期刊
FRONTIERS IN IMMUNOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2017.01183
关键词
major histocompatibility complex; LC3-associated phagocytosis; IL-1; Epstein-Barr virus; varicella zoster virus; poliovirus; coxsackievirus
类别
资金
- Swiss National Science Foundation [310030_162560, CRSII3_160708]
- Cancer Research Switzerland [KFS-4091-02-2017]
- SPARKS [15UOZ01]
- Sobek Foundation
- Swiss MS Society
- University of Zurich
- Swiss National Science Foundation (SNF) [CRSII3_160708, 310030_162560] Funding Source: Swiss National Science Foundation (SNF)
- Sparks Charity [15UOZ01] Funding Source: researchfish
Autophagy was initially described as a catabolic pathway that recycles nutrients of cytoplasmic constituents after lysosomal degradation during starvation. Since the immune system monitors products of lysosomal degradation via major histocompatibility complex (MHC) class II restricted antigen presentation, autophagy was found to process intracellular antigens for display on MHC class II molecules. In recent years, however, it has become apparent that the molecular machinery of autophagy serves phagocytes in many more membrane trafficking pathways, thereby regulating immunity to infectious disease agents. In this minireview, we will summarize the recent evidence that autophagy proteins regulate phagocyte endocytosis and exocytosis for myeloid cell activation, pathogen replication, and MHC class I and II restricted antigen presentation. Selective stimulation and inhibition of the respective functional modules of the autophagy machinery might constitute valid therapeutic options in the discussed disease settings.
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