Article
Biochemistry & Molecular Biology
Chiara Tramontano, Bruno Miranda, Giovanna Chianese, Luca De Stefano, Carlo Forestiere, Marinella Pirozzi, Ilaria Rea
Summary: This study combined inorganic diatomite nanoparticles with gelatin-stabilized gold nanoparticles to develop an optical platform for drug delivery. By increasing the thickness of the gelatin shells, the drug loading capacity was improved. Optical modeling was used to monitor drug release processes and proved to be an efficient tool for designing polymer-coated nanocarriers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Chemistry, Multidisciplinary
Abhishek Pandey
Summary: The use of cyclodextrins and their derivatives in drug delivery systems can address challenges such as poor solubility and targeted delivery. Cyclodextrin-conjugated nanoparticles offer advantages of enhanced water solubility, targeted drug delivery, and potential for various pharmaceutical applications.
ENVIRONMENTAL CHEMISTRY LETTERS
(2021)
Review
Chemistry, Multidisciplinary
Viktoriya Sokolova, Matthias Epple
Summary: Calcium phosphate nanoparticles, due to their similarity to human hard tissue, have high biocompatibility and biodegradability, making them efficient carriers for various biomolecules. They can be functionalized with fluorescing dyes for imaging, and find applications in transfection, gene silencing, imaging, immunization, and bone substitution.
CHEMISTRY-A EUROPEAN JOURNAL
(2021)
Review
Chemistry, Multidisciplinary
Xin Ma, Mathilde Lepoitevin, Christian Serre
Summary: This review summarizes the progress of MOFs in biomedical applications, focusing on their advantages, limitations, and future challenges.
MATERIALS CHEMISTRY FRONTIERS
(2021)
Review
Pharmacology & Pharmacy
Francesca Milano, Annalia Masi, Marta Madaghiele, Alessandro Sannino, Luca Salvatore, Nunzia Gallo
Summary: Gelatin, a versatile natural polymer, is extensively used in healthcare due to its biocompatibility, biodegradability, low-cost, and chemical group availability. In the field of biomedicine, gelatin is utilized as a biomaterial for the development of drug delivery systems (DDSs) using various synthesis techniques. This review focuses on the techniques commonly used for gelatin-based micro- or nano-sized DDSs, highlighting the potential of gelatin as a carrier for bioactive compounds and its ability to control drug release kinetics. The various techniques, such as desolvation, nanoprecipitation, coacervation, emulsion, electrospray, and spray drying, are discussed along with their effects on DDSs' properties. Additionally, preclinical and clinical studies involving gelatin-based DDSs are thoroughly examined.
Article
Pharmacology & Pharmacy
Carmen Moya-Lopez, Alberto Juan, Murillo Donizeti, Jesus Valcarcel, Jose A. Vazquez, Eduardo Solano, David Chapron, Patrice Bourson, Ivan Bravo, Carlos Alonso-Moreno, Pilar Clemente-Casares, Carlos Gracia-Fernandez, Alessandro Longo, Georges Salloum-Abou-Jaoude, Alberto Ocana, Manuel M. Pineiro, Carolina Hermida-Merino, Daniel Hermida-Merino
Summary: A series of bionanocomposites composed of shark gelatin hydrogels and PLA nanoparticles with different nanostructures were designed for personalized treatment approaches. The systems were customized for drug release, ease of storage and local administration, biocompatibility, and cell growth capability at the biomolecular level. The study successfully formulated nanoparticles with different antitumoral compounds and characterized the bionanocomposites using various techniques. The drug release profiles were analyzed and correlated to the nanostructure of the drug delivery system.
Review
Polymer Science
Selvakumar Murugesan, Thomas Scheibel
Summary: Chitosan, a biobased polymer, is gaining attention for its outstanding physico-chemical characteristics. Recent research shows its diverse applications in agricultural, biomedical, and bioimaging fields. Chitosan nanoparticles have demonstrated superior biological activity in regenerative medicine, wound dressings, drug delivery, and biosensing applications.
JOURNAL OF POLYMER SCIENCE
(2021)
Article
Chemistry, Physical
Wenhao Zhong, Xinyu Zhang, Yunxin Zeng, Dongjun Lin, Jun Wu
Summary: Lung diseases, including COVID-19 and lung cancers, pose a significant threat to human health, with treatment and diagnosis becoming increasingly challenging. Nanotechnology, as an emerging technology, has shown promise in improving targeted drug delivery in the lungs, offering potential for enhancing therapeutic effects.
Review
Biochemistry & Molecular Biology
Teruki Nii
Summary: Gelatin particles, serving as drug carriers, exhibit excellent drug release properties and are effective in wound healing and drug screening models.
Article
Materials Science, Multidisciplinary
Aqeel Al-Hamaidah, Mahmood Rezaee Roknabadi, Malek Bagheri Harouni, Bizhan Malaekeh-Nikouei, Asma Mahmoudi, Reza Ghanbari, Alireza Charmforoushan
Summary: We report the synthesis of a mesoporous calcium silicate superparamagnetic nanoparticle with a core-shell structure of ZnMnFe2O4@Fe-CaSiO3. The core-shell nanocomposite exhibits excellent properties including meso-porous structure, superparamagnetism at room temperature, low toxicity, large surface area, tunable pore size, and easy surface manipulation. The addition of different percentages of Fe ions onto the calcium silicate structure further enhances the magnetic properties of the core-shell structure. These mesoporous superparamagnetic nanocomposites have potential applications in drug delivery, magnetic resonance imaging, magnetic hyperthermia, and bone tissue regeneration.
MATERIALS CHEMISTRY AND PHYSICS
(2023)
Article
Biophysics
Kaichun Li, Dong Zhou, Hengqing Cui, Guoyan Mo, Yu Liu, Kaikai Zheng, Zheng Zhou, Jian Li, Ping Dai, Jing Sun, Yuhong Zhang, Jie Gao
Summary: This study developed nanoparticles for cancer treatment that can gradually release drugs in the tumor environment, achieving deep tumor penetration and efficient tumor cell therapy. The nanoparticles have good stability and biocompatibility, making them a promising and practical approach for anticancer therapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Review
Materials Science, Multidisciplinary
Saeed Siavashy, M. Soltani, Mahnaz Ahmadi, Behnaz Landi, Hedayeh Mehmanparast, Fatemeh Ghorbani-Bidkorbeh
Summary: Novel nanocarriers, such as multifunctional nanoparticles (NPs), have gained attention for their applications in medicine and treatment. Microfluidic (MF) technology offers precise control over flow rates and chemical reaction conditions, enabling the fabrication of uniform and stable particles with higher encapsulation efficiency and controlled release compared to conventional methods. This review explores the MF-based methods for NP synthesis and their advantages in developing innovative drug delivery systems. It also provides a comprehensive comparison with conventional methods, emphasizing the critical characteristics of this new category of nanocarriers. The article summarizes recent representative works on NP fabrication using MF procedures and discusses their potential and applications in drug delivery.
ADVANCED MATERIALS TECHNOLOGIES
(2022)
Article
Materials Science, Paper & Wood
Hassan M. Ibrahim, Ghada M. Taha, Ekhlas A. El-Alfy, Manal K. El-Bisi
Summary: This paper describes the use of gelatin nanoparticles for drug delivery, specifically in enhancing the treatment of bacterial and fungal infections with weakly cell-penetrating antibiotics. By loading the antibiotics into gelatin nanoparticles and incorporating them into cotton gauze, higher antimicrobial activity is achieved.
Review
Biochemistry & Molecular Biology
Ghazaleh Salmanian, S. A. Hassanzadeh-Tabrizi, Narjes Koupaei
Summary: Magnetic chitosan nanocomposites with multifunctional tasks such as localized tumor heating under magnetic field and controlled drug release are highly demanded. Combining different types of magnetic cores and engineered chitosan shells can create unique characteristics with biocompatibility, the least toxic effects, controlled drug release, and the ability to carry various medicines for long-term circulation in the body. Recent advances in the synthesis and applications of magnetic chitosan nanocomposites for hyperthermia and drug delivery are summarized in this review.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Biology
Hyang-Mi Lee, Jun Ren, Kha Mong Tran, Byeong-Min Jeon, Won-Ung Park, Hyunjoo Kim, Kyung Eun Lee, Yuna Oh, Myungback Choi, Dae-Sung Kim, Dokyun Na
Summary: Lee et al. construct a library of cell-penetrating peptides (CPP) and identify CPPs that can penetrate bacterial cells with minimal or no impact on cell viability. They demonstrate the utility of CPPs in bacterial engineering and provide new possibilities for genetic engineering and other related fields.
COMMUNICATIONS BIOLOGY
(2021)
Article
Obstetrics & Gynecology
Nawabzada Khan, Mohsin Shah, Muhammad Omar Malik, Haroon Badshah, Syed Hamid Habib, Inayat Shah, Fawad Ali Shah
Summary: The chronic use of tobacco and cannabis has been found to mildly affect semen and hormonal parameters in infertile males, resulting in a decrease in sperm count and serum LH and testosterone levels, and an increase in serum FSH levels.
Article
Biophysics
Maleeha Gul, Fawad Ali Shah, Najam-us Sahar, Imran Malik, Fakhar ud Din, Saeed Ahmad Khan, Waqar Aman, Ho-Ik Choi, Chang-Wan Lim, Ha-Yeon Noh, Jin-Su Noh, Alam Zeb, Jin-Ki Kim
Summary: The present study aimed to prepare and optimize agomelatine-loaded nanostructured lipid carriers (AGMNLCs) for enhanced in vivo antidepressant potential. The optimized AGM-NLCs showed favorable physicochemical properties and sustained drug release, leading to improved neuronal morphology and reduced inflammation in mice brain.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2022)
Article
Nanoscience & Nanotechnology
Agnes -Valencia Weiss, Daniel Schorr, Julia K. Metz, Metin Yildirim, Saeed Ahmad Khan, Marc Schneider
Summary: This study presents a method for determining the elasticity of gelatin nanoparticles and explores the possibility of tuning their elastic properties through crosslinking. The results show that loading drugs significantly affects the mechanical properties of nanoparticles, while crosslinkable macromolecules do not. Furthermore, the study found that the nanoparticles exhibit good cell compatibility.
BEILSTEIN JOURNAL OF NANOTECHNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Abdul Jabbar, Khadija Rehman, Tooba Jabri, Tasmina Kanwal, Samina Perveen, Md Abdur Rashid, Mohsin Kazi, Saeed Ahmad Khan, Salim Saifullah, Muhammad Raza Shah
Summary: Multi-drug resistant bacterial strains have caused serious health issues, leading to increased mortality, morbidity, and expensive treatment. Metal-organic frameworks (MOFs), consisting of metal ions and organic ligands, have been utilized as effective drug delivery vehicles due to their low toxicity, biodegradability, structural integrity, and surface functionalities. Polydopamine (PDA) is a versatile biocompatible polymer that can adhere to biological surfaces, potentially enhancing the antimicrobial properties of drug delivery vehicles. This study prepared PDA-coated Zn-MOFs to improve curcumin's antibacterial properties against S. aureus and E. coli, and characterized the MOFs using various analysis techniques. The findings showed that encapsulating curcumin into PDA-coated MOFs significantly enhanced its bactericidal potential, as confirmed by SEM analysis. These results suggest that the PDA-Cur-Zn-MOFs developed in this study hold great promise for long-term drug release to treat a wide range of microbial infections.
Article
Endocrinology & Metabolism
Asma Aziz, Mohsin Shah, Sami Siraj, Waheed Iqbal, Amin Jan, Imran Khan, Sajjad Ahmed, Salvatore Giovanni Vitale, Stefano Angioni
Summary: This study aimed to investigate the association between VDR gene polymorphism (ApaI) and VD deficiency with the risk of developing preeclampsia. A case-control study was conducted comparing 40 preeclamptic and 40 normotensive pregnant women for VD status and VDR gene polymorphism. Serum 25-hydroxyvitamin-D [25(OH) D] level was determined by ELISA and VDR gene polymorphism ApaI was analyzed by AS-PCR. The study showed that VDR gene polymorphism (ApaI) and VD deficiency are not associated with the risk of preeclampsia.
GYNECOLOGICAL ENDOCRINOLOGY
(2023)
Review
Pharmacology & Pharmacy
Amjad Ullah, Fahad Mohammed Aldakheel, Syed Ishtiaq Anjum, Ghulam Raza, Saeed Ahmad Khan, Ivana Tlak Gajger
Summary: Honey bee venom is a valuable product with a wide range of biological effects, and its use in apitherapy is increasing rapidly. It is composed of many biologically active substances and has various pharmacological properties, including anticancer, antimicrobial, anti-inflammatory, and anti-arthritis effects. Honey bee venom has been used for centuries in medicine and is currently being researched for more effective use in modern medicine.
SAUDI PHARMACEUTICAL JOURNAL
(2023)
Article
Medicine, General & Internal
Kalsoom Tariq, Sadia Fatima, Rubina Nazli, Syed Hamid Habib, Mohsin Shah
Summary: This study aimed to investigate the impact of high-energy nutritional supplements on appetite, appetite regulators, energy intake, and macronutrient levels among underweight primigravidae. The results revealed that high-energy nutritional supplements had a suppressive effect on energy intake and appetite in the short term.
JOURNAL OF THE PAKISTAN MEDICAL ASSOCIATION
(2023)
Article
Food Science & Technology
Aqsa Zubair, Sadia Fatima, Hamid Habib, Rubina Nazli, Inayat Shah, Mohsin Shah
Summary: Oral lipid-based nutritional supplements can improve appetite and energy intake in malnourished children, but may induce hyperglycemia and hyperlipidemia.
FOOD SCIENCE & NUTRITION
(2023)
Article
Pharmacology & Pharmacy
Kashif Hussain, Abdul Jabbar, Khwaja Ali Hasan, Muneeb Ali, Zaheer Ul-Haq, Muhammad Raza Shah, Saeed Ahmad Khan, Md Abdur Rashid, Mohsin Kazi, Muhammad Naseer Abbas
Summary: Due to the low solubility of hydrophobic drugs, nonionic surfactants are used to improve their solubility by entrapping them in lipid bilayers. Two newly synthesized nonionic surfactants, NODNH-16 and NODNH-18, were characterized and demonstrated good drug entrapment efficiency. They also showed biocompatibility and low blood hemolysis, making them safe for use. The antifungal potential of niosomes loaded with amphotericin B has been evaluated, showing promising fungicidal activity and providing a safe vehicle system for drug delivery.
Review
Endocrinology & Metabolism
Iva Pitner, Mislav Mikus, Marina Sprem Goldstajn, Antonio Simone Lagana, Vito Chiantera, Federico Ferrari, Mohsin Shah, Maurizio Nicola D'Alterio, Salvatore Giovanni Vitale, Stefano Angioni
Summary: The purpose of this narrative review is to summarize the role of progesterone levels in pregnancy outcomes for patients undergoing assisted reproductive technologies. The review found that elevated progesterone levels at different stages of the cycle can have varying effects on pregnancy rates in the in vitro fertilization cycle. Additionally, the review also discussed the differences in interpretation of elevated progesterone levels in normal and poorly responding women.
GYNECOLOGICAL ENDOCRINOLOGY
(2023)
Article
Pharmacology & Pharmacy
Danish Mazhar, Naveed Ul Haq, Mahira Zeeshan, Qurat Ul Ain, Hussain Ali, Salman Khan, Saeed Ahmad Khan
Summary: In this study, transfersomes were used to improve the oral absorption of Metformin Hydrochloride (MF HCl), an anti-diabetic drug, and increase its bioavailability. The MF-TFs were prepared using a modified thin film hydration technique and embedded in Carbopol gel containing a permeation enhancer. The resulting formulation showed smooth and spherical MF-TFs particles with sustained drug release. Skin permeation studies demonstrated superior permeability of MF-TFs gel compared to the pure drug. Glucose tolerance test and in vivo pharmacokinetic evaluation further confirmed the potential of MF-TFs gel for transdermal application in the management of type 2 diabetes mellitus (DM-II).
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2023)
Article
Polymer Science
Sana Afzal, Kashif Barkat, Muhammad Umer Ashraf, Ikrima Khalid, Yasir Mehmood, Nisar Hussain Shah, Syed Faisal Badshah, Saba Naeem, Saeed Ahmad Khan, Mohsin Kazi
Summary: The study aimed to develop bacitracin zinc-loaded patches as a new therapeutic agent for wound healing. The results showed that the polymeric network can accelerate wound healing and treatment of minor skin injuries by enhancing drug deposition.
Article
Chemistry, Analytical
Muhammad Sohail Anwar, Abad Khan, Ismail Khan, Saeed Ahmad Khan, Lateef Ahmad, Waqar Ahmad Kaleem, Ali Mahzari, Wafa Abdullah I. Al-Megrin, Ahmad Almatroudi, Khaled S. Allemailem, Fahim Ullah Khan
Summary: In this study, FTIR and HPLC were used for the identification and quantification of synthetic steroids adulterated in herbal products. The samples were extracted with methanol and quantified by HPLC using a mobile phase of methanol:water. The developed method proved to be simple, sensitive, and cost-effective for analyzing the studied steroids in dosage forms and body fluids.
MICROCHEMICAL JOURNAL
(2023)
Editorial Material
Pharmacology & Pharmacy
Abad Khan, Lateef Ahmad, Faisal Raza, Saeed Ahmad Khan, Tahir Ali
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Endocrinology & Metabolism
Sehresh Hassan, Mohsin Shah, Muhammad Omar Malik, Ehtesham Ehtesham, Syed Hamid Habib, Bushra Rauf
Summary: This study compared the effectiveness of metformin and pioglitazone therapy with resveratrol and myoinositol therapy in improving PCOS-related parameters. The results showed that resveratrol and myoinositol treatment significantly reduced serum testosterone levels, increased serum adiponectin levels, and improved menstrual regularity and stress burden.
