期刊
EUROPEAN POLYMER JOURNAL
卷 72, 期 -, 页码 566-576出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.eurpolymj.2015.04.028
关键词
Micellar hydrogel; Aliphatic hydroxy acid chain extension; Cell encapsulation; Gelation; Degradation; Elasticity
资金
- National Science Foundation [DMR1049381, IIP-1357109, CBET1403545]
- National Institute of Arthritis and Musculoskeletal and Skin Diseases of National Institutes of Health [AR063745]
- Arbeitsgemeinschaft Fur Osteosynthesefragen (AO) Foundation [C10-44J]
- University of South Carolina VP Office for Research [15510-E414]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1403545] Funding Source: National Science Foundation
- Directorate For Engineering
- Div Of Industrial Innovation & Partnersh [1500242] Funding Source: National Science Foundation
Due to their high water content and diffusivity of nutrients and biomolecules, hydrogels are very attractive as a matrix for growth factor immobilization and in situ delivery of cells to the site of regeneration in tissue engineering. The formation of micellar structures at the nanoscale in hydrogels alters the spatial distribution of the reactive groups and affects the rate and extent of crosslinking and mechanical properties of the hydrogel. Further, the degradation rate of a hydrogel is strongly affected by the proximity of water molecules to the hydrolytically degradable segments at the nanoscale. The objective of this review is to summarize the unique properties of micellar hydrogels with a focus on our previous work on star polyethylene glycol (PEG) macromonomers chain extended with short aliphatic hydroxy acid (HA) segments (SPEXA hydrogels). Micellar SPEXA hydrogels have faster gelation rates and higher compressive moduli compared to their non-micellar counterpart. Owing to their micellar structure, SPEXA hydrogels have a wide range of degradation rates from a few days to many months as opposed to non-degradable PEG gels while both gels possess similar water contents. Furthermore, the viability and differentiation of mesenchymal stem cells (MSCs) is enhanced when the cells are encapsulated in degradable micellar SPEXA gels compared with those cells encapsulated in non-micellar PEG gels. (C) 2015 Elsevier Ltd. All rights reserved.
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