Article
Clinical Neurology
Anan Shtaya, Leslie R. Bridges, Rebecca Williams, Sarah Trippier, Liqun Zhang, Anthony C. Pereira, James A. R. Nicoll, Delphine Boche, Atticus H. Hainsworth
Summary: The study identified an anti-inflammatory process occurring alongside neuroinflammation post-sICH in clinical patients, involving native microglia and blood monocytes. This novel pathway offers therapeutic targets and a treatment opportunity window for delivering therapeutics through invading monocytes during 3-5 days post-sICH.
Article
Multidisciplinary Sciences
Leon Hosang, Roger Cugota Canals, Felicia Joy van der Flier, Jacqueline Hollensteiner, Rolf Daniel, Alexander Flugel, Francesca Odoardi
Summary: The lung microbiota plays an important role in regulating the immune reactivity of the central nervous system and influencing the susceptibility to autoimmune disease development.
Review
Immunology
Natalia F. Mendes, Licio A. Velloso
Summary: Brain macrophages and microglia play important roles in immune surveillance of the central nervous system. They release key molecules to prevent further damage to the neuronal network upon inflammatory stimuli. Perivascular macrophages in the hypothalamic area are the first line of defense against pathogens and substances from the blood.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Medicine, Research & Experimental
P. Vishnyakova, A. Poltavets, E. Karpulevich, A. Maznina, V. Vtorushina, L. Mikhaleva, E. Kananykhina, A. Lokhonina, S. Kovalchuk, A. Makarov, A. Elchaninov, G. Sukhikh, T. Fatkhudinov
Summary: Macrophages play a crucial role in innate immunity and are activated by various factors. This study found that macrophages derived from CD14+ monocytes exhibit higher sensitivity to pro-inflammatory induction, showing increased levels of pro-inflammatory and anti-inflammatory cytokines compared to CD16+-derived macrophages. This data may be valuable for macrophage-based cell therapy applications, providing insights for manipulating donor monocytes for transplantation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Virology
Elena K. Kokinos, Sergey A. Tsymbal, Anastasia V. Galochkina, Svetlana A. Bezlepkina, Julia V. Nikolaeva, Sofia O. Vershinina, Anna A. Shtro, Victor V. Tatarskiy, Alexander A. Shtil, Eugenia V. Broude, Igor B. Roninson, Marina Dukhinova
Summary: Hyperactivation of the immune system is a life-threatening complication in viral and bacterial infections, especially pneumonia. This study found that a selective CDK8/19 inhibitor, Senexin B, could suppress the inflammatory response of monocytic cells to H1N1 influenza virus and bacterial lipopolysaccharides, reducing inflammation symptoms.
Article
Genetics & Heredity
Gilson P. Dorneles, Paula C. Teixeira, Alessandra Peres, Luiz Carlos Rodrigues Junior, Simone Goncalves da Fonseca, Marta Chagas Monteiro, Sarah Eller, Tiago F. Oliveira, Eliana M. Wendland, Pedro R. T. Romao
Summary: Higher levels of endotoxin and systemic inflammatory markers were found in severe COVID-19 patients compared to healthy controls and mild COVID-19 patients. Severe COVID-19 patients also exhibited higher levels of inflammatory cytokines and altered monocyte populations. The response to endotoxin stimulation differed between severe COVID-19 patients and controls, with lower cytokine production but higher levels of PGE-2.
JOURNAL OF MOLECULAR MEDICINE-JMM
(2023)
Article
Environmental Sciences
Chunyan Yao, Xiaoling Liu, Yan Tang, Chunmei Wang, Chenggang Duan, Xiaoyan Liu, Mingliang Chen, Yumeng Zhou, Enjie Tang, Ying Xiang, Yafei Li, Ailing Ji, Tongjian Cai
Summary: Microglia-mediated neuroinflammation is crucial in the pathophysiology of neurodegenerative diseases. Lipopolysaccharide (LPS) can activate microglia and induce inflammation. Matrix metalloproteinases (MMPs) and CD147 are key factors involved in microglial activation and inflammation. This study found that CD147 expression was induced in LPS-induced microglial activation, and inhibiting CD147 expression could suppress microglial activation. Furthermore, MMPs and autophagy were involved in the inflammatory activation of microglia, and inhibiting MMPs or autophagy could attenuate this activation.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2023)
Article
Pharmacology & Pharmacy
Izumi Hide, Hiroko Shiraki, Akihiro Masuda, Takuya Maeda, Mayuka Kumagai, Nao Kunishige, Yuhki Yanase, Kana Harada, Shigeru Tanaka, Norio Sakai
Summary: This study revealed that dying cell removal by inflammatory microglia is regulated by the activation of the P2Y2 receptor, which induces upregulation of the phagocytic Axl.
JOURNAL OF PHARMACOLOGICAL SCIENCES
(2023)
Article
Immunology
Fangfang Lu, Ronglin Wang, Li Xia, Tiejian Nie, Fei Gao, Shaosong Yang, Lu Huang, Kaifeng Shao, Jiankang Liu, Qian Yang
Summary: MEF2D plays a crucial role in regulating inflammatory responses in microglial cells through transcriptional regulation of genes like IRF7, affecting the expression of proinflammatory factors and immune stress levels.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Review
Hematology
Ana T. A. Sachetto, Nigel Mackman
Summary: The coagulation system is activated by bacterial lipopolysaccharide (LPS) and contributes to host defense. LPS induces expression of tissue factor (TF) in monocytes, leading to activation of the coagulation cascade. However, excessive activation of coagulation can lead to thrombosis. This review examines the mechanism of TF induction by LPS and its role in thrombosis and disseminated intravascular coagulation.
THROMBOSIS AND HAEMOSTASIS
(2023)
Article
Clinical Neurology
Conelius Ngwa, Abdullah Al Mamun, Shaohua Qi, Romana Sharmeen, Maria P. Blasco Conesa, Bhanu P. Ganesh, Bharti Manwani, Fudong Liu
Summary: This study investigated the role of interferon regulatory factor 4 (IRF4) and IRF5 in microglia and monocytes in cerebral ischemia. The findings suggest that the central IRF4/5 signaling pathway plays a critical role in cerebral ischemia and can affect microglial activation and stroke outcomes.
TRANSLATIONAL STROKE RESEARCH
(2023)
Article
Immunology
Ana P. Lopes, Cornelis P. J. Bekker, Maarten R. Hillen, Sofie L. M. Blokland, Anneline C. Hinrichs, Aridaman Pandit, Aike A. Kruize, Timothy R. D. J. Radstake, Joel A. G. van Roon
Summary: Primary Sjogren's syndrome (pSS) is characterized by infiltration of exocrine glands and B cell hyperactivity. RNA-sequencing of CD14(+) monocytes from pSS patients revealed enrichment in intermediate and non-classical monocyte profiles, associated with processes related to translation, IFN-signaling, and toll-like receptor signaling. Hub-genes identified in pSS monocytes were highly correlated with clinical features. Unsupervised hierarchical cluster analysis grouped pSS and nSS patients into four distinct clusters, with one cluster showing higher prevalence of autoantibodies and interferon scores in pSS patients.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Neurosciences
Chelsea E. Bray, Kristina G. Witcher, Dunni Adekunle-Adegbite, Michelle Ouvina, Mollie Witzel, Emma Hans, Zoe M. Tapp, Jonathan Packer, Ethan Goodman, Fangli Zhao, Titikorn Chunchai, Shane ONeil, Siriporn C. Chattipakorn, John Sheridan, Olga N. Kokiko-Cochran, Candice Askwith, Jonathan P. Godbout
Summary: Traumatic brain injury (TBI) is associated with chronic inflammation and neuropathology, which can be alleviated through turnover of trauma-associated microglia. Microglia turnover improves functional recovery and reduces immune reactivity to challenges. This study highlights the importance of targeting microglia in TBI treatment.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Ophthalmology
Nan Shu, Zhi Zhang, Xiaotang Wang, Ruonan Li, Wanqian Li, Xianyang Liu, Qi Zhang, Zhengxuan Jiang, Liming Tao, Li Zhang, Shengping Hou
Summary: The purpose of this study was to investigate the therapeutic effect of Apigenin, a flavonoid compound, on experimental autoimmune uveitis (EAU). The results showed that Apigenin could ameliorate retinal inflammation by inhibiting microglia M1 pro-inflammatory polarization, thereby reducing the severity of the disease.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2023)
Article
Immunology
Gregory E. Miller, Edith Chen, Eric Finegood, Daichi Shimbo, Steve W. Cole
Summary: Children exposed to neighborhood violence show higher systemic inflammatory activity and specific transcriptional profiles indicative of increased pro-inflammatory effector functions, potentially linking threatening experiences with health risks.
BRAIN BEHAVIOR AND IMMUNITY
(2022)
Article
Chemistry, Multidisciplinary
Vincent Mauricio Kadiri, Claudio Bussi, Andrew W. Holle, Kwanghyo Son, Hyunah Kwon, Gisela Schuetz, Maximiliano G. Gutierrez, Peer Fischer
ADVANCED MATERIALS
(2020)
Letter
Medicine, General & Internal
Catherine F. Houlihan, Nina Vora, Thomas Byrne, Dan Lewer, Gavin Kelly, Judith Heaney, Sonia Gandhi, Moira J. Spyer, Rupert Beale, Peter Cherepanov, David Moore, Richard Gilson, Steve Gamblin, George Kassiotis, Laura E. McCoy, Charles Swanton, Andrew Hayward, Eleni Nastouli
Article
Cell Biology
Elliott M. Bernard, Antony Fearns, Claudio Bussi, Pierre Santucci, Christopher J. Peddie, Rachel J. Lai, Lucy M. Collinson, Maximiliano G. Gutierrez
Summary: Xenophagy is an important defense mechanism in macrophages against pathogens like Mycobacterium tuberculosis, and the ESX-1 secretion system plays a critical role in inducing autophagosome formation and facilitating the escape of bacteria into the cytosol during infection. The study utilized human induced pluripotent stem cell-derived macrophages to investigate the spatiotemporal dynamics of the interaction between human macrophages and Mtb, revealing specific transcriptional responses and pathways dysregulated by Mtb infection.
JOURNAL OF CELL SCIENCE
(2021)
Article
Behavioral Sciences
Simona Balestrini, Matthias J. Koepp, Sonia Gandhi, Hannah M. Rickman, Gee Yen Shin, Catherine F. Houlihan, Jonny Anders-Cannon, Katri Silvennoinen, Fenglai Xiao, Sara Zagaglia, Kirsty Hudgell, Mariusz Ziomek, Paul Haimes, Adam Sampson, Annie Parker, J. Helen Cross, Rosemarie Pardington, Eleni Nastouli, Charles Swanton, Jim Aitken, Zoe Allen, Rachel Ambler, Karen Ambrose, Emma Ashton, Alida Avola, Samutheswari Balakrishnan, Caitlin Barns-Jenkins, Genevieve Barr, Sam Barrell, Souradeep Basu, Rupert Beale, Clare Beesley, Nisha Bhardwaj, Shahnaz Bibi, Ganka Bineva-Todd, Dhruva Biswas, Michael J. Blackman, Dominique Bonnet, Faye Bowker, Malgorzata Broncel, Claire Brooks, Michael D. Buck, Andrew Buckton, Timothy Budd, Alana Burrell, Louise Busby, Claudio Bussi, Simon Butterworth, Matthew Byott, Fiona Byrne, Richard Byrne, Simon Caidan, Joanna Campbell, Johnathan Canton, Ana Cardoso, Nick Carter, Luiz Carvalho, Raffaella Carzaniga, Natalie Chandler, Qu Chen, Peter Cherepanov, Laura Churchward, Graham Clark, Bobbi Clayton, Clementina Cobolli Gigli, Zena Collins, Sally Cottrell, Margaret Crawford, Laura Cubitt, Tom Cullup, Heledd Davies, Patrick Davis, Dara Davison, Vicky Dearing, Solene Debaisieux, Monica Diaz-Romero, Alison Dibbs, Jessica Diring, Paul C. Driscoll, Annalisa D'Avola, Christopher Earl, Amelia Edwards, Chris Ekin, Dimitrios Evangelopoulos, Rupert Faraway, Antony Fearns, Aaron Ferron, Efthymios Fidanis, Dan Fitz, James Fleming, Daniel Frampton, Bruno Frederico, Alessandra Gaiba, Anthony Gait, Steve Gamblin, Kathleen Gartner, Liam Gaul, Helen M. Golding, Jacki Goldman, Robert Goldstone, Belen Gomez Dominguez, Hui Gong, Paul R. Grant, Maria Greco, Mariana Grobler, Anabel Guedan, Maximiliano G. Gutierrez, Fiona Hackett, Ross Hall, Steinar Halldorsson, Suzanne Harris, Sugera Hashim, Emine Hatipoglu, Lyn Healy, Judith Heaney, Susanne Herbst, Graeme Hewitt, Theresa Higgins, Steve Hindmarsh, Rajnika Hirani, Joshua Hope, Elizabeth Horton, Beth Hoskins, Michael Howell, Louise Howitt, Jacqueline Hoyle, Mint R. Htun, Michael Hubank, Hector Huerga Encabo, Deborah Hughes, Jane Hughes, Almaz Huseynova, Ming-Shih Hwang, Rachael Instrell, Deborah Jackson, Mariam Jamal-Hanjani, Lucy Jenkins, Ming Jiang, Mark Johnson, Leigh Jones, Nnennaya Kanu, George Kassiotis, Gavin Kelly, Louise Kiely, Anastacio King Spert Teixeira, Stuart Kirk, Svend Kjaer, Ellen Knuepfer, Nikita Komarov, Paul Kotzampaltiris, Konstantinos Kousis, Tammy Krylova, Ania Kucharska, Robyn Labrum, Catherine Lambe, Michelle Lappin, Stacey-Ann Lee, Andrew Levett, Lisa Levett, Marcel Levi, Hon Wing Liu, Sam Loughlin, Wei-Ting Lu, James MacRae, Akshay Madoo, Julie A. Marczak, Mimmi Martensson, Thomas Martinez, Bishara Marzook, John Matthews, Joachim M. Matz, Samuel McCall, Laura E. McCoy, Fiona McKay, Edel C. McNamara, Carlos M. Minutti, Gita Mistry, Miriam Molina-Arcas, Beatriz Montaner, Kylie Montgomery, Catherine Moore, David Moore, Anastasia Moraiti, Lucia Moreira-Teixeira, Joyita Mukherjee, Cristina Naceur-Lombardelli, Aileen Nelson, Jerome Nicod, Luke Nightingale, Stephanie Nofal, Paul Nurse, Savita Nutan, Caroline Oedekoven, Anne O'Garra, Jean D. O'Leary, Jessica Olsen, Olga O'Neill, Nicola O'Reilly, Paula Ordonez Suarez, Neil Osborne, Amar Pabari, Aleksandra Pajak, Venizelos Papayannopoulos, Stavroula M. Paraskevopoulou, Namita Patel, Yogen Patel, Oana Paun, Nigel Peat, Laura Peces-Barba Castano, Ana Perez Caballero, Jimena Perez-Lloret, Magali S. Perrault, Abigail Perrin, Roy Poh, Enzo Z. Poirier, James M. Polke, Marc Pollitt, Lucia Prieto-Godino, Alize Proust, Clinda Puvirajasinghe, Christophe Queval, Vijaya Ramachandran, Abhinay Ramaprasad, Peter Ratcliffe, Laura Reed, Caetano Reis E Sousa, Kayleigh Richardson, Sophie Ridewood, Fiona Roberts, Rowenna Roberts, Angela Rodgers, Pablo Romero Clavijo, Annachiara Rosa, Alice Rossi, Chloe Roustan, Andrew Rowan, Erik Sahai, Aaron Sait, Katarzyna Sala, Emilie Sanchez, Theo Sanderson, Pierre Santucci, Fatima Sardar, Adam Sateriale, Jill A. Saunders, Chelsea Sawyer, Anja Schlott, Edina Schweighoffer, Sandra Segura-Bayona, Rajvee Shah Punatar, Maryam Shahmanesh, Joe Shaw, Mariana Silva Dos Santos, Margaux Silvestre, Matthew Singer, Daniel M. Snell, Ok-Ryul Song, Moira J. Spyer, Louisa Steel, Amy Strange, Adrienne E. Sullivan, Michele S. Y. Tan, Zoe H. Tautz-Davis, Effie Taylor, Gunes Taylor, Harriet B. Taylor, Alison Taylor-Beadling, Fernanda Teixeira Subtil, Berta Terre Torras, Patrick Toolan-Kerr, Francesca Torelli, Tea Toteva, Moritz Treeck, Hadija Trojer, Ming-Han C. Tsai, James M. A. Turner, Melanie Turner, Jernej Ule, Rachel Ulferts, Sharon P. Vanloo, Selvaraju Veeriah, Subramanian Venkatesan, Karen Vousden, Andreas Wack, Claire Walder, Philip A. Walker, Yiran Wang, Sophia Ward, Catharina Wenman, Luke Williams, Matthew J. Williams, Wai Keong Wong, Joshua Wright, Mary Wu, Lauren Wynne, Zheng Xiang, Melvyn Yap, Julian A. Zagalak, Davide Zecchin, Rachel Zillwood, Josemir W. Sander, Sanjay M. Sisodiya, Santhakumari Carthiyaniamma, Jane DeTisi, Julie Dick, Andrea Hill, Karin Kipper, Birinder Kullar, Sarah Norris, Fergus Rugg-Gunn, Rebecca Salvatierra, Gabriel Shaya, Astrid Sloan, Priyanka Singh, James Varley, Ben Whatley
Summary: This cohort study compared the infection prevention strategies implemented in four UK long-term care facilities during the COVID-19 pandemic. The findings suggest that enhanced surveillance of residents and caregivers can quickly contain outbreaks and reduce transmission among vulnerable populations.
EPILEPSY & BEHAVIOR
(2021)
Article
Medicine, General & Internal
Joel Hellewell, Timothy W. Russell, Rupert Beale, Gavin Kelly, Catherine Houlihan, Eleni Nastouli, Adam J. Kucharski
Summary: The study used Bayesian statistical model to analyze PCR testing data of UK healthcare workers, finding that the detection probability peaked at 77% 4 days after infection but decreased to 50% by 10 days. Testing every other day was estimated to detect 57% of symptomatic cases before onset and 94% of asymptomatic cases within 7 days if results are returned promptly.
Article
Biochemistry & Molecular Biology
Lewis Au, Annika Fendler, Scott T. C. Shepherd, Karolina Rzeniewicz, Maddalena Cerrone, Fiona Byrne, Eleanor Carlyle, Kim Edmonds, Lyra Del Rosario, John Shon, Winston A. Haynes, Barry Ward, Ben Shum, William Gordon, Camille L. Gerard, Wenyi Xie, Nalinie Joharatnam-Hogan, Kate Young, Lisa Pickering, Andrew J. S. Furness, James Larkin, Ruth Harvey, George Kassiotis, Sonia Gandhi, Charles Swanton, Charlotte Fribbens, Katalin A. Wilkinson, Robert J. Wilkinson, David K. Lau, Susana Banerjee, Naureen Starling, Ian Chau, Samra Turajlic
Summary: A rare case of cytokine release syndrome in a cancer patient following COVID-19 vaccination suggests a potential vaccine-related adverse event. While mRNA vaccines have not been linked to CRS, cancer patients are still recommended for COVID-19 vaccination as the benefit-risk profile remains favorable. Further prospective pharmacovigilance data are needed in this population to better understand any potential risks.
Letter
Oncology
Annika Fendler, Scott T. C. Shepherd, Lewis Au, Katalin A. Wilkinson, Mary Wu, Andreas M. Schmitt, Zayd Tippu, Sheima Farag, Aljosja Rogiers, Ruth Harvey, Eleanor Carlyle, Kim Edmonds, Lyra Del Rosario, Karla Lingard, Mary Mangwende, Lucy Holt, Hamid Ahmod, Justine Korteweg, Tara Foley, Taja Barber, Andrea Emslie-Henry, Niamh Caulfield-Lynch, Fiona Byrne, Benjamin Shum, Camille L. Gerard, Daqi Deng, Svend Kjaer, Ok-Ryul Song, Christophe Queval, Caitlin Kavanagh, Emma C. Wall, Edward J. Carr, Sina Namjou, Simon Caidan, Mike Gavrielides, James I. MacRae, Gavin Kelly, Kema Peat, Denise Kelly, Aida Murra, Kayleigh Kelly, Molly O'Flaherty, Robyn L. Shea, Gail Gardner, Darren Murray, Nadia Yousaf, Shaman Jhanji, Nicholas Van As, Kate Young, Andrew J. S. Furness, Lisa Pickering, Rupert Beale, Charles Swanton, Sonia Gandhi, Steve Gamblin, David L. V. Bauer, George Kassiotis, Michael Howell, Emma Nicholson, Susanna Walker, Robert J. Wilkinson, James Larkin, Samra Turajic
Article
Immunology
Emilia A. Gaviglio, Javier M. Peralta Ramos, Daniela S. Arroyo, Claudio Bussi, Pablo Iribarren, Maria C. Rodriguez-Galan
Summary: The development of neuroinflammation and progression of neurodegenerative diseases are associated with the activation and mobilization of the peripheral immune system due to systemic inflammation. This study investigated the effects of systemic sterile induced-co-expression of IL-12 and IL-18 on the establishment of a cytokine-mediated model of neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Microbiology
Pierre Santucci, Beren Aylan, Laure Botella, Elliott M. Bernard, Claudio Bussi, Enrica Pellegrino, Natalia Athanasiadi, Maximiliano G. Gutierrez
Summary: This study investigates the effect of intracellular environments on the efficacy of antibiotics against Mycobacterium tuberculosis. By using a dual live imaging approach, the researchers found that intracellular acidification is a prerequisite for the antibacterial efficacy of pyrazinamide, a first-line anti-TB drug.
Article
Multidisciplinary Sciences
Claudio Bussi, Tiaan Heunis, Enrica Pellegrino, Elliott M. Bernard, Nourdine Bah, Mariana Silva Dos Santos, Pierre Santucci, Beren Aylan, Angela Rodgers, Antony Fearns, Julia Mitschke, Christopher Moore, James MacRae, Maria Greco, Thomas Reinheckel, Matthias Trost, Maximiliano G. Gutierrez
Summary: This study reveals that limited lysosomal damage leads to changes in the mitochondrial proteome and the modulation of macrophage immunometabolism. It shows that protease leakage from lysosomes triggers a cell death-independent proteolytic remodeling of the mitochondrial proteome in macrophages.
NATURE COMMUNICATIONS
(2022)
Article
Microbiology
Beren Aylan, Elliott M. M. Bernard, Enrica Pellegrino, Laure Botella, Antony Fearns, Natalia Athanasiadi, Claudio Bussi, Pierre Santucci, Maximiliano G. G. Gutierrez
Summary: Autophagy is a cellular defence mechanism against intracellular microorganisms, including Mycobacterium tuberculosis (Mtb). The study showed that ATG7 and ATG14 are both required for restricting Mtb replication in human macrophages.
NATURE MICROBIOLOGY
(2023)
Article
Cell Biology
Enrica Pellegrino, Beren Aylan, Claudio Bussi, Antony Fearns, Elliott M. Bernard, Natalia Athanasiadi, Pierre Santucci, Laure Botella, Maximiliano G. Gutierrez
Summary: Peroxisomes play a role in restricting cytosolic Mycobacterium tuberculosis (Mtb) infection in human macrophages by increasing ROS levels.
JOURNAL OF CELL BIOLOGY
(2023)
Meeting Abstract
Respiratory System
Claudio Bussi, Mariana Silva Dos Santos, Elliott M. Bernard, Pierre B. Santucci, James I. Macrae, Maximiliano G. Gutierrez
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Oncology
Annika Fendler, Lewis Au, Scott T. C. Shepherd, Fiona Byrne, Maddalena Cerrone, Laura Amanda Boos, Karolina Rzeniewicz, William Gordon, Benjamin Shum, Camille L. Gerard, Barry Ward, Wenyi Xie, Andreas M. Schmitt, Nalinie Joharatnam-Hogan, Georgina H. Cornish, Martin Pule, Leila Mekkaoui, Kevin W. Ng, Eleanor Carlyle, Kim Edmonds, Lyra Del Rosario, Sarah Sarker, Karla Lingard, Mary Mangwende, Lucy Holt, Hamid Ahmod, Richard Stone, Camila Gomes, Helen R. Flynn, Ana Agua-Doce, Philip Hobson, Simon Caidan, Michael Howell, Mary Wu, Robert Goldstone, Margaret Crawford, Laura Cubitt, Harshil Patel, Mike Gavrielides, Emma Nye, Ambrosius P. Snijders, James MacRae, Jerome Nicod, Firza Gronthoud, Robyn L. Shea, Christina Messiou, David Cunningham, Ian Chau, Naureen Starling, Nicholas Turner, Liam Welsh, Nicholas van As, Robin L. Jones, Joanne Droney, Susana Banerjee, Kate C. Tatham, Shaman Jhanji, Mary O'Brien, Olivia Curtis, Kevin Harrington, Shreerang Bhide, Jessica Bazin, Anna Robinson, Clemency Stephenson, Tim Slattery, Yasir Khan, Zayd Tippu, Isla Leslie, Spyridon Gennatas, Alicia Okines, Alison Reid, Kate Young, Andrew J. S. Furness, Lisa Pickering, Sonia Gandhi, Steve Gamblin, Charles Swanton, Emma Nicholson, Sacheen Kumar, Nadia Yousaf, Katalin A. Wilkinson, Anthony Swerdlow, Ruth Harvey, George Kassiotis, James Larkin, Robert J. Wilkinson, Samra Turajlic
Summary: Patients with cancer have higher morbidity and mortality when infected with COVID-19. The CAPTURE study found that while most patients had immune responses against the original SARS-CoV-2, neutralizing antibody titers against variants were significantly reduced, with some patients experiencing a decrease in antibody levels. However, neutralizing antibody titers remained stable for some patients.
Article
Oncology
Annika Fendler, Scott T. C. Shepherd, Lewis Au, Katalin A. Wilkinson, Mary Wu, Fiona Byrne, Maddalena Cerrone, Andreas M. Schmitt, Nalinie Joharatnam-Hogan, Benjamin Shum, Zayd Tippu, Karolina Rzeniewicz, Laura Amanda Boos, Ruth Harvey, Eleanor Carlyle, Kim Edmonds, Lyra Del Rosario, Sarah Sarker, Karla Lingard, Mary Mangwende, Lucy Holt, Hamid Ahmod, Justine Korteweg, Tara Foley, Jessica Bazin, William Gordon, Taja Barber, Andrea Emslie-Henry, Wenyi Xie, Camille L. Gerard, Daqi Deng, Emma C. Wall, Ana Agua-Doce, Sina Namjou, Simon Caidan, Mike Gavrielides, James MacRae, Gavin Kelly, Kema Peat, Denise Kelly, Aida Murra, Kayleigh Kelly, Molly O'Flaherty, Lauren Dowdie, Natalie Ash, Firza Gronthoud, Robyn L. Shea, Gail Gardner, Darren Murray, Fiona Kinnaird, Wanyuan Cui, Javier Pascual, Simon Rodney, Justin Mencel, Olivia Curtis, Clemency Stephenson, Anna Robinson, Bhavna Oza, Sheima Farag, Isla Leslie, Aljosja Rogiers, Sunil Iyengar, Mark Ethell, Christina Messiou, David Cunningham, Ian Chau, Naureen Starling, Nicholas Turner, Liam Welsh, Nicholas van As, Robin L. Jones, Joanne Droney, Susana Banerjee, Kate C. Tatham, Mary O'Brien, Kevin Harrington, Shreerang Bhide, Alicia Okines, Alison Reid, Kate Young, Andrew J. S. Furness, Lisa Pickering, Charles Swanton, Sonia Gandhi, Steve Gamblin, David L. Bauer, George Kassiotis, Sacheen Kumar, Nadia Yousaf, Shaman Jhanji, Emma Nicholson, Michael Howell, Susanna Walker, Robert J. Wilkinson, James Larkin, Samra Turajlic
Summary: A cohort study evaluated 585 cancer patients following vaccination with BNT162b2 or AZD1222 vaccines, finding lower antibody responses in patients with hematological malignancies compared to those with solid tumors. Patients with hematological malignancies also had reduced neutralizing antibody responses compared to individuals without cancer. The study highlights the importance of managing cancer patients during the ongoing COVID-19 pandemic.
