期刊
FRONTIERS IN IMMUNOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2017.01750
关键词
angiogenesis; metabolism; sprouting; tip and stalk cells; tumor angiogenesis
类别
资金
- LE&RN/FDRS/LP Lipedema Postdoctoral Fellowship
- FWO Postdoctoral Fellowships
- PC: Federal Government Belgium grant [IUAP P7/03]
- Flemish Government
- Research Foundation Flanders (FWO)
- Foundation Leducq Transatlantic Network (ARTEMIS)
- Foundation against cancer
- European Research Council (ERC) Advanced Research Grant [EU-ERC269073]
- AXA Research Fund
Endothelial cells (ECs) line blood vessels, i.e., vital conduits for oxygen and nutrient delivery to distant tissues. While mostly present as quiescent phalanx cells throughout adult life, ECs can rapidly switch to a migratory tip cell and a proliferative stalk cell, and sprout into avascular tissue to form new blood vessels. The angiogenic switch has long been considered to be primarily orchestrated by the activity of angiogenic molecules. However, recent evidence illustrates an instrumental role of cellular metabolism in vessel sprouting, whereby ECs require specific metabolic adaptations to grow. Here, we overview the emerging picture that tip, stalk, and phalanx cells have distinct metabolic signatures and discuss how these signatures can become deregulated in pathological conditions, such as in cancer.
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