期刊
FRONTIERS IN IMMUNOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2017.00527
关键词
innate immune response; immunometabolism; electron transport chain; mitochondria; macrophages; dendritic cells; cytokines; inflammation
类别
资金
- Spanish Ministry of Economy, Industry and Competitiveness (MINECO)
- CNIC
- European Fund for Regional Development (FEDER) [SAF-2016-79040-R]
- European Commission [635122-PROCROP H2020]
- Fondation ACTERIA
- European Research Council
- MINECO
- Pro-CNIC Foundation
- Severo Ochoa Center of Excellence (MINECO) [SEV-2015-0505]
- CNIC International PhD Programme fellowship la Caixa-Severo Ochoa [OSLC-CNIC-2013-04]
- INSERM
- European FP7-Marie Curie Career Integration Grant [332881]
Sensing of microbe-associated molecular patterns or danger signals by innate immune receptors drives a complex exchange of information. Innate receptor signaling not only triggers transcriptional events but also induces profound changes in metabolic fluxes, redox balance, and metabolite abundance thereby influencing immune cell function. Mitochondria are at the core of metabolic adaptation to the changing environment. The close interaction between mitochondrial metabolism and immune signaling has emerged as a central regulator of innate sensing. Metabolic processes generate a constant flow of electrons that eventually end up in the mitochondrial electron transport chain (ETC). Two electron carriers and four respiratory complexes that can assemble as larger molecular supercomplexes compose the ETC in the mitochondrial inner membrane. While the meaning and biological relevance of such structural organization is a matter of passionate debates, recent data support that innate stimuli remodel the ETC. We will review the function of mitochondrial metabolism and ETC dynamics as innate rheostats that regulate signaling, transcription, and epigenetics to orchestrate innate immune responses.
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