Article
Immunology
Natalin J. Valeff, Maria S. Ventimiglia, Marcos Dibo, Udo R. Markert, Federico Jensen
Summary: B1 B cells, a distinct subpopulation of B cells, have been controversial in their role during pregnancy. This study revealed an expanded and proliferative splenic B1 B cell population in mice during pregnancy, accompanied by an immunoregulatory phenotype, suggesting their critical role in the intricate process of pregnancy tolerance.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Ruth Marian Guzman-Genuino, John D. Hayball, Kerrilyn R. Diener
Summary: The role of immune cells, including B cells, in pregnancy is crucial for understanding and treating pregnancy pathologies. However, the understanding of regulatory B cells is relatively limited and requires further exploration for potential therapeutic approaches.
JOURNAL OF MOLECULAR BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gianni Gerlini, Paola Di Gennaro, Nicola Pimpinelli, Serena Sestini, Lorenzo Borgognoni
Summary: Langerhans cells (LCs) are important regulators of anti-cancer immune responses, but cancer can alter their functions, leading to immune tolerance. In this study, IDO1 expression was investigated in LCs from sentinel lymph nodes (SLNs) of melanoma patients. The results showed that a subset of Langerin(+) LCs in the T cell-rich area of SLNs expressed IDO1. The expression of IDO1 did not significantly differ between SLNs with or without metastases, but was higher in SLN LCs of patients with mitotic rate > 1 in primary melanoma. Immature SLN LCs could be induced to mature after in vitro stimulation by inflammatory cytokines. These findings provide new insights for immunotherapy targeting LCs in melanoma patients.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Meng Feng, Xin Wang, Shuping Zhou, Minghao Li, Tingting Liu, Xunbin Wei, Wei Lin
Summary: CD83(+) B cells are the main source of sCD83, which alleviates the symptoms of experimental autoimmune uveitis (EAU) and reduces the percentage of T cells and DCs in the eyes and lymph nodes. These CD83(+) B cells decrease IL-1 beta, IL-18, and IFN-gamma secretion by DCs through sCD83. sCD83 interacts with GTPase Ras-related protein (Rab1a) in DCs to promote Rab1a accumulation in autolysosomes and inhibit mTORC1 phosphorylation and NLRP3 expression. Therefore, CD83(+) B cells play a regulatory role in EAU by secreting sCD83. The lack of regulation of CD83(+) B cells may be an important factor leading to hyperimmune activation in patients with autoimmune uveitis. CD83(+) B cells suppress activated DCs in uveitis, indicating the potential therapeutic role of CD83(+) B cells in uveitis.
Article
Immunology
Yikong Lin, Di Zhang, Yangyang Li, Yunyun Li, Bin Li, Meirong Du
Summary: This study revealed a crucial role of NR2F2 in regulating maternal-fetal immune tolerance through promoting Th2 differentiation of decidual CD4(+)T cells, with decreased NR2F2 expression associated with unexplained recurrent spontaneous abortion. The interaction between GATA-3 and NR2F2 was confirmed, suggesting GATA-3 may play an important role in the immunoregulatory process mediated by NR2F2, providing a potential biomarker for prediction and prevention of clinical unexplained RSA.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Si Xie, Liu Yang, Xiaoyue Bi, Wen Deng, Tingting Jiang, Yanjie Lin, Shiyu Wang, Lu Zhang, Ruyu Liu, Min Chang, Shuling Wu, Yuanjiao Gao, Hongxiao Hao, Ge Shen, Mengjiao Xu, Xiaoxue Chen, Leiping Hu, Yao Lu, Rui Song, Yao Xie, Minghui Li
Summary: The activation of CD8+ T lymphocytes is associated with the occurrence of acute and chronic hepatitis B. CD8+ T lymphocytes play an important role in the development of hepatitis B, and their activation status is correlated with the progression of the disease.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Daniel A. Michelson, Koji Hase, Tsuneyasu Kaisho, Christophe Benoist, Diane Mathis
Summary: Medullary thymic epithelial cells (mTECs) ectopically express thousands of peripheral-tissue antigens (PTAs), which drive deletion or phenotypic diversion of self-reactive immature T cells during thymic differentiation. Lineage-defining transcription factors (TFs) for distinct cell types are present in different mTEC subtypes, and these factors are essential for the accumulation of mimetic cells and the expression of PTAs, contributing to self-tolerance.
Article
Multidisciplinary Sciences
Fabienne Mazerolles, Frederic Rieux-Laucat
Summary: The expression of co-signalling receptors on T cells plays a crucial role in regulating T cell responses, and an imbalance between activating and inhibitory signals may lead to autoimmunity. Research showed that activated TEFFs and TREGs express different co-signalling receptors, and the expression of PD-L1 on activated TEFFs is correlated with their proliferation.
Article
Immunology
Pablo A. Silveira, Fiona Kupresanin, Adelina Romano, Wei-Hsun Hsu, Tsun-Ho Lo, Xinsheng Ju, Hsiao-Ting Chen, Helen Roberts, Daniel G. Baker, Georgina J. Clark
Summary: This study investigated the immunosuppressive mechanisms of anti-CD83 antibody treatment and found that it can achieve immune suppression and reduce the symptoms of autoimmune rheumatoid arthritis. The treatment selectively depleted mature dendritic cells and induced regulatory dendritic cells and regulatory T cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Shweta Mahajan, Aria Alexander, Zachary Koenig, Nicholas Saba, Nina Prasanphanich, David A. Hildeman, Claire A. Chougnet, Emily Defranco, Sandra Andorf, Tamara Tilburgs
Summary: Decidual CD8(+) T cells play a critical role in providing immunity to infection and immune tolerance for fetal and placental antigens. These cells include shared blood T cells and unique decidual T cells, and the specificity of decidual CD8(+) T cells is closely related to their function and tissue residency.
Article
Biology
Fang Ke, Zachary L. Benet, Mitra P. Maz, Jianhua Liu, Alexander L. Dent, Joanne Michelle Kahlenberg, Irina L. Grigorova, Tomohiro Kurosaki
Summary: This study found that nuclear proteins contain antigens specific to Tfr. Targeting these proteins to antigen-specific B cells in mice leads to rapid accumulation of immunosuppressive Tfr. Tfr exerts predominant inhibition on GC B cells acquiring nuclear proteins, suggesting the important role of direct cognate Tfr-GC B cells interactions in controlling effector B cell response.
Article
Oncology
Shernan G. Holtan, Constanza Savid-Frontera, Kelly Walton, Anne A. Eaton, Connor Demorest, Andrea Hoeschen, Ling Zhang, Kayla Reid, Tony Kurian, Zena Sayegh, Estefania Julia, Joseph Maakaron, Veronika Bachanova, Najla El Jurdi, Margaret L. MacMillan, Daniel J. Weisdorf, Martin Felices, Jeffrey S. Miller, Bruce R. Blazar, Marco L. Davila, Brian C. Betts
Summary: This study investigates the association between CD83 expression on GVHD effector cells and clinical outcomes after allogeneic hematopoietic cell transplantation. The results show that CD83 overexpression correlates with reduced survival and increased TRM. CD83 CAR T can eliminate autoreactive CD83+ B cells without causing B-cell aplasia. CD83 may serve as a diagnostic marker of GVHD and a therapeutic target for both GVHD and AML relapse after alloHCT.
CLINICAL CANCER RESEARCH
(2023)
Article
Immunology
Kuan-Hua Chu, Szu-Yu Lin, Bor-Luen Chiang
Summary: STAT6 plays a critical role in the generation of Treg-of-B cells, while Peyer's patch B cells are essential in regulatory T cell generation. IL-4 acts downstream of phosphorylated STAT6, maintaining the survival of Treg-of-B cells.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Linda M. Lee, Hong Zhang, Karim Lee, Horace Liang, Alexander Merleev, Flavio Vincenti, Emanual Maverakis, Angus W. Thomson, Qizhi Tang
Summary: In this study comparing arTregs expanded ex vivo using different types of antigen-presenting cells, it was found that sDCs stimulated Tregs to expand in much larger numbers. Additionally, sDC-generated arTregs expressed higher levels of CD80, CD86, and T cell-attracting chemokines, indicating their superior expansion-inducing capacity.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Johanna Raffetseder, Robert Lindau, Sigrid van der Veen, Goran Berg, Marie Larsson, Jan Ernerudh
Summary: During pregnancy, MAIT cells play dual roles in immune modulation and antimicrobial defense, requiring strict regulation to prevent pregnancy complications.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Hannah Grossebrummel, Tilmann Peter, Robert Mandelkow, Martin Weiss, Damian Muzzio, Uwe Zimmermann, Reinhard Walther, Federico Jensen, Cornelius Knabbe, Marek Zygmunt, Martin Burchardt, Matthias B. Stope
INTERNATIONAL JOURNAL OF ONCOLOGY
(2016)
Article
Immunology
I. Bommer, D. O. Muzzio, M. Zygmunt, F. Jensen
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2016)
Article
Immunology
K. B. Ziegler, D. O. Muzzio, F. Matzner, I. Bommer, M. S. Ventimiglia, K. Malinowsky, J. Ehrhardt, M. Zygmunt, F. Jensen
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2018)
Review
Reproductive Biology
Rebekka Einenkel, Marek Zygmunt, Damian Oscar Muzzio
REPRODUCTIVE BIOLOGY
(2019)
Article
Developmental Biology
Rebekka Einenkel, Katrin Regina Helene Packhaeuser, Jens Ehrhardt, Anne Tuengler, Marek Zygmunt, Damian Oscar Muzzio
Article
Developmental Biology
Imke Bommer, Lorena Juriol, Damian Muzzio, Natalin Valeff, Jens Ehrhardt, Franziska Matzner, Katharina Ziegler, Kristin Malinowsky, Maria Silvia Ventimiglia, Marek Zygmunt, Federico Jensen
Article
Oncology
Lyubomir Haralambiev, Andreas Nitsch, Rebekka Einenkel, Damian O. Muzzio, Nadine Gelbrich, Martin Burchardt, Marek Zygmunt, Axel Ekkernkamp, Matthias B. Stope, Denis Guembel
ANTICANCER RESEARCH
(2020)
Article
Developmental Biology
Carolin Froehlich, Jens Ehrhardt, Diana Krueger, Dominika Trojnarska, Marek Zygmunt, Damian Oscar Muzzio
Article
Developmental Biology
Rebekka Einenkel, Jens Ehrhardt, Kristin Hartmann, Diana Krueger, Damian Oscar Muzzio, Marek Zygmunt
Article
Immunology
Martha Heusler, Rebekka Einenkel, Jens Ehrhardt, Damian Oscar Muzzio, Marek Zygmunt
Summary: The study suggests that low concentrations of Fusobacterium nucleatum can promote trophoblastic cell invasion and induce the secretion of important mediators for pregnancy establishment. However, as concentrations of F. nucleatum increased, these effects did not improve invasiveness, hindered migration, reduced cell viability and induced alterations in the cell cycle. Some effects were also independent of lipopolysaccharide (LPS) and correlated with the expression of E-cadherin on trophoblasts.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Medicine, Research & Experimental
Andreas Nitsch, Lyubomir Haralambiev, Rebekka Einenkel, Damian O. Muzzio, Marek T. Zygmunt, Axel Ekkernkamp, Martin Burchardt, Matthias B. Stope
Article
Microbiology
Geraldine Engels, Alexandra Maximiliane Hierweger, Julia Hoffmann, Rene Thieme, Swantje Thiele, Stephanie Bertram, Carola Dreier, Patricia Resa-Infante, Henning Jacobsen, Kristin Thiele, Malik Alawi, Daniela Indenbirken, Adam Grundhoff, Svenja Siebels, Nicole Fischer, Violeta Stojanovska, Damian Muzzio, Federico Jensen, Khalil Karimi, Hans-Willi Mittruecker, Petra Clara Arck, Guelsah Gabriel
CELL HOST & MICROBE
(2017)
Article
Developmental Biology
Damian O. Muzzio, Katharina B. Ziegler, Jens Ehrhardt, Marek Zygmunt, Federico Jensen
Review
Pharmacology & Pharmacy
Damian Muzzio, Maria L. Foglia, Martin F. Desimone, Marek Zygmunt
CURRENT PHARMACEUTICAL DESIGN
(2017)