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Chemistry, Physical
Stephen C. L. Hall, Cecilia Tognoloni, Richard A. Campbell, Joanna Richens, Paul O'Shea, Ann E. Terry, Gareth J. Price, Tim R. Dafforn, Karen J. Edler, Thomas Arnold
Summary: This study investigates the dynamic behavior of nanodiscs with different membrane charges and polymer chemistry. The findings reveal that in the presence of external lipids, polymer chains embed throughout lipid membranes, and nanodiscs exchange lipids and polymer with monolayers.
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Chemistry, Physical
Marcelo Caparotta, Marcelo Puiatti, Diego Masone
Summary: Styrene-maleic acid copolymers are a detergent-free alternative for membrane protein isolation, and can stabilize the fusion pore. Only copolymers within intra-organelles have the capability to stabilize the fusion pore.
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Biochemistry & Molecular Biology
Olena Korotych, Thao T. Nguyen, Brandon C. Reagan, Tessa M. Burch-Smith, Barry D. Bruce
Summary: The study identified five highly efficient pSMA copolymers that can effectively extract membrane protein complexes from thylakoid membranes, showing promise in extracting MPCs from chloroplast thylakoids. Based on the differential extraction of protein complexes from spinach and pea thylakoids by pSMAs, the polymers can be divided into two groups: unfunctionalized polymers and ester derivatives.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
(2021)
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Chemistry, Physical
Cheol Jeong, Ryan Franklin, Karen J. Edler, Kenno Vanommeslaeghe, Susan Krueger, Joseph E. Curtis
Summary: Lipid nanodiscs are promising reagents to solubilize membrane proteins in nativelike environments and characterize them. Small-angle neutron scattering can determine the low-resolution structures of proteins, and contrast variation methods can enhance this process. It is possible to eliminate the scattering of the nanodisc by tuning the neutron scattering length densities.
JOURNAL OF PHYSICAL CHEMISTRY B
(2022)
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Biochemistry & Molecular Biology
Arvind Anand, Morgan LeDoyt, Carson Karanian, Amit Luthra, Mary Koszelak-Rosenblum, Michael G. Malkowski, Robbins Puthenveetil, Olga Vinogradova, Justin D. Radolf
JOURNAL OF BIOLOGICAL CHEMISTRY
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Biochemistry & Molecular Biology
Khiem Nguyen, Jin Li, Robbins Puthenveetil, Xiaochen Lin, Michael M. Poe, Chia-Hung Christine Hsiao, Olga Vinogradova, Andrew J. Wiemer
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Chemistry, Medicinal
Rebekah R. Shippy, Xiaochen Lin, Sherry S. Agabiti, Jin Li, Brendan M. Zangari, Benjamin J. Foust, Michael M. Poe, Chia-Hung Christine Hsiao, Olga Vinogradova, David F. Wiemer, Andrew J. Wiemer
JOURNAL OF MEDICINAL CHEMISTRY
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Chemistry, Multidisciplinary
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CHEMICAL COMMUNICATIONS
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Robbins Puthenveetil, Sanjiv Kumar, Melissa J. Caimano, Abhishek Dey, Arvind Anand, Olga Vinogradova, Justin D. Radolf
SCIENTIFIC REPORTS
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Review
Biochemistry & Molecular Biology
Robbins Puthenveetil, Olga Vinogradova
JOURNAL OF BIOLOGICAL CHEMISTRY
(2019)
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Biochemistry & Molecular Biology
Robbins Puthenveetil, Eric T. Christenson, Olga Vinogradova
Summary: This review discusses various techniques used in studying protein dynamics, including NMR, cryo-EM, and X-ray crystallography, as well as methods for conformational trapping using specific binders. It also showcases the application of biophysical techniques such as FRET, EPR, and computational approaches in GPCRs, transporters, and ion channels.
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Biochemistry & Molecular Biology
Chia-Hung Christine Hsiao, Khiem Nguyen, Yiming Jin, Olga Vinogradova, Andrew J. Wiemer
Summary: The study reveals the important role of BTN2A1 in the detection of phosphoantigens (pAgs) and identifies the interaction between the internal domains of BTN2A1 and BTN3A1, which is regulated by pAgs.
CELL CHEMICAL BIOLOGY
(2022)
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Biochemistry & Molecular Biology
Rambon Shamilov, Olga Vinogradova, Brian J. Aneskievich
Meeting Abstract
Immunology
Andrew J. Wiemer, Khiem Nguyen, Jin Li, Robbins Puthenveetil, Xiaochen Lin, Chia-Hung Christine Hsiao, Olga Vinogradova
JOURNAL OF IMMUNOLOGY
(2017)
Meeting Abstract
Chemistry, Multidisciplinary
Priya Katyal, Yongkun Yang, Hongwei Xia, Olga Vinogradova, Yao Lin
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY
(2015)