Article
Microbiology
Katherine A. Willard, Ashley P. Barry, Cliff I. Oduor, John Michael Ong'echa, Jeffrey A. Bailey, Ann M. Moormann, Micah A. Luftig
Summary: In this study, we describe an unusual spontaneous lytic phenotype in EBV strains isolated from Kenyan endemic Burkitt lymphoma patients. These findings provide insight into viral and host factors involved in this process and the potential contribution of promiscuous lytic activity to the formation of EBV-associated diseases.
Article
Multidisciplinary Sciences
Deborah K. Johnson, Kaylia M. Reynolds, Brian D. Poole, Matthew D. Montierth, Vera M. Todd, April Barnado, Mary F. Davis
Summary: Patients with autoimmune disorders have altered cancer risks compared to the general population, with a strong association between viral infection and increased cancer risk. SLE and MS patients are more susceptible to viral infections, and preventing viral infections through vaccination may help control cancer risk for these patients.
Review
Virology
Guo-Long Bu, Chu Xie, Yin-Feng Kang, Mu-Sheng Zeng, Cong Sun
Summary: This review article discusses the tropism and molecular mechanism of EBV infection. The interactions between the virus and B cells and epithelial cells differ, and the entry process relies on heterogenous glycoprotein-receptor interactions.
Review
Gastroenterology & Hepatology
Mayo Hirabayashi, Damien Georges, Gary M. Clifford, Catherine de Martel
Summary: In this study, the proportion of Epstein-Barr virus (EBV)-positive gastric cancer was systematically explored. The prevalence of EBV in gastric tumors was 7.5%, higher in men, diffuse type, and proximal region. Developing an effective EBV vaccine could potentially prevent 81,000 EBV-associated gastric cancer cases annually.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Oncology
Mike Dorothea, Jia Xie, Stephanie Pei Tung Yiu, Alan Kwok Shing Chiang
Summary: This review summarizes the oncogenic roles of Epstein-Barr virus (EBV) lytic proteins, which are expressed during the latent and lytic replication cycles of the virus, and categorizes them based on the cancer hallmarks displayed. The oncogenic properties of several EBV lytic proteins are postulated by comparing the evolutionary conserved oncogenic mechanisms in other herpesviruses and oncoviruses.
Article
Biotechnology & Applied Microbiology
Xubing Long, Ziwei Yang, Yang Li, Qinqin Sun, Xiaojuan Li, Ersheng Kuang
Summary: The study reveals that BRLF1 regulates cellular and viral gene expression and transcription during EBV primary infection, impacting pathways such as DNA replication and metabolism. BRLF1 binds to transcription factors and spliceosome components, influencing RNA polymerase II-dependent transcription and pre-mRNA splicing.
Article
Pathology
Sudipta Samanta, Muthukaruppan Swaminathan, Jianing Hu, Khai Tuck Lee, Ajitha Sundaresan, Chuan Keng Goh, Chor Hiang Siow, Kwok Seng Loh, Soh Ha Chan, Joshua K. Tay, Ian Cheong
Summary: The use of immunofluorescence assay for detecting serum Epstein-Barr virus antibodies is the gold standard screening test for nasopharyngeal cancer in high-risk populations. This study demonstrates that integrating deep learning with automated fuzzy inference can improve the scalability and accuracy of NPC detection.
AMERICAN JOURNAL OF PATHOLOGY
(2022)
Article
Immunology
Mariann Gyoengyoesi, Dominika Lukovic, Julia Mester-Tonczar, Katrin Zlabinger, Patrick Einzinger, Andreas Spannbauer, Victor Schweiger, Katharina Schefberger, Eslam Samaha, Jutta Bergler-Klein, Martin Riesenhuber, Christian Nitsche, Christian Hengstenberg, Patrick Mucher, Helmuth Haslacher, Monika Breuer, Robert Strassl, Elisabeth Puchhammer-Stoeckl, Christian Loewe, Dietrich Beitzke, Ena Hasimbegovic, Thomas A. Zelniker
Summary: This study evaluated the reactivation of parvovirus-B19 and Herpesviridae family members in patients with long-COVID syndrome and found that vaccination with monovalent COVID-19 vaccines was associated with reduced fatigue and multiorgan symptoms. It also led to lower levels of DNA virus-related IgM, plasma IgG subfractions, cytomegalovirus IgG and IgM, and EBV IgM titers.
Article
Microbiology
Guillaume N. Fiches, Zhenyu Wu, Dawei Zhou, Ayan Biswas, Tai-Wei Li, Weili Kong, Maxime Jean, Netty G. Santoso, Jian Zhu
Summary: Understanding the dynamic interaction between KSHV and host metabolic pathways is important for developing therapies for KSHV-associated malignancies. In this study, we showed that KSHV modulates polyamine metabolism to promote eIF5A hypusination and translation of critical KSHV proteins. We also demonstrated that inhibitors targeting these pathways can effectively suppress KSHV infection. These findings provide new insights into KSHV-induced alterations of host metabolism and offer potential therapeutic targets for treating KSHV-associated malignancies.
Article
Virology
Mingqian Xu, Liang Zhang, Jinfu Feng, Shuaibing Yang, Yixuan Wang, Yuyi Wang, Meiyang Chen, Li Zhou, Junjie Zhang, Qingsong Qin
Summary: EBV-associated gastric cancer is a subtype of gastric cancer characterized by the presence of EBV genome and limited viral gene expression in malignant epithelial cells. Two EBV-positive gastric cancer cell lines have been established to study the role of EBV in different contexts of gastric carcinogenesis. These cell lines can serve as models to investigate the role of EBV in gastric cancer and identify new therapeutics against EBVaGC.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Medicine, Research & Experimental
Meichun Zeng, Qingjun Jia, Jingjing Chen, Liming Xu, Li Xie, Qinglin Cheng, Qingchun Li, Ming Xiao, Zijian Fang
Summary: The relationship between plasma EBV-DNA load (PEDL) and Epstein-Barr virus (EBV)-encoded small RNA (EBER) during the early treatment of lymphoma is not well-established. This study found that although EBER affects the levels of PEDL, there is poor concordance between EBER and qualitative analysis of PEDL (qPEDL).
CLINICAL AND EXPERIMENTAL MEDICINE
(2023)
Article
Multidisciplinary Sciences
Munetoshi Hinata, Tetsuo Ushiku
Summary: A histology-based deep learning model was constructed to efficiently screen EBV and MSI/dMMR subtypes in gastric cancers, showing high accuracy in detecting the subgroup and highlighting intraepithelial lymphocytosis as a discriminative characteristic shared by EBV and MSI/dMMR tumors. This model offers a potential economical and less time-consuming alternative for stratifying patients who respond to ICIs.
SCIENTIFIC REPORTS
(2021)
Article
Biology
Jessica A. Farrell, Kelsey Yetsko, Liam Whitmore, Jenny Whilde, Catherine B. Eastman, Devon Rollinson Ramia, Rachel Thomas, Paul Linser, Simon Creer, Brooke Burkhalter, Christine Schnitzler, David J. Duffy
Summary: ChHV5 is shed into the water column, likely as a transmission route for sea turtle fibropapillomatosis; shedding dynamics and tumor burden are correlated. The virus is latent in fibropapillomatosis, and high viral loads primarily come from latent virus.
COMMUNICATIONS BIOLOGY
(2021)
Article
Immunology
Yaxian Ma, Peiling Zhang, Yuhan Bao, Hui Luo, Jiachen Wang, Liang Huang, Miao Zheng
Summary: Chronic active Epstein-Barr virus (CAEBV) disease is a high-mortality disease characterized by persistent infectious mononucleosis-like symptoms. This study analyzed the outcomes of PD-1 inhibitors treatment for CAEBV patients and found that the treatment had a high response rate and tolerable toxicity.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Virology
Ting Shi, Linlin Huang, Zhengrong Chen, Jianmei Tian
Summary: This study investigated the characteristics of primary EBV infection and reactivation in children in Suzhou, China, finding that primary EBV infection was more common in children aged 36 to <72 months and often led to infectious mononucleosis. Reactivation of EBV mainly occurred in children aged 8 to <36 months and was identified as a risk factor for hemophagocytic lymphohistiocytosis (HLH). Among reactivated patients, HLH had a higher viral load compared to EBV infection and respiratory infection.
JOURNAL OF MEDICAL VIROLOGY
(2021)
Review
Endocrinology & Metabolism
Jose Augusto Sgarbi, Laura Sterian Ward
Summary: The treatment decision for subclinical hypothyroidism (Shypo) should take into account a thorough investigation of the patient's condition, integrating relevant clinical data such as TSH levels, age, quality of life, comorbidities, and cardiovascular risk. A more cautious and conservative approach is needed for older and frail patients with the risk of treatment potentially outweighing the benefits.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2021)
Article
Endocrinology & Metabolism
Karina Colombera Peres, Larissa Teodoro, Lais Helena Pereira Amaral, Elisangela Souza Teixeira, Icleia Siqueira Barreto, Leandro Luiz Lopes de Freitas, Valdemar Maximo, Ligia Montalli Assumpcao, Natassia Elena Bufalo, Laura Sterian Ward
Summary: This study identified SNPs and gene expression changes associated with aggressiveness of PTC; TGFB1 polymorphism rs1800472 may contribute to PTC aggressiveness; Evaluation of TGFB1 and TGFBR1 mRNA levels may aid in identifying malignancy in thyroid nodules.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2021)
Letter
Oncology
Reydson Alcides de Lima-Souza, Joao Figueira Scarini, Erika Said Abu Egal, Livia Ramalho Crescencio, Jezreel Corre da Costa, Mario Fernandez Sobral Silva, Alfio Jose Tincani, Rogerio Oliveira Gondak, Albina Altemani, Fernanda Viviane Mariano
Summary: A 60-year-old male patient with Secretory Carcinoma (SC) was diagnosed based on pathological examination of tumor cells secreting eosinophilic material. The immunohistochemical panel confirmed the diagnosis as Secretory Carcinoma ex pleomorphic adenoma (SCXPA) due to the positivity for specific markers.
Editorial Material
Oncology
Lucas Leite Cunha, Guilherme Augusto Barcelos Domingues, Elaine Cristina Morari, Fernando Augusto Soares, Jose Vassallo, Laura Sterian Ward
Summary: The study indicates that the immune microenvironment may be correlated with the differentiation status of thyroid cancer. IL-6 positivity is associated with infiltration in malignant tumors. This concept could assist in determining patients who require more attention.
CANCER CELL INTERNATIONAL
(2021)
Article
Dentistry, Oral Surgery & Medicine
Reydson Alcides de Lima-Souza, Joao Figueira Scarini, Luccas Lavareze, Carolina Emerick, Livia Ramalho Crescencio, Romenia Ramos Domingues, Adriana Franco Paes Leme, Bruno Augusto Linhares Almeida Mariz, Debora Campanella Bastos, Renato Assis Machado, Alfio Jose Tincani, Andre Del Negro, Carlos Takahiro Chone, Luiz Paulo Kowalski, Erika Said Abu Egal, Albina Altemani, Fernanda Viviane Mariano
Summary: This study analyzed the proteomic profile of salivary pleomorphic adenoma (PA) and carcinoma ex pleomorphic adenoma (CXPA) samples, and identified seven potential protein signatures that may be associated with the acquisition of a malignant phenotype.
Article
Oncology
Joao Figurira Scarini, Bruno Augesto Linhares Almeida Mariz, Reydson Alcides de Lima-Souza, Luccas Lavareze, Carolina Emerick, Alfio Jose Tincani, Erika Said Abu Egal, Albina Altemani, Fernanda Vivane Mariano
Summary: Spindle cell carcinoma is a rare variant of squamous cell carcinoma that has carcinomatous and sarcomatous components. This study reported a challenging morphological diagnosis of spindle cell carcinoma, with specific immunohistochemical markers showing positive and negative results.
Article
Ophthalmology
Reydson Alcides De Lima-Souza, Natalia de Magalhaes Rodrigues, Joao Figueira Scarini, Mario Fernandez Sobral Silva, Alfio Jose Tincani, Erika Said Abu Egal, Albina Altemani, Fernanda Viviane Mariano
Summary: The study revealed higher expression of markers associated with glycolytic and lipid metabolism in CXPA tumor tissue samples, indicating a potential metabolic shift towards lipogenesis in cancer cells.
INTERNATIONAL OPHTHALMOLOGY
(2022)
Article
Anesthesiology
Jose Alexandre Colli Neto, Artur Udelsmann, Gilson Barreto, Alfio Jose Tincani
BRAZILIAN JOURNAL OF ANESTHESIOLOGY
(2022)
Review
Oncology
Lucas Leite Cunha, Laura Sterian Ward
Summary: Thyroid cancer provides a valuable model for studying tumor immune microenvironment due to its immune response characteristics. The cellular composition of the microenvironment is associated with the clinical aggressiveness of the cancer, and genetic signatures can be used to develop prognostic models. Immunotherapy shows promise as a treatment strategy, especially for advanced thyroid cancer, but further research is needed to improve its effectiveness.
ENDOCRINE-RELATED CANCER
(2022)
Review
Immunology
Lucas Leite Cunha, Victor Alexandre dos Santos Valsecchi, Laura Sterian Ward
Summary: The immune response is remodeled with aging, which is called immunosenescence. Some scientists believe immunosenescence is an adaptation of the immune system to the aging environment, while others think aging leads to chronic inflammation. Studying immunosenescence can bring practical innovations to medicine and the health system.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Endocrinology & Metabolism
Laura Sterian Ward, Rafael Selbach Scheffel, Ana O. Hoff, Carolina Ferraz, Fernanda Vaisman
Summary: Advancements in diagnostic methods and understanding of molecular pathophysiology have led to individualized management of patients with thyroid cancer. Patients with papillary thyroid carcinoma (PTC) are considered to have low mortality and disease persistence/recurrence risk, resulting in less invasive or intensive therapies. This article provides a position statement based on recent evidence, guiding the management decisions for low-risk PTC patients.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2022)
Article
Endocrinology & Metabolism
Guilherme Augusto Barcelos Domingues, Marina Malta Letro Kizys, Carolina Castro Porto Silva Janovsky, Rui Monteiro de Barros Maciel, Magnus Regios Dias-da-Silva, Joao Roberto Maciel Martins, Cleber Pinto Camacho, Lucas Leite Cunha
Summary: This article reports the genetic assessment of a 20-year-old female patient diagnosed with a cribriform-morular variant of papillary thyroid carcinoma and familial adenomatous polyposis. The study found an overrepresentation of single nucleotide variants in extracellular matrix interactions and cell adhesion genes, while an underrepresentation of SNVs in genes related to autophagy and cell cycle control was observed. The researchers hypothesize that these alterations may help explain the patient's colonic manifestations and thyroid cancer.
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2022)
Letter
Endocrinology & Metabolism
Alfio Tincani, Carlos Lehn, Claudio Cernea, Emilson Queiroz, Fernando Dias, Fernando Walder, Flavio Hojaij, Francisco Monteiro, Jacob Kligerman, Jose Podesta, Lenine Brandao, Luiz Eduardo Barbalho de Mello, Luiz Medina, Marcio Abrahao, Marcos Tavares, Mauro Barbosa, Onivaldo Cervantes, Paula Demetrio, Ricardo Curioso, Roberto Lima, Sergio Arap, Sylvio Vasconcellos
ARCHIVES OF ENDOCRINOLOGY METABOLISM
(2021)
Article
Biology
J. R. Basso, L. G. Z. Bizinoto, G. A. Limone, M. M. S. S. Enokihara, K. do Espirito-Santo Filho, A. R. Fonseca, R. C. Agondi, A. F. T. de Gois, L. L. Cunha
Summary: This article reports a rare case of episodic angioedema with eosinophilia associated with urticarial vasculitis. The patient experienced recurrent episodes of facial angioedema and urticaria, along with abnormal blood test results. Skin biopsies suggested urticarial vasculitis, indicating a possible shared pathophysiological mechanism between the two conditions.
BRAZILIAN JOURNAL OF MEDICAL AND BIOLOGICAL RESEARCH
(2021)
