Article
Biochemistry & Molecular Biology
Meng Huang, Yan Wang, Zhenning Wang, Qiaozhen Qin, Heyang Zhang, Shuirong Liu, Jiantong Cui, Yu Zhang, Xiaoxia Jiang, Lulu Xu
Summary: The study shows that miR-134-5p inhibits osteoclast formation through targeting the Itgb1 gene and regulating the MAPK pathway, suggesting it could be a potential target for osteoporosis therapy.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2022)
Review
Medicine, Research & Experimental
Zhichao Wang, Wenjie Xie, Hongzai Guan
Summary: MicroRNAs are small non-coding RNAs that interact with their target mRNAs to degrade them or inhibit translation. Dysregulation of miRNAs is associated with various human cancers and plays a role in the development of cancer pathology. MiR-328 has been implicated in multiple human cancers and considered a key regulator. It is involved in biological processes such as cell proliferation, apoptosis, invasion, migration, and epithelial-mesenchymal transition. This review combines basic and clinical studies to demonstrate that miR-328 promotes tumorigenesis and metastasis in human cancer and discusses its diagnostic, prognostic, and therapeutic value.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Multidisciplinary Sciences
Richard Molnar, Laszlo Szabo, Andras Tomesz, Arpad Deutsch, Richard Darago, Nowrasteh Ghodratollah, Timea Varjas, Balazs Nemeth, Ferenc Budan, Istvan Kiss
Summary: This study investigated the effects of olive oil and TFAs on the expression patterns of miRs and mTOR in mouse liver, spleen, and kidney. Olive oil showed protective, antioxidant, and anti-inflammatory effects, while TFAs exhibited damaging, inflammatory, and carcinogenic properties. The results suggest the presence of negative feedback regulatory mechanisms between these dietary components.
Review
Biochemistry & Molecular Biology
Petra Korac, Mariastefania Antica, Maja Matulic
Summary: miR-7 is an ancient miRNA involved in cell signaling pathways, acting primarily as a tumor suppressor by inhibiting cell proliferation and promoting apoptosis. It also has additional roles in cell regulation and protection, with potential for use in biotherapeutics.
Article
Food Science & Technology
Fan Zhang, Xiu-Xiu Zhang, Jian-Guo Zhang, Kiran Thakur, Jesus Simal-Gandara, Miguel A. Prieto, Mohammad Rizwan Khan, Hui Cao, Zhao-Jun Wei
Summary: miRNA-6236-p5_4 plays a crucial role in the anticancer activity of AA in endometrial carcinoma. It is involved in regulating cell proliferation, cell cycle arrest, apoptosis, and migration. The PI3K-Akt, p53, Ras, and Rap1 signaling pathways, as well as CDK6, PIK3CB, and KRAS genes, are identified as key regulators in this process.
FOOD AND CHEMICAL TOXICOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Yin Li, Yihan Zhang, Yuhao Zou, Shiwei Duan
Summary: MiR-4295 is a unique miRNA with a wide range of biological functions involved in various cancers. It can both be dysregulated and also have a tumor-suppressing function, and its expression is associated with prognosis and therapeutic response to drugs.
Article
Cell Biology
Tsu-Yang Chao, Theresa Kordass, Wolfram Osen, Stefan B. Eichmueller
Summary: The miRNAs miR-134-3p and miR-224-3p were found to directly interact with the SOX9 gene and inhibit its expression in breast cancer cells. These two miRNAs were down-regulated in breast cancer tissues, suggesting their potential role as tumor suppressors in breast cancer progression.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Yuqin Ding, Yuting Huang, Fanrong Zhang, Lijie Gong, Chenlu Liang, Kaijing Ding, Xiangming He, Xiaowen Ding, Yiding Chen
Summary: Our study investigated the role of lncRNA TDRKH-AS1 in breast cancer (BC). We found that TDRKH-AS1 was upregulated in BC tissues and cell lines, and its high expression was associated with advanced stages and poor outcomes in BC patients. Knockdown of TDRKH-AS1 inhibited BC cell proliferation and invasion. Mechanistically, TDRKH-AS1 acted as a sponge for miR-134-5p, thereby promoting the expression of cAMP response element-binding protein 1 (CREB1), a downstream target of miR-134-5p. In vivo experiments confirmed the tumor-promoting role of TDRKH-AS1 in BC.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Medicine, Research & Experimental
Seyede Fatemeh Hosseini, Setareh Javanshir-giv, Hanieh Soleimani, Homa Mollaei, Farzad Sadri, Zohreh Rezaei
Summary: MicroRNA production in tumorigenesis is dysregulated by various processes, leading to dysfunctional and dysregulated miRNAs. These miRNAs have been identified as potential biomarkers for human cancer, although further evaluation is necessary. The miR-28 family, especially miR-28-5p and miR-28-3p, play essential roles in various cancers and can serve as diagnostic biomarkers for prognosis and early detection of cancers.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Surendra Kumar Sagar
Summary: This review focuses on the function of miR-106b and its downstream targets in cancer, providing insights into how miR-106b regulates cancer cell proliferation, migration, invasion, and metastasis by modulating tumor suppressor genes. The potential of miR-106b as a candidate for detection, diagnosis, and prognosis assessment in different cancer types is highlighted.
Review
Cell Biology
Qiudan Zhang, Chenming Zhong, Qianqian Yan, Ling-hui Zeng, Wei Gao, Shiwei Duan
Summary: miR-874 is frequently dysregulated in various cancers and non-cancer diseases, and its dysfunction is closely associated with the diagnosis, prognosis, and efficacy of chemotherapy drugs. It participates in ceRNA networks and regulates multiple signaling pathways involved in tumor cell processes. miR-874 has the potential to serve as a diagnostic and prognostic biomarker in cancer and has implications for clinical applications.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Pathology
Huldani Huldani, Shadia Hamoud Alshahrani, Yasir Qasim Almajidi, Rosario Mireya Romero-Parra, Ahmed Hjazi, Hashem O. Alsaab, Khulood H. Oudaha, Beneen M. Hussien, Muhja Ahmed, Seyed Reza Hosseini Fard
Summary: Noncoding RNAs, such as microRNAs, play important roles in regulating cellular functions by targeting specific genes. MiR-495-3p has been identified as a crucial player in cancer pathogenesis and has potential as a prognostic and diagnostic biomarker, as well as a modifier of cancer cell chemotherapy resistance.
PATHOLOGY RESEARCH AND PRACTICE
(2023)
Article
Biochemistry & Molecular Biology
Lu Qi, Lu Wang, Fuyao Song, Zhenhua Ding, Ying Zhang
Summary: This study identified miR-4469 as a tumor suppressor in colorectal cancer (CRC) and found that its regulatory mechanism mainly involves the infiltration of inflammatory cells in cancer tissues.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2022)
Review
Biochemistry & Molecular Biology
Da Young Lee, Jung Nyeo Chun, Minsoo Cho, Insuk So, Ju-Hong Jeon
Summary: E2F8 is a multifaceted transcription factor that is involved in various aspects of cancer development and progression. It has the ability to promote cancer cell proliferation and survival while also exhibiting tumor-suppressing activity. This review highlights the recent progress in understanding the role of E2F8 in human cancers and its implications for developing therapeutic strategies.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Oncology
Mackenzie L. Davenport, John B. Echols, Austin D. Silva, Joshua C. Anderson, Philip Owens, Clayton Yates, Qing Wei, Shuko Harada, Douglas R. Hurst, Mick D. Edmonds
Summary: miR-31 demonstrates oncogenic properties in specific subtypes of lung cancer, highlighting its potential as a therapeutic target in these subtypes.
Article
Cell Biology
Junzhen Fan, Zhenjian Zhuo, Guoqing Chen, Huizhong Niu, Zhonghua Yang, Jiao Zhang, Yong Li, Suhong Li, Jiwen Cheng, Li Li, Jing He, Xianqiang Wang
Summary: This study found a significant association between certain SNPs of the FTO gene and the risk of hepatoblastoma, particularly rs9939609 T > A, which was associated with a decreased risk. These findings provide clues for further research on the role of the FTO gene in hepatoblastoma.
Letter
Pediatrics
Yong-Ping Chen, Yu-Xiang Liao, Zhen-Jian Zhuo, Li Yuan, Hui-Ran Lin, Lei Miao, Xia Li, Xiao-Kai Huang, Jing-Ying Zhou, Jun Bian, Jing He
WORLD JOURNAL OF PEDIATRICS
(2022)
Article
Genetics & Heredity
Lei Lin, Changmi Deng, Chunlei Zhou, Xinxin Zhang, Jinhong Zhu, Jiabin Liu, Haiyan Wu, Jing He
Summary: In this study, the association between NSUN2 rs13181449 polymorphism and neuroblastoma susceptibility was investigated in a Chinese population. The results showed that the rs13181449 polymorphism was significantly associated with a reduced risk of neuroblastoma. Further analysis revealed that this protective effect was observed in children with age >18 months, boys, and those with early INSS stages.
Article
Multidisciplinary Sciences
Jue Tang, Jing He, Huiqin Guo, Huiran Lin, Meng Li, Tianyou Yang, Hai-Yun Wang, Di Li, Jiabin Liu, Le Li, Huimin Xia, Zhenjian Zhuo, Lei Miao
Summary: This study revealed the potential predictive role of PTBP2 in thoracic neuroblastoma (NB) patients. It showed that PTBP2 induced chemotactic activity in tumor-associated monocytes and macrophages, inhibiting NB growth and dissemination. This work highlighted the pathological and biological role of PTBP2 in NB development and predicted a favorable prognosis in thoracic NB.
Letter
Medicine, General & Internal
Linqing Deng, Ruixi Hua, Zhengtao Zhang, Jinhong Zhu, Jiao Zhang, Jiwen Cheng, Suhong Li, Haixia Zhou, Guochang Liu, Jing He, Wen Fu
CHINESE MEDICAL JOURNAL
(2023)
Article
Cell Biology
Jiaming Chang, Lei Lin, Chunlei Zhou, Xinxin Zhang, Tianyou Yang, Haiyan Wu, Yan Zou, Jing He
Summary: Common genetic mutations are absent in neuroblastoma, but TET1 gene polymorphisms are significantly associated with increased neuroblastoma risk. The rs3998860 G > A and rs12781492 A > C polymorphisms are closely related to increased risk, and they have an impact on the expression of STOX1 mRNA. Further research is required for the potential mechanism and therapeutic prospects in neuroblastoma.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Medical Laboratory Technology
Meng Li, Xinxin Zhang, Jiabin Liu, Chunlei Zhou, Lei Miao, Jing He, Haiyan Wu, Ruizhong Zhang
Summary: This study investigated the association between two GPC2 polymorphisms (rs1918353 G>A and rs7799441 C>T) and neuroblastoma risk in Chinese children. The results showed no significant association between these polymorphisms and susceptibility to neuroblastoma.
JOURNAL OF CLINICAL LABORATORY ANALYSIS
(2023)
Article
Biochemistry & Molecular Biology
Susu Jiang, Xiuhong Sun, Xinxin Zhang, Chunlei Zhou, Haiyan Wu, Jing He, Wenhan Yang
Summary: This study reveals that the MIR938 rs2505901 T>C polymorphism may be a potential risk factor for neuroblastoma in Chinese children.
BIOSCIENCE REPORTS
(2023)
Article
Genetics & Heredity
Xiaofeng Chang, Jinhong Zhu, Rui-Xi Hua, Changmi Deng, Jiao Zhang, Jiwen Cheng, Suhong Li, Haixia Zhou, Jing He, Huanmin Wang
Summary: This study reveals a significant association between the rs236110 C > A polymorphism in TRMT6 gene and susceptibility to Wilms tumor in children. This polymorphism may serve as an important biomarker for risk prediction of pediatric tumors.
Article
Cell Biology
Lin Ma, Jinhong Zhu, Jiao Zhang, Wenli Zhang, Yong Li, Zhonghua Yang, Suhong Li, Jiwen Cheng, Li Li, Jing He, Peng Liu
Summary: This study identified three susceptibility loci in the TRMT6 gene that are significantly associated with the risk of hepatoblastoma, and children with high-risk genotypes are more likely to develop hepatoblastoma compared to those without risk genotypes.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE
(2023)
Article
Oncology
Yufeng Han, Jiaming Chang, Lei Lin, Chunlei Zhou, Jinhong Zhu, Haiyan Wu, Jing He, Wen Fu
Summary: This study found that the miR-100 rs1834306 A > G polymorphism is associated with neuroblastoma susceptibility, and this polymorphism reduces the risk of neuroblastoma, especially for mediastinal tumors. More large-scale case-control studies are needed to verify this conclusion.
Article
Oncology
Linqing Deng, Rui-Xi Hua, Changmi Deng, Jinhong Zhu, Zhengtao Zhang, Jiwen Cheng, Jiao Zhang, Haixia Zhou, Suhong Li, Jichen Ruan, Guochang Liu, Jing He, Wen Fu
Summary: This study found that the rs6586250 C > T polymorphism of the WDR4 gene is significantly associated with the susceptibility to Wilms tumor. The findings suggest that this gene polymorphism may be involved in the genetic mechanism of this tumor.
Article
Oncology
Qian Guan, Huiran Lin, Wenfeng Hua, Lei Lin, Jiabin Liu, Linqing Deng, Jiao Zhang, Jiwen Cheng, Zhonghua Yang, Yong Li, Jun Bian, Haixia Zhou, Suhong Li, Li Li, Lei Miao, Huimin Xia, Jing He, Zhenjian Zhuo
Summary: The rs8400 G>A polymorphism in the ALKBH5 gene is found to be associated with neuroblastoma susceptibility and progression. This genetic variation leads to a decreased regulation of ALKBH5 by miR-186-3p, thereby promoting the occurrence and development of neuroblastoma.
CHINESE JOURNAL OF CANCER RESEARCH
(2023)
Article
Oncology
Mingming Wang, Yufu Zhang, Min Liu, Yuna Jia, Jing He, Xiangrong Xu, Haiyan Shi, Yunqing Zhang, Jing Zhang, Yusi Liu
Summary: This study investigated the impact of human umbilical cord mesenchymal stem cell (HUC-MSC) supernatants on glioblastoma (GBM) cell lines. Results showed that HUC-MSCs supernatants inhibited cell proliferation, migration, and invasion while promoting apoptosis. These effects were mediated through the IL-6/JAK2/STAT3 signaling pathway.