Chronic Inflammation in Immune Aging: Role of Pattern Recognition Receptor Crosstalk with the Telomere Complex?

Celiac disease autoimmunity is associated with leukocyte telomere shortening in older adults: The U.S. National Health and Nutrition Examination Survey

(2017) Elena Kamycheva et al.   EXPERIMENTAL GERONTOLOGY

Proinflammatory Cytokines IL-6 and TNF-α Increased Telomerase Activity through NF-κB/STAT1/STAT3 Activation, and Withaferin A Inhibited the Signaling in Colorectal Cancer Cells

(2017) Seyung S. Chung et al.   MEDIATORS OF INFLAMMATION

Arterial stiffness by oscillometric device and telomere lenght in juvenile idiopathic artrhitis with no cardiovascular risk factors: a cross-sectional study

(2017) Maria Mercedes Picarelli et al.   Pediatric Rheumatology

Inflammaging and ‘Garb-aging’

(2017) Claudio Franceschi et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Helicobacter pylori-induced chronic inflammation causes telomere shortening of gastric mucosa by promoting PARP-1-mediated non-homologous end joining of DNA

(2016) Wei-Ping Lee et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Human memory T cells with a naive phenotype accumulate with aging and respond to persistent viruses

(2016) Vesna Pulko et al.   NATURE IMMUNOLOGY

The crosstalk of telomere dysfunction and inflammation through cell-free TERRA containing exosomes

(2016) Zhuo Wang et al.   RNA Biology

Telomerase reverse transcriptase acts in a feedback loop with NF-κB pathway to regulate macrophage polarization in alcoholic liver disease

(2016) Xiao-qin Wu et al.   Scientific Reports

Novel loci and pathways significantly associated with longevity

(2016) Yi Zeng et al.   Scientific Reports

Mechanisms Underlying T Cell Immunosenescence: Aging and Cytomegalovirus Infection

(2016) Wenjuan Tu et al.   Frontiers in Microbiology

The Telomere/Telomerase System in Chronic Inflammatory Diseases. Cause or Effect?

(2016) Vasileios Kordinas et al.   Genes

Sepsis Induces Hematopoietic Stem Cell Exhaustion and Myelosuppression through Distinct Contributions of TRIF and MYD88

(2016) Huajia Zhang et al.   Stem Cell Reports

Toll-like receptor 7 affects the pathogenesis of non-alcoholic fatty liver disease

(2016) Sokho Kim et al.   Scientific Reports

DAMPs and influenza virus infection in ageing

(2015) Ramar Perumal Samy et al.   AGEING RESEARCH REVIEWS

Global analyses revealed age-related alterations in innate immune responses after stimulation of pathogen recognition receptors

(2015) Talibah U. Metcalf et al.   AGING CELL

TLR2 and TLR4 Expression and Inflammatory Cytokines are Altered in the Airway Epithelium of Those with Alcohol Use Disorders

(2015) Kristina L. Bailey et al.   ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH

LPS-stimulated human bone marrow stroma cells support myeloid cell development and progenitor cell maintenance

(2015) Patrick Ziegler et al.   ANNALS OF HEMATOLOGY

The complement system and toll-like receptors as integrated players in the pathophysiology of atherosclerosis

(2015) Anders Hovland et al.   ATHEROSCLEROSIS

Telomere Dysfunction Drives Aberrant Hematopoietic Differentiation and Myelodysplastic Syndrome

(2015) Simona Colla et al.   CANCER CELL

Early Telomerase Inactivation Accelerates Aging Independently of Telomere Length

(2015) Zhengwei Xie et al.   CELL

Chronic Hepatitis B Virus Infection: The Relation between Hepatitis B Antigen Expression, Telomere Length, Senescence, Inflammation and Fibrosis

(2015) Phaedra M. Tachtatzis et al.   PLoS One

Emerging Roles of Innate Immune Signaling and Toll-Like Receptors in Fibrosis and Systemic Sclerosis

(2015) Swati Bhattacharyya et al.   Current Rheumatology Reports

Telomere shortening correlates to dysplasia but not to DNA aneuploidy in longstanding ulcerative colitis

(2014) Mariann Friis-Ottessen et al.   BMC GASTROENTEROLOGY

Cellular senescence and the senescent secretory phenotype in age-related chronic diseases

(2014) Yi Zhu et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Circulating mitochondrial DNA increases with age and is a familiar trait: Implications for “inflamm-aging”

(2014) Marcello Pinti et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Dietary restriction ameliorates haematopoietic ageing independent of telomerase, whilst lack of telomerase and short telomeres exacerbates the ageing phenotype

(2014) Nouf Al-Ajmi et al.   EXPERIMENTAL GERONTOLOGY

Leukocyte telomere length associates with prospective mortality independent of immune-related parameters and known genetic markers

(2014) Joris Deelen et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

Inflamm-aging does not simply reflect increases in pro-inflammatory markers

(2014) Vincent Morrisette-Thomas et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Chronic inflammation induces telomere dysfunction and accelerates ageing in mice

(2014) Diana Jurk et al.   Nature Communications

Toll-like receptors in systemic lupus erythematosus: potential for personalized treatment

(2014) Teja Celhar et al.   Frontiers in Pharmacology

Emerging Role of Endosomal Toll-Like Receptors in Rheumatoid Arthritis

(2014) Ryan Thwaites et al.   Frontiers in Immunology

Brief Report: Shortened Telomere Length in Patients With Systemic Lupus Erythematosus

(2013) Sahena Haque et al.   ARTHRITIS AND RHEUMATISM

Oxidative stress in angiogenesis and vascular disease

(2013) Y.-W. Kim et al.   BLOOD

The Hallmarks of Aging

(2013) Carlos López-Otín et al.   CELL

Disordered Toll-like receptor 2 responses in the pathogenesis of pulmonary sarcoidosis

(2013) M. I. Gabrilovich et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Role of toll-like receptors in systemic sclerosis

(2013) Marzena Ciechomska et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Toll-Like Receptors in Atherosclerosis

(2013) Mika Falck-Hansen et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The roles of senescence and telomere shortening in cardiovascular disease

(2013) Frej Fyhrquist et al.   Nature Reviews Cardiology

Surface expression and genotypes of Toll-like receptors 2 and 4 in patients with juvenile idiopathic arthritis and systemic lupus erythematosus

(2013) Martina Kirchner et al.   Pediatric Rheumatology

Chronic TLR Signaling Impairs the Long-Term Repopulating Potential of Hematopoietic Stem Cells of Wild Type but Not Id1 Deficient Mice

(2013) Ying Zhao et al.   PLoS One

Telomere Dynamics in Mice and Humans

(2013) Rodrigo T. Calado et al.   SEMINARS IN HEMATOLOGY

Hematopoietic Stem and Progenitor Cell Activation During Chronic Dermatitis Provoked by Constitutively Active Aryl-Hydrocarbon Receptor Driven by Keratin 14 Promoter

(2013) Shohei Murakami et al.   TOXICOLOGICAL SCIENCES

Idiopathic inflammatory myopathies: pathogenic mechanisms of muscle weakness

(2013) Sree Rayavarapu et al.   Skeletal Muscle

Steady-state neutrophil homeostasis is dependent on TLR4/TRIF signaling

(2012) S. Bugl et al.   BLOOD

Demand-adapted regulation of early hematopoiesis in infection and inflammation

(2012) H. Takizawa et al.   BLOOD

Candida albicansstimulatesin vivodifferentiation of haematopoietic stem and progenitor cells towards macrophages by a TLR2-dependent signalling

(2012) Javier Megías et al.   CELLULAR MICROBIOLOGY

Telomere length and regulatory proteins in human skeletal muscle with and without ongoing regenerative cycles

(2012) Elodie Ponsot et al.   EXPERIMENTAL PHYSIOLOGY

Dysregulated Hematopoietic Stem and Progenitor Cell Activity Promotes Interleukin-23-Driven Chronic Intestinal Inflammation

(2012) Thibault Griseri et al.   IMMUNITY

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Cutting Edge: LPS-Induced Emergency Myelopoiesis Depends on TLR4-Expressing Nonhematopoietic Cells

(2012) S. Boettcher et al.   JOURNAL OF IMMUNOLOGY

TLR Signaling and DNA Repair: Are They Associated?

(2012) Erin Harberts et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Telomerase directly regulates NF-κB-dependent transcription

(2012) Arkasubhra Ghosh et al.   NATURE CELL BIOLOGY

Connection between Telomerase Activity in PBMC and Markers of Inflammation and Endothelial Dysfunction in Patients with Metabolic Syndrome

(2012) Elias Rentoukas et al.   PLoS One

Wnt/ -Catenin Signaling Regulates Telomerase in Stem Cells and Cancer Cells

(2012) K. Hoffmeyer et al.   SCIENCE

Innate immunosenescence: Effect of aging on cells and receptors of the innate immune system in humans

(2012) Rafael Solana et al.   SEMINARS IN IMMUNOLOGY

Telomerase reverse transcriptase protects ATM-deficient hematopoietic stem cells from ROS-induced apoptosis through a telomere-independent mechanism

(2011) E. Nitta et al.   BLOOD

Bone marrow dendritic cell progenitors sense pathogens via Toll-like receptors and subsequently migrate to inflamed lymph nodes

(2011) M. A. Schmid et al.   BLOOD

Extramedullary Hematopoiesis Generates Ly-6C high Monocytes That Infiltrate Atherosclerotic Lesions

(2011) Clinton S. Robbins et al.   CIRCULATION

Toll-like receptors and macrophage activation in atherosclerosis

(2011) Anusha N. Seneviratne et al.   CLINICA CHIMICA ACTA

Inflammation and mesenchymal stem cell aging

(2011) Günter Lepperdinger   CURRENT OPINION IN IMMUNOLOGY

Hematopoiesis sculpted by pathogens: Toll-like receptors and inflammatory mediators directly activate stem cells

(2011) Julie R. Boiko et al.   CYTOKINE

Helicobacter pylori Activates Calpain via Toll-Like Receptor 2 To Disrupt Adherens Junctions in Human Gastric Epithelial Cells

(2011) Pamela M. O'Connor et al.   INFECTION AND IMMUNITY

Corticosteroids shift the Toll-like receptor response pattern of primary-isolated murine liver cells from an inflammatory to an anti-inflammatory state

(2011) R. Broering et al.   INTERNATIONAL IMMUNOLOGY

Dynamic variation in cycling of hematopoietic stem cells in steady state and inflammation

(2011) Hitoshi Takizawa et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chronic Exposure to a TLR Ligand Injures Hematopoietic Stem Cells

(2011) B. L. Esplin et al.   JOURNAL OF IMMUNOLOGY

Innate and adaptive immunosenescence

(2010) Shradha Agarwal et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Telomerase Activation in Atherosclerosis and Induction of Telomerase Reverse Transcriptase Expression by Inflammatory Stimuli in Macrophages

(2010) Florence Gizard et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CpG Oligodeoxynucleotides as TLR9 Agonists

(2010) Gaurav K. Gupta et al.   BIODRUGS

Outcomes of pediatric bone marrow transplantation for leukemia and myelodysplasia using matched sibling, mismatched related, or matched unrelated donors

(2010) P. J. Shaw et al.   BLOOD

hTERT Overexpression Alleviates Intracellular ROS Production, Improves Mitochondrial Function, and Inhibits ROS-Mediated Apoptosis in Cancer Cells

(2010) I. R. Indran et al.   CANCER RESEARCH

Age-Associated Decrease in TLR Function in Primary Human Dendritic Cells Predicts Influenza Vaccine Response

(2010) Alexander Panda et al.   JOURNAL OF IMMUNOLOGY

Alcoholics show reduced telomere length in the oesophagus

(2010) Junko Aida et al.   JOURNAL OF PATHOLOGY

Inflammatory Role of Toll-Like Receptors in Human and Murine Adipose Tissue

(2010) Odile Poulain-Godefroy et al.   MEDIATORS OF INFLAMMATION

Quiescent haematopoietic stem cells are activated by IFN-γ in response to chronic infection

(2010) Megan T. Baldridge et al.   NATURE

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

Telomere-Mediated Chromosomal Instability Triggers TLR4 Induced Inflammation and Death in Mice

(2010) Rabindra N. Bhattacharjee et al.   PLoS One

RAGE signaling in inflammation and arterial aging

(2009) Li Lin   Frontiers in Bioscience-Landmark

Toll-like receptors as targets in chronic liver diseases

(2009) A Mencin et al.   GUT

Inflammatory Regulation by TLR3 in Acute Hepatitis

(2009) X. Xiao et al.   JOURNAL OF IMMUNOLOGY

Telomere Shortening and Oxidative Stress in Aged Macrophages Results in Impaired STAT5a Phosphorylation

(2009) C. Sebastian et al.   JOURNAL OF IMMUNOLOGY

Selective Expansion of the Monocytic Lineage Directed by Bacterial Infection

(2009) N. V. Serbina et al.   JOURNAL OF IMMUNOLOGY

Helicobacter pylori Induces MAPK Phosphorylation and AP-1 Activation via a NOD1-Dependent Mechanism

(2009) C. C. Allison et al.   JOURNAL OF IMMUNOLOGY

Aging-Related Alterations of Subtelomeric Methylation in Sarcoidosis Patients

(2009) T. Maeda et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

The TLR1/2 agonist PAM3CSK4 instructs commitment of human hematopoietic stem cells to a myeloid cell fate

(2009) K De Luca et al.   LEUKEMIA

Flow cytometric detection of human telomerase reverse transcriptase (hTERT) expression in a subpopulation of bone marrow cells

(2009) Hiroshi Handa et al.   LEUKEMIA RESEARCH

High Mobility Group Box 1: a potential therapeutic target for systemic lupus erythematosus

(2009) Hai-Feng Pan et al.   MOLECULAR BIOLOGY REPORTS

Tocilizumab

(2009) Clemens Scheinecker et al.   NATURE REVIEWS DRUG DISCOVERY

Telomerase insufficiency in rheumatoid arthritis

(2009) H. Fujii et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human innate immunosenescence: causes and consequences for immunity in old age

(2009) Alexander Panda et al.   TRENDS IN IMMUNOLOGY

The role of Toll-like receptors in rheumatoid arthritis

(2009) Qi-Quan Huang et al.   Current Rheumatology Reports

CD19 Regulates Skin and Lung Fibrosis via Toll-Like Receptor Signaling in a Model of Bleomycin-Induced Scleroderma

(2008) Ayumi Yoshizaki et al.   AMERICAN JOURNAL OF PATHOLOGY

How Shelterin Protects Mammalian Telomeres

(2008) Wilhelm Palm et al.   Annual Review of Genetics

Premature aging of the immune system in children with juvenile idiopathic arthritis

(2008) Martina Prelog et al.   ARTHRITIS AND RHEUMATISM

Expression profiles and function of Toll-like receptors 2 and 4 in peripheral blood mononuclear cells of chronic hepatitis B patients

(2008) Zhiao Chen et al.   CLINICAL IMMUNOLOGY

Ulcerative Colitis Is a Disease of Accelerated Colon Aging: Evidence From Telomere Attrition and DNA Damage

(2008) Rosa Ana Risques et al.   GASTROENTEROLOGY

Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence

(2008) Motoko Sasaki et al.   HEPATOLOGY

Cigarette smoke increases Toll-like receptor 4 and modifies lipopolysaccharide-mediated responses in airway epithelial cells

(2008) Elisabetta Pace et al.   IMMUNOLOGY

Deconstructing stem cell self-renewal: genetic insights into cell-cycle regulation

(2008) Keith W. Orford et al.   NATURE REVIEWS GENETICS

Telomere shortening in chronic obstructive pulmonary disease

(2008) Joyce M.J. Houben et al.   RESPIRATORY MEDICINE

Cytoplasmic Expression of Human Telomerase Catalytic Protein (hTERT) in Neutrophils: An Immunoelectron Microscopy Study

(2008) Sébastien Lepreux et al.   ULTRASTRUCTURAL PATHOLOGY

Expression of functional Toll-like receptors 2 and 4 in human aortic valve interstitial cells: potential roles in aortic valve inflammation and stenosis

(2007) Xianzhong Meng et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY