Article
Neurosciences
Qianyun Chen, Jill Abrigo, Min Deng, Lin Shi, Yi-Xiang Wang, Winnie Chiu Wing Chu
Summary: This study investigated white matter alterations in patients within the Alzheimer's continuum. Diffusion tensor imaging (DTI) measurements revealed widespread WM changes, specifically in the hippocampal cingulum, cingulum of the cingulate gyrus, and uncinate fasciculus. Early diffusion alterations in the hippocampal cingulum were correlated with tau pathology, suggesting their potential as biomarkers in preclinical AD.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Article
Neurosciences
Jenna N. Adams, Theresa M. Harrison, Anne Maass, Suzanne L. Baker, William J. Jagust
Summary: This study aimed to investigate the mechanisms underlying the initial accumulation of tau pathology and the predictive roles of age, AP, and neural activity in tau accumulation. The results showed that older age, higher neural activity, and higher baseline EC tau levels were associated with tau accumulation. Additionally, AP facilitated the spread of tau.
JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Xi Chen, Kaitlin E. Cassady, Jenna N. Adams, Theresa M. Harrison, Suzanne L. Baker, William J. Jagust
Summary: Studies suggest that tau deposition begins in the anterolateral entorhinal cortex during normal aging and is facilitated by the presence of beta-amyloid, potentially marking the onset of Alzheimer's disease. Higher tau deposition in the anterior-temporal memory network is associated with faster memory decline, especially in individuals with beta-amyloid. When all three tau measures are considered, only tau in the anterior-temporal region significantly predicts memory decline.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Neurosciences
Heidi I. L. Jacobs, Adrienne O'Donnell, Claudia L. Satizabal, Cristina Lois, Daniel Kojis, Bernard J. Hanseeuw, Emma Thibault, Justin S. Sanchez, Rachel F. Buckley, Qiong Yang, Charles DeCarli, Ron Killiany, Muralidharan Sargurupremraj, Reisa A. Sperling, Keith A. Johnson, Alexa S. Beiser, Sudha Seshadri
Summary: The study found that lower volumes of the medulla, pons, or midbrain were associated with greater neocortical amyloid burden. However, no associations were found between brainstem volumes and tau deposition.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Neurosciences
Diana Valdes Cabrera, Penelope Smyth, Gregg Blevins, Derek Emery, Christian Beaulieu
Summary: DTI and volumetric MRI revealed white matter and deep grey matter abnormalities in the limbic system of MS patients. The fornix, thalamus, and hippocampus displayed atrophy and/or abnormal diffusion metrics, with the fornix showing the most extensive changes, mainly in those with cognitive impairment. These findings suggest a strong correlation between microstructural abnormalities in the limbic system and cognitive deficits in MS.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2022)
Article
Neurosciences
Joseph R. Winer, Allison Morehouse, Laura Fenton, Theresa M. Harrison, Lylian Ayangma, Mark Reed, Samika Kumar, Suzanne L. Baker, William J. Jagust, Matthew P. Walker
Summary: This study found that early-stage tau and Aβ deposition in Alzheimer's disease can impact sleep, with tau burden leading to worse objective sleep and Aβ burden associated with decreased self-reported sleep quality. Aβ deposition also predicts a mismatch between objective and subjective sleep evaluation, with individuals underestimating their sleep, which is further linked to worse executive function.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Clinical Neurology
Kaitlin B. Casaletto, Emma Nichols, Vahan Aslanyan, Stephanie M. Simone, Jennifer S. Rabin, Renaud La Joie, Adam M. Brickman, Kristen Dams-O'Connor, Priya Palta, Raj G. Kumar, Kristen M. George, Claudia L. Satizabal, Julie Schneider, Judy Pa
Summary: Females with Alzheimer's disease are more susceptible than males, and microglial activation plays an important mediating role in females but not males. This finding is crucial for understanding the pathogenesis of Alzheimer's disease and providing precision health care.
Article
Neurosciences
Petrice M. Cogswell, Heather J. Wiste, Matthew L. Senjem, Jeffrey L. Gunter, Stephen D. Weigand, Christopher G. Schwarz, Arvin Arani, Terry M. Therneau, Val J. Lowe, David S. Knopman, Hugo Botha, Jonathan Graff-Radford, David T. Jones, Kejal Kantarci, Prashanthi Vemuri, Bradley F. Boeve, Michelle M. Mielke, Ronald C. Petersen, Clifford R. Jack
Summary: This study investigates the associations between QSM and established markers of Alzheimer's disease. It found that increased susceptibility in deep and inferior gray nuclei is related to aging, cognitive impairment, amyloid deposition, and off-target binding of the tau ligand. Associations were also seen between susceptibility and amyloid PET, tau PET, and cortical gray matter volume in the medial temporal lobe. Additionally, iron content was found to be insufficient in the cortex for reliable detection using QSM.
Article
Geriatrics & Gerontology
Amelia D. Hines, Stephanie McGrath, Amanda S. Latham, Breonna Kusick, Lisa Mulligan, McKenzie L. Richards, Julie A. Moreno
Summary: Canine cognitive dysfunction (CCD) syndrome is a naturally occurring disease in aged dogs, similar to Alzheimer's disease (AD) in humans, but little is known about the pathological aging of the canine brain. In this study, we found increased glial cells, neuroinflammation, and accumulation of proteins associated with neurodegenerative diseases in the brains of aged canines. We also identified a potential predictor for CCD, phosphorylation of tau at threonine 217.
FRONTIERS IN AGING NEUROSCIENCE
(2023)
Review
Nutrition & Dietetics
Tobias Ziegler, Melina Tsiountsioura, Lisa Meixner-Goetz, Gerhard Cvirn, Manfred Lamprecht
Summary: With the increasing elderly population, neurodegenerative diseases are on the rise, making it important to detect brain aging early and slow down its progression. Neurotrophins such as BDNF and NGF, as well as amyloid-beta and tau proteins, play significant roles in cognitive function and aging. Polyphenols, a class of plant-metabolites, have gained attention for their health benefits and anti-oxidative properties in relation to these biomarkers.
Article
Psychology, Multidisciplinary
Karra D. Harrington, Andrew J. Aschenbrenner, Paul Maruff, Colin L. Masters, Anne M. Fagan, Tammie L. S. Benzinger, Brian A. Gordon, Carlos Cruchaga, John C. Morris, Jason Hassenstab
Summary: Neurodegenerative disease is common among older adults and can bias estimates of cognitive change towards decline in otherwise healthy older adults when the presence of early neurodegenerative disease is not accounted for. By adjusting for biomarker status, it was found that cognitively normal older adults did not show decline in any cognitive domain.
PSYCHOLOGICAL SCIENCE
(2021)
Article
Multidisciplinary Sciences
Kevin A. Murray, Carolyn J. Hu, Sarah L. Griner, Hope Pan, Jeannette T. Bowler, Romany Abskharon, Gregory M. Rosenberg, Xinyi Cheng, Paul M. Seidler, David S. Eisenberg
Summary: Neurodegenerative diseases are characterized by the accumulation of aggregated proteins, and inhibiting the formation of these aggregates is a potential therapeutic strategy. Using de novo protein design, researchers have developed a library of mini-protein inhibitors that specifically target the amyloid structures of tau, Aβ, and α Syn. These inhibitors show promising results in preventing aggregation and rescuing motor deficits in animal models of PD and AD.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Clinical Neurology
Ashvini Keshavan, Josef Pannee, Thomas K. Karikari, Juan Lantero Rodriguez, Nicholas J. Ashton, Jennifer M. Nicholas, David M. Cash, William Coath, Christopher A. Lane, Thomas D. Parker, Kirsty Lu, Sarah M. Buchanan, Sarah E. Keuss, Sarah-Naomi James, Heidi Murray-Smith, Andrew Wong, Anna Barnes, John C. Dickson, Amanda Heslegrave, Erik Portelius, Marcus Richards, Nick C. Fox, Henrik Zetterberg, Kaj Blennow, Jonathan M. Schott
Summary: The study compared three different blood-based techniques for identifying early stage Alzheimer's disease, with mass spectrometry plasma measures performing significantly better than other measures.
Article
Clinical Neurology
Ashvini Keshavan, Josef Pannee, Thomas K. Karikari, Juan Lantero Rodriguez, Nicholas J. Ashton, Jennifer M. Nicholas, David M. Cash, William Coath, Christopher A. Lane, Thomas D. Parker, Kirsty Lu, Sarah M. Buchanan, Sarah E. Keuss, Sarah-Naomi James, Heidi Murray-Smith, Andrew Wong, Anna Barnes, John C. Dickson, Amanda Heslegrave, Erik Portelius, Marcus Richards, Nick C. Fox, Henrik Zetterberg, Kaj Blennow, Jonathan M. Schott
Summary: The study compared three different blood-based techniques to detect amyloid PET positivity in dementia-free individuals, finding that mass spectrometry plasma measures performed significantly better than other measures, with higher sensitivity and specificity for detecting amyloid PET positivity.
Article
Neuroimaging
Ibrahim Shaikh, Christian Beaulieu, Myrlene Gee, Cheryl R. McCreary, Andrew E. Beaudin, Diana Valdes-Cabrera, Eric E. Smith, Richard Camicioli
Summary: Diffusion tensor imaging metrics of the fornix were compared between patients with cerebral amyloid angiopathy (CAA), Alzheimer's disease (AD), Mild Cognitive Impairment (MCI), and healthy controls. The study found significant diffusion changes in the fornix of CAA, AD, and MCI patients compared to controls, suggesting differences in the mechanisms of fornix diffusion abnormalities between CAA and AD/MCI.
NEUROIMAGE-CLINICAL
(2022)
Article
Geriatrics & Gerontology
Elizabeth K. Rhodus, Justin Barber, Erin L. Abner, Shoshana H. Bardach, Allison Gibson, Gregory A. Jicha
Summary: There is significant overlap in behaviors characteristic of ASD and BPSD in adults with ADRD, suggesting a need for further research into causes and therapeutic approaches.
AGING & MENTAL HEALTH
(2022)
Article
Clinical Neurology
Zachary Winder, Tiffany L. Sudduth, Sonya Anderson, Ela Patel, Janna Neltner, Barbara J. Martin, Katherine E. Snyder, Erin L. Abner, Gregory A. Jicha, Peter T. Nelson, Donna M. Wilcock
Summary: The study evaluated the relationship between plasma biomarkers and neuropathology associated with Alzheimer's disease (AD) and vascular contributions to cognitive impairment and dementia (VCID). The results showed certain plasma biomarkers were associated with AD and VCID pathology, providing support for further research in using plasma biomarkers as a clinical screening tool.
ALZHEIMERS & DEMENTIA
(2023)
Article
Geriatrics & Gerontology
Lidija Milicic, Michael Vacher, Tenielle Porter, Vincent Dore, Samantha C. Burnham, Pierrick Bourgeat, Rosita Shishegar, James Doecke, Nicola J. Armstrong, Rick Tankard, Paul Maruff, Colin L. Masters, Christopher C. Rowe, Victor L. Villemagne, Simon M. Laws
Summary: This study comprehensively investigated the relationship between five recognized measures of age acceleration based on DNA methylation patterns and cognition as well as AD-related neuroimaging phenotypes. Significant associations were observed between age acceleration and hippocampal volume, but not with other Alzheimer's disease-related phenotypes.
Article
Geriatrics & Gerontology
Jiehui Jiang, Can Sheng, Guanqun Chen, Chunhua Liu, Shichen Jin, Lanlan Li, Xueyan Jiang, Ying Han
Summary: Exploring individual hallmarks of brain ageing is important. In this study, the age-related glucose metabolism pattern (ARGMP) is proposed as a potential index to characterize brain ageing in cognitively normal elderly individuals and predict high conversion risk into cognitive impairment.
Article
Neurosciences
Doaa G. Ali, Ahmed A. Bahrani, Justin M. Barber, Riham H. El Khouli, Brian T. Gold, Jordan P. Harp, Yang Jiang, Donna M. Wilcock, Gregory A. Jicha
Summary: This study found that early focal regional amyloid deposition in the brain is associated with changes in executive function, but not memory, in preclinical Alzheimer's disease (pAD).
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Correction
Multidisciplinary Sciences
Tingxiang Yan, Jingjing Liang, Ju Gao, Luwen Wang, Hisashi Fujioka, Xiaofeng Zhu, Xinglong Wang
NATURE COMMUNICATIONS
(2022)
Article
Clinical Neurology
Timothy J. Libecap, Valentinos Zachariou, Christopher E. Bauer, Donna M. Wilcock, Gregory A. Jicha, Flavius D. Raslau, Brian T. Gold
Summary: Emerging evidence suggests that enlarged perivascular spaces (ePVS) may be a clinically significant neuroimaging marker of global cognitive function related to cerebral small vessel disease (cSVD). This study found a negative association between ePVS and MoCA scores, as well as a positive association with WMH volumes, indicating that ePVS burden, particularly in the centrum semiovale, may be a clinically significant neuroimaging marker of global cognitive dysfunction related to cSVD.
FRONTIERS IN NEUROLOGY
(2022)
Article
Clinical Neurology
Seth A. A. Gale, Judith Heidebrink, Joshua Grill, Jonathan Graff-Radford, Gregory A. A. Jicha, William Menard, Milap Nowrangi, Susie Sami, Shirley Sirivong, Sarah Walter, Jason Karlawish
Summary: With the increasing use of information technologies in clinical research and care, the dissemination of personal health information has become more widespread. However, this also brings higher risks of unwanted disclosure, especially for individuals with preclinical Alzheimer's disease, which can lead to personal harms. There is currently inadequate legal protection for these individuals.
Article
Multidisciplinary Sciences
Alireza Fathian, Yousef Jamali, Mohammad Reza Raoufy
Summary: This study used resting state fMRI data to analyze the trend of functional connectivity alterations in different stages of Alzheimer's disease. It found non-linear network characteristics changes, especially in the early stage of the disease, and indicated differences between the diseased groups and the cognitively normal group.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Nirmal Verma, Gopal Viswanathan Velmurugan, Edric Winford, Han Coburn, Deepak Kotiya, Noah Leibold, Laura Radulescu, Sanda Despa, Kuey C. Chen, Linda J. Van Eldik, Peter T. Nelson, Donna M. Wilcock, Gregory A. Jicha, Ann M. Stowe, Larry B. Goldstein, David K. Powel, Jeffrey H. Walton, Manuel F. Navedo, Matthew A. Nystoriak, Andrew J. Murray, Geert Jan Biessels, Claire Troakes, Henrik Zetterberg, John Hardy, Tammaryn Lashley, Florin Despa
Summary: Impairment of vascular pathways contributes to Alzheimer's disease. Blood amylin secreted from the pancreas perturbs cerebral A beta clearance, leading to amylin and A beta co-deposits in the brain microvasculature. Altering bloodborne amylin could potentially reduce cerebrovascular amylin deposits and A beta pathology.
COMMUNICATIONS BIOLOGY
(2023)
Article
Cell Biology
Yuanbing Jiang, Xiaopu Zhou, Hiu Yi Wong, Li Ouyang, Fanny C. F. Ip, Vicky M. N. Chau, Shun-Fat Lau, Wei Wu, Daniel Y. K. Wong, Heukjin Seo, Wing-Yu Fu, Nicole C. H. Lai, Yuewen Chen, Yu Chen, Estella P. S. Tong, Vincent C. T. Mok, Timothy C. Y. Kwok, Kin Y. Mok, Maryam Shoai, Benoit Lehallier, Patricia Moran Losada, Eleanor O'Brien, Tenielle Porter, Simon M. Laws, John Hardy, Tony Wyss-Coray, Colin L. Masters, Amy K. Y. Fu, Nancy Y. Ip
Summary: Changes in circulating protein levels are associated with AD, but their specific roles in AD are still unclear. In this study, the researchers identified a new disease-causing factor, soluble ST2 (sST2), and a genetic variant, rs1921622, that downregulates sST2 levels. They found that increased sST2 levels are associated with more severe pathological changes in female individuals with AD, and decreased sST2 levels lower AD risk and related endophenotypes, especially in Chinese populations. Transcriptome and immunohistochemical studies revealed that sST2 regulates Aβ pathology through microglial activation and Aβ clearance.
Article
Clinical Neurology
Erica M. Weekman, Zach Winder, Colin B. Rogers, Erin L. Abner, Tiffany L. Sudduth, Ela Patel, Adam J. Dugan, Shuling X. Fister, Brandi Wasek, Peter T. Nelson, Gregory A. Jicha, Teodoro Bottiglieri, David W. Fardo, Donna M. Wilcock
Summary: Vascular contributions to cognitive impairment and dementia (VCID) is a major cause of dementia. Hyperhomocysteinemia (HHcy) is an underappreciated, modifiable risk factor for VCID. This study found that HHcy is associated with downregulation of inflammatory gene expression and significant glial and vascular pathology changes.
ALZHEIMERS & DEMENTIA-TRANSLATIONAL RESEARCH & CLINICAL INTERVENTIONS
(2022)
Article
Clinical Neurology
D. C. Moga, E. L. Abner, F. A. Schmitt, L. Eckmann, M. Huffmyer, A. Martinez, B. F. Beech, R. George, R. H. El Khouli, D. Ali, G. A. Jicha
Summary: Medication therapy management can reduce inappropriate medication use in older adults at risk for Alzheimer's Disease and has beneficial cognitive effects in those with preclinical Alzheimer's Disease. However, no statistically significant effects were observed in the overall study group or in those without preclinical cerebral amyloidosis.
JPAD-JOURNAL OF PREVENTION OF ALZHEIMERS DISEASE
(2022)
Article
Psychiatry
Zhengshi Yang, Jessica Z. K. Caldwell, Jeffrey L. Cummings, Aaron Ritter, Jefferson W. Kinney, Dietmar Cordes
Summary: The purpose of this study was to assess the impact of pathological aging on caudate functional connectivity in individuals with mild cognitive impairment (MCI) and investigate the role of sex and amyloid in this process. The results showed that the MCI group had a significantly stronger age-related increase in caudate nodal strength compared to the cognitive normal (CN) group. The aging effect on caudate nodal strength was significant only for women with MCI, and the connectivity between the caudate and ventral prefrontal cortex played a substantial role in this aging effect. The study suggests that caudate nodal strength may serve as a sensitive biomarker of pathological aging in women with MCI.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Geriatrics & Gerontology
Elizabeth K. Rhodus, Elizabeth G. Hunter, Graham D. Rowles, Shoshana H. Bardach, Kelly Parsons, Justin Barber, MaryEllen Thompson, Gregory A. Jicha
Summary: This study explored the relationship between sensory processing, behavior, and environmental features in individuals with mild cognitive impairment (MCI) or dementia. The findings suggest that tailored environmental adaptations based on sensory preferences may help reduce disruptive behaviors in these individuals.
GERONTOLOGY AND GERIATRIC MEDICINE
(2022)
