Article
Cell Biology
Liang Gao, Chao He, Aizhen Yang, Haibing Zhou, Qingxian Lu, Raymond B. Birge, Yi Wu
Summary: This study investigates the role of Tyro3, Axl, and Mertk in the pathogenesis of rheumatoid arthritis. The results demonstrate that Axl and Mertk-deficient mice develop more severe antibody-induced arthritis, accompanied by increased levels of cytokines in the joints. In contrast, Tyro3-deficient mice show diminished joint inflammation. Furthermore, TAMs show distinct expression patterns, with monocytes expressing Axl and Mertk while neutrophils express Axl and Tyro3.
CELL COMMUNICATION AND SIGNALING
(2023)
Article
Multidisciplinary Sciences
Janik Engelmann, Jennifer Zarrer, Victoria Gensch, Kristoffer Riecken, Nikolaus Berenbrok, The Vinh Luu, Antonia Beitzen-Heineke, Maria Elena Vargas-Delgado, Klaus Pantel, Carsten Bokemeyer, Somasekhar Bhamidipati, Ihab S. Darwish, Esteban Masuda, Tal Burstyn-Cohen, Emily J. Alberto, Sourav Ghosh, Carla Rothlin, Eric Hesse, Hanna Taipaleenmaki, Isabel Ben-Batalla, Sonja Loges
Summary: This study demonstrates the reciprocal effects of TAM receptors MERTK and TYRO3 in maintaining the balance of bone homeostasis. Blocking MERTK can increase osteoblast numbers and promote bone formation, consequently reducing cancer-induced bone loss and improving survival.
NATURE COMMUNICATIONS
(2022)
Article
Cell Biology
Jessica M. Rosin, Candace M. Marsters, Faizan Malik, Rena Far, Lata Adnani, Carol Schuurmans, Quentin J. Pittman, Deborah M. Kurrasch
Summary: This study found that embryonic microglia show a strong responsiveness to insults during gestation, coordinating an innate immune response and playing a crucial role in the critical window for neurodevelopment.
Article
Oncology
Viralkumar Davra, Sushil Kumar, Ke Geng, David Calianese, Dhriti Mehta, Varsha Gadiyar, Canan Kasikara, Kevin C. Lahey, Yun-Juan Chang, Michael Wichroski, Chan Gao, Mariana S. De Lorenzo, Sergei Kotenko, Tessa Bergsbaken, Pankaj K. Mishra, William C. Gause, Michael Quigley, Thomas E. Spires, Raymond B. Birge
Summary: This study demonstrates that targeting Axl expressed on tumor cells and Mertk in the tumor microenvironment could enhance current immunotherapies. Axl and Mertk have distinct functional activities in breast cancer, affecting host antitumor response.
Article
Chemistry, Multidisciplinary
Young Joo Lee, Miso Park, Hyun Young Kim, Jin-Ki Kim, Won-Ki Kim, Sung Chul Lim, Keon Wook Kang
Summary: The study investigates the role of circulating small extracellular vesicles (csEVs) in vascular smooth muscle cell (VSMC) functions and reveals that csEVs enhance cell proliferation and migration via the membrane phosphatidylserine (PS). Further experiments demonstrate the essential role of csEVs in neointima formation and uncover the involvement of AXL and MerTK pathways in mediating the effects of csEVs. Dual inhibition of AXL/MerTK effectively hinders csEV-mediated proliferation and migration of VSMCs, suggesting the potential of dual AXL/MerTK inhibitors in treating vascular diseases.
ACTA PHARMACOLOGICA SINICA
(2023)
Article
Chemistry, Physical
Natsuko Furukawa, Xuejie Chen, Satoshi Asano, Marina Matsumoto, Yuxin Wu, Kohei Murata, Atsuko Takeuchi, Chisato Tode, Taiki Homma, Ryohto Koharazawa, Kouki Usami, Jian-Ke Tie, Yoshihisa Hirota, Yoshitomo Suhara
Summary: Prior to utilization in the body, dietary vitamin K homologues undergo conversion to MK-4 through cleavage of the side chain and prenylation. The electron deficiency at the C-1' position of the allyl moiety is crucial for prenylation. A new vitamin K derivative with a ketone group was synthesized, and its conversion to MK-4 was investigated. The introduction of the ketone group at the C-1' position induced conversion to MK-4 analog, similar to natural phylloquinone.
JOURNAL OF MOLECULAR STRUCTURE
(2023)
Article
Hematology
Xuejie Chen, Yizhou Liu, Natsuko Furukawa, Da-Yun Jin, G. Paul Savage, Darrel W. Stafford, Yoshitomo Suhara, Craig M. Williams, Jian-Ke Tie
Summary: This study identified a vitamin K analogue that acts as a VKA and is tolerant to genetic variations in the target enzyme.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2021)
Article
Biology
Thais S. Rigoni, Natalia S. Vellozo, Kamila Guimaraes-Pinto, Mariela Cabral-Piccin, Laryssa Fabiano-Coelho, Thayane C. Matos-Silva, Alessandra A. Filardy, Christina M. Takiya, Marcela F. Lopes
Summary: Axl receptor participates in the efferocytosis of apoptotic lymphocytes during Trypanosoma cruzi infection, impacting macrophage-mediated immunity. Axl(-/-) macrophages enhance M1 responses induced by immune T cells and improve parasite infection and cardiac inflammation.
COMMUNICATIONS BIOLOGY
(2022)
Review
Medicine, General & Internal
Kai-Hung Wang, Dah-Ching Ding
Summary: This article discusses the expression of RTKs in normal and tumor tissues, the pleiotropic role of the TAM family of RTKs in cellular activities, their roles in cancer and immune cells, and cancer therapies targeting TAM receptors. Further research is needed to understand the function of TAM receptors in immune cells for developing new targeted immunotherapies for cancer.
TZU CHI MEDICAL JOURNAL
(2021)
Article
Biochemistry & Molecular Biology
Xuejie Chen, Natsuko Furukawa, Da-Yun Jin, Yizhou Liu, Darrel W. Stafford, Craig M. Williams, Yoshitomo Suhara, Jian-Ke Tie
Summary: UBIAD1 mutations can impact MK-4 biosynthesis but may not necessarily affect VKD carboxylation activity. Different mutations have varying degrees of effects on MK-4 biosynthesis and VKD carboxylation.
Article
Chemistry, Analytical
Dilip Kumar Singh, Abdul Basit, Allan E. Rettie, Nathan Alade, Kenneth Thummel, Bhagwat Prasad
Summary: Gamma carboxylation is a crucial post-translational modification involved in maintaining biological stability. This study utilizes liquid chromatography-mass spectrometry with an alkaline mobile phase and polarity switching technique to simultaneously identify and quantify gamma-carboxylated proteins. This method provides insights into the active state of VKDPs.
ANALYTICA CHIMICA ACTA
(2023)
Article
Nutrition & Dietetics
Ulf Schott, Cecilia Augustsson, Luukas Lilover, Caroline Ulfsdotter Nilsson, Louise Walther-Sturesson, Thomas Kander
Summary: The study aimed to evaluate the effects of intravenously administered vitamin K1 on Gas6 and its sAxl receptor levels in intensive care patients. Results showed a small increase in Gas6 after vitamin K1 injection, with no significant changes in sAxl levels. Gas6 was not correlated with PT-INR and coagulation factors, but showed association with protein S and dp-ucMGP.
Article
Biochemistry & Molecular Biology
Guomin Shen, Meng Gao, Qing Cao, Weikai Li
Summary: This article systematically summarizes the structural and functional characteristics of FIX and the pathogenic mechanisms of identified mutations in hemophilia B patients. It discusses various mechanisms of FIX deficiency caused by different types of mutations, such as deletions, insertions, duplications, and point mutations, and their effects on bleeding phenotypes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Endocrinology & Metabolism
Nahid Karamzad, Esmaeil Faraji, Shaghayegh Adeli, Mark J. M. Sullman, Bahram Pourghassem Gargari
Summary: The present study suggests that MK-7 supplementation may be effective in improving PIVKAII levels in T2DM patients, but does not have a significant effect on dp-ucMGP, inflammatory status, or body composition indices.
NUTRITION & DIABETES
(2022)
Article
Oncology
Na Rae Park, Yeon-Ju Lee, Seung-Hoon Lee, Jung-Eun Kim
Summary: In this study, the inhibitory effect of UCMA with different carboxylation status on breast cancer cell lines was investigated. It was found that carboxylated UCMA protein had a stronger inhibitory effect on cell migration, invasion, and colony formation compared to undercarboxylated UCMA protein. These findings provide valuable insights for the development of UCMA-based anti-cancer drugs.
ANTICANCER RESEARCH
(2023)
Meeting Abstract
Oncology
Nitu Bansal, Stanley Kimani, Kamlendra Singh, Thomas Comollo, Sushi Kumar, Vladyslav Kholodovych, Youyi Peng, William Welsh, Bertino Joseph, Raymond B. Birge
Article
Cell Biology
Stanley G. Kimani, Sushil Kumar, Viralkumar Davra, Yun-Juan Chang, Canan Kasikara, Ke Geng, Wen-I Tsou, Shenyan Wang, Mainul Hoque, Andrej Bohac, Anita Lewis-Antes, Mariana S. De Lorenzo, Sergei V. Kotenko, Raymond B. Birge
CELL COMMUNICATION AND SIGNALING
(2016)
Editorial Material
Biochemistry & Molecular Biology
Sushil Kumar, Raymond B. Birge
Review
Oncology
Viralkumar Davra, Stanley G. Kimani, David Calianese, Raymond B. Birge
Review
Immunology
Sushil Kumar, David Calianese, Raymond B. Birge
IMMUNOLOGICAL REVIEWS
(2017)
Article
Oncology
Sushil Kumar, Bin Lu, Viralkumar Davra, Peter Hornbeck, Kazuya Machida, Raymond B. Birge
MOLECULAR CANCER RESEARCH
(2018)
Article
Oncology
Canan Kasikara, Sushil Kumar, Stanley Kimani, Wen-I Tsou, Ke Geng, Viralkumar Davra, Ganapathy Sriram, Connor Devoe, Khanh-Quynh N. Nguyen, Anita Antes, Allen Krantz, Grzegorz Rymarczyk, Andrzej Wilczynski, Cyril Empig, Bruce Freimark, Michael Gray, Kyle Schlunegger, Jeff Hutchins, Sergei V. Kotenko, Raymond B. Birge
MOLECULAR CANCER RESEARCH
(2017)
Article
Multidisciplinary Sciences
Stanley G. Kimani, Sushil Kumar, Nitu Bansal, Kamalendra Singh, Vladyslav Kholodovych, Thomas Comollo, Youyi Peng, Sergei V. Kotenko, Stefan G. Sarafianos, Joseph R. Bertino, William J. Welsh, Raymond B. Birge
SCIENTIFIC REPORTS
(2017)
Meeting Abstract
Oncology
Shelly Hsieh, Khanh Q. Nguyen, Stanley Kimani, Raymond B. Birge
Meeting Abstract
Oncology
William J. Welsh, Vladyslav Kholodovych, Raymond Birge, Tom Comollo, Stanley Kimani, Kamal Singh
Article
Biochemistry & Molecular Biology
Khanh-Quynh N. Nguyen, Wen-I Tsou, Daniel A. Calarese, Stanley G. Kimani, Sukhwinder Singh, Shelly Hsieh, Yongzhang Liu, Bin Lu, Yi Wu, Scott J. Garforth, Steve C. Almo, Sergei V. Kotenko, Raymond B. Birge
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Chemistry, Organic
Stanley Kimani, Goutam Ghosh, Ashwini Ghogare, Benjamin Rudshteyn, Dorota Bartusik, Tayyaba Hasan, Alexander Greer
JOURNAL OF ORGANIC CHEMISTRY
(2012)
Article
Immunology
Stanley Gititu Kimani, Ke Geng, Canan Kasikara, Sushil Kumar, Ganapathy Sriram, Yi Wu, Raymond B. Birge
FRONTIERS IN IMMUNOLOGY
(2014)