Translating Mechanism of Regulatory Action of Tolerogenic Dendritic Cells to Monitoring Endpoints in Clinical Trials

Differential transcriptome of tolerogenic versus inflammatory dendritic cells points to modulated T1D genetic risk and enriched immune regulation

(2017) T Nikolic et al.   GENES AND IMMUNITY

Immunopathogenesis of Rheumatoid Arthritis

(2017) Gary S. Firestein et al.   IMMUNITY

Autologous tolerogenic dendritic cells derived from monocytes of systemic lupus erythematosus patients and healthy donors show a stable and immunosuppressive phenotype

(2017) Javiera Obreque et al.   IMMUNOLOGY

Generation of human islet-specific regulatory T cells by TCR gene transfer

(2017) Caroline M. Hull et al.   JOURNAL OF AUTOIMMUNITY

Autoimmunity against a defective ribosomal insulin gene product in type 1 diabetes

(2017) Maria J L Kracht et al.   NATURE MEDICINE

Type 1 diabetes induction in humanized mice

(2017) Shulian Tan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory B cells: Phenotype, function and role in transplantation

(2017) CM Wortel et al.   TRANSPLANT IMMUNOLOGY

Autologous tolerogenic dendritic cells for rheumatoid and inflammatory arthritis

(2016) G M Bell et al.   ANNALS OF THE RHEUMATIC DISEASES

The Warburg Effect: How Does it Benefit Cancer Cells?

(2016) Maria V. Liberti et al.   TRENDS IN BIOCHEMICAL SCIENCES

Minimum information about tolerogenic antigen-presenting cells (MITAP): a first step towards reproducibility and standardisation of cellular therapies

(2016) Phillip Lord et al.   PeerJ

Intraperitoneal Administration of Autologous Tolerogenic Dendritic Cells for Refractory Crohn’s Disease: A Phase I Study

(2015) Aranzazu Jauregui-Amezaga et al.   Journal of Crohns & Colitis

MERTK as negative regulator of human T cell activation

(2015) Raquel Cabezo´n et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Clinical Use of Tolerogenic Dendritic Cells-Harmonization Approach in European Collaborative Effort

(2015) Anja Ten Brinke et al.   MEDIATORS OF INFLAMMATION

T cell receptor reversed polarity recognition of a self-antigen major histocompatibility complex

(2015) Dennis X Beringer et al.   NATURE IMMUNOLOGY

Citrullinated peptide dendritic cell immunotherapy in HLA risk genotype–positive rheumatoid arthritis patients

(2015) Helen Benham et al.   Science Translational Medicine

Vitamin D3 Induces Tolerance in Human Dendritic Cells by Activation of Intracellular Metabolic Pathways

(2015) Gabriela Bomfim Ferreira et al.   Cell Reports

Gene Expression Profiling of Human Monocyte-derived Dendritic Cells – Searching for Molecular Regulators of Tolerogenicity

(2015) Katina Schinnerling et al.   Frontiers in Immunology

Tolerogenic Dendritic Cells for Regulatory T Cell Induction in Man

(2015) Verena K. Raker et al.   Frontiers in Immunology

Immune modulation in humans: implications for type 1 diabetes mellitus

(2014) Bart O. Roep et al.   Nature Reviews Endocrinology

Biomarkers in type 1 diabetes

(2014) James E. Tooley et al.   Current Opinion in Endocrinology Diabetes and Obesity

Regulatory Dendritic Cells for Immunotherapy in Immunologic Diseases

(2014) John R. Gordon et al.   Frontiers in Immunology

Immune Monitoring of Islet and Pancreas Transplant Recipients

(2013) J. R. F. Abreu et al.   Current Diabetes Reports

Foxp3+regulatory T cells are activated in spite of B7-CD28 and CD40-CD40L blockade

(2013) Isabel Vogel et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Type 1 Regulatory T Cells and Regulatory B Cells Induced by Tolerogenic Dendritic Cells

(2013) R. Volchenkov et al.   SCANDINAVIAN JOURNAL OF IMMUNOLOGY

Antigen-Specific Tolerance by Autologous Myelin Peptide-Coupled Cells: A Phase 1 Trial in Multiple Sclerosis

(2013) A. Lutterotti et al.   Science Translational Medicine

Dendritic cells and the promise of antigen-specific therapy in rheumatoid arthritis

(2013) Ranjeny Thomas   ARTHRITIS RESEARCH & THERAPY

A role for tolerogenic dendritic cell-induced B-regulatory cells in type 1 diabetes mellitus

(2013) Nick Giannoukakis et al.   Current Opinion in Endocrinology Diabetes and Obesity

Antigen Targets of Type 1 Diabetes Autoimmunity

(2013) B. O. Roep et al.   Cold Spring Harbor Perspectives in Medicine

Regulatory Multitasking of Tolerogenic Dendritic Cells – Lessons Taken from Vitamin D3-Treated Tolerogenic Dendritic Cells

(2013) Tatjana Nikolic et al.   Frontiers in Immunology

A rapid diagnostic test for human regulatory T-cell function to enable regulatory T-cell therapy

(2012) J. B. Canavan et al.   BLOOD

Circulating Preproinsulin Signal Peptide-Specific CD8 T Cells Restricted by the Susceptibility Molecule HLA-A24 Are Expanded at Onset of Type 1 Diabetes and Kill  -Cells

(2012) D. Kronenberg et al.   DIABETES

Stable antigen-specific T-cell hyporesponsiveness induced by tolerogenic dendritic cells from multiple sclerosis patients

(2012) Dàlia Raϊch-Regué et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Tolerogenic dendritic cells impede priming of naïve CD8+T cells and deplete memory CD8+T cells

(2012) Fleur S. Kleijwegt et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The problems and promises of research into human immunology and autoimmune disease

(2012) Bart O Roep et al.   NATURE MEDICINE

Gram-Negative Enterobacteria Induce Tolerogenic Maturation in Dexamethasone Conditioned Dendritic Cells

(2012) Raquel Cabezón et al.   PLoS One

IL-10-generated tolerogenic dendritic cells are optimal for functional regulatory T cell induction — A comparative study of human clinical-applicable DC

(2011) Martine A. Boks et al.   CLINICAL IMMUNOLOGY

Phase I (Safety) Study of Autologous Tolerogenic Dendritic Cells in Type 1 Diabetic Patients

(2011) N. Giannoukakis et al.   DIABETES CARE

Transfer of Regulatory Properties from Tolerogenic to Proinflammatory Dendritic Cells via Induced Autoreactive Regulatory T Cells

(2011) F. S. Kleijwegt et al.   JOURNAL OF IMMUNOLOGY

Differential Protein Pathways in 1,25-Dihydroxyvitamin D3 and Dexamethasone Modulated Tolerogenic Human Dendritic Cells

(2011) Gabriela Bomfim Ferreira et al.   JOURNAL OF PROTEOME RESEARCH

Comparative study of clinical grade human tolerogenic dendritic cells

(2011) M Naranjo-Gómez et al.   Journal of Translational Medicine

Trans-Endocytosis of CD80 and CD86: A Molecular Basis for the Cell-Extrinsic Function of CTLA-4

(2011) O. S. Qureshi et al.   SCIENCE

Intracellular metabolic pathways control immune tolerance

(2011) Claudio Procaccini et al.   TRENDS IN IMMUNOLOGY

Induced Foxp3+ regulatory T cells: a potential new weapon to treat autoimmune and inflammatory diseases?

(2011) Q. Lan et al.   Journal of Molecular Cell Biology

Generation and characterisation of therapeutic tolerogenic dendritic cells for rheumatoid arthritis

(2010) R. A. Harry et al.   ANNALS OF THE RHEUMATIC DISEASES

The regulatory role of dendritic cells in the induction and maintenance of T-cell tolerance

(2010) Ivan Zanoni et al.   AUTOIMMUNITY

Critical Role for TNF in the Induction of Human Antigen-Specific Regulatory T Cells by Tolerogenic Dendritic Cells

(2010) F. S. Kleijwegt et al.   JOURNAL OF IMMUNOLOGY

Understanding dendritic cell biology and its role in immunological disorders through proteomic profiling

(2010) Gabriela Bomfim Ferreira et al.   Proteomics Clinical Applications

Induction of Treg by monocyte-derived DC modulated by vitamin D3or dexamethasone: Differential role for PD-L1

(2009) Wendy W. J. Unger et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function

(2009) Mark D. Pescovitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

Proteome analysis demonstrates profound alterations in human dendritic cell nature by TX527, an analogue of vitamin D

(2009) Gabriela Bomfim Ferreira et al.   PROTEOMICS

CTLs are targeted to kill β cells in patients with type 1 diabetes through recognition of a glucose-regulated preproinsulin epitope

(2008) Ania Skowera et al.   JOURNAL OF CLINICAL INVESTIGATION