Review
Oncology
Yasaman Iranmanesh, Biao Jiang, Okoye C. Favour, Zhangqi Dou, Jiawei Wu, Jinfan Li, Chongran Sun
Summary: Glioblastoma (GBM) is a deadly primary brain malignancy with limited response to existing therapies, mainly due to glioblastoma stem cells (GSCs) which play a crucial role in therapy resistance. Mitochondria have been identified as important regulators in maintaining GSCs and potential targets for novel therapeutic strategies.
FRONTIERS IN ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Carolin Seifert, Ellen Balz, Susann Herzog, Anna Korolev, Sebastian Gassmann, Heiko Paland, Matthias A. Fink, Markus Grube, Sascha Marx, Gabriele Jedlitschky, Mladen Tzvetkov, Bernhard H. Rauch, Henry W. S. Schroeder, Sandra Bien-Moeller
Summary: Research has shown that PIM1 kinase plays a significant role in the behavior of glioblastoma stem cells, and its inhibition can lead to the death of these stem-like cells, suggesting a potential approach for glioblastoma therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Arianna Casciati, Mirella Tanori, Isabella Gianlorenzi, Elena Rampazzo, Luca Persano, Giampietro Viola, Alice Cani, Silvia Bresolin, Carmela Marino, Mariateresa Mancuso, Caterina Merla
Summary: Glioblastoma multiforme (GBM) is the most common brain cancer in adults, and current therapies have limited effectiveness. Research has shown that high intensity ultra-short pulsed electric fields (PEFs) can affect the growth and differentiation of GBM cells and neurospheres, potentially providing a promising treatment option.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biology
Xue Yang, Ying Wang, Valentina Rovella, Eleonora Candi, Wei Jia, Francesca Bernassola, Pierluigi Bove, Mauro Piacentini, Manuel Scimeca, Giuseppe Sica, Giuseppe Tisone, Alessandro Mauriello, Lixin Wei, Gerry Melino, Yufang Shi
Summary: Natural ageing of organisms and age-related diseases are mainly caused by stem cell ageing and inflammaging. Mesenchymal stem cells (MSCs) have high immune-regulating capacity and are potential candidates for immune-related disease treatment. However, MSC application is not satisfactory for some patients, especially the elderly, possibly due to changes in MSCs with ageing, including reduced cell population and differentiation ability, decreased migratory and homing capacity, and defective immunosuppression. It is important to explore the relationship between inflammaging and aged MSCs in order to prevent age-related diseases and improve the therapeutic effects of MSCs. This review discusses the changes in naturally ageing MSCs mainly from an inflammation perspective and proposes ideas for rejuvenating aged MSCs in future treatments.
Review
Cell Biology
Yelei Cen, Guohua Lou, Jinjin Qi, Min Zheng, Yanning Liu
Summary: Mesenchymal stem cells (MSCs) show promise as an alternative treatment for liver disease due to their ability to regenerate, inhibit fibrosis, and regulate the immune system. Impaired mitochondrial function is a common feature in liver diseases, leading to ATP synthesis dysfunction, decreased respiratory chain activity, and altered mitochondrial dynamics. Recent evidence suggests that MSCs can not only replace damaged cells and have paracrine effects, but also regulate mitochondrial dysfunction in liver disease. This review comprehensively discusses the role of mitochondrial dysfunction in liver disease and how MSCs can target it, as well as recent advances in modifying MSCs to enhance their functions in treating liver disease.
CELL COMMUNICATION AND SIGNALING
(2023)
Review
Engineering, Biomedical
Nityanand Prakash, Jiseong Kim, Jieun Jeon, Siyeon Kim, Yoshie Arai, Alvin Bacero Bello, Hansoo Park, Soo-Hong Lee
Summary: The use of mesenchymal stem cells (MSCs) in clinical applications has significantly increased in the past decade due to their differentiation potential and immunomodulatory properties. However, the heterogeneity among MSC sources, as well as limitations in adult-sourced MSCs, have posed challenges for their effective use. Recent research has focused on generating MSCs from pluripotent stem cells (PSCs), such as induced pluripotent stem cells (iPSCs), to overcome these limitations.
BIOMATERIALS RESEARCH
(2023)
Article
Oncology
Zhenbo Tu, Antoine E. Karnoub
Summary: Mesenchymal stem/stromal cells (MSCs) are a heterogeneous population of fibroblastic progenitor cells that reside in multiple tissues around the body and have the ability to differentiate into various connective tissue cells. They play critical regulatory roles in breast tumor development and progression, participating in multiple aspects of the process.
SEMINARS IN CANCER BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Mythreye Venkatesan, Nicholas Zhang, Benoit Marteau, Yukina Yajima, Nerea Ortiz De Zarate Garcia, Zhou Fang, Thomas Hu, Shuangyi Cai, Adam Ford, Harrison Olszewski, Andrew Borst, Ahmet F. Coskun
Summary: Organelles play important roles in human health and disease by maintaining homeostasis, regulating growth and aging, and generating energy. Studying the distribution of organelles at the single-cell level is crucial for understanding cellular function. In this study, rapid multiplexed immunofluorescence (RapMIF) was used to investigate the spatial organization of organelle proteins in mesenchymal stem cells (MSCs) from bone marrow (BM) and umbilical cord (UC). The results showed that UC MSCs exhibited higher organelle expression and spatially spread distribution of mitochondria compared to BM MSCs, providing insights into the interrelations between organelles and the characteristics of MSC subtypes.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Elia Bari, Fulvio Tartara, Fabio Cofano, Giuseppe di Perna, Diego Garbossa, Sara Perteghella, Marzio Sorlini, Delia Mandracchia, Lorella Giovannelli, Paolo Gaetani, Maria Luisa Torre, Lorena Segale
Summary: The study found that the mesenchymal stem cell-secretome Lyosecretome has a significant improvement effect on the osteoinductive and osteoconductive properties of titanium cages, leading to increased mineralized matrix when used during culturing.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Physiology
Sara Petrillo, Tullio Genova, Giorgia Chinigo, Ilaria Roato, Giorgia Scarpellino, Joanna Kopecka, Fiorella Altruda, Emanuela Tolosano, Chiara Riganti, Federico Mussano, Luca Munaron
Summary: This study reveals the molecular mechanism underlying the interaction between endothelial cells and osteodifferentiating stem cells during bone tissue renewal. Specifically, endothelial cells induce osteodifferentiation in stem cells through the secretion of soluble factors, while stem cells promote vascular network formation by recruiting endothelial cells. Moreover, endothelial cells enhance anaerobic glycolysis in stem cells without compromising their oxidative metabolic shift required for osteodifferentiation.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Immunology
Kimia Kardani, Judit Sanchez Gil, Samuel D. Rabkin
Summary: Glioblastoma (GBM) is a highly lethal cancer with poor prognosis. Glioblastoma stem-like cells (GSCs), which possess self-renewal and tumor-initiating abilities, play a crucial role in driving tumor heterogeneity and resistance to therapy. Oncolytic herpes simplex viruses (oHSVs), genetically-engineered to selectively target and kill cancer cells, including GSCs, have shown promise in clinical trials and can be combined with other therapies to enhance treatment efficacy.
FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Maya A. Dymova, Natalia S. Vasileva, Elena Kuligina, Yulya Savinovskaya, Nikita D. Zinchenko, Alisa B. Ageenko, Sergey Mishinov, Grigory A. Stepanov, Vladimir A. Richter, Dmitry Semenov
Summary: The formation of neurospheres in GBM cells is accompanied by changes in the expression of miRNAs and their target mRNAs. Upregulated miRNAs are associated with decreased levels of their target mRNAs, while downregulated miRNAs are associated with increased levels of their target mRNAs. These miRNAs and their target mRNAs may play important roles in the regulation of malignant growth and invasion in GBM.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2022)
Article
Immunology
Nabila Boukelmoune, Geoffroy Laumet, Yongfu Tang, Jiacheng Ma, Itee Mahant, Susmita K. Singh, Cora Nijboer, Manon Benders, Annemieke Kavelaars, Cobi J. Heijnen
Summary: The study showed that nasal administration of mesenchymal stem cells can completely reverse chemotherapy-induced peripheral neuropathy and associated mitochondrial abnormalities. This reversal is achieved through the production of IL-10, which is crucial for resolving mechanical allodynia, recovering nerve fibers, and restoring mitochondrial function.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Biochemistry & Molecular Biology
Yizuo Song, Ruyi Li, Miaomiao Ye, Chunyu Pan, Lihong Zheng, Zhi-wei Wang, Xueqiong Zhu
Summary: This study found that MSCs from different tissues exhibit different chemotaxis towards cervical cancer cells, with chorion-derived MSC (CD-MSC) showing the strongest tropic capacity. The CXCL12/CXCR4 pathway was identified to contribute to the differential chemotaxis of MSCs to cervical cancer cells.
Article
Biochemistry & Molecular Biology
Katarzyna Stefanska, Lucie Nemcova, Malgorzata Blatkiewicz, Wojciech Pienkowski, Marcin Rucinski, Maciej Zabel, Paul Mozdziak, Marzenna Podhorska-Okolow, Piotr Dziegiel, Bartosz Kempisty
Summary: Wharton's jelly-derived mesenchymal stem cells (WJ-MSCs) possess multilineage differentiation potential and specific surface markers. In this study, RNA sequencing analysis revealed differentially expressed genes associated with apoptosis and identified upregulation of ZBTB16 and FOXO1, as well as downregulation of TGFA, in all differentiated groups. Additionally, several novel marker genes related to WJ-MSCs differentiation were identified. This study sheds light on the molecular mechanisms involved in long-term culture and differentiation of WJ-MSCs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Tomas Smutny, Jan Dusek, Lucie Hyrsova, Jana Nekvindova, Alzbeta Horvatova, Stanislav Micuda, Sabine Gerbal-Chaloin, Petr Pavek
ACTA PHARMACEUTICA SINICA B
(2020)
Article
Food Science & Technology
Karen Lambert, Claire Gondeau, Philippe Briolotti, Valerie Scheuermann, Martine Daujat-Chavanieu, Franck Aimond
FOOD AND CHEMICAL TOXICOLOGY
(2020)
Review
Biochemistry & Molecular Biology
Jean Nakhle, Anne-Marie Rodriguez, Marie-Luce Vignais
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2020)
Article
Cell Biology
Nicolas Creusot, Matthieu Gassiot, Elina Alaterre, Barbara Chiavarina, Marina Grimaldi, Abdelhay Boulahtouf, Lucia Toporova, Sabine Gerbal-Chaloin, Martine Daujat-Chavanieu, Alice Matheux, Roger Rahmani, Celine Gongora, Alexandre Evrard, Philippe Pourquier, Patrick Balaguer
Article
Biology
Rozenn Riou, Meriem Ladli, Sabine Gerbal-Chaloin, Pascale Bossard, Angelique Gougelet, Cecile Godard, Robin Loesch, Isabelle Lagoutte, Franck Lager, Julien Calderaro, Alexandre Dos Santos, Zhong Wang, Frederique Verdier, Sabine Colnot
Review
Cell Biology
Amel Nasri, Florent Foisset, Engi Ahmed, Zakaria Lahmar, Isabelle Vachier, Christian Jorgensen, Said Assou, Arnaud Bourdin, John De Vos
Summary: Mesenchymal cells play crucial roles in lung development, regeneration, and diseases, especially in chronic obstructive pulmonary disease.
Article
Cell Biology
Abrar Ul Haq Khan, Hamideh Salehi, Catherine Alexia, Jose M. Valdivielso, Milica Bozic, Isabel C. Lopez-Mejia, Lluis Fajas, Sabine Gerbal-Chaloin, Martine Daujat-Chavanieu, Delphine Gitenay, Martin Villalba
Summary: This study shows that glucose starvation or sustained pyruvate dehydrogenase activation can induce genetic remodeling to enhance fatty acid oxidation in cells. The signaling pathway MEK5/ERK5 plays a key role in this process, regulating lipid transport, activation of acyl-CoA synthetase long-chain family members, and induction of acyl-CoA dehydrogenases.
Review
Biochemistry & Molecular Biology
Yujie Song, Christian Jorgensen
Summary: This review highlights the potential of mesenchymal stromal cells (MSCs) in treating osteoarthritis (OA), focusing on their chondrogenic and immunomodulatory potential. The review provides an overview of the effects of MSCs in preclinical and clinical studies of OA treatment, comparing different MSC sources. Furthermore, the review summarizes the current evidence for the assessment of cartilage in OA using magnetic resonance imaging (MRI) and second-look arthroscopy after MSC therapy.
Article
Biochemistry & Molecular Biology
Lenka Jourova, Eva Anzenbacherova, Zdenek Dostal, Pavel Anzenbacher, Philippe Briolotti, Emilie Rigal, Martine Daujat-Chavanieu, Sabine Gerbal-Chaloin
Summary: Modulation of gut microbiome composition as a therapeutic strategy may affect hepatic drug metabolism through microbial metabolites.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2022)
Review
Biochemistry & Molecular Biology
Giuliana Minani Bertolino, Marie Maumus, Christian Jorgensen, Daniele Noel
Summary: Extracellular vesicles (EVs) isolated from induced pluripotent stem cells (iMSCs) show promise in regenerative medicine for the treatment of various diseases. However, the heterogeneity between MSC donors may lead to batch-to-batch variability in the use of EVs as cell-free therapeutic agents.
Review
Cell Biology
Martine Daujat-Chavanieu, Sabine Gerbal-Chaloin
Review
Pharmacology & Pharmacy
Martine Daujat-Chavanieu, Marta Kot
PHARMACOLOGY & THERAPEUTICS
(2020)