Article
Biology
Jose Manuel Garcia-Martinez, Ana Chocarro-Calvo, Javier Martinez-Useros, Maria Jesus Fernandez-Acenero, M. Carmen Fiuza, Jose Caceres-Rentero, Antonio De la Vieja, Antonio Barbachano, Alberto Munoz, Maria Jesus Larriba, Custodia Garcia Jimenez
Summary: Posttranslational modifications of epigenetic modifiers provide a mechanism for rapid adaptations in cancer cells. The study shows that 1,25(OH)(2)D-3 activates SIRT1 by auto-deacetylation in colon cancer cells, inhibiting cell proliferation.
Review
Nutrition & Dietetics
Ana Palanca, Francisco Javier Ampudia-Blasco, Jose T. Real
Summary: Thyroid cancer is increasing in incidence and vitamin D may have a role in its prevention. However, the exact role of vitamin D in thyroid cancer development is controversial. Some studies suggest elevated serum vitamin D levels have a protective role, while others show no inverse relationship with the occurrence of thyroid cancer. Circulating vitamin D concentration is inversely correlated with disease aggressiveness and poor prognosis.
Review
Medicine, Research & Experimental
Ayodeji A. Olabiyi, Daniela F. Passos, Jean Lucas G. da Silva, Maria R. C. Schetinger, Daniela B. Rosa Leal
Summary: Vitamin D plays crucial roles in bone health and immune modulation, potentially serving as a useful adjunct in cancer therapy, with the purinergic system identified as a potential treatment target.
Review
Biochemistry & Molecular Biology
Euclides Avila, Bryan Javier Noriega-Mejia, Jocelyn Gonzalez-Macias, Ulises Cortes-Hernandez, Janice Garcia-Quiroz, Rocio Garcia-Becerra, Lorenza Diaz
Summary: Vitamin D and the vitamin D endocrine system play a crucial role in regulating calcium homeostasis and have antitumoral effects in various human cancers, including cervical cancer. Studies have shown an inverse relationship between cervical neoplasia and vitamin D levels. This review supports the idea that the vitamin D endocrine system has a preventive role in cervical cancer, particularly in the early stages, by suppressing cell proliferation, promoting apoptosis, modulating inflammatory responses, and potentially clearing HPV-dependent lesions. However, vitamin D seems to have little effectiveness in advanced cervical cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Nutrition & Dietetics
Karina Piatek, Martin Schepelmann, Enikoe Kallay
Summary: Ovarian cancer is a deadly cancer in women, but the current treatments have debilitating side effects. Therefore, there is a need for new treatments with fewer side effects. Vitamin D has anticancer effects, but high doses cause hypercalcemia. Researchers are looking for analogs of vitamin D to reduce side effects.
Article
Oncology
Qiao-Li Wang, Chao Ma, Chen Yuan, Qian Shi, Brian M. Wolpin, Yin Zhang, Charles S. Fuchs, Jeffrey Meyer, Tyler Zemla, En Cheng, Priya Kumthekar, Katherine A. Guthrie, Felix Couture, Philip Kuebler, Pankaj Kumar, Benjamin Tan, Smitha Krishnamurthi, Richard M. Goldberg, Alan Venook, Charles Blanke, Anthony F. Shields, Eileen M. O'Reilly, Jeffrey A. Meyerhardt, Kimmie Ng
Summary: The purpose of this study was to assess the association between plasma 25-hydroxyvitamin D (25(OH)D) levels and outcomes in colon cancer patients and to determine whether circulating inflammatory cytokines mediate this association. The results showed that nondeficient vitamin D status was significantly associated with improved disease-free survival, overall survival, and time to recurrence in patients with stage III colon cancer. The mediation analysis revealed that sTNF-R2 played a mediating role, while CRP and IL6 did not.
CLINICAL CANCER RESEARCH
(2023)
Review
Oncology
Justine Vanhevel, Lieve Verlinden, Stefanie Doms, Hans Wildiers, Annemieke Verstuyf
Summary: The active form of vitamin D-3, 1,25-dihydroxyvitamin D-3 (1,25(OH)(2)D-3), plays a key role in regulating calcium and phosphate levels. Low levels of 25(OH)D, a marker for 1,25(OH)(2)D-3, are associated with an increased risk of breast cancer (BC) development. However, vitamin D-3 supplementation does not show a significant decrease in BC incidence. 1,25(OH)(2)D-3 or its analogues may have more potential anticancer activity when combined with existing cancer therapies.
ENDOCRINE-RELATED CANCER
(2022)
Review
Biochemistry & Molecular Biology
Yao Chen, Jue Hou, Zhangang Xiao, Yueshui Zhao, Fukuan Du, Xu Wu, Mingxing Li, Yu Chen, Lin Zhang, Chi Hin Cho, Qinglian Wen, Wei Hu, Jing Shen
Summary: Vitamin D supplementation is associated with reduced cancer risk and a good prognosis, especially in gastrointestinal cancer. It plays a key role in the development of gastrointestinal cancer and has immunomodulatory, anti-inflammatory, and anti-infection effects. Research supports the beneficial effects of vitamin D in cancer and inflammatory diseases, but more clinical trials are needed for reliable conclusions.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Oncology
Ashank Bains, Taha Mur, Nathan Wallace, Jacob Pieter Noordzij
Summary: Thyroid cancer is the most common endocrine malignancy in the United States, with papillary thyroid cancer as the most common subtype. Despite controversial debates, the potential role of vitamin D in cancer-related pathways and its significance as a prognostic marker in papillary thyroid cancer has gained attention. Previous literature has highlighted the anti-proliferative, anti-inflammatory, and pro-differentiation effects of vitamin D in various cancers, while ongoing studies aim to establish a definitive link between vitamin D status and papillary thyroid carcinoma.
Article
Multidisciplinary Sciences
Ahmed Abdelgawad, Abdelwahab Hashem, Ahmed Mosbah, Laila A. Eissa
Summary: Serum levels of 25-hydroxyvitamin D (25(OHD)) are associated with the diagnosis and prognosis of bladder cancer. Patients with bladder cancer have lower levels of 25(OHD), especially those with muscle invasive cancer. However, baseline serum 25(OHD) does not predict recurrence in patients with non-muscle-invasive bladder cancer.
Review
Biochemistry & Molecular Biology
Tudor Lucian Pop, Claudia Sirbe, Gabriel Benta, Alexandra Mititelu, Alina Grama
Summary: Vitamin D plays a crucial role in phospho-calcium metabolism, maintaining calcium levels, and bone health development. Deficiency in vitamin D has been linked to fibrosis progression in chronic liver disease. Vitamin D binding protein, synthesized by the liver, is involved in vitamin D transportation and inflammatory response. A better understanding of the involvement of vitamin D, vitamin D receptors, and vitamin D binding protein in liver inflammation and fibrogenesis could lead to new strategies for diagnosis, prognosis, and treatment of liver diseases.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Nutrition & Dietetics
Man Hung, Wendy C. Birmingham, Monica Ocampo, Amir Mohajeri
Summary: Cardiovascular diseases (CVD) are the leading cause of death in the United States. This study aimed to determine the association between reported CVD and serum 25-hydroxyvitamin D [25(OH)D]. Using data from the National Health and Nutrition Examination Survey, the study found that deficiency and insufficiency of 25(OH)D were associated with CVD, while adequacy of 25(OH)D was not. Healthcare professionals may consider vitamin D supplementation to improve cardiovascular health in adults for CVD prevention.
Article
Nutrition & Dietetics
Linnea Huss, Salma Tuna Butt, Signe Borgquist, Karin Elebro, Malte Sandsveden, Jonas Manjer, Ann Rosendahl
Summary: This study found no association between pre-diagnostic levels of vitamin D and the expression of VDRs in breast cancer, nor did vitamin D levels influence the association between VDR expression and breast cancer mortality.
Article
Biochemistry & Molecular Biology
Karina Piatek, Andrzej Kutner, Dan Cacsire Castillo-Tong, Teresa Manhardt, Nadja Kupper, Urszula Nowak, Michal Chodynski, Ewa Marcinkowska, Enikoe Kallay, Martin Schepelmann
Summary: This study found that newly developed low calcemic vitamin D analogs (an1,25Ds) can be used as anticancer agents in ovarian cancer cells, with PRI-5202 showing the best efficacy. The potency of these analogs and their ability to increase CYP24A1 expression in HGSOC cell lines were dependent on the cell line and chemical structure, suggesting that further optimization of the analogs' structure may lead to new treatment options for ovarian cancer.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Niklas S. Jensen, Markus Wehland, Petra M. Wise, Daniela Grimm
Summary: Hypertension is a major global health burden, with an increasing prevalence due to aging populations and sedentary lifestyles. While there is evidence of the role of vitamin D in regulating blood pressure, its direct antihypertensive effect remains unclear. However, supplementing vitamin D in combination with other antihypertensive agents may have promising results.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
