Review
Immunology
MingHua Cui, YueHui Liu, Li Cheng, Tao Li, YongZhi Deng, Da Liu
Summary: Ovarian cancer is a highly deadly malignancy among women, and its complex pathogenesis remains largely unknown. The tumor microenvironment plays a crucial role in tumor progression and treatment. MicroRNAs have been shown to regulate ovarian cancer development by affecting the tumor microenvironment. Therefore, identifying new tumor biomarkers and therapeutic targets is of great significance for ovarian cancer treatment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Ravikumar Muthuswamy, A. J. Robert McGray, Sebastiano Battaglia, Wenjun He, Anthony Miliotto, Cheryl Eppolito, Junko Matsuzaki, Tsuji Takemasa, Richard Koya, Thinle Chodon, Brian D. Lichty, Protul Shrikant, Kunle Odunsi
Summary: Resident memory CD8 T cells, characterized by their ability to reside in peripheral tissues, play a crucial role in adaptive sentinel activity and amplifying immune responses. The study focused on the chemotactic mechanisms governing the localization, retention, and residency of memory CD8 T cells in the ovarian tumor microenvironment. Results indicated that CXCR6 is a key marker for resident memory tumor-specific CD8 T cells, with its deficiency resulting in reduced retention in tumor tissues and poor control of ovarian cancer. Further research is needed to explore the potential of utilizing CXCR6 to enhance resident memory responses in cancer.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Paulina Borzdzilowska, Ilona Bednarek
Summary: The diversity and role of exosomes in the microenvironment make them an important focus in cancer development. This study evaluated the effect of exosomes derived from ovarian cancer cells on gene expression in fibroblasts, and attempted to assess the indirect impact of cisplatin and/or alpha-mangostin on metastasis. The results showed that these chemotherapeutic agents not only directly affected tumor cells, but also contributed to delaying metastasis development indirectly through exosomes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Oncology
Nadiah Abu, Nurul Ainaa Adilah Rus Bakarurraini
Summary: The interdependency between cancer cells and immune cells is crucial to understanding cancer pathogenesis. Extracellular vesicles (EVs) released by both cancer and immune cells act as messengers in this process. Tumor-derived EVs have been found to interact with immune cells, especially T cells, while T cell-derived EVs also play immunomodulatory roles. This mini-review aims to explore the impact of tumor-derived EVs and T cell-derived EVs on cancer immunosuppression, highlighting the interplay between different types of EVs and their effects on tumor immunity. The role of EVs in various types of T cells, including CD8(+), CD4(+) Th17, and Treg cells, is also discussed. Furthermore, limitations and future directions regarding this research are addressed, contributing to a better understanding of the functions of these tiny mediators.
Article
Oncology
Qiushi Tang, Shuo Yang, Guangpeng He, Hongyu Zheng, Sheng Zhang, Jiaxing Liu, Shibo Wei, Qing Fan, Xueqiang Peng, Xinyu Li, Dewei Zhang, Liang Yang, Hangyu Li
Summary: Tumor-derived exosomes (TDEs) play a critical role in regulating the immune microenvironment of tumors and have the ability to suppress immune responses, thus impacting the effectiveness of cancer therapy. By delivering suppressive factors to immune cells, TDEs directly or indirectly influence immune cell function and antitumor activities. TDE-based therapy is emerging as a promising strategy for inhibiting tumor progression and enhancing antitumor immunity.
Review
Pharmacology & Pharmacy
Ya-Nan Pi, Bai-Rong Xia, Ming-Zhu Jin, Wei-Lin Jin, Ge Lou
Summary: Cancer immunotherapy targeting the tumor immune microenvironment is considered revolutionary, with exosomes playing a crucial role in mediating intercellular communication and possibly serving as an adjuvant therapeutic strategy for immune-based combination therapy.
BIOCHEMICAL PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Yuju Zhou, Ying Zhang, Huan Gong, Siqi Luo, Yan Cui
Summary: Exosomes, small extracellular vesicles secreted by various cell types, have shown great potential in cancer therapy and diagnosis. They can deliver therapeutic molecules to tumor cells and serve as biomarkers for early cancer detection and treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Oncology
Livia Elena Sima, Siqi Chen, Horacio Cardenas, Guangyuan Zhao, Yinu Wang, Cristina Ivan, Hao Huang, Bin Zhang, Daniela Matei
Summary: The study showed that host TG2 deficiency delayed tumor growth, increased infiltration of CD8(+) T cells, and decreased myeloid cell numbers in the peritoneal fluid. Loss of TG2 enhanced tumor antigen-specific CD8(+) T cell cytotoxic responses and reduced immune-suppressive signals in the tumor microenvironment, leading to decreased tumor burden.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2021)
Article
Multidisciplinary Sciences
Chunyang Jiang, Xu Li, Bingsheng Sun, Na Zhang, Jing Li, Shijing Yue, Xiaoli Hu
Summary: This study demonstrates the role of ALAHM in tumor-derived extracellular vesicles (EVs) in promoting liver metastasis of lung adenocarcinoma (LUAD) cells. ALAHM enhances the proliferation, invasion, and migration of LUAD cells, and induces hepatocyte secretion of HGF. The findings suggest that LUAD-cell-derived EVs containing ALAHM contribute to the progression of liver metastasis in LUAD.
Article
Cell Biology
Ziming Jiang, Yiming Zhang, Yu Zhang, Zhankui Jia, Zhengguo Zhang, Jinjian Yang
Summary: The study revealed that exosomes released by bladder cancer cells can promote the immunosuppressive polarization of macrophages, facilitating tumor growth. This process is mediated by down-regulation of PTEN and activation of AKT/STAT3/6 signaling. Inhibiting the generation or secretion of exosomes can suppress the immunosuppressive transformation of macrophages, thereby inhibiting tumor growth.
CELL COMMUNICATION AND SIGNALING
(2021)
Review
Oncology
Daniele Fanale, Alessandra Dimino, Erika Pedone, Chiara Brando, Lidia Rita Corsini, Clarissa Filorizzo, Alessia Fiorino, Maria Chiara Lisanti, Luigi Magrin, Ugo Randazzo, Tancredi Didier Bazan Russo, Antonio Russo, Viviana Bazan
Summary: In this review, the prognostic and predictive role of tumor-infiltrating lymphocytes (TILs) in ovarian cancer (OC) is discussed. Despite the immunogenic potential of OC, immunotherapy has not yielded expected results. Understanding factors influencing infiltration and the crosstalk between cancer and immune cells in the tumor microenvironment (TME) is crucial for unraveling heterogeneity in clinical outcomes. TILs have been recognized as clinically relevant markers for improved survival in OC, and may help identify OC patients who may benefit from immunotherapy.
Article
Medicine, Research & Experimental
V. A. Subramanian, Ravindra Kumar Bairwa, Pradeep Kumar Sharma, Bhawana Bissa
Summary: This article discusses the roles of autophagy and exosomes in the cancer cell's adaptation to the tumor microenvironment and how the two pathways are coordinately regulated to facilitate cancer cell survival.
Article
Oncology
Kelly Boelaars, Laura Goossens-Kruijssen, Di Wang, Charlotte M. de Winde, Ernesto Rodriguez, Dimitri Lindijer, Babet Springer, Irene van der Haar avila, Aram de Haas, Laetitia Wehry, Louis Boon, Reina E. Mebius, Nadine van Montfoort, Manfred Wuhrer, Joke M. M. den Haan, Sandra J. van Vliet, Yvette van Kooyk
Summary: Pancreatic ductal adenocarcinoma (PDAC) is a deadly cancer, and immunotherapy has been unsuccessful in its treatment. This study shows that tumor-derived sialic acids play a critical role in shaping the immune landscape of PDAC. The absence of sialic acids allows for better infiltration of T cells into the tumor, resulting in improved response to immunotherapy.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Oncology
Fabiana Pani, Yoshinori Yasuda, Sylvie T. Rousseau, Kevin C. Bermea, Solmaz Roshanmehr, Rulin Wang, Srinivasan Yegnasubramanian, Patrizio Caturegli, Luigi Adamo
Summary: The pre-conditioning of the immune system can modulate the therapeutic effect of immune checkpoint inhibitors (ICI); however, the mechanisms behind this phenomenon are still unclear. This study showed that the simultaneous induction of immune-mediated thyroiditis (IET) and papillary thyroid cancer (PTC) in mice resulted in a decreased incidence of PTC in response to ICI treatment.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2022)
Article
Oncology
Veronica Finisguerra, Tereza Dvorakova, Matteo Formenti, Pierre Van Meerbeeck, Lionel Mignion, Bernard Gallez, Benoit J. van den Eynde
Summary: Despite limitations in certain tumor types and patients, immunotherapies have achieved revolutionary success in cancer treatment. However, the efficacy of immunotherapies is dependent on the viability and functionality of tumor antigen-specific CD8 T cells within the immunosuppressive tumor microenvironment, where oxygen levels are often low. This study reveals that the antidiabetic drug metformin can improve CD8 T cell fitness in hypoxia, increasing their proliferation and cytokine production, and enhancing their infiltration and survival in hypoxic tumor areas. This presents a promising strategy to overcome resistance to immunotherapy in hypoxic and immunosuppressive tumors.
JOURNAL FOR IMMUNOTHERAPY OF CANCER
(2023)
Article
Biochemistry & Molecular Biology
Min-Min Yu, Gen-ju Wang, Kai-Hua Wu, Song-Lin Xue, Li-Li Ju, Qian-rui Li, Ai-Wei Xiong, Guo-ping Yin
Summary: miR-373-3p functions as a novel anti-tumor microRNA in cervical cancer by targeting AKT1, leading to decreased cell proliferation and inhibited tumor growth.
ACTA BIOCHIMICA POLONICA
(2021)
Article
Obstetrics & Gynecology
Minmin Yu, Songlin Xue, Xin Chen, Kaihua Wu, Lili Ju, Juan Tang, Aiwei Xiong, Xiaoxiang Chen, Xiaoyan Ying
Summary: This study aimed to investigate the role of UCA1a in cervical cancer and found that UCA1a interacts with PKM2 to regulate proliferation of Hela cells, possibly through ubiquitination degradation of PKM2. These findings have important implications for understanding the progression mechanism of cervical cancer.
REPRODUCTIVE SCIENCES
(2023)
Article
Oncology
Ai-Wei Xiong, Ting Miao, Kai-Hua Wu, Shu-Li Zhao, Min-Min Yu
Summary: This multi-institutional investigation studied the impact of overweight on the outcomes of locally advanced cervical cancers treated with curative chemoradiation. The findings showed that overweight patients had lower response rates and shorter disease-free and overall survival. Overweight was identified as a risk factor for poor treatment response.
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
(2022)
Article
Oncology
Ai -Wei Xiong, Ting Miao, Kai-Hua Wu, Shu-Li Zhao, Min -Min Yu
Summary: The regression of human papilloma virus infection can be positively influenced by 6 weeks of aerobic exercise, especially for non-16/18 high-risk HPV infection, leading to a decrease in current HPV infection rate and newly diagnosed HPV infection rate.
EUROPEAN JOURNAL OF GYNAECOLOGICAL ONCOLOGY
(2022)