Article
Multidisciplinary Sciences
Da-Hyun Kim, Min-Ji Kim, Seon-Yeong Kwak, Jaemin Jeong, Dongho Choi, Soon Won Choi, Jaechul Ryu, Kyung-Sun Kang
Summary: Decellularized extracellular matrix scaffold is widely used for organ engineering, but matrix decomposition and inflammation after transplantation hinder its clinical success. In this study, nano-graphene oxide was used to modify the properties of decellularized liver scaffolds, resulting in enhanced resistance to degradation and reduced inflammation. The introduction of nano-graphene oxide also protected the scaffolds against in vivo degradation, leading to functional bioengineered livers and improved therapeutic effects.
NATURE COMMUNICATIONS
(2023)
Article
Medicine, Research & Experimental
Megha Srinivas, Preeti Sharma, Siddharth Jhunjhunwala
Summary: Research findings suggest that immune cells can phagocytose particles under constant fluidic flow. Different cell types show similar or better uptake rates under flow conditions. Even in the presence of crowded red blood cells, neutrophils and monocytes are able to uptake particles while flowing.
MOLECULAR PHARMACEUTICS
(2021)
Review
Biochemistry & Molecular Biology
Marcelle Mehu, Chandrakala Aluganti Narasimhulu, Dinender K. Singla
Summary: Atherosclerosis is a chronic disease characterized by damage to the intima, inflammatory cell recruitment, and lipid accumulation followed by calcification and plaque rupture. Inflammation is believed to play a crucial role in the development and progression of the disease. This paper discusses the various types of inflammatory cells involved in atherosclerosis and their significance in the disease's development and progression. Understanding the role of these cells at different stages of the disease provides valuable insights for targeted therapy.
Article
Toxicology
Nga T. Nguyen, David S. Umbaugh, Sawyer Smith, Olamide B. Adelusi, Giselle Sanchez-Guerrero, Anup Ramachandran, Hartmut Jaeschke
Summary: Acetaminophen (APAP) overdose is a major cause of acute liver failure, and the role of neutrophils in APAP-induced liver injury is controversial. This study found that neutrophils, recruited through the neutrophil chemoattractant Cxcl2, have no effect on liver injury after a low dose of APAP (300 mg/kg), but aggravate the injury after a high dose (600 mg/kg). Treating mice with an anti-Cxcl2 antibody reduced neutrophil accumulation and liver injury. These findings suggest that neutrophils play a role in APAP-induced liver injury only at severe overdoses.
ARCHIVES OF TOXICOLOGY
(2023)
Article
Biology
Rafaela M. Guimares, Conceico E. Anibal-Silva, Marcela Davoli-Ferreira, Francisco Isaac F. Gomes, Atlante Mendes, Maria C. M. Cavallini, Miriam M. Fonseca, Samara Damasceno, Larissa P. Andrade, Marco Colonna, Cyril Rivat, Fernando Q. Cunha, Jose C. Alves-Filho, Thiago M. Cunha
Summary: After peripheral nerve injury, there is an increase in the number of macrophages in the sensory ganglia due to the proliferation of resident macrophages rather than infiltration of peripheral blood monocytes. These proliferating macrophages produce pro-inflammatory cytokines and participate in the development of neuropathic pain. Signaling through CX3CR1 is involved in the proliferation of macrophages in the sensory ganglia and neuropathic pain development.
Article
Cell Biology
Mengjing Li, Tao Ling, Fengmeng Teng, Chao Hu, Zhongping Su, Chen Zhang, Xiang Li, Ting Zhao, Xianmin Mu, Yingchang Li, Jinshun Pan, Qiang You
Summary: CD5 molecule like (CD5L) is increased in mouse livers following acetaminophen (APAP) overdose, and CD5L deficiency can mitigate APAP-induced liver injury. This suggests that CD5L may be a potential therapeutic target for the prevention and treatment of APAP hepatotoxicity.
CELL DEATH DISCOVERY
(2021)
Review
Cell Biology
Huiting Guo, Shiwei Chen, Mingjie Xie, Cheng Zhou, Min Zheng
Summary: APAP-induced acute liver injury is primarily caused by neutrophils, which also play a role in tissue repair and resolution of inflammation.
CELL PROLIFERATION
(2021)
Review
Biology
Tao Yang, Han Wang, Xiao Wang, Jun Li, Longfeng Jiang
Summary: Drug-induced liver injury (DILI) refers to liver damage caused by drugs or their metabolites. Acetyl-para-aminophenol (APAP) is the leading cause of acute liver failure. The immune responses in APAP-induced liver injury (AILI) have been extensively studied, but results have been inconsistent. This review summarizes the dual role of immune cells in AILI and discusses the contradictory findings in the literature.
Review
Medicine, General & Internal
William T. Nash, Mark D. Okusa
Summary: Macrophages play a crucial role in the pathogenesis of AKI, potentially influencing the progression of inflammation and injury resolution. A comprehensive understanding of the role and regulation of macrophages and myeloid cells in AKI may provide valuable insights for disease intervention.
FRONTIERS IN MEDICINE
(2021)
Article
Pathology
Rudragouda Channappanavar, Muneeswaran Selvaraj, Sunil More, Stanley Perlman
Summary: Alveolar macrophages (AMs) play a critical role in the pathogenesis of Middle East respiratory syndrome coronavirus (MERS-CoV) infection by maintaining an optimal virus-specific T-cell response and controlling excessive inflammation during later stages of infection.
VETERINARY PATHOLOGY
(2022)
Review
Immunology
Matheus B. Carneiro, Nathan C. Peters
Summary: This review focuses on the interaction between Leishmania amazonensis infection and host innate immune response, particularly addressing the impact of adaptive immunity on phagocytic host cell recruitment and activation. Experimental observations indicate that most mouse strains are susceptible to L. amazonensis infection, unlike other Leishmania species. The CD4(+) T helper (Th)1/Th2 paradigm does not fully explain the chronic disease established by L. amazonensis, with recent findings complicating the understanding of the Th1/Th2 paradigm.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Chan Mo, Shuwen Xie, Bin Liu, Weichao Zhong, Ting Zeng, Sha Huang, Yuqi Lai, Guanghui Deng, Chuying Zhou, Weixin Yan, Yuyao Chen, Shaohui Huang, Lei Gao, Zhiping Lv
Summary: The study demonstrates that IDO1 affects the recruitment of immune cells by inhibiting DCs maturation and subsequent T cell proliferation, exacerbating the progression of liver fibrosis. Targeting IDO1 to ameliorate immune responses in the hepatic and splenic microenvironment may be essential for therapeutic effects on liver fibrosis.
CELL DEATH & DISEASE
(2021)
Article
Pharmacology & Pharmacy
Anahita Abdali, Goran Marinkovic
Summary: This review summarizes key cells, processes, and tissue compartments involved in myelopoiesis during steady state, atherosclerosis development, and myocardial infarction.
PHARMACOLOGICAL RESEARCH
(2021)
Review
Immunology
Stephen J. Jenkins, Judith E. Allen
Summary: Macrophages share common functions but also exhibit tissue-specific functionality. They may persist through tissue perturbations and inflammatory events, impacting cell function.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Review
Immunology
Takayuki Tanaka, Takeshi Shiba, Yoshitaka Honda, Kazushi Izawa, Takahiro Yasumi, Megumu K. Saito, Ryuta Nishikomori
Summary: The concept of autoinflammation refers to unprovoked episodes of inflammation without production of autoantibodies or autoreactive T cells. Induced pluripotent stem cells (iPSCs) have the potential to model diseases in vitro and be used for drug screening and cell replacement therapy. This review provides an overview of advances in research on autoinflammatory diseases using iPSC-derived monocytes/macrophages.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biology
Mor Gross-Vered, Sebastien Trzebanski, Anat Shemer, Biana Bernshtein, Caterina Curato, Gil Stelzer, Tomer-Meir Salame, Eyal David, Sigalit Boura-Halfon, Louise Chappell-Maor, Dena Leshkowitz, Steffen Jung
Article
Immunology
Amir Giladi, Lisa Katharina Wagner, Hanjie Li, Dorothea Doerr, Chiara Medaglia, Franziska Paul, Anat Shemer, Steffen Jung, Simon Yona, Matthias Mack, Achim Leutz, Ido Amit, Alexander Mildner
Article
Immunology
Takahiro Masuda, Lukas Amann, Roman Sankowski, Ori Staszewski, Maximilian Lenz, Paolo d'Errico, Nicolas Snaidero, Marta Joana Costa Jordao, Chotima Boettcher, Katrin Kierdorf, Steffen Jung, Josef Priller, Thomas Misgeld, Andreas Vlachos, Melanie Meyer Luehmann, Klaus-Peter Knobeloch, Marco Prinz
Article
Immunology
Jung-Seok Kim, Masha Kolesnikov, Shany Peled-Hajaj, Isabelle Scheyltjens, Yuan Xia, Sebastien Trzebanski, Zhana Haimon, Anat Shemer, Alisa Lubart, Hannah Van Hove, Louise Chappell-Maor, Sigalit Boura-Halfon, Kiavash Movahedi, Pablo Blinder, Steffen Jung
Summary: Research has revealed the developmental and molecular heterogeneity of tissue macrophages, as well as their diverse roles in physiology and pathophysiology. By establishing a binary transgenic system in the brain, specific populations of macrophages, such as parenchymal microglia and vasculature-associated macrophages, can be targeted and analyzed for their differential responses to challenges using a method called RiboTag. This study demonstrates the value of binary transgenesis in dissecting tissue macrophage compartments and understanding their functions.
Editorial Material
Cell Biology
Anmol Kulkarni, Steffen Jung
Summary: The etiology of inflammatory bowel disorders (IBDs) involves a combination of genetic and environmental factors. Research has shown that certain food colorants may have the potential to cause colitis similar to IBD.
Article
Immunology
Adi Biram, Jingjing Liu, Hadas Hezroni, Natalia Davidzohn, Dominik Schmiedel, Eman Khatib-Massalha, Montaser Haddad, Amalie Grenov, Sacha Lebon, Tomer Meir Salame, Nili Dezorella, Dotan Hoffman, Paula Abou Karam, Moshe Biton, Tsvee Lapidot, Mats Bemark, Roi Avraham, Steffen Jung, Ziv Shulman
Summary: Consecutive exposures to different pathogens can alter the host immune response. This study found that bacterial infection disrupts pre-existing immune responses and recruits Sca-1+ monocytes into lymphoid organs. This disruption is associated with impaired cellular respiration and is dependent on TNF alpha and IFN gamma. This phenomenon is observed in both vaccine supplementation and infection with Listeria monocytogenes.
Article
Multidisciplinary Sciences
Elisabeth H. Vollmann, Kristin Rattay, Olga Barreiro, Aude Thiriot, Rebecca A. Fuhlbrigge, Vladimir Vrbanac, Ki-Wook Kim, Steffen Jung, Andrew M. Tager, Ulrich H. von Andrian
Summary: This study demonstrates a specialized subset of thymic dendritic cells that are positioned near microvessels and extend cellular processes into the bloodstream to sample soluble macromolecules and assist in T cell selection. These cells play a crucial role in the rigorous selection of T cells in the thymus to ensure self-tolerance and prevent autoimmunity by actively acquiring circulating blood-borne antigens.
NATURE COMMUNICATIONS
(2021)
Article
Chemistry, Multidisciplinary
Anna-Katharina Mueller, Ulrike A. Koehler, Sebastien Trzebanski, Yaron Vinik, Harsha Mohan Raj, Jean-Antoine Girault, Nir Ben-Chetrit, Antonio Maraver, Steffen Jung, Sima Lev
Summary: This study finds that macrophage infiltration in mammary tumors is associated with tumor progression, metastasis, and poor clinical outcome. Ablation of the TYRO3 kinase PYK2 can reduce the number of infiltrating macrophages, inhibit tumor angiogenesis and growth, and modulate monocyte recruitment, macrophage polarization, and tumor angiogenesis. Targeting PYK2 may be an effective strategy to modulate the tumor microenvironment and sensitize breast cancer to immunotherapy.
Article
Biology
Ekaterini Maria Lyras, Karin Zimmermann, Lisa Katharina Wagner, Dorothea Doerr, Christoph S. N. Klose, Cornelius Fischer, Steffen Jung, Simon Yona, Avi-Hai Hovav, Werner Stenzel, Steffen Dommerich, Thomas Conrad, Achim Leutz, Alexander Mildner
Summary: In this study, the immune composition of the murine tongue was characterized using single-cell RNA-sequencing and in situ immunophenotyping. Distinct immune cell populations were identified, and two specific subsets of tongue-resident macrophages were described. The findings provide a starting point for further research on tongue immune physiology and pathology, including cancer and taste disorders.
Article
Immunology
Michelle Stakenborg, Saeed Abdurahiman, Veronica De Simone, Gera Goverse, Nathalie Stakenborg, Lies van Baarle, Qin Wu, Dimitri Pirottin, Jung-Seok Kim, Louise Chappell-Maor, Isabel Pintelon, Sofie Thys, Emilie Pollenus, Louis Boon, Philippe Van den Steen, Marlene Hao, Jo A. Van Ginderachter, Guy E. Boeckxstaens, Jean-Pierre Timmermans, Steffen Jung, Thomas Marichal, Sales Ibiza, Gianluca Matteoli
Summary: Monocyte-derived macrophages (M phi s) play crucial roles in regulating muscularis inflammation. This study investigates the heterogeneity of M phi s at different stages of muscularis inflammation and identifies environmental cues that attract and activate tissue-protective M phi s. Results reveal the presence of two main pro-resolving M phi subpopulations during the resolution of muscularis inflammation, and the activation of EGCs in response to micro-environmental damage is shown to stimulate monocyte infiltration and the subsequent differentiation into anti-inflammatory M phi s. Additionally, CSF1-CSF1R signaling is essential for monocyte differentiation and EGC proliferation during muscularis inflammation.
MUCOSAL IMMUNOLOGY
(2022)
Article
Immunology
Kaveri Banerjee, Avinoam Ratzabi, Itai M. Caspit, Or Ganon, Pablo Blinder, Steffen Jung, Reuven Stein
Summary: Gliomas, the most common primary brain tumors, are influenced by the tumor microenvironment comprised of tumor-associated microglia (TA-MG) and monocyte-derived macrophages (MDM). This study reveals the distinct spatial and temporal differences between TA-MG and MDM during glioma progression. TA-MG are found both inside and outside the tumor but are eliminated as the tumor progresses, while MDM are only present inside the tumor. Additionally, the study shows that TA-MG and MDM exhibit different enrichment in the perivascular area. These findings highlight the unique roles of TA-MG and MDM in glioma progression.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Immunology
Zhana Haimon, Gal Ronit Frumer, Jung-Seok Kim, Sebastien Trzebanski, Rebecca Haffner-Krausz, Shifra Ben-Dor, Ziv Porat, Andreas Muschaweckh, Louise Chappell-Maor, Sigalit Boura-Halfon, Thomas Korn, Steffen Jung
Summary: Microglia, the brain macrophages, play a critical role in brain development and homeostasis. They interact with T cells through antigen presentation, costimulation, and coinhibition. In autoimmune neuroinflammation, microglia have significant non-redundant cognate and cytokine-mediated interactions with regulatory T cells.
Article
Neurosciences
Sebastiaan De Schepper, Judy Z. Z. Ge, Gerard Crowley, Lais S. S. Ferreira, Dylan Garceau, Christina E. E. Toomey, Dimitra Sokolova, Javier Rueda-Carrasco, Sun-Hye Shin, Jung-Seok Kim, Thomas Childs, Tammaryn Lashley, Jemima J. J. Burden, Michael Sasner, Carlo Sala Frigerio, Steffen Jung, Soyon Hong
Summary: Microglia mediate aberrant synapse engulfment in Alzheimer's disease (AD), but the underlying mechanisms are poorly understood. Here the authors show a perivascular cells-to-microglia crosstalk that induces microglia phagocytic state resulting in synapse engulfment in two mouse models of AD.
NATURE NEUROSCIENCE
(2023)
Review
Neurosciences
Gal Ronit Frumer, Sun-Hye Shin, Steffen Jung, Jung-Seok Kim
Summary: This article reviews recent advances in our understanding of brain macrophage heterogeneity, including microglia and border-associated macrophages, with a focus on the mouse. The strengths and limitations of the experimental approaches are discussed, which have provided new insights and hold promise for further understanding the mechanisms of brain macrophages and potentially harnessing their activities for CNS pathology management.
Review
Neurosciences
Rosa C. Paolicelli, Amanda Sierra, Beth Stevens, Marie-Eve Tremblay, Adriano Aguzzi, Bahareh Ajami, Ido Amit, Etienne Audinat, Ingo Bechmann, Mariko Bennett, Frederick Bennett, Alain Bessis, Knut Biber, Staci Bilbo, Mathew Blurton-Jones, Erik Boddeke, Dora Brites, Bert Brone, Guy C. Brown, Oleg Butovsky, Monica J. Carson, Bernardo Castellano, Marco Colonna, Sally A. Cowley, Colm Cunningham, Dimitrios Davalos, Philip L. De Jager, Bart de Strooper, Adam Denes, Bart J. L. Eggen, Ukpong Eyo, Elena Galea, Sonia Garel, Florent Ginhoux, Christopher K. Glass, Ozgun Gokce, Diego Gomez-Nicola, Berta Gonzalez, Siamon Gordon, Manuel B. Graeber, Andrew D. Greenhalgh, Pierre Gressens, Melanie Greter, David H. Gutmann, Christian Haass, Michael T. Heneka, Frank L. Heppner, Soyon Hong, David A. Hume, Steffen Jung, Helmut Kettenmann, Jonathan Kipnis, Ryuta Koyama, Greg Lemke, Marina Lynch, Ania Majewska, Marzia Malcangio, Tarja Malm, Renzo Mancuso, Takahiro Masuda, Michela Matteoli, Barry W. McColl, Veronique E. Miron, Anna Victoria Molofsky, Michelle Monje, Eva Mracsko, Agnes Nadjar, Jonas J. Neher, Urte Neniskyte, Harald Neumann, Mami Noda, Bo Peng, Francesca Peri, V. Hugh Perry, Phillip G. Popovich, Clare Pridans, Josef Priller, Marco Prinz, Davide Ragozzino, Richard M. Ransohoff, Michael W. Salter, Anne Schaefer, Dorothy P. Schafer, Michal Schwartz, Mikael Simons, Cody J. Smith, Wolfgang J. Streit, Tuan Leng Tay, Li-Huei Tsai, Alexei Verkhratsky, Rommy von Bernhardi, Hiroaki Wake, Valerie Wittamer, Susanne A. Wolf, Long-Jun Wu, Tony Wyss-Coray
Summary: Microglial research has made significant progress, but the current classification system fails to accurately describe their diversity, leading to misconceptions about their functions. To address this issue, a group of multidisciplinary experts has proposed a naming framework and recommendations to help researchers better understand and describe the different states and functions of microglia.
