Review
Biochemistry & Molecular Biology
Hyunjung Park, Sangjik Lee, Jaehun Lee, Hyuk Moon, Simon Weonsang Ro
Summary: This review highlights the importance of the JAK/STAT pathway in hepatocellular carcinoma (HCC) and its association with factors such as chronic inflammation and cirrhosis. It also summarizes recent advancements in targeting the JAK/STAT pathway for HCC treatment, emphasizing the potential of this pathway as a promising avenue for therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Mohamad Mahjoor, Golnaz Mahmoudvand, Simin Farokhi, Alireza Shadab, Mojtaba Kashfi, Hamed Afkhami
Summary: The JAK/STAT signaling cascade plays a crucial role in regulating cell growth and differentiation, as well as immune responses and viral pathogenesis.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Pathology
Ahmed Hjazi, Rasha Fadhel Obaid, Sally Saad Ali, Bekhzod Abdullaev, Hashem O. Alsaab, Huldani Huldani, Rosario Mireya Romero-Parra, Yasser Fakri Mustafa, Beneen M. Hussien, Sarah Jaafar Saadoon
Summary: Long non-coding RNAs (lncRNAs) transcribed from the human genome have emerged as important regulators in cellular activities, particularly in controlling gene expression. They have been found to regulate various factors related to tumorigenesis through the JAK-STAT signaling pathway, either by directly targeting or indirectly modulating its components. Moreover, lncRNAs can also act as downstream effectors of the pathway. The relationship between JAK-STAT signaling and lncRNAs varies among different types of cancers, and lncRNAs play a dual role in tumorigenesis or tumor suppression. This review focuses on the reciprocal regulation and functions of lncRNAs and the JAK-STAT pathway, providing insights into potential targets for clinical therapeutics.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Chemistry, Physical
Khaled Mukaddam, Sabrina Ruggiero, Steffen M. Berger, Dietmar Cholewa, Sebastian Kuhl, Daniel Vegh, Michael Payer, Michael M. Bornstein, Farah Alhawasli, Elizaveta Fasler-Kan
Summary: Zirconia implants have become widely used in dentistry due to their superior biological compatibility compared to traditional titanium implants, as they reduce bacterial adhesion, inflammation, and cellular interaction. This study investigated the activation of the JAK-STAT signaling pathway in osteoblast-like cells (MG-63) on zirconia and titanium surfaces using different cytokines. The results showed that various cytokines activated different STAT proteins on both surfaces, indicating the activation of the JAK-STAT pathway. The upregulation of MHC class I and class II proteins was observed when MG-63 cells were incubated on zirconia and titanium discs.
Article
Biochemistry & Molecular Biology
Stefan Rose-John
Summary: IL-6 is a cytokine involved in immunity, neural cell maintenance, and metabolism. It is synthesized by various cells and its levels are elevated during infection and inflammation. IL-6 binds to a receptor complex and can also act on cells without the IL-6 receptor through trans-signaling.
Article
Fisheries
Gunasekara Chathura Wikumpriya, Madhuranga Walawedurage Srinith Prabhatha, Jiye Lee, Chan-Hee Kim
Summary: In this study, cDNA sequences of two SOCS genes, LvSOCS6 and LvSOCS7, were cloned from the whiteleg shrimp. It was found that these genes play significant roles in modulating cytokine signaling and immune responses, and are expressed in various tissues. The expression of LvSOCS6 and LvSOCS7 is associated with the JAK/STAT pathway.
Review
Pharmacology & Pharmacy
Qianqian Yin, Longyun Wang, Haiyang Yu, Daquan Chen, Wenwei Zhu, Changgang Sun
Summary: The JAK-STAT signaling pathway is closely related to cell proliferation, apoptosis, differentiation, and inflammatory response, essential for inhibiting inflammation, initiating innate immunity, and coordinating adaptive immune mechanisms. Various plant polyphenol compounds play a role in suppressing abnormal activation in the JAK-STAT pathway, showing significant effects in anti-inflammatory, antitumor, and cardiovascular disease control.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
David Millrine, Robert H. Jenkins, Stuart T. O. Hughes, Simon A. Jones
Summary: Understanding the molecular mechanisms behind functional pleiotropy in cytokines presents a significant challenge for researchers. While cytokine-receptor cross-reactivity and shared signalling pathways are believed to be major contributors to pleiotropy, studies on Jak-STAT cytokine signalling have revealed interesting biochemical and epigenetic factors influencing transcription factor regulation and cytokine responses. The regulatory interplay between STAT transcription factors and their convergence to specific genomic enhancers plays a role in fine-tuning cytokine responses to control host immunity, functional characteristics, and tissue homeostasis and repair.
Article
Cell Biology
Nathanael A. Caveney, Robert A. Saxton, Deepa Waghray, Caleb R. Glassman, Naotaka Tsutsumi, Stevan R. Hubbard, Christopher Garcia
Summary: Janus kinases (JAKs) play a key role in cytokine signaling by mediating the transduction of signals downstream of cytokine receptors. The cryoelectron microscopy structure of a mouse JAK1 complex provides insights into the trans-activation step of JAK signaling and the allosteric mechanisms of JAK inhibition.
Article
Gastroenterology & Hepatology
Feixue Wang, Xiang Zhang, Weixin Liu, Yunfei Zhou, Wenchao Wei, Dabin Liu, Chi Chun Wong, Joseph J. Y. Sung, Jun Yu
Summary: Activated NK cells in the liver promote NASH development by releasing pro-inflammatory cytokines and enhancing NASH progression through the cytokine-JAK-STAT1/3 axis. Modulation of NK cells may serve as a potential therapeutic strategy for NASH.
CELLULAR AND MOLECULAR GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Pharmacology & Pharmacy
Qiuyu Pang, Lu You, Xiangmin Meng, Yumeng Li, Tian Deng, Deyong Li, Bingmei Zhu
Summary: The JAK/STAT signaling pathway plays a crucial role in cell growth, differentiation, immune response, and hematopoietic system development. It has been found to have regulatory functions in various cardiovascular diseases, such as myocardial ischemia-reperfusion injury, acute myocardial infarction, hypertension, myocarditis, heart failure, angiogenesis, and fibrosis.
BIOCHEMICAL PHARMACOLOGY
(2023)
Article
Environmental Sciences
Mengke Tang, Yifan Zhao, Yue Zhai, Yufan Zhang, Yalin Liu, Ting Liu, Jiaojiao Wu, Leyi He, Ye Yao, Peng Xue, Miao He, Yanyi Xu, Shaoqing Feng, Weidong Qu, Yubin Zhang
Summary: This study reveals the impact of Hg on the development of monocytes. Treatment with HgCl2 promotes the differentiation of monocytes and increases their quantity through activating certain signaling pathways. The increased monopoiesis by Hg is associated with an increased inflammatory status.
ENVIRONMENTAL POLLUTION
(2023)
Article
Medicine, General & Internal
Malgorzata Galecka, Janusz Szemraj, Kuan-Pin Su, Angelos Halaris, Michael Maes, Aleksandra Skiba, Piotr Galecki, Katarzyna Blizniewska-Kowalska
Summary: This study found that there is increased expression of JAK3 and decreased expression of STAT1 in depressed patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Immunology
Aaron B. Schultz, David G. Kugler, Luis Nivelo, Nicolas Vitari, Laura P. Doyle, Svetlana Ristin, Lothar Hennighausen, John J. O'Shea, Dragana Jankovic, Alejandro V. Villarino
Summary: During acute infection with Toxoplasma gondii, transgenic mice lacking T cell intrinsic STAT1 signaling exhibit lethal immuno-pathology characterized by aberrant Th1-type responses. This is caused by reduced IL-10 and increased IL-13 production, which is not dependent on STAT3. ChIP-seq data mining showed that STAT1 and STAT3 co-localize at the Il10 locus, indicating their role in regulating IL-10 production.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Environmental Sciences
Xin Yu, Linfeng Li, Matthew T. V. Chan, William Ka Kei Wu
Summary: Research suggests that there may be a correlation between herpes zoster and COVID-19 through similar subset of genes involved in cytokine-cytokine receptor interaction. Both diseases show augmented Th17 cell differentiation and IL-17 signaling.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Article
Immunology
Lijuan Wei, Shanshan Zhu, Menghui Li, Fangxuan Li, Feng Wei, Juntian Liu, Xiubao Ren
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Oncology
Meng Shen, Jian Wang, Wenwen Yu, Chen Zhang, Min Liu, Kaiyuan Wang, Lili Yang, Feng Wei, Shizhen Emily Wang, Qian Sun, Xiubao Ren
Article
Oncology
Kaiyuan Wang, Yu Zheng, Yinli Yang, Jian Wang, Baihui Li, Feng Wei, Hongwei Zhao, Xiubao Ren
FRONTIERS IN ONCOLOGY
(2019)
Article
Oncology
Congfang Guo, Hua Zhao, Yu Wang, Shuai Bai, Zizhong Yang, Feng Wei, Xiubao Ran
FRONTIERS IN ONCOLOGY
(2019)
Article
Cell Biology
Qian Sun, Xiying Zhang, Limei Wang, Xujie Gao, Yanjuan Xiong, Liang Liu, Feng Wei, Lili Yang, Xiubao Ren
CELL DEATH & DISEASE
(2019)
Article
Radiology, Nuclear Medicine & Medical Imaging
Yang Wang, Ning Zhao, Zhanbo Wu, Na Pan, Xuejie Shen, Ting Liu, Feng Wei, Jian You, Wengui Xu, Xiubao Ren
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2020)
Article
Oncology
Zhenzhen Hui, Feng Wei, Hongliang Ren, Wengui Xu, Xiubao Ren
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2020)
Article
Cell Biology
Min Liu, Feng Wei, Jian Wang, Wenwen Yu, Meng Shen, Ting Liu, Dong Zhang, Yang Wang, Xiubao Ren, Qian Sun
Summary: MDSCs activate the PI3K/AKT/NF-kappa B pathway in B cells via the PD-1/PD-L1 axis, regulating the immunosuppressive function of Bregs. Inhibition of PD-1/PD-L1 or PI3K/AKT signaling suppresses tumor growth and the immunosuppressive functions of Bregs. Dual suppression of PD-1/PD-L1 and PI3K/AKT shows better antitumor effect.
CELL DEATH & DISEASE
(2021)
Article
Immunology
Zhenzhen Hui, Jiali Zhang, Yu Zheng, Lili Yang, Wenwen Yu, Yang An, Feng Wei, Xiubao Ren
Summary: The study successfully expanded Treg cells from colorectal cancer patients using a rapamycin-based in vitro procedure, and conducted single-cell sequencing to explore Treg cell characteristics. The findings revealed distinct transcriptomic features of different subsets of Treg cells, highlighting the potential for alternative therapeutic strategies in autoimmune disease and cancer.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Cihui Yan, Jingjing Chang, Xinmiao Song, Ying Qi, Zhenyu Ji, Ting Liu, Wenwen Yu, Feng Wei, Lili Yang, Xiubao Ren
Summary: The study revealed that MSCs from lung cancer promoted tumor metastasis and tumorigenesis by inducing partial EMT and upregulating stem cell-related genes in lung cancer cells. These findings suggest that LC-MSCs may serve as potential targets or vehicles for lung cancer therapy.
Article
Oncology
Kaiyuan Wang, Jian Wang, Ting Liu, Wenwen Yu, Nan Dong, Chen Zhang, Wenbin Xia, Feng Wei, Lili Yang, Xiubao Ren
Summary: The study found that M3G can promote PD-L1 expression in NSCLC cells through the TLR4 pathway, affect the cytotoxicity of CTL through the PI3K signaling pathway, and thus promote tumor immune escape. Additionally, M3G can also promote tumor growth and metastasis.
CANCER BIOLOGY & MEDICINE
(2021)
Review
Oncology
Ziqing Zeng, Feng Wei, Xiubao Ren
CANCER BIOLOGY & MEDICINE
(2020)
Meeting Abstract
Immunology
F. Wei, X. Ren
EUROPEAN JOURNAL OF IMMUNOLOGY
(2019)
Article
Oncology
Cihui Yan, Jingjing Chang, Xinmiao Song, Fan Yan, Wenwen Yu, Yang An, Feng Wei, Lili Yang, Xiubao Ren
CANCER BIOLOGY & MEDICINE
(2019)
Article
Oncology
Ziqing Zeng, Fan Yang, Yunliang Wang, Hua Zhao, Feng Wei, Peng Zhang, Xiying Zhang, Xiubao Ren