Article
Chemistry, Multidisciplinary
Weiwei Wang, Jing Zhao, Changlong Hao, Shudong Hu, Chen Chen, Yi Cao, Zhengyu Xu, Jun Guo, Liguang Xu, Maozhong Sun, Chuanlai Xu, Hua Kuang
Summary: This study discovers the potential of chiral nanomaterials as immunoadjuvants for the prevention and treatment of cancer. Chiral nanoparticles enhance immune response and inhibit tumor growth through the stimulation of specific cell types, showing better therapeutic effects compared to achiral nanoparticles.
ADVANCED MATERIALS
(2022)
Article
Biology
Nicholas J. Hess, Nikhila S. Bharadwaj, Elizabeth A. Bobeck, Courtney E. McDougal, Shidong Ma, John-Demian Sauer, Amy W. Hudson, Jenny E. Gumperz
Summary: Co-transplanted allogeneic CD4(+) iNKT cells interact with monocytes and T cells in the graft to coordinate pro-hematopoietic and immunoregulatory pathways in a human umbilical cord blood xenotransplantation model. The nexus of iNKT cells, monocytes, and cord blood T cells leads to enhanced hematopoietic stem and progenitor cell activity and suppression of T-cell inflammatory responses, resulting in successful long-term hematopoietic engraftment without pretransplant conditioning.
LIFE SCIENCE ALLIANCE
(2021)
Review
Immunology
Yingyu Qin, Xueyang Bao, Mingzhu Zheng
Summary: CD8(+) T cells from the adaptive immune system and iNKT cells from the innate-like T lymphocytes both play important roles in defending against infections and cancers. CD8(+) T cell-based immunotherapy is a promising approach for the eradication of tumor cells, and iNKT cells contribute to CD8(+) T cell immunity through cross-priming and memory formation. This review also discusses recent advances in understanding the mechanisms of memory CD8(+) T cell differentiation and aging-induced impairment of T cell immunity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Jiang Zhang, Stephanie Le Gras, Kevin Pouxvielh, Fabrice Faure, Lucie Fallone, Nicolas Kern, Marion Moreews, Anne-Laure Mathieu, Raphael Schneider, Quentin Marliac, Mathieu Jung, Aurore Berton, Simon Hayek, Pierre-Olivier Vidalain, Antoine Marcais, Garvin Dodard, Anne Dejean, Laurent Brossay, Yad Ghavi-Helm, Thierry Walzer
Summary: EOMES and T-BET, two related transcription factors, regulate distinct developmental processes in Natural Killer cell development by sharing a large proportion of target genes but exhibiting differential expression patterns and associated co-factors.
NATURE COMMUNICATIONS
(2021)
Article
Immunology
Suzan Adin-Cinar, Metin Yusuf Gelmez, Nilgun Akdeniz, Gulce Ozcit-Gurel, Ayca Kiykim, Elif Karakoc-Aydiner, Isil Barlan, Gunnur Deniz
Summary: Primary immune deficiencies (PID) are a group of over 400 genetic defects affecting the development and function of the immune system. Common Variable Immunodeficiency (CVID), Ataxia Telangiectasia (AT), and Agammaglobulinemia (AG) are examples of common immunodeficiency syndromes. This study focused on the analysis of NK and iNKT cells in patients with CVID, AT, and AG, revealing alterations in NK subsets, receptor expression, and cytokine production in pediatric patients compared to healthy individuals.
IMMUNOLOGY LETTERS
(2021)
Article
Immunology
Lauren Daniel, Marion Tassery, Clara Lateur, Antoine Thierry, Andre Herbelin, Jean-Marc Gombert, Alice Barbarin
Summary: Immunosenescence is a physiological process associated with changes in the immune system, particularly involving CD8 T cells. The newly described innate E(+) CD8 T cells may exhibit an exacerbated senescent phenotype in a chronic inflammatory environment, especially in kidney transplant and cytomegalovirus-infected patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Dan Lv, Muhammad Babar Khawar, Zhengyan Liang, Yu Gao, Haibo Sun
Summary: Immunotherapy has become a significant treatment strategy for cancer patients. Targeting cancer neoantigens through major histocompatibility complex (MHC) molecules, which result from highly immunogenic non-synonymous somatic mutations, is a promising approach for cancer immunotherapy. Current therapeutic options include neoantigen vaccines and adoptive T-cell therapy, which are being tested in clinical trials for various malignancies. This review focuses on the use of neoantigens as cancer therapy targets and discusses neoantigen identification, clinical usage of personalized neoantigen-based therapy, and the development of off-the-shelf products based on shared neoantigens. Additionally, the review introduces and discusses the potential impact of the neoantigen-MHC complex on natural killer (NK) cell antitumor function, suggesting a novel method to enhance immune response-induced cytotoxicity against malignancies.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Xiaobo Cheng, Jing Wang, Chenli Qiu, Yanling Jin, Bili Xia, Ran Qin, Huiliang Hu, Jia Yan, Xiaoyan Zhang, Jianqing Xu
Summary: This study is an ongoing single-arm exploratory clinical trial that used iNKT cells, PD-1+CD8+ T cells, and dendritic cells as treatment for patients. Preliminary results showed manageable tolerance and positive tumor response for this immunotherapy.
CLINICAL IMMUNOLOGY
(2022)
Review
Oncology
Julian Burks, Purevdorj B. Olkhanud, Jay A. Berzofsky
Summary: Gastrointestinal cancers are a group of complex cancers that affect the digestive system. NKT cells, with their immunoregulatory properties, play a crucial role in tumor immunity and can have either anti-tumor or pro-tumor effects depending on the cytokine profile expressed and the type of GI cancer.
Article
Cell Biology
Menghao You, Jingjing Liu, Jie Li, Ce Ji, Haochen Ni, Wenhui Guo, Jiarui Zhang, Weiwei Jia, Zhao Wang, Yajiao Zhang, Yingpeng Yao, Guotao Yu, Huanyu Ji, Xiaohu Wang, Dali Han, Xuguang Du, Meng Michelle Xu, Shuyang Yu
Summary: The study reveals that Mettl3, an N6-methyladenosine (m6A) methyltransferase, is involved in innate immune cell regulation. It shows that Mettl3 intrinsically controls the development and function of invariant natural killer T (iNKT) cells through m6A-dependent mechanisms. Deficiency of Mettl3 disrupts the expression of iNKT cell-related genes and alters m6A modification, leading to impairments in proliferation, differentiation, and cytokine secretion of iNKT cells. The study also identifies Creb1 as a key downstream target of Mettl3, and ectopic expression of Creb1 can rescue the developmental defects in Mettl3-deficient iNKT cells.
Article
Immunology
Guangwei Cui, Akihiro Shimba, Jianshi Jin, Taisaku Ogawa, Yukiko Muramoto, Hitoshi Miyachi, Shinya Abe, Takuma Asahi, Shizue Tani-Ichi, Johannes M. Dijkstra, Yayoi Iwamoto, Kirill Kryukov, Yuanbo Zhu, Daichi Takami, Takahiro Hara, Satsuki Kitano, Yan Xu, Hajime Morita, Moyu Zhang, Lynn Zreka, Keishi Miyata, Takashi Kanaya, Shinya Okumura, Takashi Ito, Etsuro Hatano, Yoshimasa Takahashi, Hiroshi Watarai, Yuichi Oike, Tadashi Imanishi, Hiroshi Ohno, Toshiaki Ohteki, Nagahiro Minato, Masato Kubo, Georg A. Hollander, Hideki Ueno, Takeshi Noda, Katsuyuki Shiroguchi, Koichi Ikuta
Summary: This study reveals a circulating subset of iNKT cells, C2 iNKT cells, with NK cell-like properties distinct from conventional tissue-resident iNKT cells. C2 iNKT cells protect against tumor metastasis and promote antiviral immune responses.
SCIENCE IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Mallory Paynich Murray, Isaac Engel, Gregory Seumois, Sara Herrera-De la Mata, Sandy Lucette Rosales, Ashu Sethi, Ashmitaa Logandha Ramamoorthy Premlal, Goo-Young Seo, Jason Greenbaum, Pandurangan Vijayanand, James P. Scott-Browne, Mitchell Kronenberg
Summary: The study found that iNKT cell subsets are similar regardless of tissue location, with lung iNKT cells possessing the most distinct location-specific features possibly due to increased activation. Following antigenic stimulation, iNKT cells undergo chromatin and transcriptional changes, giving rise to additional subsets.
NATURE COMMUNICATIONS
(2021)
Article
Multidisciplinary Sciences
Yan-Ruide Li, Samuel Zeng, Zachary Spencer Dunn, Yang Zhou, Zhe Li, Jiaji Yu, Yu-Chen Wang, Josh Ku, Noah Cook, Adam Kramer, Lili Yang
Summary: Third-party HSC-engineered human iNKT cells, generated using a combination of HSC gene engineering and in vitro HSC differentiation, closely resemble endogenous human iNKT cells in phenotype and functionality. These cells display potent anti-GvHD functions without negatively impacting tumor eradication by allogeneic T cells, making them a promising off-the-shelf cell therapy candidate for GvHD prophylaxis.
Article
Immunology
Svjetlana Raus, Jarrett Lopez-Scarim, Joshua Luthy, Eva Billerbeck
Summary: This study investigated the role of invariant natural killer T (iNKT) cells during hepacivirus infection in an immune-competent mouse model. The findings showed that rodent hepacivirus infection activated iNKT cell subsets and resulted in production of type 2 cytokines. Lack of iNKT cells led to higher levels of liver injury during infection and enhanced effector functions of hepatic antiviral T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Takahiro Aoki, Shinichiro Motohashi, Haruhiko Koseki
Summary: iNKT cells are a subset of innate-like T cells that are restricted by CD1d and activated by recognizing glycolipid antigens. Researchers have successfully differentiated iPSCs into iNKT cells with anti-tumor activity, and the first-in-human clinical trial of iPSC-iNKT cell therapy is currently ongoing.
INFLAMMATION AND REGENERATION
(2023)
Article
Multidisciplinary Sciences
Marianela C. Serradell, Lucia L. Rupil, Roman A. Martino, Cesar G. Prucca, Pedro G. Carranza, Alicia Saura, Elmer A. Fernandez, Pablo R. Gargantini, Albano H. Tenaglia, Juan P. Petiti, Renata R. Tonelli, Nicolas Reinoso-Vizcaino, Jose Echenique, Luciana Berod, Eliane Piaggio, Bertrand Bellier, Tim Sparwasser, David Klatzmann, Hugo D. Lujan
NATURE COMMUNICATIONS
(2019)
Article
Oncology
Pamela Caudana, Nicolas Gonzalo Nunez, Philippe De La Rochere, Anais Pinto, Jordan Denizeau, Ruby Alonso, Leticia Laura Niborski, Olivier Lantz, Christine Sedlik, Eliane Piaggio
CANCER IMMUNOLOGY RESEARCH
(2019)
Article
Oncology
Alexandra Frazao, Meriem Messaoudene, Nicolas Nunez, Nicolas Dulphy, France Roussin, Christine Sedlik, Laurence Zitvogel, Eliane Piaggio, Antoine Toubert, Anne Caignard
CANCER IMMUNOLOGY RESEARCH
(2019)
Article
Hematology
Emilie Cayssials, Florence Jacomet, Nathalie Piccirilli, Lucie Lefevre, Lydia Roy, Francois Guilhot, Jean-Claude Chomel, Xavier Leleu, Jean-Marc Gombert, Andre Herbelin, Alice Barbarin
BRITISH JOURNAL OF HAEMATOLOGY
(2019)
Article
Multidisciplinary Sciences
Alice Barbarin, Myriam Abdallah, Lucie Lefevre, Nathalie Piccirilli, Emilie Cayssials, Lydia Roy, Jean-Marc Gombert, Andre Herbelin
SCIENTIFIC REPORTS
(2020)
Article
Oncology
Emilie Cayssials, Jose Torregrosa-Diaz, Pilar Gallego-Hernanz, Florence Tartarin, Thomas Systchenko, Natacha Maillard, Deborah Desmier, Antoine Machet, Emmanuel Fleck, Anne Corby, Carine Motard, Guillaume Denis, Andre Herbelin, Jean-Marc Gombert, Lydia Roy, Stephanie Ragot, Xavier Leleu, Francois Guilhot, Jean-Claude Chomel
Review
Urology & Nephrology
Lea Dufour, Maroua Ferhat, Aurelie Robin, Sofiane Inal, Frederic Favreau, Jean-Michel Goujon, Thierry Hauet, Jean-Marc Gombert, Andre Herbelin, Antoine Thierry
NEPHROLOGIE & THERAPEUTIQUE
(2020)
Article
Immunology
Lauren Daniel, Marion Tassery, Clara Lateur, Antoine Thierry, Andre Herbelin, Jean-Marc Gombert, Alice Barbarin
Summary: Immunosenescence is a physiological process associated with changes in the immune system, particularly involving CD8 T cells. The newly described innate E(+) CD8 T cells may exhibit an exacerbated senescent phenotype in a chronic inflammatory environment, especially in kidney transplant and cytomegalovirus-infected patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Louise Barbier, Aurelie Robin, Remy Sindayigaya, Heloise Ducousso, Fanny Dujardin, Antoine Thierry, Thierry Hauet, Jean-Philippe Girard, Luc Pellerin, Jean-Marc Gombert, Andre Herbelin, Ephrem Salame
Summary: The study found that IL-33 plays a significant role in liver injury, as evidenced by experiments in mouse models and human liver transplant patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maria Estefania Viano, Natalia Soledad Baez, Constanza Savid-Frontera, Nicolas Leonel Lidon, Deborah L. L. Hodge, Andre Herbelin, Jean-Marc Gombert, Alice Barbarin, Maria Cecilia Rodriguez-Galan
Summary: Virtual memory CD8(+) T cells, a heterogeneous group of cells with memory characteristics, have been observed in nonimmunized mice for decades and were also found in healthy humans. This review discusses their biology in murine models and their cellular equivalent in humans.
JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
(2022)
Meeting Abstract
Immunology
L. Barbier, H. Ducousso, A. Robin, A. Thierry, T. Hauet, J. -M Gombert, E. Salame, A. Herbelin
Meeting Abstract
Surgery
Louise Barbier, Aurelie Robin, Heloise Ducousso, Antoine Thierry, Thierry Hauet, Jean-Marc Gombert, Ephrem Salame, Andre Herbelin
TRANSPLANT INTERNATIONAL
(2019)
Meeting Abstract
Surgery
Lauren Daniel, Clara Lateur, Alice Barbarin, Antoine Thierry, Andre Herbelin, Jean-Marc Gombert
TRANSPLANT INTERNATIONAL
(2019)
Meeting Abstract
Surgery
L. Daniel, C. Lateur, A. Barbarin, A. Thierry, A. Herbelin, J. M. Gombert
TRANSPLANT INTERNATIONAL
(2019)