Article
Clinical Neurology
Kwang-Dong Choi, Jeong-Yeon Kim, Seo-Young Choi, Eun Hye Oh, Hyun-Min Lee, Jieun Roh, Jae-Hwan Choi
Summary: 22q11.2 deformation syndrome (22q11.2DS) is a rare genetic disorder that can cause hearing impairment and vertigo, often associated with inner ear malformations. In this case, the patient experienced fluctuating sensorineural hearing loss, especially in the left ear.
FRONTIERS IN NEUROLOGY
(2021)
Article
Medicine, General & Internal
Yi Zhang, Chenyi Wei, Zhengtao Sun, Yue Wu, Zhengli Chen, Bo Liu
Summary: Strict clinical management can help preserve or improve hearing in patients with Meniere's disease. The restoration time varies across different stages, with shorter restoration time in the early stages. The initial hearing stage, age, and audiogram pattern are related to hearing improvement.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Otorhinolaryngology
Joon-Pyo Hong, Jung-Yup Lee, Min-Beom Kim
Summary: This study aimed to investigate the patterns of impairment in peripheral vestibular organs in sudden sensorineural hearing loss (SSNHL) with and without vertigo. The data of 165 SSNHL patients from January 2017 to December 2022 were retrospectively analyzed. The study found that the most frequently impaired vestibular organ in SSNHL_V patients was the posterior semicircular canal, while in SSNHL_N patients it was the saccule. The presence of vertigo may require different treatments for SSNHL.
OTOLARYNGOLOGY-HEAD AND NECK SURGERY
(2023)
Article
Clinical Neurology
Daogong Zhang, Yafeng Lv, Xiaofei Li, Yongdong Song, Ligang Kong, Zhaomin Fan, Haibo Wang
Summary: Resection of the lateral wall of the endolymphatic sac is an effective and safe therapy for intractable Meniere's disease, providing effective control of vertiginous symptoms without significant complications.
FRONTIERS IN NEUROLOGY
(2022)
Review
Clinical Neurology
Calvin J. Kersbergen, Bryan K. Ward
Summary: Meniere's disease is an inner ear disorder with unknown cause, often presenting with distressing symptoms like vertigo. Surgical treatments, including manipulation of the membranous labyrinth, have been used historically but can lead to variable degrees of hearing loss in patients. More research is needed to better understand the relationship between endolymphatic hydrops, Meniere's disease pathophysiology, and patient symptoms.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Sarah Diorflar, Caroline Guigou, Edouard Daguet, Jean-Loup Bensimon, Michel Toupet, Alexis Bozorg-Grayeli
Summary: The aim of this study was to compare different MRI diagnostic criteria for endolymphatic hydrops (EH) and investigate the relation between audiovestibular and MRI findings in Meniere's disease (MD). The results showed that SURI was the best criterion related to the disease side, and the coherence between MRI and audio vestibular tests improved with a short delay.
FRONTIERS IN NEUROLOGY
(2023)
Article
Oncology
Ryne Holmberg, Mikella Robinson, Samuel F. Gilbert, Omar Lujano-Olazaba, Jennifer A. Waters, Emily Kogan, Candyd Lace R. Velasquez, Denay Stevenson, Luisjesus S. Cruz, Logan J. Alexander, Jacqueline Lara, Emily M. Mu, Jared Rafael Camillo, Benjamin G. Bitler, Tom Huxford, Carrie D. House
Summary: Disease recurrence in high-grade serous ovarian cancer may be attributed to resistant cancer stem-like cells (CSC) that can reestablish tumors. The study reveals that the TNF-like weak inducer of apoptosis (TWEAK) and its receptor, Fn14, play a role in activating the alternative NF-xB signaling pathway in ovarian tumors after chemotherapy. Furthermore, TWEAK enhances the characteristics of CSCs and induces the expression of the CSC marker CD117 in ovarian cancer cells. Blocking the TWEAK-Fn14-RelB signaling cascade prolongs survival in a mouse model of ovarian cancer treated with carboplatin chemotherapy.
MOLECULAR CANCER RESEARCH
(2023)
Article
Pediatrics
Yan-Hong Li, Bing Liu, Yang Yang, Min Chen, Wei Liu, Jian-Bo Shao, Xiao Zhang, Jie Zhang, Xin Ni
Summary: The study evaluated the relationship between vestibular and auditory functions in pediatric patients with sudden sensorineural hearing loss (SSHL). Results showed that children with vertigo symptoms and abnormal caloric test results had higher initial hearing thresholds and lower recovery rates. Assessments of vertigo symptoms and vestibular function are useful tools in predicting pediatric SSHL patient disease severity and prognosis.
WORLD JOURNAL OF PEDIATRICS
(2021)
Article
Medicine, General & Internal
Yuanping Zhu, Sihai He, Kang Liao, Meihua Li, Zhibin Zhao, Hongyan Jiang
Summary: This study aimed to characterize the clinical profiles and short-term outcomes of adult patients with full-frequency idiopathic sudden sensorineural hearing loss (ISSNHL) treated uniformly with combination therapy and to determine the prognostic predictors for the combination therapy. A retrospective review of 131 eligible cases was conducted, and all enrolled cases received a standardized combination therapy. The recovery rate was 57.3% and accompanying vertigo and low BMI were identified as independent predictors of poor prognosis.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Otorhinolaryngology
Marie N. Shimanuki, Seiichi Shinden, Naoki Oishi, Noriomi Suzuki, Kaho Iwabu, Tsubasa Kitama, Amina Kida, Koji Sakamoto, Kaoru Ogawa
Summary: Age, initial hearing level, vertigo, and hearing improvement on days 6-7 after treatment initiation were identified as independent predictors of hearing recovery in idiopathic sudden sensorineural hearing loss (ISSHL). Older age, higher initial hearing level, and presence of vertigo contributed to poor prognosis, while patients without these factors and with significant hearing improvement had a higher chance of complete recovery.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2021)
Review
Neurosciences
Francis A. M. Manno, Raul Rodriguez-Cruces, Rachit Kumar, J. Tilak Ratnanather, Condon Lau
Summary: Hearing loss, a heterogeneous disorder, is found to impact grey and white matter in nearly every brain region according to MRI studies. Congenital loss decreases grey matter in frontal lobe most, while acquired loss shows significant decreases in both frontal and insula grey matter. Different impacts on hemispheres are observed between congenital and acquired hearing loss.
Review
Medicine, Research & Experimental
Shadi Ahmadmehrabi, Jason Brant, Douglas J. Epstein, Michael J. Ruckenstein, Daniel J. Rader
Summary: The traditional focus in literature and clinical practice on adult-onset hearing loss has been on environmental risk factors, but recent studies have shown increasing evidence of gene-environment interactions playing a role in adult cases of HL. Susceptibility loci for age-related HL have been identified, and genes related to postlingual nonsyndromic HL continue to be discovered through individual reports and genome-wide association studies.
Article
Clinical Neurology
Ricardo Wegmann-Vicuna, Raquel Manrique-Huarte, Diego Calavia-Gil, Eduardo Martin-Sanz, Pedro Marques, Nicolas Perez-Fernandez
Summary: The reduction in vestibulo-ocular reflex (VOR) gain measured with the video head-impulse test (vHIT) 1 month after the first intratympanic injection can predict the need for additional injections to control vertigo spells in patients with intractable Meniere's disease (MD). Single intratympanic treatment with gentamicin is effective and has limited impact on hearing in MD patients.
FRONTIERS IN NEUROLOGY
(2022)
Article
Medicine, Research & Experimental
Andras Molnar, Stefani Maihoub, Laszlo Tamas, Agnes Szirmai
Summary: The study found that adding intratympanic steroid therapy to betahistine did not improve outcomes in treating vertigo attacks in patients with Meniere's disease. There was no significant difference between the groups in terms of vertigo attack occurrence, indicating the need for further prospective studies for a more detailed analysis.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2021)
Article
Integrative & Complementary Medicine
Yuemei Li, Zhe Lv, Haixia Han, Xiaofang Jia, Lijiao Guo
Summary: This study analyzed the vestibular function characteristics of patients with Meniere's disease and acute hypophonic sensorineural hearing loss in order to identify more reliable and objective ancillary tests. The results showed that factors such as age, head posture, and stimulus type influenced the test results. However, the small sample size limited the comprehensive assessment of vestibular function differences between the two patient groups.
EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
(2022)
Editorial Material
Neurosciences
Jose A. Lopez-Escamez, Arnaud Attye
JOURNAL OF VESTIBULAR RESEARCH-EQUILIBRIUM & ORIENTATION
(2023)
Letter
Infectious Diseases
Juan Riestra-Ayora, Maria Garrote-Garrote, Cristina Molina-Quiros, Eduardo Martin-Sanz
ENFERMEDADES INFECCIOSAS Y MICROBIOLOGIA CLINICA
(2023)
Article
Biochemistry & Molecular Biology
Menglin Zheng, Satoshi Okawa, Miren Bravo, Fei Chen, Maria-Luz Martinez-Chantar, Antonio del Sol
Summary: This article introduces a database called ChemPert, which contains transcriptional response data of non-cancer cell types to various perturbations. It also mentions a computational tool that uses non-cancer cell datasets for more accurate predictions of perturbation responses and drugs. This research is important for further studies on compound screening in non-cancer cells.
NUCLEIC ACIDS RESEARCH
(2023)
Article
Cell Biology
Sascha Jung, Javier Arcos Hodar, Antonio del Sol
Summary: In this study, MultiTIMER, the first multi-tissue aging clock, is presented. It can measure the biological age of cells from their transcriptional profiles by evaluating key cellular processes, instead of the chronological age. The authors applied MultiTIMER to a large number of transcriptional profiles and demonstrated its accuracy in responding to cellular stressors, known interventions, and dysregulated cellular functions.
Article
Medicine, General & Internal
Nicolas Perez-Fernandez, Sara Saez Coronado, Cristina Zulueta-Santos, Fernando Neria Serrano, Jorge Rey-Martinez, Melisa Blanco, Raquel Manrique-Huarte
Summary: Benign paroxysmal positional vertigo (BPPV) and bilateral vestibulopathy (BVL) are two distinct forms of vestibular disorder that can occur in the same patient. A retrospective review of patient data over a 15-year period found this coincidence in 23 patients, accounting for 0.4%. Sequential occurrence was more common (10/23) with BPPV diagnosed first, while simultaneous presentation occurred in 9/23 patients. A prospective study in BPPV patients found a slightly higher frequency of bilateral vestibular loss (6/405).
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Biology
Ismael Aran-Tapia, Andres Soto-Varela, Vicente Perez-Munuzuri, Sofia Santos-Perez, Ismael Aran, Alberto P. Munuzuri
Summary: Computational modelling can help personalize the diagnosis of vestibular diseases, particularly in the context of the Head Impulse Test. This study highlights the importance of considering the orientation of the cupulae in order to ensure optimal conditions for testing the vestibular function.
COMPUTERS IN BIOLOGY AND MEDICINE
(2023)
Review
Otorhinolaryngology
Alejandro Rivero-de-Aguilar, Andres Soto-Varela, Marilina Puente-Hernandez, Jesus Porta-Etessam
Summary: This study aims to review vestibular disorders from a practical perspective and provide guidance to physicians involved in the emergency care of patients with vestibular symptoms. Based on the main causes of vestibular disorders, they can be categorized into three syndromic entities (acute, recurrent, and chronic vestibular syndromes). This review provides clinicians with useful tools to approach their patients with vestibular symptoms in the emergency room.
EUROPEAN ARCHIVES OF OTO-RHINO-LARYNGOLOGY
(2023)
Article
Clinical Neurology
Juan Manuel Espinosa-Sanchez, Alex Gomez-Marin, Fernando de Castro
Summary: The origins of cybernetics can be traced back to two influential papers published in 1943. The first paper established the concept of purposeful behavior being controlled by negative feedback, while the second paper proposed the idea of interconnected neurons acting as logical operators. These ideas caught the attention of von Neumann, who was working on the development of the first stored-program computer. Subsequent meetings were held between 1946 and 1953 to further explore these concepts. The contribution of Spanish neurophysiologist Rafael Lorente de No in the early days of cybernetics is noteworthy, as he not only participated in key conferences but also provided the first neurobiological demonstration of a feedback loop.
Editorial Material
Medicine, General & Internal
Nicolas Perez-Fernandez, Angel Ramos-Macias
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Victor Suarez-Vega, Raquel Manrique-Huarte, Pablo Dominguez, Melissa Blanco, Alberto Alonso-Burgos, Nicolas Perez-Fernandez
Summary: This study aimed to quantitatively measure vestibular hydrops in patients with Meniere's disease using the 3D-REAL-IR imaging technique and correlate it with qualitative grading scales. The results showed that this imaging technique can reliably assess the severity of vestibular hydrops in daily clinical practice.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Neurosciences
Dietmar Basta, Marcos Rossi-Izquierdo, Kai Wonneberger, Cibele Brugnera, Roseli Saraiva Moreira Bittar, Mario Edvin Greters, Arne Ernst, Andres Soto-Varela
Summary: The individualized vibrotactile neurofeedback training (IVNT) is highly effective in improving balance, reducing self-perceived disability, and improving gait in patients with confirmed bilateral vestibulopathy (BVP).
Article
Biochemistry & Molecular Biology
Mikhail Raevskiy, Vladislav Yanvarev, Sascha Jung, Antonio Del Sol, Yulia A. Medvedeva
Summary: Epi-Impute is a computational method that uses expression and epigenomic data to impute dropouts in single-cell RNA-seq data, reducing imputation error and preserving gene-gene and cell-cell relationships. It outperforms existing methods, especially for sparse datasets, and allows for the discovery of functionally relevant cell clusters.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, Research & Experimental
Eduardo Martin-Sanz, Marta Chaure-Cordero, Juan Riestra-Ayora, Rocio Gonzalez-Marquez, Irene Marmol-Szombathy, Jonathan Esteban-Sanchez
Summary: This study assessed the clinical significance of the Bow and Lean Test (BLT) for diagnosing different types of vertical canal Benign Paroxysmal Positional Vertigo (BPPV). The results showed that BLT had a certain sensitivity and specificity in diagnosing different types of BPPV, but there may be variations in the results due to differences in patient characteristics and test execution.
Article
Otorhinolaryngology
Melissa Blanco Pareja, Gloria Liano Esteso, Victor Suarez-Vega, Raquel Manrique-Huarte, Pablo Dominguez, Nicolas Perez-Fernandez
Summary: This study retrospectively reviewed the data of 10 patients with suspected inner ear hemorrhage and evaluated the lesional patterns from radiological and functional aspects. The results showed that only a portion of patients with sensorineural hearing loss had a correlation between MRI findings and dysfunction in the inner ear. Therefore, specific MRI sequences should be requested to rule out inner ear hemorrhage in patients with sensorineural hearing loss.
ACTA OTO-LARYNGOLOGICA
(2023)
Article
Allergy
Lourdes Ortiz-Fernandez, Javier Martin, Marta E. Alarcon-Riquelme
Summary: Systemic lupus erythematosus, systemic sclerosis, rheumatoid arthritis, and Sjogren's syndrome are major autoimmune rheumatic diseases with complex etiologies influenced by environmental and genetic factors. The HLA region is the strongest susceptibility factor for these conditions, and non-HLA risk genetic variants have also been discovered.
CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY
(2023)