The Electrogenic Na+/K+ Pump Is a Key Determinant of Repolarization Abnormality Susceptibility in Human Ventricular Cardiomyocytes: A Population-Based Simulation Study

Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy

(2016) Elisa Passini et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Early afterdepolarizations promote transmural reentry in ischemic human ventricles with reduced repolarization reserve

(2016) Sara Dutta et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

In Vivo and In Silico Investigation Into Mechanisms of Frequency Dependence of Repolarization Alternans in Human Ventricular CardiomyocytesNovelty and Significance

(2015) Xin Zhou et al.   CIRCULATION RESEARCH

ABCB1gene variants, digoxin and risk of sudden cardiac death in a general population

(2015) Maartje N Niemeijer et al.   HEART

Na+/Ca2+exchange and Na+/K+-ATPase in the heart

(2015) Michael J. Shattock et al.   JOURNAL OF PHYSIOLOGY-LONDON

How do sex hormones modify arrhythmogenesis in long QT syndrome? Sex hormone effects on arrhythmogenic substrate and triggered activity

(2014) Katja E. Odening et al.   HEART RHYTHM

A Study of Early Afterdepolarizations in a Model for Human Ventricular Tissue

(2014) Nele Vandersickel et al.   PLoS One

Inter-Subject Variability in Human Atrial Action Potential in Sinus Rhythm versus Chronic Atrial Fibrillation

(2014) Carlos Sánchez et al.   PLoS One

Na+ transport in the normal and failing heart — Remember the balance

(2013) Sanda Despa et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ionic mechanisms limiting cardiac repolarization reserve in humans compared to dogs

(2013) Norbert Jost et al.   JOURNAL OF PHYSIOLOGY-LONDON

Na/K pump regulation of cardiac repolarization: insights from a systems biology approach

(2013) Alfonso Bueno-Orovio et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Experimentally calibrated population of models predicts and explains intersubject variability in cardiac cellular electrophysiology

(2013) Oliver J. Britton et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MICE Models: Superior to the HERG Model in Predicting Torsade de Pointes

(2013) James Kramer et al.   Scientific Reports

Circadian rhythms govern cardiac repolarization and arrhythmogenesis

(2012) Darwin Jeyaraj et al.   NATURE

In Vivo Human Left-to-Right Ventricular Differences in Rate Adaptation Transiently Increase Pro-Arrhythmic Risk following Rate Acceleration

(2012) Alfonso Bueno-Orovio et al.   PLoS One

MicroRNA regulation of cardiac conduction and arrhythmias

(2012) Gene H. Kim   Translational Research

Cardiac ventricular repolarization reserve: a principle for understanding drug-related proarrhythmic risk

(2011) András Varró et al.   BRITISH JOURNAL OF PHARMACOLOGY

Quantification of repolarization reserve to understand interpatient variability in the response to proarrhythmic drugs: A computational analysis

(2011) Amrita X. Sarkar et al.   HEART RHYTHM

Refining repolarization reserve

(2011) Dan M. Roden et al.   HEART RHYTHM

Multiple models to capture the variability in biological neurons and networks

(2011) Eve Marder et al.   NATURE NEUROSCIENCE

Simulation of the Undiseased Human Cardiac Ventricular Action Potential: Model Formulation and Experimental Validation

(2011) Thomas O'Hara et al.   PLoS Computational Biology

So Little Source, So Much Sink: Requirements for Afterdepolarizations to Propagate in Tissue

(2010) Yuanfang Xie et al.   BIOPHYSICAL JOURNAL

Irregularly Appearing Early Afterdepolarizations in Cardiac Myocytes: Random Fluctuations or Dynamical Chaos?

(2010) Daisuke Sato et al.   BIOPHYSICAL JOURNAL

Early afterdepolarizations and cardiac arrhythmias

(2010) James N. Weiss et al.   HEART RHYTHM

Diastolic Intracellular Calcium-Membrane Voltage Coupling Gain and Postshock Arrhythmias

(2009) Mitsunori Maruyama et al.   CIRCULATION RESEARCH

Ion-channel mRNA-expression profiling: Insights into cardiac remodeling and arrhythmic substrates

(2009) Stanley Nattel et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Remodelling of cardiac repolarization: how homeostatic responses can lead to arrhythmogenesis

(2008) G. Michael et al.   CARDIOVASCULAR RESEARCH

Feedback Remodeling of Cardiac Potassium Current Expression

(2008) Ling Xiao et al.   CIRCULATION

Cellular Signaling Underlying Atrial Tachycardia Remodeling of L-type Calcium Current

(2008) Xiao Yan Qi et al.   CIRCULATION RESEARCH

Sex, Age, and Regional Differences in L-Type Calcium Current Are Important Determinants of Arrhythmia Phenotype in Rabbit Hearts With Drug-Induced Long QT Type 2

(2008) Carl Sims et al.   CIRCULATION RESEARCH

Collation, assessment and analysis of literaturein vitrodata on hERG receptor blocking potency for subsequent modeling of drugs' cardiotoxic properties

(2008) Sebastian Polak et al.   JOURNAL OF APPLIED TOXICOLOGY

Mechanisms of Disease: ion channel remodeling in the failing ventricle

(2008) Robert D Nass et al.   Nature clinical practice. Cardiovascular medicine