Article
Nanoscience & Nanotechnology
Dong An, Xin Wu, Yaolin Gong, Wenlu Li, Guidong Dai, Xiaofei Lu, Liangmin Yu, Wen Xiu Ren, Meng Qiu, Jian Shu
Summary: A new nanoplatform has been developed in this study, which combines manganese ions and biocompatible PEG to give the nanosheets multi-modal functions for thermal therapy and chemodynamic treatment guided by magnetic resonance imaging. The nanosheets can act as contrast agents for T1-weighted MRI and convert cellular H2O2 into highly toxic hydroxyl radicals for chemodynamic therapy.
Article
Biophysics
Shuang-hui Huang, Si Peng, Qiu-yue Wang, Qiu-hui Hu, Run-qin Zhang, Ling Liu, Qiang Liu, Juan Lin, Qing-han Zhou
Summary: The combination of chemo-photothermal therapy using gold nanorods (GNRs) has shown superior therapeutic efficiency compared to mono-chemotherapy in cancer treatment, attracting interest worldwide. pH-sensitively zwitterionic polypeptide conjugated GNRs were designed to overcome challenges such as high cytotoxicity and unsatisfactory therapy effects, displaying positive surface charge transition for enhanced cellular uptake, pH-sensitive drug release, and efficient tumor cell killing through NIR photothermal conversion.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Review
Nanoscience & Nanotechnology
Yan Yang, Xi Zheng, Lu Chen, Xuefeng Gong, Hao Yang, Xingmei Duan, Yuxuan Zhu
Summary: Cancer is the second leading cause of death in the world and poses a serious threat to human health. Nanomedicine, particularly gold nanoparticles (AuNPs), has emerged as a promising technology for overcoming the limitations of conventional cancer therapies. This review discusses the current achievements and clinical trials of AuNPs in anticancer applications, as well as the challenges in translating basic findings into the clinic, providing a reference for future research.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2022)
Article
Nanoscience & Nanotechnology
Xing-Qun Pu, Xiao-Jie Ju, Lei Zhang, Quan-Wei Cai, Yu-Qiong Liu, Han-Yu Peng, Rui Xie, Wei Wang, Zhuang Liu, Liang-Yin Chu
Summary: A novel class of multifunctional responsive nanoparticles was designed and fabricated as drug nanocarriers for synergetic chemo-photothermal therapy of tumors. These nanoparticles demonstrated good biocompatibility and outstanding photothermal conversion efficiency, with controlled drug release under low pH and high temperature conditions. Experimental results showed that the nanoparticles were phagocytosed by tumor cells and released drugs in acidic environments, with higher efficacy in combined chemo and photothermal therapy compared to individual treatments.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Review
Chemistry, Multidisciplinary
Subin Son, Jungryun Kim, Jaewon Kim, Byungkook Kim, Jieun Lee, Yuri Kim, Mingle Li, Heemin Kang, Jong Seung Kim
Summary: Light-based phototherapy has limitations in cancer treatment due to its limited penetration depth. To overcome these limitations, various energy sources such as ultrasound, chemiluminescence, radiation, microwave, electricity, and magnetic field have been developed. Combining these energy sources with other strategies or therapies can improve the effectiveness of cancer treatment.
CHEMICAL SOCIETY REVIEWS
(2022)
Review
Chemistry, Multidisciplinary
Song Shen, Jichuan Qiu, Da Huo, Younan Xia
Summary: Photothermal therapy shows great potential in killing cancer cells through hyperthermia. The efficacy is affected by various parameters, including the laser, photothermal transducers, spatial distribution of the transducers, bioeffect of the tissue (heat-sink effect, thermal conductivity), and real-time temperature monitoring.
Article
Pharmacology & Pharmacy
Manshi Patel, Arati Prabhu
Summary: In recent years, fusion technology platforms that combine various treatments such as photodynamic therapy, photothermal therapy, and hyperthermia have emerged as safe and effective strategies for cancer treatment. These therapies use metal and magnetic nanoparticles to produce reactive oxygen species or heat, providing a potential solution for tumor treatment. The integration of light, heat, magnetism, and traditional treatments for precise interventions against cancer is considered a future trend in cancer therapeutics.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Engineering, Biomedical
Zachary R. Stephen, Miqin Zhang
Summary: Immunotherapy has shown success in certain cancers, and combinational approaches with hyperthermia therapy are being explored to enhance its effectiveness. Nanoparticle-based hyperthermia increases tumor immunogenicity and permeability, particularly effective in solid tumors.
ADVANCED HEALTHCARE MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Nandan Gupta, Rishabha Malviya
Summary: The use of gold nanoparticles in photothermal therapy for cancer treatment is highlighted in this communication, showing their potential in warning cancer cells to other therapies, modulating cellular permeability and delivery, and achieving effective therapy management.
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
(2021)
Article
Nanoscience & Nanotechnology
Linxue Zhang, Shuang Chen, Rong Ma, Lijun Zhu, Ting Yan, Gulinigaer Alimu, Zhong Du, Nuernisha Alifu, Xueliang Zhang
Summary: Gold nanorods have been widely used in biomedical applications due to their adjustable optical and stable chemical properties, especially in the photothermal therapy of cancer. Surface modification can enhance the biocompatibility and stability of gold nanorods, making them more suitable for biomedical applications. The designed NIR-I-excitable photothermal theranostic nanoplatform Au@PEG NRs showed superior biocompatibility and chemical stability, making it promising for applications in cervical cancer treatment.
ACS APPLIED NANO MATERIALS
(2021)
Review
Biochemistry & Molecular Biology
Prashant Kesharwani, Ruiyang Ma, Liang Sang, Mahak Fatima, Afsana Sheikh, Mohammed A. S. Abourehab, Neelima Gupta, Zhe-Sheng Chen, Yun Zhou
Summary: Cancer is a devastating disease, and more efficient, non-invasive therapies with minimal side effects are needed. Gold nanoparticles with impressive optical properties have been at the forefront of bioengineered cancer therapy. This review discusses the optical features of gold nanoparticles and highlights the recent research on their application, especially gold nanorods, in combating various cancers such as breast, lung, colon, oral, prostate, and pancreatic cancer.
Article
Nanoscience & Nanotechnology
Runzan Zhang, Xianya Qin, Junyu Lu, Hongbo Xu, Siyu Zhao, Xiaonan Li, Conglian Yang, Li Kong, Yuanyuan Guo, Zhiping Zhang
Summary: Microbiota-based tumor immunotherapy has become a hotspot in cancer research. However, using microorganisms alone for antitumor therapy was unsatisfactory. In this study, gold nanoparticles and platinum nanoparticles were synthesized based on yeast microcapsules to activate the immune response for antitumor treatment in synergy with chemodynamic therapy and photothermal therapy. The results showed that this immunological nanomaterial significantly improved the tumor microenvironments, effectively inhibiting or even eradicating primary tumors and improving the overall survival of mice. Therefore, yeast microcapsule-based immunomodulatory nanoparticles could be an effective cancer treatment modality.
ACS APPLIED MATERIALS & INTERFACES
(2023)
Review
Chemistry, Analytical
Anilkumar Thaghalli Shivanna, Banendu Sunder Dash, Jyh-Ping Chen
Summary: Functionalized magnetic nanoparticles (fMNPs) are versatile for cancer therapy and can provide a multimodal platform. They can convert magnetic or light energy to heat, enabling magnetic hyperthermia and photothermal therapy. Additionally, they can be used in combination therapies due to their versatile properties. This review focuses on the applications of fMNPs in cancer therapy.
Article
Pharmacology & Pharmacy
Huai-An Chen, Yu-Jen Lu, Banendu Sunder Dash, Yin-Kai Chao, Jyh-Ping Chen
Summary: Combination chemo-photothermal therapy using HA/PMNPc nanoparticles can effectively treat cancer by reducing the dose of chemotherapeutic drugs and inducing cell death through heat generation. The nanoparticles exhibit targeted delivery, pH-sensitive drug release, and hyperthermia effects, resulting in higher cytotoxicity and apoptosis in cancer cells. In vivo studies demonstrate that the treatment modality inhibits tumor growth and increases survival time in mice.
Review
Pharmacology & Pharmacy
Andreia Granja, Marina Pinheiro, Celia T. Sousa, Salette Reis
Summary: Breast cancer is the leading cause of cancer-related deaths among women, and new treatment options are needed due to limitations of current therapeutics. Hyperthermia, particularly in combination with chemotherapy and radiotherapy, shows promise in improving breast cancer therapy. The association of hyperthermia with nanotechnology, such as photothermal therapy (PTT), has gained attention and gold nanostructures are emerging as excellent PTT agents for breast cancer management.
BIOCHEMICAL PHARMACOLOGY
(2021)
