期刊
FRONTIERS IN IMMUNOLOGY
卷 8, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2017.00489
关键词
T follicular helper cells; T cell memory; T follicular helper cell subsets; germinal centres; T cell heterogeneity
类别
资金
- Wellcome Trust [094815]
- MRC Capacity Building Ph.D. studentship
- Medical Research Council [1101599] Funding Source: researchfish
T follicular helper cells (Tfh) provide crucial signals for germinal center ( GC) formation, but Tfh populations are heterogeneous. While PD1(hi) Tfh are important in the GC response, the function of the PD1(lo) Tfh-like subset is unknown. We show that these cells, like the PD1(hi) GC-Tfh, depend upon B cells; however, their entry to follicles is independent of CXCR5 or cognate interactions with B cells. The differentiation into PD1hi Tfh is dependent on MHC class II interactions with B cells and requires CXCR5. Our data suggest a Tfh differentiation pathway that is initially B cell-independent, then dependent on non-cognate B cell interactions, and finally following cognate interaction with B cells and CXCR5-ligands allows the formation of GC-Tfh. The PD1(lo) Tfh-like cells make early cytokine responses and may represent precursors of CD4 memory cells.
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