Article
Gastroenterology & Hepatology
Ankit Malik, Jean M. Brudvig, Barbie J. Gadsden, Alexander D. Ethridge, Linda S. Mansfield
Summary: This study demonstrates the link between Campylobacter jejuni and the autoimmune disease Guillain-Barré syndrome and identifies the roles of Siglec-1 and IL-4 in its development. The mouse model developed in this study provides potential therapeutic interventions for this disease.
Article
Microbiology
Jessica L. St. Charles, Phillip T. Brooks, Julia A. Bell, Husnain Ahmed, Mia Van Allen, Shannon D. Manning, Linda S. Mansfield
Summary: This study found a close relationship between C. jejuni strains from sick calves and those infecting family members, suggesting zoonotic transmission. Additionally, despite repeated exposure to C. jejuni strains with LOS known to elicit autoimmune reactions, the family members did not develop GBS.
FRONTIERS IN MICROBIOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Josef Finsterer
Summary: Guillain-Barre syndrome is a rare neuro-immunological disorder that usually occurs after a previous gastrointestinal or respiratory infection. The most common triggers are infections, with Campylobacter jejuni, Mycoplasma pneumoniae, and cytomegalovirus being the most common infectious agents. The clinical presentation varies depending on the structure of pathogenic lipo-oligosaccharides. Molecular mimicry between pathogen surface structures and nerve components may explain the pathophysiology of GBS.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Willi Quino, Junior Caro-Castro, Orson Mestanza, Veronica Hurtado, Maria Luz Zamudio, Gloria Cruz-Gonzales, Ronnie G. Gavilan
Summary: This article describes the molecular epidemiology of C. jejuni strains (ST-2993) associated with a large Guillain-Barre Syndrome (GBS) outbreak in Peru, with a connection found between Peruvian and Chinese GBS strains through phylogenetic analysis. The study also revealed the presence of ST-2993 strains in isolates recovered before the outbreak, indicating a need for increased surveillance of C. jejuni to prevent future GBS outbreaks. The close relationship between human and chicken strains suggests chickens as a probable reservoir.
MICROBIOLOGY SPECTRUM
(2022)
Article
Multidisciplinary Sciences
Amber Hameed, Julian M. Ketley, Alexandra Woodacre, Lee R. Machado, Gemma L. Marsden
Summary: This study conducted a classification and frequency analysis of LOS genotypes in C. jejuni and C. coli. The results showed that class B is the most abundant LOS class in C. jejuni, while class III is the most abundant LOS locus type in C. coli.
Article
Clinical Neurology
Praveen P. Sharma, Doniparthi Seshagiri, Madhu Nagappa, Thrinath Mullapudi, Nikhitha Sreenivas, Saikat Dey, Sumanth Shivaram, Rahul Wahatule, Vijay Kumawat, Binu V. Sreekumaran Nair, Sriganesh Kamath, Sanjib Sinha, Arun B. Taly, Monojit Debnath
Summary: The IL-33/ST2 immune axis is suggested to play an important role in Guillain-Barre syndrome (GBS). Genetic variants of the Il1rl1 gene may contribute to the risk of GBS, and plasma sST2 levels may serve as a biomarker for the severity of GBS.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Medicine, General & Internal
Fang-e Shi, Mei-fang Chen, Yong-jie Li, Gui-ying Dong, Ji-hong Zhu
Summary: In this report, we describe a case of hemophagocytic lymphohistiocytosis (HLH) caused by C. jejuni infection, who presented with multiple clinical manifestations of peripheral nerve injury and was eventually diagnosed with Guillain-Barre Syndrome (GBS). After treatment with dexamethasone combined with immunoglobulin, the patient showed partial recovery of neurological symptoms.
FRONTIERS IN MEDICINE
(2022)
Article
Multidisciplinary Sciences
Yuli Melisa Sierra-Arguello, Gustavo Perdoncini, Laura Beatriz Rodrigues, Luciana Ruschel dos Santos, Karen Apellanis Borges, Thales Quedi Furian, Carlos Tadeu Pippi Salle, Hamilton Luiz de Souza Moraes, Marcos Jose Pereira Gomes, Vladimir Pinheiro do Nascimento
Summary: Campylobacter jejuni is a common cause of foodborne illnesses worldwide, with limited research on strains isolated from Latin-American countries. This study in Southern Brazil identified 140 C. jejuni strains from various poultry sources and analyzed their virulence markers, providing insight into factors related to the occurrence of this pathogen and their epidemiology. The PCR analysis revealed 25 different virulence profiles, with certain combinations of virulence genes being more common among the strains.
SCIENTIFIC REPORTS
(2021)
Article
Infectious Diseases
Satoru Akase, Keiko Yokoyama, Hiromi Obata, Chie Monma, Noriko Konishi, Kaoru Hatakeyama, Dai Saiki, Masako Maeda, Chikako Asayama, Jun Suzuki, Kenji Sadamasu
Summary: C. jejuni HS:19 exhibits high clonality in Japan, regardless of its origin. This finding is important for understanding the epidemiological characteristics of foodborne pathogens and their association with the diseases they cause.
JAPANESE JOURNAL OF INFECTIOUS DISEASES
(2022)
Review
Microbiology
Norman Latov
Summary: Infection with Campylobacter jejuni (Cj) is found in approximately 30% of Guillain-Barre syndrome (GBS) patients, with a 77 to 100-fold increased risk of GBS following Cj infection. GBS is predominantly of the axonal subtype and is mediated by IgG antibodies to peripheral nerve gangliosides that cross-react with oligosaccharides in Cj lipopolysaccharides (LPS). The development of autoimmune disease is thought to be induced by molecular mimicry, where immune reactivity to a cross-reactive epitope in the infectious organism and normal tissue can occur. Cj infection can activate various inflammatory pathways, leading to immune tolerance disruption and autoimmune induction. Understanding the immune mechanisms involved in the development of autoantibodies and neuropathy would aid in comprehending the relationship between infection and autoimmunity and support the development of more effective preventive interventions and therapies.
Article
Medicine, General & Internal
Kiyoshi Takemoto, Makoto Kawahara, Kazuaki Atagi
Summary: This case report describes a 21-year-old male patient who experienced recurrent GBS, with a previous GBS episode at the age of 19 caused by C. jejuni infection. Despite re-infection with C. jejuni, the symptoms were more severe than the first episode and different anti-ganglioside antibodies were identified.
Article
Microbiology
Xiaoqi Zang, Hongyue Lv, Haiyan Tang, Xinan Jiao, Jinlin Huang
Summary: This study analyzed 1609 Campylobacter jejuni isolates from various ecological origins in China. The results showed that disease associated capsular genotypes and LOS classes over-represented in human isolates were also dominant in animals, especially cattle. High-risk lineages CC-22, CC-464, and CC-21, found in human isolates with GBS worldwide, were also present in food animal isolates with disease associated capsular types, indicating a potential clonal spread across different regions and hosts.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Agriculture, Dairy & Animal Science
Jorge Rivera-Gomis, Pedro Marin, Cristina Martinez-Conesa, Julio Otal, Maria Jose Jordan, Elisa Escudero, Maria Jose Cubero
Summary: The study evaluated antimicrobial susceptibility of commensal bacteria in Spanish laying hens, finding varying levels of resistance, with some strains showing resistance to key drugs used in human medicine. This highlights the potential public health risk posed by laying hens as a source of antimicrobial resistance for humans.
Article
Neurosciences
Alex S. Aguirre, Kelly L. Teran, Dennis Lopez
Summary: This article presents a case of a pediatric patient with acute meningitis and Guillain-Barre Syndrome (GBS) following a COVID-19 infection, highlighting the importance of recognizing uncommon symptoms in pediatric patients.
INTERNATIONAL JOURNAL OF NEUROSCIENCE
(2023)
Article
Microbiology
Roberta Torres de Melo, Carolyne Ferreira Dumont, Raquelline Figueiredo Braz, Guilherme Paz Monteiro, Micaela Guidotti Takeuchi, Eduarda Cristina Alves Lourenzatto, Jandra Pacheco dos Santos, Daise Aparecida Rossi
Summary: Poultry-derived C. jejuni strains exhibit higher genetic diversity and adaptability compared to human-derived strains, with greater potential for pathogenicity. Human strains show lower virulence and adaptability, as well as significant differences in molecular typing, indicating a less specialized adaptation to causing disease in humans.
CURRENT MICROBIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chee Bing Ong, Kazuyoshi Kumagai, Phillip T. Brooks, Christina Brandenberger, Ryan P. Lewandowski, Daven N. Jackson-Humbles, Rance Nault, Timothy R. Zacharewski, James G. Wagner, Jack R. Harkema
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2016)
Article
Microbiology
Phillip T. Brooks, Kelsey A. Brakel, Julia A. Bell, Christopher E. Bejcek, Trey Gilpin, Jean M. Brudvig, Linda S. Mansfield
Article
Biochemistry & Molecular Biology
Hongling Yuan, Guoxing Fu, Phillip T. Brooks, Irene Weber, Giovanni Gadda
Article
Immunology
Phillip T. Brooks, Julia A. Bell, Christopher E. Bejcek, Ankit Malik, Linda S. Mansfield
JOURNAL OF NEUROIMMUNOLOGY
(2019)