Review
Biochemistry & Molecular Biology
Francisca Felix, Catarina C. V. Oliveira, Elsa Cabrita
Summary: The study focuses on the effects of novel antioxidants in protecting fish cells, highlighting the importance of antioxidants in fish reproduction and their potential in improving gamete quality. The review discusses various types of antioxidants and their mechanisms of action, with a particular emphasis on the protective role of melatonin in preventing oxidative stress damage on fish spermatozoa.
Article
Veterinary Sciences
Sina Salavati, Asghar Mogheiseh, Saeed Nazifi, Atefeh Amiri, Behrooz Nikahval
Summary: This study found that administering melatonin to dogs before and after ovariohysterectomy can increase antioxidant enzyme concentrations and decrease oxidative stress levels.
BMC VETERINARY RESEARCH
(2021)
Review
Plant Sciences
Sameer H. Qari, Muhammad Umair Hassan, Muhammad Umer Chattha, Athar Mahmood, Maria Naqve, Muhammad Nawaz, Lorenzo Barbanti, Maryam A. Alahdal, Maha Aljabri
Summary: Cold stress is a major constraint for plant growth and development. The application of melatonin, a critical bio-stimulant, has been found to improve plant performance under cold stress by maintaining membrane integrity, water uptake, photosynthetic efficiency, and antioxidant activities.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Nutrition & Dietetics
Haitao Qu
Summary: The Oxidative Balance Score (OBS), a systematic tool to assess the effects of diet and lifestyle on oxidative stress, was found to be negatively correlated with periodontitis in US adults. Participants in the highest quartile of OBS had a 29% lower risk of periodontitis compared to those in the lowest quartile.
FRONTIERS IN NUTRITION
(2023)
Article
Environmental Sciences
Mohamed Amr El-Missiry, Sameh Shabana, Sara J. Ghazala, Azza I. Othman, Maggie E. Amer
Summary: The study demonstrated that melatonin has potential neuroprotective properties in reducing inflammation, oxidative stress, and apoptosis in the brains of rats exposed to gamma radiation. This suggests that melatonin may have beneficial effects in clinical and occupational settings involving radiation exposure. Further research is needed to fully understand its neuroprotective effects in humans.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2021)
Review
Immunology
Muhammad Ikrann, Hyun Young Park, Tahir Ali, Myeong Ok Kim
Summary: Melatonin has shown potential regulatory effects against TBI-induced neurodegeneration, but further research is needed to better understand and utilize its therapeutic benefits.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Maria Jose Lopez-Martinez, Damian Escribano, Alba Ortin-Bustillo, Lorena Franco-Martinez, Luis Guillermo Gonzalez-Arostegui, Jose Joaquin Ceron, Camila Peres Rubio
Summary: This study aimed to evaluate the changes in salivary biomarkers of redox status in pigs with experimentally induced sepsis. The results showed that sepsis caused significant changes in various antioxidant capacity markers in pig saliva, suggesting the potential use of these biomarkers for monitoring pig health.
Article
Psychiatry
Gianluca Pandolfo, Giovanni Genovese, Antonio Bruno, Domenica Campolo, Valeria Tigano, Mariateresa Cristani, Marco Casciaro, Giovanni Pioggia, Sebastiano Gangemi
Summary: The pathophysiology of schizophrenia is still not well understood. Genetic factors and oxidative stress play key roles in its development and progression. Oxidative stress leads to the continuous production of oxidation products, such as AGEs and AOPPs, which interact with their receptors, amplifying the production of reactive oxygen species (ROS) and pro-inflammatory cytokines. In this study, plasma levels of AGEs and AOPPs were found to be significantly higher in schizophrenia patients compared to controls, confirming their involvement in mental disorders. Antioxidant nutraceuticals and a healthy lifestyle could reduce oxidative stress and alleviate schizophrenia symptoms.
PSYCHIATRY RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Vinicius Ruan Neves dos Santos, Deborah Ribeiro Frazao, Railson de Oliveira Ferreira, Paulo Fernando Santos Mendes, Daiane Claydes Baia-da-Silva, Deiweson Souza-Monteiro, Leonardo Oliveira Bittencourt, Joao Daniel Mendonca de Moura, Jose Messias Perdigao, Bruno Jose Brito Teixeira, Everton Luiz Pompeu Varela, Gabriela de Souza Balbinot, Sandro Percario, Herve Rogez, Cassiano Kuchenbecker Rosing, Fabricio Mezzomo Collares, Rafael Rodrigues Lima
Summary: The study found that supplementation with acai could increase blood antioxidant capacity, reduce lipid peroxidation, and decrease alveolar bone loss caused by experimental periodontitis. Furthermore, acai could modulate oxidative biochemistry and bone microstructure.
Article
Biology
Salima Senouci, Dalila Ait Yahia, Djamila Bouziane, Mahmoud Mehadj, Willy J. Malaisse
Summary: The study found that salivary levels of MDA and carbonyls were elevated in periodontitis patients, while TAC, GSH, and uric acid levels were decreased. Furthermore, high levels of TNF-alpha, IL-1 beta, and IgA were also observed in these patients. Clinical indicators had positive correlations with salivary biomarkers, but negative correlations were seen with antioxidants.
Review
Biochemistry & Molecular Biology
Martha Cebile Jobe, Doctor M. N. Mthiyane, Phiwayinkosi V. Dludla, Sithandiwe E. Mazibuko-Mbeje, Damian C. Onwudiwe, Mulunda Mwanza
Summary: Aflatoxin B1 is a harmful substance that can cause liver damage in broiler chickens through oxidative stress and malonaldehyde build-up. Phytochemicals have shown potential therapeutic effects in reducing aflatoxin toxicity by inhibiting the production of reactive oxygen species and enhancing intracellular antioxidant enzymes. Experimental models and database searches have provided evidence supporting the protective role of phytochemicals against aflatoxin-induced cytotoxicity. Activation of Nrf2 and its downstream antioxidant genes may be a potential therapeutic mechanism by which phytochemicals neutralize oxidative stress. Further research is needed to determine the efficacy of phytochemicals as a therapeutic intervention for mycotoxin control in broilers.
Article
Gastroenterology & Hepatology
Josieli R. Colares, Renata M. Hartmann, Elizangela G. Schemitt, Sandielly R. B. Fonseca, Marilda S. Brasil, Jaqueline N. Picada, Alexandre S. Dias, Aline F. Bueno, Claudio A. Marroni, Norma P. Marroni
Summary: The study evaluated the effects of MLT on oxidative stress, inflammatory process, and DNA damage in an experimental model of secondary biliary cirrhosis. Administration of MLT significantly reduced inflammatory markers, oxidative stress levels, and DNA damage in the treated groups.
WORLD JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Veronica M. Sola, Juan J. Aguilar, Adrian Farias, Ana P. Vazquez Mosquera, Maria E. Peralta Lopez, Agata R. Carpentieri
Summary: Melatonin (MEL) has antioxidant properties and promotes osteogenic differentiation. In this study, it was found that MEL increased alkaline phosphatase activity and differentiation of gingival mesenchymal stem cells (GMSCs) into osteoblasts, while protecting GMSCs from oxidative stress-induced damage. These findings suggest the potential use of MEL as a bone-regenerative therapy in periodontal diseases.
CELL BIOCHEMISTRY AND FUNCTION
(2022)
Article
Biochemistry & Molecular Biology
Ailen G. Hvozda Arana, S. Fabian Lerner, Claudia G. Reides, Mario Contin, Valeria Tripodi, Romina M. Lasagni Vitar, Sandra M. Ferreira
Summary: Increasing evidence suggests that glaucoma affects the ocular surface. This study aims to investigate the cellular mechanisms underlying the glaucoma-associated corneal alterations in an animal model. The findings show that glaucoma induces a redox imbalance in the ipsilateral cornea with an adaptive response of the contralateral one.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2023)
Article
Biochemistry & Molecular Biology
Iwona Olszewska-Czyz, Kristina Kralik, Marin Tota, Jelena Prpic
Summary: Periodontitis is a common oral disease caused by bacteria and immune responses. This study shows that the addition of hyaluronic acid to non-surgical periodontal therapy can increase antioxidants in saliva and improve the prognosis and results of periodontal therapy. Additionally, the levels of gingival inflammation and periodontal destruction are closely related to these markers.
