Article
Medicine, Research & Experimental
Sana Siddiqui, Kristina Johansson, Alex Joo, Luke R. Bonser, Kyung Duk Koh, Olivier Le Tonqueze, Samaneh Bolourchi, Rodriel A. Bautista, Lorna Zlock, Theodore L. Roth, Alexander Marson, Nirav R. Bhakta, K. Mark Ansel, Walter E. Finkbeiner, David J. Erle, Prescott G. Woodruff
Summary: The study identifies miR-141 as a key regulator of pathological airway mucus production induced by IL-13, with disruption leading to decreased goblet cell frequency and reduced mucus secretion. This miRNA may offer a novel therapeutic target for airway diseases.
Article
Agriculture, Dairy & Animal Science
Malwina Slowikowska, Joanna Bajzert, Julia Miller, Tadeusz Stefaniak, Artur Niedzwiedz
Summary: This study aimed to evaluate the dynamics of circulating immune complexes (CICs) in equine asthma patients during exacerbation, remission, and treatment. The results showed that CIC levels did not support the diagnosis of equine asthma syndrome but could be useful in monitoring patients' conditions.
Article
Agriculture, Dairy & Animal Science
Luca Stucchi, Francesco Ferrucci, Michela Bullone, Raffaele L. Dellaca, Jean Pierre Lavoie
Summary: This study evaluated the sensitivity of within-breath analysis and oscillometry in detecting subclinical airway obstruction in horses with asthma. The results showed that within-breath oscillometry is sensitive in discriminating horses with severe asthma from control horses, and it can identify an increase in expiratory reactance similar to that observed in human asthmatic patients. Evaluating inspiratory and expiratory reactance could be promising in distinguishing between horses with asthma in remission and control horses.
Article
Biochemistry & Molecular Biology
Yu-Jen Chen, Chia-Tien Hsu, Shang-Feng Tsai, Cheng-Hsu Chen
Summary: Chronic allograft dysfunction (CAD) is a major condition affecting long-term kidney graft survival. In this study, the correlation between plasma miR-21 and the severity of CAD was investigated. RNA sequencing was performed and differentially expressed miRNAs in CAD were identified. MiR-21-5p, miR-20a-5p, and miR-101-3p were found to be associated with the TGF-beta pathway and CAD. These findings may lead to the development of early prediction miRNA biomarkers and therapeutic tools for CAD in the field of kidney transplantation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Immunology
Rachel E. Crossland, Jean Norden, Sakhila Ghimire, Mateja Kralj Juric, Kim F. Pearce, Clare Lendrem, Matthew Collin, Eva Mischak-Weissinger, Ernst Holler, Hildegard T. Greinix, Anne M. Dickinson
Summary: The study found that miR-155 and miR-146a were upregulated in gastrointestinal and skin tissue samples of aGvHD patients, and their expression levels in serum and urine samples were also associated with the risk of developing aGvHD. These results support the potential of miR-155 and miR-146a as biomarkers for aGvHD, but further investigation is needed to understand their role in generalized inflammation and specific pathophysiology.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Edvan do Carmo Santos, Gabriela Imbassahy Valentim Melo, Paulo Vinicius Bispo Santana, Idaiara Graziele Silva Quadros, Setondji Cocou Modeste Alexandre Yahouedehou, Caroline Conceicao da Guarda, Rayra Pereira Santiago, Luciana Magalhaes Fiuza, Suellen Pinheiro Carvalho, Elisangela Vitoria Adorno, Carla Martins Kaneto, Teresa Cristina Cardoso Fonseca, Marilda Souza Goncalves, Milena Magalhaes Aleluia
Summary: This study demonstrates that elevated expression of circulating miR-199a-5p and miR-144 and reduced expression of miR-126 are associated with sickle leg ulcers (SLU) and hemolytic biomarkers. These microRNAs have potential diagnostic and prognostic value in SLU and may play a role in the pathophysiology of the disease.
Article
Agriculture, Dairy & Animal Science
Chiara Maria Lo Feudo, Luca Stucchi, Elena Alberti, Bianca Conturba, Enrica Zucca, Francesco Ferrucci
Summary: Equine asthma is a respiratory syndrome similar to human asthma, with mild-moderate and severe classifications. Environmental allergens trigger hypersensitivity responses in asthmatic horses, with insects, Dermatophagoides spp., and dog epithelium being the most common allergens. Type-I hypersensitivity plays a major role in severe equine asthma, while type-IV hypersensitivity is more involved in milder forms. Intradermal testing is effective in identifying hypersensitivity to specific allergens in equine medicine.
Article
Toxicology
B. Sun, Z. Qu, G. L. Cheng, Y. W. Yang, Y. F. Miao, X. G. Chen, X. B. Zhou, B. Li
Summary: The study investigated the urinary microRNA expression profile in a gentamicin-induced acute kidney injury canine model and found that miR-15b and -30a may be promising biomarkers for renal toxicity, with diagnostic values superior to traditional serum biomarkers. Furthermore, the levels of miR-15b and -30a in urine samples correlated significantly with their levels in kidney tissue samples.
TOXICOLOGY LETTERS
(2021)
Article
Biochemistry & Molecular Biology
Meyer Elbaz, Julien Faccini, Clemence Laperche, Marie-Helene Grazide, Jean-Bernard Ruidavets, Cecile Vindis
Summary: Circulating miR-223 and miR-186 are promising predictive biomarkers for long-term mortality after MI.
Article
Immunology
Fen Liu, Jintao Zhang, Dong Zhang, Quin Qi, Wenjing Cui, Yun Pan, Xiaofei Liu, Jiawei Xu, Xinrui Qiao, Zihan Wang, Liang Dong
Summary: This study reveals the crucial role of the miR-200b-3p/FSTL1 axis in regulating airway remodeling and inflammation in asthma.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Article
Clinical Neurology
Rukiye Tekdemir, Yavuz Selvi, Kursat Altinbas, Nadir Kocak
Summary: This study found that miRNAs play an important role in the pathogenesis of bipolar disorder and may serve as biomarkers for diagnosis and screening of the disorder.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Gastroenterology & Hepatology
Katherine Johnson, Peter J. Leary, Olivier Govaere, Matthew J. Barter, Sarah H. Charlton, Simon J. Cockell, Dina Tiniakos, Michalina Zatorska, Pierre Bedossa, M. Julia Brosnan, Jeremy F. Cobbold, Mattias Ekstedt, Guruprasad P. Aithal, Karine Clement, Joern M. Schattenberg, Jerome Boursier, Vlad Ratziu, Elisabetta Bugianesi, Quentin M. Anstee, Ann K. Daly
Summary: The study found that serum miR-193a-5p levels are strongly correlated with NAFLD activity grade and fibrosis stage. MiR-193a-5p may play a role in the hepatic response to oxidative stress and is a potential circulating biomarker for progressive NAFLD.
Article
Allergy
Emilio Nunez-Borque, Sergio Fernandez-Bravo, Pablo Rodriguez Del Rio, Ebrahim Mohammed Alwashali, David Lopez-Dominguez, Maria Dolores Gutierrez-Blazquez, Jose Julio Laguna, Jaime Tome-Amat, Julio Gallego-Delgado, Alicia Gomez-Lopez, Diana Betancor, Javier Cuesta-Herranz, Maria Dolores Ibanez-Sandin, Alberto Benito-Martin, Vanesa Esteban
Summary: This study characterized the human miRNA profile during anaphylaxis in children, identifying miR-21-3p and miR-487b-3p as potential diagnostic markers and highlighting molecular pathways related to inflammation and immune system regulation. Furthermore, endothelial cells were found to increase miR-21-3p intracellularly and release it in response to anaphylaxis.
PEDIATRIC ALLERGY AND IMMUNOLOGY
(2021)
Article
Plant Sciences
Ibrahim Sulaiman, Emmanuel Oshiogwe Okwuofu, Norhafizah Mohtarrudin, Jonathan Chee Woei Lim, Johnson Stanslas
Summary: The standardized Andrographis paniculata 50% ethanol extract (APEE50) showed anti-inflammatory effects in a mouse asthma model by down-regulating Th2 cytokine gene expression and oxidative stress levels.
JOURNAL OF ETHNOPHARMACOLOGY
(2024)
Article
Pathology
Nasrin Hadi, Faezeh Namazi, Fatemeh Ketabchi, Farinaz Khosravian, Behnaz Nateghi, Alireza Talebi, Masoud Baghi, Hamidreza Mianesaz, Fateme Zare, Mansoor Salehi
Summary: MicroRNAs (miRNAs) play a significant role in cancer, and this study identified 5 miRNAs associated with chronic lymphocytic leukemia (CLL). The results showed that the expression levels of these miRNAs were significantly altered in CLL patients. Furthermore, the expression levels of TGFBR1 and TGFBR2 were also decreased. These miRNAs could potentially serve as biomarkers for early diagnosis and prognosis of CLL.
PATHOLOGY RESEARCH AND PRACTICE
(2022)
Article
Veterinary Sciences
Lucia Unger, Vidhya Jagannathan, Alicja Pacholewska, Tosso Leeb, Vinzenz Gerber
JOURNAL OF VETERINARY INTERNAL MEDICINE
(2019)
Article
Biochemistry & Molecular Biology
Erik W. Martin, Alicja Pacholewska, Heta Patel, Himanshu Dashora, Myong-Hee Sung
Article
Genetics & Heredity
Jasmin Nessler, Petra Hug, Paul J. J. Mandigers, Peter A. J. Leegwater, Vidhya Jagannathan, Anibh M. Das, Marco Rosati, Kaspar Matiasek, Adrian C. Sewell, Marion Kornberg, Marina Hoffmann, Petra Wolf, Andrea Fischer, Andrea Tipold, Tosso Leeb
Article
Genetics & Heredity
Dominique J. Wiener, Katia R. Groch, Magdalena A. T. Brunner, Tosso Leeb, Vidhya Jagannathan, Monika M. Welle
Article
Genetics & Heredity
Matthias F. Hulliger, Alicja Pacholewska, Amandine Vargas, Jean-Pierre Lavoie, Tosso Leeb, Vincent Gerber, Vidhya Jagannathan
Article
Genetics & Heredity
Nadja Gerber, Magdalena A. T. Brunner, Vidhya Jagannathan, Tosso Leeb, Nora M. Gerhards, Monika M. Welle, Martina Dettwiler
Summary: This study investigated transcriptional differences between canine CETL and IMD, aiming to establish discriminatory markers for further research. The research found distinct gene expression profiles in CETL and IMD, with differentially expressed genes potentially serving as discriminatory markers but needing further validation.
Article
Biochemistry & Molecular Biology
Alicja Pacholewska, Christina Grimm, Carmen D. Herling, Matthias Lienhard, Anja Koenigs, Bernd Timmermann, Janine Altmueller, Oliver Muecke, Hans Christian Reinhardt, Christoph Plass, Ralf Herwig, Michael Hallek, Michal R. Schweiger
Summary: Mutations in splicing factor genes, especially SF3B1, have a negative impact on the survival of cancer patients, particularly those with chronic lymphocytic leukemia (CLL). This study found that SF3B1(mut) CLL patients displayed local decreases in methylation levels at specific genomic regions, mainly near telomeric regions, which were enriched in cancer-related signaling genes. The mutations in SF3B1 were found to exclusively occur in two out of three epigenetic stages of the originating B cells, indicating additional epigenetic aberrations caused by the mutations during carcinogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Genetics & Heredity
Vidhya Jagannathan, Christophe Hitte, Jeffrey M. Kidd, Patrick Masterson, Terence D. Murphy, Sarah Emery, Brian Davis, Reuben M. Buckley, Yan-Hu Liu, Xiang-Quan Zhang, Tosso Leeb, Ya-Ping Zhang, Elaine A. Ostrander, Guo-Dong Wang
Summary: By utilizing long-read technologies, an improved highly contiguous genome assembly of Tasha has been created, increasing sequence contiguity, closing gaps, and improving gene annotation by identifying new protein-coding transcripts.
Article
Genetics & Heredity
Silvie Neradilova, Alexandria M. Schauer, Jessica J. Hayward, Magdalena A. T. Brunner, Magdalena Bohutinska, Vidhya Jagannathan, Laurie B. Connell, Adam R. Boyko, Monika M. Welle, Barbora Cerna Bolfikova
Summary: Non-inflammatory alopecia is a common skin problem in dogs that affects the integrity of their coat and appearance. This study focused on the Cesky Fousek breed, which frequently experiences atypical recurrent flank alopecia (aRFA). The genetic cause of aRFA is unknown, so this study aimed to identify the associated variants using histological, genomic, and transcriptomic data. Through a genome-wide association study (GWAS) and comparison of gene expression patterns, several candidate genes were identified, suggesting a polygenic basis for aRFA. These genes are involved in metabolic pathways related to collagen formation, muscle structure/contraction, lipid metabolism, and the immune system.
Article
Genetics & Heredity
Sophie Elena Sage, Pamela Nicholson, Tosso Leeb, Vinzenz Gerber, Vidhya Jagannathan
Summary: The study utilized long-read sequencing technology to generate full-length transcript sequences in equine BALF cells, resulting in 14,234 full-length transcript isoforms. Among these transcripts, 3428 were newly discovered, along with 10,806 known transcripts, including fusion transcripts.
Article
Cell Biology
Mahamat Babagana, Kyu-Seon Oh, Sayantan Chakraborty, Alicja Pacholewska, Mohammad Aqdas, Myong-Hee Sung
Summary: The study reveals that tissue-resident macrophages undergo specific and significant transcriptional changes with age across different organs and sexes, primarily involving important innate immune functions such as antigen presentation, cytokine production, and cell adhesion. The hedgehog (Hh) signaling pathway may play a crucial role in aging, as in vivo suppression or in vitro activation of this pathway can affect the expression of proinflammatory cytokines. These findings suggest that targeting the Hh signaling pathway could be a potential intervention to mitigate age-associated inflammation and related diseases.
Meeting Abstract
Immunology
Kyu-Seon Oh, Mahamat Babagana, Alicja Pacholewska, Sayantan Chakraborty, Jisu Ha, Songjoon Baek, Myong-Hee Sung
JOURNAL OF IMMUNOLOGY
(2020)
Meeting Abstract
Immunology
Mia Sung, Mahamat Babagana, Kyu-Seon Oh, Sayantan Chakraborty, Alicja Pacholewska, Takashi Furusawa, Michael Bustin
JOURNAL OF IMMUNOLOGY
(2020)