Baicalin Inhibits NOD-Like Receptor Family, Pyrin Containing Domain 3 Inflammasome Activation in Murine Macrophages by Augmenting Protein Kinase A Signaling

Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders

(2017) Biswanath Dinda et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

(2017) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

NLRP3 inflammasome assembly is regulated by phosphorylation of the pyrin domain

(2017) Andrea Stutz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The NLRP3 and Pyrin Inflammasomes: Implications in the Pathophysiology of Autoinflammatory Diseases

(2017) Carlos de Torre-Minguela et al.   Frontiers in Immunology

Baicalin Down-Regulates IL-1β-Stimulated Extracellular Matrix Production in Nasal Fibroblasts

(2017) Jae-Min Shin et al.   PLoS One

Inflammasome Complexes: Emerging Mechanisms and Effector Functions

(2016) Vijay A.K. Rathinam et al.   CELL

Pyroptosis is driven by non-selective gasdermin-D pore and its morphology is different from MLKL channel-mediated necroptosis

(2016) Xin Chen et al.   CELL RESEARCH

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

Bile Acids Control Inflammation and Metabolic Disorder through Inhibition of NLRP3 Inflammasome

(2016) Chuansheng Guo et al.   IMMUNITY

The anti-inflammatory effects of baicalin through suppression of NLRP3 inflammasome pathway in LPS-challenged piglet mononuclear phagocytes

(2016) Chun Ye et al.   Innate Immunity

Baicalin attenuates lipopolysaccharide induced inflammation and apoptosis of cow mammary epithelial cells by regulating NF-κB and HSP72

(2016) Wenhao Yang et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Baicalin attenuates inflammation in mice with OVA-induced asthma by inhibiting NF-κB and suppressing CCR7/CCL19/CCL21

(2016) Jiaqi Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

The Regulatory Role of Rolipram on Inflammatory Mediators and Cholinergic/Adrenergic Stimulation-Induced Signals in Isolated Primary Mouse Submandibular Gland Cells

(2016) Dong Un Lee et al.   MEDIATORS OF INFLAMMATION

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

NLRP3 inflammasome inhibition is disrupted in a group of auto-inflammatory disease CAPS mutations

(2016) Leanne Mortimer et al.   NATURE IMMUNOLOGY

Mechanism and Regulation of NLRP3 Inflammasome Activation

(2016) Yuan He et al.   TRENDS IN BIOCHEMICAL SCIENCES

The HMGB1 protein induces a metabolic type of tumour cell death by blocking aerobic respiration

(2016) Georg Gdynia et al.   Nature Communications

Berberine augments ATP-induced inflammasome activation in macrophages by enhancing AMPK signaling

(2016) Chen-Guang Li et al.   Oncotarget

ATP-Induced Inflammasome Activation and Pyroptosis Is Regulated by AMP-Activated Protein Kinase in Macrophages

(2016) Qing-Bing Zha et al.   Frontiers in Immunology

Scutellaria baicalensis , the golden herb from the garden of Chinese medicinal plants

(2016) Qing Zhao et al.   Science Bulletin

Dopamine Controls Systemic Inflammation through Inhibition of NLRP3 Inflammasome

(2015) Yiqing Yan et al.   CELL

Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion

(2015) Wan-ting He et al.   CELL RESEARCH

Molecular mechanisms regulating NLRP3 inflammasome activation

(2015) Eun-Kyeong Jo et al.   Cellular & Molecular Immunology

The P2X7 receptor directly interacts with the NLRP3 inflammasome scaffold protein

(2015) Alessia Franceschini et al.   FASEB JOURNAL

Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock

(2015) Dahai Yang et al.   IMMUNITY

Regulation of inflammasome activation

(2015) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

(2015) Jianjin Shi et al.   NATURE

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

(2015) Rebecca C Coll et al.   NATURE MEDICINE

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

The BH3-mimetic gossypol and noncytotoxic doses of valproic acid induce apoptosis by suppressing cyclin-A2/Akt/FOXO3a signaling

(2015) Gao-Xiang Zhao et al.   Oncotarget

Diverse Activators of the NLRP3 Inflammasome Promote IL-1β Secretion by Triggering Necrosis

(2015) Sean P. Cullen et al.   Cell Reports

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

The Immunoprotective Activity of Baicalin in Mouse Model of Cecal Ligation and Puncture-Induced Sepsis

(2014) Xinhua Hu et al.   CELL BIOCHEMISTRY AND BIOPHYSICS

Clinical and Molecular Genetics of the Phosphodiesterases (PDEs)

(2014) Monalisa F. Azevedo et al.   ENDOCRINE REVIEWS

Toll-Like Receptor-Triggered Calcium Mobilization Protects Mice against Bacterial Infection through Extracellular ATP Release

(2014) Hua Ren et al.   INFECTION AND IMMUNITY

Macrophages sense and kill bacteria through carbon monoxide–dependent inflammasome activation

(2014) Barbara Wegiel et al.   JOURNAL OF CLINICAL INVESTIGATION

Potential Therapeutic Effects of Baicalein, Baicalin, and Wogonin in Ocular Disorders

(2014) Jing-Ru Xiao et al.   JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS

Baicalin Inhibits High-Mobility Group Box 1 Release and Improves Survival in Experimental Sepsis

(2014) Hongling Wang et al.   SHOCK

Caspase-11 Controls Interleukin-1β Release through Degradation of TRPC1

(2014) Bénédicte F. Py et al.   Cell Reports

New Insights into Mechanisms Controlling the NLRP3 Inflammasome and Its Role in Lung Disease

(2013) Dominic De Nardo et al.   AMERICAN JOURNAL OF PATHOLOGY

Release of extracellular ATP by bacteria during growth

(2013) Roberto Mempin et al.   BMC MICROBIOLOGY

ASC/caspase-1/IL-1β signaling triggers inflammatory responses by promoting HMGB1 induction in liver ischemia/reperfusion injury

(2013) Naoko Kamo et al.   HEPATOLOGY

NLRP3 inflammasome activation results in hepatocyte pyroptosis, liver inflammation, and fibrosis in mice

(2013) Alexander Wree et al.   HEPATOLOGY

3,4-Methylenedioxy-β-nitrostyrene Inhibits NLRP3 Inflammasome Activation by Blocking Assembly of the Inflammasome

(2013) Yuan He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Noncanonical Inflammasome Activation by Intracellular LPS Independent of TLR4

(2013) N. Kayagaki et al.   SCIENCE

HMGB1 in vascular diseases: Its role in vascular inflammation and atherosclerosis

(2012) A.W.S. de Souza et al.   AUTOIMMUNITY REVIEWS

Treating inflammation by blocking interleukin-1 in a broad spectrum of diseases

(2012) Charles A. Dinarello et al.   NATURE REVIEWS DRUG DISCOVERY

Baicalin Improves Survival in a Murine Model of Polymicrobial Sepsis via Suppressing Inflammatory Response and Lymphocyte Apoptosis

(2012) Jiali Zhu et al.   PLoS One

Caspase-1-induced pyroptotic cell death

(2011) Edward A. Miao et al.   IMMUNOLOGICAL REVIEWS

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1  and IL-18 secretion in an autocrine way

(2008) A. Piccini et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological PKA Inhibition: All May Not Be What It Seems

(2008) A. J. Murray   Science Signaling

Baicalin inhibits macrophage activation by lipopolysaccharide and protects mice from endotoxin shock

(2007) Lin-lin Liu et al.   BIOCHEMICAL PHARMACOLOGY