Article
Multidisciplinary Sciences
Hadrien Bense, Martin van Hecke
Summary: The study focuses on the nonlinear response of complex materials, revealing intricate transition pathways that can be precisely observed and manipulated through the compression of elastic sheets. Each state in the pathway can be encoded by binary bits, and the strength of their interactions plays a crucial role in determining the pathways.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Biochemistry & Molecular Biology
Misuzu Ueki, Masayuki Iwamoto
Summary: This study established an experimental procedure to evaluate membrane curvature-induced structural changes in the potassium channel KcsA, showing that a large membrane curvature significantly affects the activation gate conformation of the channel.
Article
Biochemistry & Molecular Biology
Aubrey Weigel, Chi-Lun Chang, Gleb Shtengel, C. Shan Xu, David P. Hoffman, Melanie Freeman, Nirmala Iyer, Jesse Aaron, Satya Khuon, John Bogovic, Wei Qiu, Harald F. Hess, Jennifer Lippincott-Schwartz
Summary: Cellular versatility relies on accurate trafficking of proteins to their organelles, particularly through the secretory pathway which involves an elaborate network of interconnected tubules originating from the endoplasmic reticulum. COPII protein regulates cargo entry at the ER neck region, while COPI protein escorts tubular entities towards the Golgi apparatus via microtubule-directed movement.
Article
Biophysics
Henry J. Lessen, Kayla C. Sapp, Andrew H. Beaven, Rana Ashkar, Alexander J. Sodt
Summary: Membrane reshaping is crucial in biological processes, and the chemical composition of lipid membranes plays a significant role in determining their mechanical properties and shape. This study highlights the importance of specific chemical interactions between lipids in multicomponent bilayers and the impact of these interactions on bilayer stiffness. It also identifies two mechanisms of bilayer softening: diffusional softening and conformational softening.
BIOPHYSICAL JOURNAL
(2022)
Article
Mechanics
Umesh Kumar, Rashmi Ranjan Das
Summary: The research focuses on analyzing adhesion failures in non-planar T-joint regions, identifying saddle points as the most vulnerable areas for adhesion/cohesion failures. Computational fracture mechanics show that adhesion failure plays a significant role in joint fractures, leading to mode-I fracture around saddle points. Different stacking sequences can improve joint resistance against micro and macro failure ranges.
COMPOSITE STRUCTURES
(2021)
Review
Biochemistry & Molecular Biology
Marcus K. Dymond
Summary: Lipid monolayer spontaneous curvatures play a key role in determining the curvature elastic energy in a lipid aggregate, influencing membrane protein function and phospholipid regulatory pathways. Despite the theoretical existence of many different lipid molecules, only a few lipid spontaneous curvatures have been determined so far.
CHEMISTRY AND PHYSICS OF LIPIDS
(2021)
Article
Engineering, Multidisciplinary
Pan Gao, Jiepeng Liu, Xuanding Wang, Yubo Jiao, Wenchen Shan
Summary: This article quantitatively investigates the concrete damage of circular CFST columns during axial compression based on the acoustic emission (AE) technique. It proposes a new method for processing and analyzing AE parameters, which effectively enhances the dimensionality of real-time monitoring information on the damage of concrete filled in the steel tube. The study also includes a sensitivity analysis of the axial compression process and an analysis of the crack evolution mechanism using the Improved b (Ib) value calculated from the AE amplitudes.
STRUCTURAL HEALTH MONITORING-AN INTERNATIONAL JOURNAL
(2023)
Article
Chemistry, Physical
Faxing Ding, Changbin Liao, En Wang, Fei Lyu, Yunlong Xu, Yicen Liu, Yuan Feng, Zhihai Shang
Summary: This paper investigated the composite behavior of concrete-filled circular aluminum alloy tubular stub columns under axial compression, proposing a composite action model and design formula based on finite element analysis. The predicted results were in good agreement with experimental and FE analytical results, indicating the proposed formula is more accurate and convenient to use compared to current design methods.
Article
Engineering, Multidisciplinary
Pan Gao, Jiepeng Liu, Xuanding Wang, Yubo Jiao, Wenchen Shan
Summary: This study evaluated the damage characteristics of concrete in CFST columns using the acoustic emission (AE) technique. The results showed that the AE results could divide the compression process of specimens into five stages, and the cumulative AE energy, amplitude, and hits were found to be linearly related to the applied load. Additionally, the damage percentage of specimens at different stages was influenced by the width and width-to-thickness ratio.
Article
Engineering, Civil
Xi-Feng Yan, Yan-Gang Zhao, Siqi Lin, Haizhong Zhang
Summary: The study experimentally investigated the confining stress paths (CSPs) of confined concrete in circular CFDST stub columns and their impact on compressive strength, finding that CSPs induced by the external tube are significantly influenced by column variables, while those induced by the internal tube show no obvious trend. Based on the experimental results, a compressive strength model considering the CSP effect was developed for estimating the ultimate strength of CFDST columns. Comparisons with existing models show a higher accuracy of predictions for the proposed model.
THIN-WALLED STRUCTURES
(2021)
Article
Multidisciplinary Sciences
Kang-Cheng Liu, Hudson Pace, Elin Larsson, Shakhawath Hossain, Aleksei Kabedev, Ankita Shukla, Vanessa Jerschabek, Jagan Mohan, Christel A. S. Bergstrom, Marta Bally, Christian Schwieger, Madlen Hubert, Richard Lundmark
Summary: Caveolae, important plasma membrane invaginations, are shaped by the coat protein Cavin1. This study reveals the mechanism of Cavin1 assembly at the membrane interface, involving initial PI(4,5)P-2-dependent membrane adsorption, subsequent partial separation and membrane insertion. This intricate mechanism facilitates membrane curvature generation and dynamic assembly-disassembly of Cavin1 at the membrane.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Julia Bahja, Marcus K. Dymond
Summary: Oxidative stress affects lipid membranes by reducing stored curvature elastic energy, which can potentially be mitigated by compounds that increase stored curvature elastic energy; Age-related changes in lipid composition may represent a homeostatic response of cells to compensate for the accumulation of in vivo lipid oxidation products.
FREE RADICAL BIOLOGY AND MEDICINE
(2021)
Review
Biochemistry & Molecular Biology
Marina N. Iriondo, Asier Etxaniz, Zurine Anton, L. Ruth Montes, Alicia Alonso
Summary: Autophagy is a crucial process for cell self-repair and survival, involving the formation of autophagosomes that deliver cargo for degradation and re-use. The complex event of autophagosome formation requires specific proteins and membrane biogenesis, with curvature playing a key role in the process.
BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES
(2021)
Article
Biochemistry & Molecular Biology
Rose Whiting, Pangaea W. Finn, Andrew Bogard, Fulton McKinney, Dallin Pankratz, Aviana R. Smith, Elen A. Gardner, Daniel Fologea
Summary: Studies have shown that the curvature of lipid membranes influences permeability, with most experiments using flat membranes ignoring this physiological relevance. By adapting an experimental system with differential hydrostatic pressure on a lipid membrane and measuring capacitance and conductance, a strong correlation between membrane geometry changes and conductance was observed. This system may help understand the intricate relationship between membrane mechanics, cellular functionalities, and mechanical stimulation effects.
Article
Engineering, Mechanical
Choon-Peng Chng, Yoel Sadovsky, K. Jimmy Hsia, Changjin Huang
Summary: The physico-mechanical properties of nanoscale lipid vesicles play a crucial role in their interaction with biological systems. The interplay between vesicle size and stiffness is essential for understanding their biological functions and optimizing diagnostics and therapeutics. Molecular dynamics simulations reveal that the softening of nano-vesicles is closely related to changes in membrane structure, providing a valuable insight for further exploration in biophysics and biomedical applications of nano-vesicles.
EXTREME MECHANICS LETTERS
(2021)
Article
Multidisciplinary Sciences
Dmitrii Chalin, Charlotte Bureau, Andrea Parmeggiani, Sergei Rochal, Karima Kissa, Ivan Golushko
Summary: This study investigates the mechanism of blood cell formation and the role of mechanical stress in this process, highlighting the suitability of the zebrafish model for such studies. By developing a new DA micromechanical model, the researchers explored the mechanisms driving the shape changes of the DA and individual ECs.
SCIENTIFIC REPORTS
(2021)
Correction
Multidisciplinary Sciences
Dmitrii Chalin, Charlotte Bureau, Andrea Parmeggiani, Sergei Rochal, Karima Kissa, Ivan Golushko
SCIENTIFIC REPORTS
(2021)
Article
Nanoscience & Nanotechnology
Olga Konevtsova, Dania S. Roshal, Sergei B. Rochal
Summary: This study develops a theory of complex Moire patterns in bilayer nanostructures and explains the physicochemical regularities of coating formation. By introducing an outer tubular virtual lattice, the successful sorting of single-walled carbon nanotubes is clarified. The study also identifies other organic molecules and polymers suitable for effective carbon nanotube sorting.
Article
Materials Science, Biomaterials
Olga V. Konevtsova, Ivan Yu. Golushko, Rudolf Podgornik, Sergei B. Rochal
Summary: Using recent Zika virus structural data, researchers have discovered a hidden symmetry of protein order in the virus shells, which challenges the existing model of capsid structures. The study also proposed a new structural model for non-infectious subviral particles and explained the transition of the outer shell from a trimeric to a dimeric state.
BIOMATERIALS SCIENCE
(2022)
Article
Materials Science, Multidisciplinary
Pavel Evgenjevich Timoshenko, Alexander Lerer, Sergei Bernardovich Rochal
Summary: This study focuses on single-walled carbon nanotubes (SWCNTs) with a length of 1-50 μm and finds that their surface plasmon-polariton (SPP) resonance occurs within the terahertz frequency range, making them suitable for designing frequency-selective surfaces (FSS). By solving a numerical model of electromagnetic wave diffraction on a two-dimensional periodic SWCNT lattice, the frequency dependence of reflecting and transmitting electromagnetic waves near the SPP resonance for FSSs is studied. The results show that the resonances are within the lower-frequency part of the terahertz range.
INTERNATIONAL JOURNAL OF SMART AND NANO MATERIALS
(2023)
Article
Chemistry, Multidisciplinary
Olga V. Konevtsova, Ivan Yu. Golushko, Rudolf Podgornik, Sergei B. Rochal
Summary: Unlike other viruses, Cypoviruses have a doubly protected genome due to being embedded in a perfect polyhedrin crystal. A symmetry-based approach is proposed to predict the interface structure between the capsids and the crystal. The study reveals a remarkable match between the surfaces of Cypovirus and the polyhedrin matrix, highlighting the important role of VP5 proteins in embedding the virus and discussing the relationship between protein activity and superstructure formation.
NANOSCALE ADVANCES
(2023)
Article
Materials Science, Multidisciplinary
D. V. Chalin, S. B. Rochal
Summary: In this study, a phenomenological crystallization theory of spherical nanoclusters is developed, and a method based on constructing irreducible octahedral density functions is proposed to predict the structures of spherical nanoobjects. The theory explains the structures of various metal nanoclusters, metal-organic polyhedra, and membrane protein polyhedral nanoparticles, and predicts more complex chiral and achiral spherical structures. The relationship between the constructed octahedral functions and spherical lattices is also discussed.
Article
Chemistry, Physical
Sergei B. Rochal, Olga V. Konevtsova, Ivan Yu. Golushko, Rudolf Podgornik
Summary: Understanding the principles of protein arrangement in viral capsids and similar protein shells can lead to the development of new antiviral strategies and the design of artificial protein cages. By analyzing small spherical shells made from a single type of protein, researchers have discovered correlations between protein mass centers and packing arrangements, as well as proposed models for different shapes and anisotropy of proteins. The study also reveals energy and symmetry reasons controlling capsid structures, including handedness and interprotein bonds.
Article
Chemistry, Multidisciplinary
Sergei B. Rochal, Olga Konevtsova, Daria S. Roshal, Anze Bozic, Ivan Yu Golushko, Rudolf Podgornik
Summary: Understanding the principles and mechanisms of protein packing and morphological transformations in virus shells is crucial for developing antiviral strategies. This study focuses on icosahedral viral capsids and models them as symmetrical groups of identical particles, which leads to packings similar to real capsids. The study also investigates the structural changes and electrostatic charge modifications in protein trimers during the maturation of a Flavivirus shell.
NANOSCALE ADVANCES
(2022)
Article
Multidisciplinary Sciences
Daria S. Roshal, Marianne Martin, Kirill Fedorenko, Ivan Golushko, Virginie Molle, Stephen Baghdiguian, Sergei B. Rochal
Summary: This study demonstrates that the hyper-proliferation of cancer cells disrupts the universal paradigm of polygonal distribution in epithelial cells, resulting in randomly organized structures. It also shows that normal epithelial cells have more ordered structures due to their lower proliferation rates and more effective relaxation of mechanical stress.
JOURNAL OF THE ROYAL SOCIETY INTERFACE
(2022)
Article
Materials Science, Multidisciplinary
D. Chalin, D. Levshov, A. E. Myasnikova, S. B. Rochal
Summary: We develop a general theory of electron band structure for twisted bilayer graphene and double-walled carbon nanotubes within the framework of the tight-binding approximation. We propose a method to construct effective Hamiltonians that accurately describe the low-energy spectrum of these materials. We also discuss the flattening of low-energy bands with decreasing twist angle.
