Uterine Natural Killer Cells: Functional Distinctions and Influence on Pregnancy in Humans and Mice

Human Innate Lymphoid Cell Subsets Possess Tissue-Type Based Heterogeneity in Phenotype and Frequency

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Emerging concepts and future challenges in innate lymphoid cell biology

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Activating KIR2DS4 Is Expressed by Uterine NK Cells and Contributes to Successful Pregnancy

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Innate lymphoid cells as regulators of immunity, inflammation and tissue homeostasis

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The Residual Innate Lymphoid Cells in NFIL3-Deficient Mice Support Suboptimal Maternal Adaptations to Pregnancy

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Unique Eomes+ NK Cell Subsets Are Present in Uterus and Decidua During Early Pregnancy

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Identification of a Human Natural Killer Cell Lineage-Restricted Progenitor in Fetal and Adult Tissues

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Co-evolution of NK receptors and HLA ligands in humans is driven by reproduction

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The Structure of the Atypical Killer Cell Immunoglobulin-like Receptor, KIR2DL4

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Composition, Development, and Function of Uterine Innate Lymphoid Cells

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Polymorphic HLA-C Receptors Balance the Functional Characteristics ofKIRHaplotypes

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Cutting Edge: Identification and Characterization of Human Intrahepatic CD49a+NK Cells

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Innate lymphoid cells: A new paradigm in immunology

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Natural cytotoxicity receptor splice variants orchestrate the distinct functions of human natural killer cell subtypes

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Differentiation of Type 1 ILCs from a Common Progenitor to All Helper-like Innate Lymphoid Cell Lineages

(2014) Christoph S.N. Klose et al.   CELL

Ly49 receptors activate angiogenic mouse DBA+ uterine natural killer cells

(2014) Patricia DA Lima et al.   Cellular & Molecular Immunology

Uterine NK cells: active regulators at the maternal-fetal interface

(2014) Ashley Moffett et al.   JOURNAL OF CLINICAL INVESTIGATION

The transcription factor E4bp4/Nfil3 controls commitment to the NK lineage and directly regulates Eomes and Id2 expression

(2014) Victoria Male et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Critical and Differential Roles of NKp46- and NKp30-Activating Receptors Expressed by Uterine NK Cells in Early Pregnancy

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Killer Ig-Like Receptor Expression in Uterine NK Cells Is Biased toward Recognition of HLA-C and Alters with Gestational Age

(2014) A. M. Sharkey et al.   JOURNAL OF IMMUNOLOGY

Unique Receptor Repertoire in Mouse Uterine NK cells

(2014) H. Yadi et al.   JOURNAL OF IMMUNOLOGY

Human NKG2E Is Expressed and Forms an Intracytoplasmic Complex with CD94 and DAP12

(2014) Gerasim A. Orbelyan et al.   JOURNAL OF IMMUNOLOGY

Maternal KIR in Combination with Paternal HLA-C2 Regulate Human Birth Weight

(2014) S. E. Hiby et al.   JOURNAL OF IMMUNOLOGY

Differential Requirement for Nfil3 during NK Cell Development

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Cutting Edge: Salivary Gland NK Cells Develop Independently of Nfil3 in Steady-State

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Identification of diverse innate lymphoid cells in human decidua

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The IPD and IMGT/HLA database: allele variant databases

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Stromal Cells from Human Decidua Exert a Strong Inhibitory Effect on NK Cell Function and Dendritic Cell Differentiation

(2014) Daniele Croxatto et al.   PLoS One

MHC-dependent inhibition of uterine NK cells impedes fetal growth and decidual vascular remodelling

(2014) Jens Kieckbusch et al.   Nature Communications

The Transcription Factor AHR Prevents the Differentiation of a Stage 3 Innate Lymphoid Cell Subset to Natural Killer Cells

(2014) Tiffany Hughes et al.   Cell Reports

Tissue-resident natural killer (NK) cells are cell lineages distinct from thymic and conventional splenic NK cells

(2014) Dorothy K Sojka et al.   eLife

Characterization of T-Bet and Eomes in Peripheral Human Immune Cells

(2014) James J. Knox et al.   Frontiers in Immunology

Controlling Natural Killer Cell Responses: Integration of Signals for Activation and Inhibition

(2013) Eric O. Long et al.   Annual Review of Immunology

Regulation of Ligands for the NKG2D Activating Receptor

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In vivo generation of decidual natural killer cells from resident hematopoietic progenitors

(2013) L. Chiossone et al.   HAEMATOLOGICA

Spiral Artery Remodeling and Trophoblast Invasion in Preeclampsia and Fetal Growth Restriction

(2013) Fiona Lyall et al.   HYPERTENSION

Intraepithelial Type 1 Innate Lymphoid Cells Are a Unique Subset of IL-12- and IL-15-Responsive IFN-γ-Producing Cells

(2013) Anja Fuchs et al.   IMMUNITY

Natural killer cell deficiency

(2013) Jordan S. Orange   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Maternal uterine NK cell–activating receptor KIR2DS1 enhances placentation

(2013) Shiqiu Xiong et al.   JOURNAL OF CLINICAL INVESTIGATION

Liver-resident NK cells confer adaptive immunity in skin-contact inflammation

(2013) Hui Peng et al.   JOURNAL OF CLINICAL INVESTIGATION

Conversion of Peripheral Blood NK Cells to a Decidual NK-like Phenotype by a Cocktail of Defined Factors

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Receptors for non-MHC ligands contribute to uterine natural killer cell activation during pregnancy in mice

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Natural Killer Cell Inhibitory Receptor Expression in Humans and Mice: A Closer Look

(2013) Michal Sternberg-Simon et al.   Frontiers in Immunology

The Ly49 Gene Family. A Brief Guide to the Nomenclature, Genetics, and Role in Intracellular Infection

(2013) Alan Rowe Schenkel et al.   Frontiers in Immunology

DBA-Lectin Reactivity Defines Mouse Uterine Natural Killer Cell Subsets with Biased Gene Expression1

(2012) Zhilin Chen et al.   BIOLOGY OF REPRODUCTION

Imaging of Vascular Development in Early Mouse Decidua and Its Association with Leukocytes and Trophoblasts1

(2012) B. Anne Croy et al.   BIOLOGY OF REPRODUCTION

Impaired natural killer cell self-education and "missing-self" responses in Ly49-deficient mice

(2012) S. Belanger et al.   BLOOD

Skewing of the NK Cell Repertoire by MHC Class I via Quantitatively Controlled Enrichment and Contraction of Specific Ly49 Subsets

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Matrix metalloproteinase expression and activity in trophoblast-decidual tissues at organogenesis in CF-1 mouse

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Impaired decidual natural killer cell regulation of vascular remodelling in early human pregnancies with high uterine artery resistance

(2012) Rupsha Fraser et al.   JOURNAL OF PATHOLOGY

Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells

(2012) Daniel M Andrews et al.   NATURE IMMUNOLOGY

Placenta accreta: Pathogenesis of a 20th century iatrogenic uterine disease

(2012) E. Jauniaux et al.   PLACENTA

First Trimester Pregnancy Decidual Natural Killer Cells Contain and Spontaneously Release High Quantities of Granulysin

(2011) Danijela Veljkovic Vujaklija et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Identification of the earliest natural killer cell-committed progenitor in murine bone marrow

(2011) J. W. Fathman et al.   BLOOD

CD94 Is Essential for NK Cell-Mediated Resistance to a Lethal Viral Disease

(2011) Min Fang et al.   IMMUNITY

Coordinate regulation of tissue macrophage and dendritic cell population dynamics by CSF-1

(2011) Elisa Tagliani et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Ex vivo functional responses to HLA-G differ between blood and decidual NK cells

(2011) R. Apps et al.   MOLECULAR HUMAN REPRODUCTION

Human decidua and invasive trophoblasts are rich sources of nearly all human matrix metalloproteinases

(2011) Jelena Anacker et al.   MOLECULAR HUMAN REPRODUCTION

Natural killer cells direct hemochorial placentation by regulating hypoxia-inducible factor dependent trophoblast lineage decisions

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CD34+ hematopoietic precursors are present in human decidua and differentiate into natural killer cells upon interaction with stromal cells

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Paternal MHC expression on mouse trophoblast affects uterine vascularization and fetal growth

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Innate or Adaptive Immunity? The Example of Natural Killer Cells

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Vascular-Leukocyte Interactions

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The Unique Properties of Uterine NK Cells

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Murine Trophoblast Cells Induce NK Cell Interferon-Gamma Production Through KLRK11

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Natural killer cell-triggered vascular transformation: maternal care before birth?

(2010) Jianhong Zhang et al.   Cellular & Molecular Immunology

Regulation of extravillous trophoblast invasion by uterine natural killer cells is dependent on gestational age

(2010) G. E. Lash et al.   HUMAN REPRODUCTION

Spiral Arterial Remodeling Is Not Essential for Normal Blood Pressure Regulation in Pregnant Mice

(2010) Suzanne D. Burke et al.   HYPERTENSION

Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2

(2010) Susan E. Hiby et al.   JOURNAL OF CLINICAL INVESTIGATION

Immature NK Cells, Capable of Producing IL-22, Are Present in Human Uterine Mucosa

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Intact NKG2D-Independent Function of NK Cells Chronically Stimulated with the NKG2D Ligand Rae-1

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The expanding family of innate lymphoid cells: regulators and effectors of immunity and tissue remodeling

(2010) Hergen Spits et al.   NATURE IMMUNOLOGY

Interleukin-8 (CXCL8) stimulates trophoblast cell migration and invasion by increasing levels of matrix metalloproteinase (MMP)2 and MMP9 and integrins α5 and β1

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Evidence for Immune Cell Involvement in Decidual Spiral Arteriole Remodeling in Early Human Pregnancy

(2009) Samantha D. Smith et al.   AMERICAN JOURNAL OF PATHOLOGY

Murine Endometrial and Decidual NK1.1+ Natural Killer Cells Display a B220+CD11c+ Cell Surface Phenotype1

(2009) Thomas V. Mallidi et al.   BIOLOGY OF REPRODUCTION

Education of human natural killer cells by activating killer cell immunoglobulin-like receptors

(2009) C. Fauriat et al.   BLOOD

Maturation of mouse NK cells is a 4-stage developmental program

(2009) L. Chiossone et al.   BLOOD

Immune cells in the placental bed

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KIR2DS4 is a product of gene conversion with KIR3DL2 that introduced specificity for HLA-A*11 while diminishing avidity for HLA-C

(2009) Thorsten Graef et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Decidual leucocyte populations in early to late gestation normal human pregnancy

(2009) P.J. Williams et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Rheological and Physiological Consequences of Conversion of the Maternal Spiral Arteries for Uteroplacental Blood Flow during Human Pregnancy

(2009) G.J. Burton et al.   PLACENTA

The strength of inhibitory input during education quantitatively tunes the functional responsiveness of individual natural killer cells

(2008) P. Brodin et al.   BLOOD

MHC class I-specific inhibitory receptors and their ligands structure diverse human NK-cell repertoires toward a balance of missing self-response

(2008) M. Yawata et al.   BLOOD

Ly49 cluster sequence analysis in a mouse model of diabetes: an expanded repertoire of activating receptors in the NOD genome

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Natural-killer cell ligands at the maternal-fetal interface: UL-16 binding proteins, MHC class-I chain related molecules, HLA-F and CD48

(2008) R. Apps et al.   HUMAN REPRODUCTION

Association of maternal killer-cell immunoglobulin-like receptors and parental HLA-C genotypes with recurrent miscarriage

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Human leucocyte antigen (HLA) expression of primary trophoblast cells and placental cell lines, determined using single antigen beads to characterize allotype specificities of anti-HLA antibodies

(2008) Richard Apps et al.   IMMUNOLOGY

Regulatory role of NKp44, NKp46, DNAM-1 and NKG2D receptors in the interaction between NK cells and trophoblast cells. Evidence for divergent functional profiles of decidual versus peripheral NK cells

(2008) P. Vacca et al.   INTERNATIONAL IMMUNOLOGY