Article
Microbiology
Adriana A. Pedroso, Margie D. Lee, John J. Maurer
Summary: Transfer of intestinal microbiota from adult to juvenile animals reduces Salmonella prevalence and abundance in chickens. Specific member species in the bacterial community correlate with Salmonella abundance in the chicken ceca, with exclusive species potentially reducing Salmonella while permissive species could predict super-shedders. The link between intestinal bacterial species diversity and the presence of specific member species with Salmonella abundance is strongly supported.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Agriculture, Dairy & Animal Science
Michael H. Kogut, Mariano Enrique Fernandez Miyakawa
Summary: The gastrointestinal ecosystem involves interactions between the host, gut microbiota, and external environment. Paratyphoid Salmonella in chickens have evolved a unique survival strategy, minimizing the inflammatory response during the initial infection to enhance disease resistance and inducing immunometabolic reprogramming to alter host defense and facilitate asymptomatic carriage of the bacterial pathogen.
Article
Immunology
Anne Wisgalla, Caren Ramien, Mathias Streitz, Stephan Schlickeiser, Andreea-Roxana Lupu, Anke Diemert, Eva Tolosa, Petra C. Arck, Judith Bellmann-Strobl, Nadja Siebert, Christoph Heesen, Friedemann Paul, Manuel A. Friese, Carmen Infante-Duarte, Stefan M. Gold
Summary: During pregnancy, there are significant shifts in NK cell populations, with an increase in CD56(bright) NK cells and a decrease in CD56(dim) NK cells. These changes occur in both pregnant women with multiple sclerosis and healthy pregnant women, potentially contributing to disease amelioration in multiple sclerosis during pregnancy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Agriculture, Dairy & Animal Science
Mamadou Thiam, Astrid Lissette Barreto Sanchez, Jin Zhang, Maiqing Zheng, Jie Wen, Guiping Zhao, Qiao Wang
Summary: The H/L ratio is associated with intestinal immunity and could be a potential resistance indicator in chickens, with individuals displaying enhanced intestinal barrier function and immunity when having a low H/L ratio. The study suggests that selecting poultry with a low H/L ratio may improve survival, immune response, and resistance to Salmonella infection.
Article
Infectious Diseases
Giulia Giovagnoni, Famatta Perry, Benedetta Tugnoli, Andrea Piva, Ester Grilli, Ryan J. Arsenault
Summary: The immunometabolic role of antibiotics and plant extracts was studied on a chicken macrophage-like cell line during a Salmonella Enteritidis infection. Oxytetracycline, thyme essential oil, and capsicum oleoresin showed no significant impact, while garlic oil affected glycolysis. Gentamicin and grape seed extract exhibited the best immunometabolic profile, helping the host with immune response activation and maintaining a less inflammatory status metabolically.
Article
Gastroenterology & Hepatology
Yihang Li, Kyan M. Thelen, Karina Matos Fernandez, Rahul Nelli, Mahsa Fardisi, Mrigendra Rajput, Nathalie L. Trottier, Genaro A. Contreras, Adam J. Moeser
Summary: These studies reveal that early-life adversity in the form of early weaning in pigs causes a developmental shift in intestinal glucose transport from SGLT1 toward GLUT2-mediated transport. Early weaning also induced markers of metabolic inflammation including persistent elevations in blood glucose and the inflammatory marker CRP, along with increased visceral adiposity. Altered intestinal glucose transport might contribute to increased risk for inflammatory and metabolic diseases associated with early-life adversity.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
(2022)
Article
Multidisciplinary Sciences
Bram Van den Bergh, Hannah Schramke, Joran Elie Michiels, Tom E. P. Kimkes, Jakub Leszek Radzikowski, Johannes Schimpf, Silke R. Vedelaar, Sabrina Burschel, Liselot Dewachter, Nikola Loncar, Alexander Schmidt, Tim Meijer, Maarten Fauvart, Thorsten Friedrich, Jan Michiels, Matthias Heinemann
Summary: Antibiotic persisters are phenotypic variants within an isogenic bacterial population that are transiently tolerant to antibiotic treatment. This study provides evidence that cytoplasmic acidification, amplified by a compromised respiratory complex I, can act as a signaling hub for perturbed metabolic homeostasis in antibiotic persisters.
NATURE COMMUNICATIONS
(2022)
Article
Microbiology
Yanan Li, Thomas K. Wood, Weiwei Zhang, Chenghua Li
Summary: The study found that active cells of V. splendidus can more readily become persister cells in the presence of A. japonicus coelomic fluids, leading to a potential threat to hosts due to the ability of these persister cells to escape the immune system. The coelomic fluids-induced persister cells show similar phenotypes and resuscitation patterns as antibiotic-induced persister cells, indicating a potential mechanism for the pathogen V. splendidus to evade the host immune system during infection.
ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Microbiology
Sofia Ribeiro, Joana Mourao, Angela Novais, Joana Campos, Luisa Peixe, Patricia Antunes
Summary: The study evaluated the occurrence of MCR-E in 53 chicken-meat batches from 29 Portuguese farms shortly after colistin withdrawal. It found high rates of multidrug-resistant Escherichia coli and Klebsiella pneumoniae clones in the chicken-meat batches, some persisting over time. The diverse locations of the MCR-1 plasmid and the potential effectiveness of colistin withdrawal in poultry production were highlighted.
ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Toxicology
Elena Kozlova, Matthew C. Valdez, Maximillian E. Denys, Anthony E. Bishay, Julia M. Krum, Kayhon M. Rabbani, Valeria Carrillo, Gwendolyn M. Gonzalez, Gregory Lampel, Jasmin D. Tran, Brigitte M. Vazquez, Laura M. Anchondo, Syed A. Uddin, Nicole M. Huffman, Eduardo Monarrez, Duraan S. Olomi, Bhuvaneswari D. Chinthirla, Richard E. Hartman, Prasada Rao S. Kodavanti, Gladys Chompre, Allison L. Phillips, Heather M. Stapleton, Bernhard Henkelmann, Karl-Werner Schramm, Margarita C. Curras-Collazo
Summary: The study demonstrated that maternal exposure to DE-71 PBDEs can produce adverse effects on offspring's neurobehavioral and neurochemical functions, resulting in ASD-like phenotypes. These effects may stem from early neurodevelopmental reprogramming within central social and memory networks.
ARCHIVES OF TOXICOLOGY
(2022)
Article
Medicine, Research & Experimental
Valerie Trendelenburg, Sabine Doelle-Bierke, Nathalie Unterleider, Aikaterina Alexiou, Birgit Kalb, Lara Meixner, Stephanie Heller, Susanne Lau, Young-Ae Lee, Florent Fauchere, Julian Braun, Magda Babina, Sabine Altrichter, Till Birkner, Stephanie Roll, Josefine Dobbertin-Welsch, Margitta Worm, Kirsten Beyer
Summary: This study aims to investigate whether consuming low allergen amounts below the individual threshold can promote natural tolerance development, and whether regular allergen consumption can prevent the (re-)development of peanut or tree nut allergy.