, D. Dima, R. Leech, B. M. Seemungal, D. J. Sharp, A. M. Bronstein
BRAIN STRUCTURE & FUNCTION
(2017)
Article
Clinical Neurology
Hena Ahmad, R. Edward Roberts, Mitesh Patel, Rhannon Lobo, Barry Seemungal, Qadeer Arshad, Adolfo Bronstein
Editorial Material
Clinical Neurology
Min Xiang, Stefan Glasauer, Barry M. Seemungal
Article
Clinical Neurology
Nadja F. Bednarczuk, Angela Bonsu, Marta Casanovas Ortega, Anne-Sophie Fluri, John Chan, Heiko Rust, Fabiano de Melo, Mishaal Sharif, Barry M. Seemungal, John F. Golding, Diego Kaski, Adolfo M. Bronstein, Qadeer Arshad
Article
Clinical Neurology
Hani J. Marcus, Heidi Paine, Matthew Sargeant, Susie Wolstenholme, Katie Collins, Natalie Marroney, Qadeer Arshad, Kevin Tsang, Brynmor Jones, Rebecca Smith, Mark H. Wilson, Heiko M. Rust, Barry M. Seemungal
JOURNAL OF NEUROLOGY
(2019)
Article
Clinical Neurology
Lauren Harris, Sofie Hateley, K. T. Tsang, M. Wilson, B. M. Seemungal
JOURNAL OF NEUROLOGY
(2020)
Letter
Clinical Neurology
Thomas Lempert, Barry M. Seemungal
Article
Neurosciences
Aasef G. Shaikh, Adolfo Bronstein, Sergio Carmona, Yoon-Hee Cha, Catherine Cho, Fatema F. Ghasia, Daniel Gold, Kemar E. Green, Christoph Helmchen, Richard T. Ibitoye, Jorge Kattah, Ji-Soo Kim, Sudhir Kothari, Mario Manto, Barry M. Seemungal, Dominik Straumann, Michael Strupp, David Szmulewicz, Alexander Tarnutzer, Ali Tehrani, Caroline Tilikete, Miriam Welgampola, Guillermo Zalazar, Amir Kheradmand
Summary: Virtual healthcare practices have seen significant growth in the modern era, especially accelerated by the challenges posed by the COVID-19 pandemic. Guidelines on remote examination methods in neurotology have become crucial, aiming to diagnose inner-ear, brainstem, and cerebellum diseases effectively. The focus has been on determining urgent medical care needs for patients with vestibular disorders versus those who can be managed on an expedited outpatient basis.
Article
Clinical Neurology
Elena Calzolari, Mariya Chepisheva, Rebecca M. Smith, Mohammad Mahmud, Peter J. Hellyer, Vassilios Tahtis, Qadeer Arshad, Amy Jolly, Mark Wilson, Heiko Rust, David J. Sharp, Barry M. Seemungal
Summary: Vestibular dysfunction is common in patients with TBI and requires a multi-level assessment due to the varied areas of damage. Patients with vestibular agnosia experience more severe imbalance, potentially linked to direct and indirect effects of white matter tract damage in the brain.
Letter
Clinical Neurology
Heiko M. Rust, Rebecca M. Smith, Mohammad Mahmud, John F. Golding, Barry M. Seemungal
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2022)
Article
Medicine, General & Internal
Rebecca M. Smith, Caroline Burgess, Vassilios Tahtis, Jonathan Marsden, Barry M. Seemungal
Summary: This study aims to identify and explore healthcare professional barriers or facilitators to managing vestibular dysfunction in acute traumatic brain injury (aTBI). Results showed that vestibular assessment and treatment were not routinely undertaken by trauma ward staff, and there were uncertainties and gaps in patient care. Therapists were identified as appropriate healthcare professionals to adopt new behaviors regarding management of vestibular dysfunction.
Review
Medicine, Research & Experimental
Matteo Ciocca, Barry M. Seemungal, Yen F. Tai
Summary: This study reviewed preclinical and clinical studies of spinal cord stimulation (SCS) for treating gait dysfunction in Parkinson's disease (PD) and other parkinsonian disorders. While animal studies showed positive results, the outcomes of human studies were inconsistent. Limitations in the field include the lack of blind and statistically powered studies, heterogeneity in patient selection and study outcomes, and poor understanding of the mechanisms of action of SCS.
Article
Sport Sciences
Thomas A. Connor, J. Michio Clark, Jayaratnam Jayamohan, Matt Stewart, Adrian McGoldrick, Claire Williams, Barry M. Seemungal, Rebecca Smith, Roy Burek, Michael D. Gilchrist
SPORTS MEDICINE-OPEN
(2019)
Article
Clinical Neurology
Q. Arshad, R. E. Roberts, H. Ahmad, R. Lobo, M. Patel, T. Ham, D. J. Sharp, B. M. Seemungal
CLINICAL NEUROLOGY AND NEUROSURGERY
(2017)
Article
Medicine, Research & Experimental
Rebecca M. Smith, Natalie Marroney, Jenna Beattie, Abby Newdick, Vassilios Tahtis, Caroline Burgess, Jonathan Marsden, Barry M. Seemungal
PILOT AND FEASIBILITY STUDIES
(2020)