Article
Infectious Diseases
Helene M. Flatby, Humaira Rasheed, Anuradha Ravi, Laurent F. Thomas, Kristin Liyanarachi, Jan E. Afset, Andrew T. DeWan, Ben M. Brumpton, Kristian Hveem, Bjorn O. Asvold, Gunnar S. Simonsen, Anne-Sofie Furberg, Jan K. Damas, Erik Solligard, Tormod Rogne
Summary: Lower respiratory tract infections (LRTIs) are a major cause of morbidity and mortality globally. A genome-wide association study (GWAS) identified a strong association between the 15q25.1 locus and LRTI susceptibility. Additionally, factors such as smoking, overweight, obesity, and hypertension were found to increase the risk of LRTIs.
CLINICAL MICROBIOLOGY AND INFECTION
(2022)
Article
Medicine, General & Internal
Pia Holma, Paula Pesonen, Minna K. Karjalainen, Marjo-Riitta Jaervelin, Sara Vaeyrynen, Eeva Sliz, Anni Heikkilae, Mikko R. J. Seppaenen, Johannes Kettunen, Juha Auvinen, Timo Hautala
Summary: Smoking and genetic variation (FCGR2B and TNFRSF13B) were found to be the most important factors determining serum IgG concentration. The study also found that low serum IgG was associated with antibiotic use and sinus surgery, while high serum IgG was associated with pneumonia incidence and total number of pneumonia episodes.
Article
Public, Environmental & Occupational Health
Haruna Kawachi, Masayuki Teramoto, Isao Muraki, Kokoro Shirai, Kazumasa Yamagishi, Akiko Tamakoshi, Hiroyasu Iso
Summary: This study examined the association between childhood secondhand smoke exposure and the risk of respiratory disease mortality among non-smoking adults. The findings suggest that living with three or more smoking family members during childhood is associated with an increased risk of respiratory disease-related mortality in adulthood among women.
JOURNAL OF PUBLIC HEALTH
(2023)
Article
Respiratory System
Laura M. Paulin, Michael J. Halenar, Kathryn C. Edwards, Kristin Lauten, Cassandra A. Stanton, Kristie Taylor, Dorothy Hatsukami, Andrew Hyland, Todd MacKenzie, Martin C. Mahoney, Ray Niaura, Dennis Trinidad, Carlos Blanco, Wilson M. Compton, Lisa D. Gardner, Heather L. Kimmel, Dana Lauterstein, Daniela Marshall, James D. Sargent
Summary: This study in the Population Assessment of Tobacco and Health (PATH) Study found an association between non-cigarette tobacco use and the risk of chronic obstructive pulmonary disease (COPD). All categories involving cigarette and e-cigarette use were associated with higher COPD prevalence, while quitting tobacco was protective against COPD development.
RESPIRATORY RESEARCH
(2022)
Article
Cardiac & Cardiovascular Systems
Su-Min Jeong, Jung Eun Yoo, Junhee Park, Wonyoung Jung, Kyu Na Lee, Kyungdo Han, Cheol Min Lee, Ki-Woong Nam, Seung-Pyo Lee, Dong Wook Shin
Summary: This study examined the association between smoking behavior change and the risk of cardiovascular disease incidence and mortality in patients with type 2 diabetes mellitus (T2DM). The results showed that quitting smoking was associated with a significantly decreased risk of myocardial infarction and ischemic stroke, whereas reducing smoking was not significantly associated with these risks.
CARDIOVASCULAR DIABETOLOGY
(2023)
Article
Infectious Diseases
Vijay Singh, Pallavi Upadhyay, Jairus Reddy, John Granger
Summary: This study investigated bacterial and viral co-infections in COVID-19 patients and found a lower rate of viral co-infections overall, but significant levels of Staphylococcus aureus and Epstein-Barr virus co-infections in SARS-CoV-2-positive patients. The findings contribute to our understanding of the current pandemic and can assist clinicians in making better patient care decisions.
INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Medicine, General & Internal
Yun Su Sim, Jin Hwa Lee, Eung Gu Lee, Joon Young Choi, Chang-Hoon Lee, Tai Joon An, Yeonhee Park, Young Soon Yoon, Joo Hun Park, Kwang Ha Yoo
Summary: We evaluated the association between COPD medications used in the 6 months before acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) and the pathogens identified during AE-COPD. Medical records of 1177 patients diagnosed with AE-COPD were analyzed retrospectively. The use of inhaled corticosteroid (ICS) and systemic steroid was analyzed in relation to the microorganisms identified during AE-COPD. Bacteria were more frequently identified in patients using ICS and systemic steroids, and the risk of Pseudomonas aeruginosa infection increased in patients who used systemic steroids.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Respiratory System
Miguel J. Divo, Congjian Liu, Francesca Polverino, Peter J. Castaldi, Bartolome R. Celli, Yohannes Tesfaigzi
Summary: A predictive model consisting of FEV1/FVC, smoking history, BMI, and symptoms of chronic bronchitis can help identify middle-aged smokers at high risk of developing chronic airflow limitation.
EUROPEAN RESPIRATORY JOURNAL
(2023)
Article
Oncology
Hyung-Suk Yoon, Xiao-Ou Shu, Hui Cai, Wei Zheng, Jie Wu, Wanqing Wen, Regina Courtney, Chris Shidal, Tim Waterboer, William J. Blot, Qiuyin Cai
Summary: This study found an association between Helicobacter pylori infection and lung cancer risk, which may be related to specific H. pylori antigens. The association between H. pylori infection and lung cancer risk may be more evident among African Americans and may be modified by smoking habits.
Article
Medicine, General & Internal
Woon H. Chong, Hau Chieng, Anupama Tiwari, Scott Beegle, Paul J. Feustel, Sana Ghalib, Ali Hani Al-Tarbsheh, Esha Jain, Jeannette Mullins, Megan Keenan, Amit Chopra
Summary: The incidence of secondary pulmonary infections (SPI) in hospitalized COVID-19 patients was 5%. Lower nadir lymphocyte count during hospitalization was associated with an increased risk of developing SPI. The levels of CRP and D-dimer on admission, and the peak levels of procalcitonin and CRP during hospitalization were higher in patients with SPI.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2022)
Article
Infectious Diseases
Marco Ripa, Laura Galli, Andrea Poli, Chiara Oltolini, Vincenzo Spagnuolo, Andrea Mastrangelo, Camilla Muccini, Giacomo Monti, Giacomo De Luca, Giovanni Landoni, Lorenzo Dagna, Massimo Clementi, Patrizia Rovere Querini, Fabio Ciceri, Moreno Tresoldi, Adriano Lazzarin, Alberto Zangrillo, Paolo Scarpellini, Antonella Castagna
Summary: The study aimed to describe the incidence and predictive factors of secondary infections in COVID-19 patients. Risk factors identified for secondary infections included low lymphocyte count, baseline PaO2/FiO2 decrease, and ICU admission within the first 48 hours.
CLINICAL MICROBIOLOGY AND INFECTION
(2021)
Article
Respiratory System
Elizabeth J. Becker, Alen Faiz, Maarten van den Berge, Wim Timens, Pieter S. Hiemstra, Kristopher Clark, Gang Liu, Xiaohui Xiao, Yuriy O. Alekseyev, George O'Connor, Stephen Lam, Avrum Spira, Marc E. Lenburg, Katrina Steiling
Summary: The study identified and replicated an airway gene expression signature associated with the rate of FEV1 decline in individuals with COPD. Genes that are elevated in individuals with a more rapid FEV1 decline are significantly enriched among the genes altered by modulation of XBP1 and are related to mucin production. These findings suggest that molecular processes related to the rate of FEV1 decline can be detected in the airway epithelium, potentially serving as an early indicator of rapid FEV1 decline in both smokers with and without COPD.
Article
Respiratory System
Jingzhou Zhang, Hanfei Xu, Dandi Qiao, Dawn L. DeMeo, Edwin K. Silverman, George T. O'Connor, Brian D. Hobbs, Josee Dupuis, Michael H. Cho, Matthew Moll
Summary: This study found that a polygenic risk score for COPD is associated with earlier age of diagnosis and has predictive value when combined with known early-life risk factors.
EUROPEAN RESPIRATORY JOURNAL
(2022)
Review
Medicine, General & Internal
Maeva Zysman, Chantal Raherison-Semjen
Summary: Chronic obstructive pulmonary disease (COPD) is equally prevalent among women and men since 2008, mainly due to increased exposure to tobacco and biomass fuels. Women with COPD tend to have different clinical presentations and higher susceptibility to smoking and pollutants. Treatment limitations for women include under-diagnosis and fewer medical consultations.
FRONTIERS IN MEDICINE
(2022)
Article
Physiology
Christine Dalgard, Fang Wang, Ingrid Louise Titlestad, Kirsten Ohm Kyvik, Jorgen Vestbo, Grith Lykke Sorensen
Summary: The pulmonary surfactant protein D (SP-D) is a key component of the innate immune system in the lungs and has been suggested as a marker for smoke-induced lung injury. Studies have shown a correlation between high serum SP-D levels and low lung function measurements in smokers and COPD patients. Longitudinal twin studies in Denmark have revealed that baseline serum SP-D levels can predict future decline in lung function in smokers.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2021)
Letter
Rheumatology
Shahab Abtahi, Johanna H. M. Driessen, Andrea M. Burden, Patrick C. Souverein, Joop P. van den Bergh, Tjeerd P. van Staa, Annelies Boonen, Frank de Vries
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Letter
Rheumatology
Shahab Abtahi, Johanna H. M. Driessen, Andrea M. Burden, Patrick C. Souverein, Joop P. van den Bergh, Annelies Boonen
ANNALS OF THE RHEUMATIC DISEASES
(2023)
Article
Urology & Nephrology
J. J. van Raaij, K. H. Hua, F. de Vries, Paddy K. C. Janssen
Summary: This study aimed to investigate the relationship between the His452Tyr polymorphism of the 5-HT2A receptor and the pathogenesis and intravaginal ejaculation latency time (IELT) differences in patients with lifelong premature ejaculation (LPE). The results showed no correlation between the polymorphism and IELT distribution in LPE patients.
INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH
(2023)
Article
Gastroenterology & Hepatology
Martin S. Schulz, Jan Mengers, Wenyi Gu, Andreas Drolz, Philip G. Ferstl, Alex Amoros, Frank E. Uschner, Nora Ackermann, Georg Guttenberg, Alexander Queck, Maximilian J. Brol, Christiana Graf, Philipp Stoffers, Anna-Lena Laguna De La Vera, Carla Cremonese, Hans-Peter Erasmus, Martin W. Welker, Achim Grunewaldt, Vincente Arroyo, Jorg Bojunga, Javier Fernandez, Stefan Zeuzem, Johannes Kluwe, Kai-Hendrik Peiffer, Christoph Welsch, Valentin Fuhrmann, Gernot Rohde, Jonel Trebicka
Summary: In ACLF patients, both pulmonary failure and mechanical ventilation are associated with worse prognosis. The grade of pulmonary impairment should be considered in the risk assessment for ACLF patients.
LIVER INTERNATIONAL
(2023)
Review
Medicine, General & Internal
Ianthe Piscaer, Rob Janssen, Frits M. E. Franssen, Leon J. Schurgers, Emiel F. M. Wouters
Summary: Patients with chronic obstructive pulmonary disease (COPD) often have multiple co-occurring conditions and systemic manifestations. Vitamin A, vitamin D, and vitamin K are all potentially involved in COPD pathogenesis. In this review, the potential role of vitamin K in the systemic manifestations of COPD is discussed, including its effects on prevalent co-occurring chronic conditions such as cardiovascular disorders, chronic kidney disease, osteoporosis, and sarcopenia. Recommendations for future clinical studies are also provided.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Environmental Sciences
Yuqin Zeng, Martijn A. Spruit, Qichen Deng, Frits M. E. Franssen, Ping Chen
Summary: This study aimed to measure the differences between male and female patients with COPD in terms of risk factors, symptoms, quality of life, and drug prescriptions. The results showed that female patients with COPD had lower educational levels and were less likely to be married. Compared to male patients, female patients had more complaints of cough, breathlessness, decreased activity, decreased confidence, sleep problems, and lack of energy. In addition, more women were prescribed triple therapy.
Article
Public, Environmental & Occupational Health
J. L. Gulikers, A. J. van Veelen, J. H. M. Driessen, P. C. Souverein, V. C. G. Tjan-Heijnen, L. E. L. Hendriks, R. M. J. M. van Geel, S. Croes
Summary: The number of general practices contributing to the CPRD database GOLD is decreasing, which may impact the feasibility of studies requiring large sample sizes. CPRD Aurum, a data source containing information from practices using EMIS software, is being used for CPRD studies. This study compares the characteristics and overall survival of lung cancer patients in Aurum and GOLD, and assesses their potential eligibility for randomized clinical trials.
PHARMACOEPIDEMIOLOGY AND DRUG SAFETY
(2023)
Article
Oncology
Anita J. W. M. Brouns, Lizza E. L. Hendriks, Iris J. Robbesom-van den Berge, Annemariek J. H. M. Driessen, Guido M. J. M. Roemen, Britt L. . J. van Herpen, Zoe Dekkers, Bas Heitzer, Daphne J. G. Leunissen, Laura Moonen, Ragnar Lunde, Marcel Westenend, Marjolein van Driel, Ernst-Jan M. Speel, Anne-Marie C. Dingemans
Summary: Bone metastases are common in NSCLC patients and are associated with increased RANKL gene expression and RANKL/OPG gene ratio.
FRONTIERS IN ONCOLOGY
(2023)
Article
Oncology
Ard van Veelen, G. D. Marijn Veerman, Marjon V. Verschueren, Judith L. Gulikers, Christi M. J. Steendam, Anita J. W. M. Brouns, Safiye Dursun, Marthe S. Paats, Vivianne C. G. Tjan-Heijnen, Cor van der Leest, Anne-Marie C. Dingemans, Ron H. J. Mathijssen, Ewoudt M. W. van de Garde, Patrick Souverein, Johanna H. M. Driessen, Lizza E. L. Hendriks, Robin M. J. M. van Geel, Sander Croes
Summary: This Dutch multicenter cohort study analyzed data from patients with metastatic non-small cell lung cancer who were treated with osimertinib. The results showed that low BMI, high steady-state plasma concentration, and male sex were associated with shorter progression-free survival (PFS) and/or overall survival (OS). In contrast, female patients and those with exon 19 deletion had longer PFS. Age was not associated with the effectiveness outcomes of osimertinib.
INTERNATIONAL JOURNAL OF CANCER
(2023)
Article
Health Care Sciences & Services
Gernot Rohde, Monika Eichinger, Sven Glaeser, Marion Heiss-Neumann, Jan Kehrmann, Claus Neurohr, Marko Obradovic, Tim Kroeger-Kilian, Tobias Loebel, Christian Taube
Summary: This article presents the best practices for managing patients with NTM-PD in Germany, including diagnosis, treatment, and ongoing management. Through a survey and interviews with medical and administrative staff from multiple treatment centers, key practices for improving patient care were identified. Future challenges and possible improvements were also discussed.
Meeting Abstract
Endocrinology & Metabolism
Veerle van Hulten, Cindy Sarodnik, Johanna Driessen, Sandrine Bours, Nicklas Rasmussen, Rikke Viggers, Nicolaas Schaper, Annemarie Koster, Marleen van Greevenbroek, Carla van der Kallen, Coen Stehouwer, Joop van den Bergh
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Meeting Abstract
Endocrinology & Metabolism
Merle Schene, Hanna Willems, Annemariek Driessen, Lisanne Vranken, Robert van der Velde, Joop van den Bergh, Caroline Wyers
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Article
Endocrinology & Metabolism
M. R. Schene, K. Meijer, D. Cheung, H. C. Willems, J. H. M. Driessen, L. Vranken, J. P. van den Bergh, C. E. Wyers
Summary: Physical capacity (PC) and physical activity (PA) are used to categorize physical performance in the can do, do do framework. This study examined the physical performance of patients attending the fracture liaison service (FLS). It was found that approximately 20% of the patients were unable to perform certain physical activities but still engaged in them, and they had a higher prevalence of fall and fracture risk factors compared to those who could perform the activities.
CALCIFIED TISSUE INTERNATIONAL
(2023)
Article
Oncology
Eleni Domzaridou, Tjeerd Van Staa, Andrew G. Renehan, Natalie Cook, William Welfare, Darren M. Ashcroft, Victoria Palin
Summary: This study examines the association between antibiotic treatment and long-term mortality in cancer patients, finding that antibiotic use shortly before cancer diagnosis may reduce the effectiveness of chemotherapy and immunotherapy.