Review
Biochemistry & Molecular Biology
Teresa de los Reyes Corrales, Maria Losada-Perez, Sergio Casas-Tinto
Summary: The JNK signaling pathway is crucial in the central nervous system, playing a central role in combating pathophysiological insults during development and adulthood. It is involved in various diseases such as glioblastoma, regeneration/repair after injury, neurodegeneration, and neuronal cell death.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Artem A. Venediktov, Olga Yu Bushueva, Varvara A. Kudryavtseva, Egor A. Kuzmin, Aleksandra V. Moiseeva, Anna Baldycheva, Igor Meglinski, Gennadii A. Piavchenko
Summary: This review highlights the recent progress in the study of heat shock proteins (Hsp70) in neurodegenerative diseases (NDs) and emphasizes their crucial role in pathological aggregation. The field has seen significant advancements in recent years with numerous studies being published each month. The review summarizes the role of Hsp70 in common NDs such as AD, PD, and ALS, and connects translational research and clinical trials to medical practice. It also outlines available options to regulate Hsp70 activity in NDs.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Review
Chemistry, Medicinal
Priya Singh, Deepika Singh, Pooja Srivastava, Gauri Mishra, Anjani K. K. Tiwari
Summary: The lack of information about in vivo impairments and tools for assessing brain penetrance and efficiency of newly designed drugs has hindered the development of treatments for new central nervous system diseases.
DRUG DEVELOPMENT RESEARCH
(2023)
Article
Clinical Neurology
Nicole Pizzorni, Andrea Ciammola, Giovanni Casazza, Daniela Ginocchio, Federica Bianchi, Sarah Feroldi, Barbara Poletti, Lorenzo Nanetti, Caterina Mariotti, Gabriele Mora, Antonio Schindler
Summary: Older age, disease severity, increased number of masticatory cycles, and impaired swallowing safety during meals are significant predictors of malnutrition risk in patients with neurodegenerative diseases.Identifying oral phase impairment and meal difficulties early through a multidimensional swallowing assessment is crucial for preventing malnutrition.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Review
Biochemistry & Molecular Biology
Manju, Navneeta Bharadvaja
Summary: With the increasing prevalence of neurodegenerative disorders, there is a need for an efficient and long-lasting treatment. Scientists have recently turned to investigating compounds derived from plants and herbs, such as ginseng, for potential therapeutic medications. Ginseng's compounds ginsenosides or panaxosides have shown positive impacts in ameliorating various disease conditions, making it a possible candidate for treating neurodegenerative disorders. Further research is necessary to confirm the stability and effectiveness of ginsenosides in this application.
MOLECULAR BIOTECHNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Korina Karagianni, Spyros Pettas, Georgia Christoforidou, Eirini Kanata, Nikolaos Bekas, Konstantinos Xanthopoulos, Dimitra Dafou, Theodoros Sklaviadis
Summary: RNA editing plays a role in transcriptome diversification by modifying RNA in relation to genome-encoded information. This review focuses on RNA editing in psychiatric, neurological, neurodegenerative, and autoimmune brain disorders and discusses its potential as a therapeutic and diagnostic target. However, further research is needed to fully understand the mechanisms of RNA editing in disease development.
Review
Medicine, Research & Experimental
Sandip Godse, Lina Zhou, Swarna Sakshi, Bhupesh Singla, Udai P. Singh, Santosh Kumar
Summary: Neurological disorders pose a global challenge and require innovative therapeutic approaches. Curcumin, a natural compound with antioxidant and anti-inflammatory properties, shows potential as an adjuvant therapy for central nervous system diseases. However, its limited bioavailability and permeability to the blood-brain barrier hinder its therapeutic efficacy. Nanocarriers can facilitate curcumin delivery, improving its bioavailability and blood-brain barrier permeability, and revolutionizing treatment outcomes for neurological disorders.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2023)
Review
Biochemistry & Molecular Biology
Yujuan Li, Mengxin Que, Xuan Wang, Gaofeng Zhan, Zhiqiang Zhou, Xiaoxiao Luo, Shiyong Li
Summary: Astrocytes, the most abundant cells in the brain, play a significant role in sleep regulation but their dysfunction may contribute to sleep disorders and increase the risk of other diseases. This review examines the role of astrocytes in sleep disorders, discusses potential mechanisms, and highlights the importance of further research.
Review
Biochemistry & Molecular Biology
Vitoria Ramos, Mariana Reis, Leonor Ferreira, Ana Margarida Silva, Ricardo Ferraz, Monica Vieira, Vitor Vasconcelos, Rosario Martins
Summary: Neurodegenerative diseases are characterized by progressive and irreversible neuronal loss, and there are currently no available cures. Cyanobacterial compounds have anti-neurodegenerative properties and can be valuable in the field of treatment.
Review
Pharmacology & Pharmacy
Feng-Dan Zhu, Yu-Jiao Hu, Lu Yu, Xiao-Gang Zhou, Jian-Ming Wu, Yong Tang, Da-Lian Qin, Qing-Ze Fan, An-Guo Wu
Summary: Neuroinflammation is a common feature of neurodegenerative diseases, and inhibiting the over-activation of microglia is a promising approach for treatment.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Xiaoyu Song, Wanfu Wu, Margaret Warner, Jan-Ake Gustafsson
Summary: This review discusses the role of liver X receptors (LXRs) in glial cells in the central nervous system (CNS). LXRs regulate genes involved in cholesterol homeostasis, inflammatory responses, and glutamate homeostasis. Studies on LXR knockout mice have shown that LXR beta is crucial for the health of various types of neurons in both CNS and peripheral nervous system. LXRs are also important for cerebrospinal fluid homeostasis. Despite the neurological deficits observed in LXR-deficient rodents, defective LXR signaling has only been identified in multiple sclerosis among human neurodegenerative diseases. Targeting LXRs in glial cells may hold potential for treating neurodegenerative diseases and disorders caused by abnormal neuronal migration during development.
Article
Biochemistry & Molecular Biology
Rajib Paul, Joyobrato Nath, Satinath Paul, Muhammed Khairujjaman Mazumder, Banashree Chetia Phukan, Rubina Roy, Pallab Bhattacharya, Anupom Borah
Summary: 7,8-dihydroxyflavone (DHF) is a naturally-occurring flavone with neuroprotective properties that can combat various neurological disorders, exhibiting antioxidant and anti-inflammatory effects.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Pharmacology & Pharmacy
Yu Dong, Xu-Xu Zhuang, Yi-Ting Wang, Jieqiong Tan, Du Feng, Min Li, Qing Zhong, Zhiyin Song, Han-Ming Shen, Evandro F. Fang, Jia-Hong Lu
Summary: Maintaining mitochondrial homeostasis is crucial for treating various diseases, and mitophagy, the selective degradation of mitochondria, has shown promising therapeutic potential. However, there are frequent methodological flaws in studies on chemical mitophagy modulators, leading to unreliable conclusions. This review aims to summarize the molecular mechanisms of mitophagy, propose a characterization system for mitophagy modulators, analyze the methods used in previous studies, and provide novel targets for pharmacological intervention.
PHARMACOLOGICAL RESEARCH
(2023)
Article
Geriatrics & Gerontology
Shahram Oveisgharan, Lei Yu, Tianhao Wang, Julie A. Schneider, David A. Bennett, Aron S. Buchman
Summary: This study investigated the relationship between different brain pathologies and declining motor function in older adults. The findings suggest that neurodegenerative pathologies are associated with declining grip strength, while cerebrovascular disease (CVD) pathologies are associated with declining gait function. Furthermore, CVD pathologies have a greater impact on declining gait function compared to neurodegenerative pathologies.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2023)
Article
Neurosciences
Samuel S. Duffy, Jessica P. Hayes, Nathan T. Fiore, Gila Moalem-Taylor
Summary: The article highlights the important role of microglia in the central nervous system, discussing their different states in neurological diseases and the regulatory effects of the endocannabinoid system on their activity.
Review
Clinical Neurology
Enes Akyuz, Alina Arulsamy, Shams Hasanli, Elif Bilge Yilmaz, Mohd. Farooq Shaikh
Summary: Epilepsy is a common neurological disease that can cause various complications, including vision impairments. These visual phenomena may occur before, during, or after seizures and vary depending on the type and location of epilepsy. Some antiseizure medications may also contribute to visual disturbances. A lack of understanding about the relevance and manifestation of visual complications in epilepsy can lead to misdiagnosis and inadequate treatment. This review aims to discuss common epilepsy-associated visual phenomena and their relationship to seizure onset site, with the goal of reducing the risk of permanent vision deficits among epilepsy patients.
Review
Biochemistry & Molecular Biology
Jonaid Ahmad Malik, Zahid Yaseen, Lahari Thotapalli, Sakeel Ahmed, Mohd Farooq Shaikh, Sirajudheen Anwar
Summary: Schizophrenia is a complex mental disorder caused by an imbalance in neurotransmitters. Animal models based on dopamine, glutamate, and serotonin have been developed to understand the pathophysiology of the disorder and develop new therapeutic approaches. Genetic factors have also been identified, and new targets like the orexin system and cannabinoid receptors are being explored for treatment. Non-pharmacological models have been developed to mimic the symptoms of schizophrenia and test new drug therapies. This review highlights the available animal models and behavioral tests in the study of schizophrenia.
MOLECULAR BIOLOGY REPORTS
(2023)
Review
Neurosciences
Brendan Su Mee Hui, Lee Rui Zhi, Thaarvena Retinasamy, Alina Arulsamy, Christine Shing Wei Law, Mohd. Farooq Shaikh, Keng Yoon Yeong
Summary: Neurodegenerative diseases impose a significant burden on populations worldwide, and interferon-alpha (IFN-alpha) has been suggested as a potential therapeutic target for these diseases. However, the exact role of IFN-alpha in neurodegeneration remains unclear and requires further investigation.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Review
Neurosciences
Yee Liew, Thaarvena Retinasamy, Alina Arulsamy, Idrish Ali, Nigel C. Jones, Terence J. O'Brien, Mohd Farooq Shaikh
Summary: This systematic review investigates the shared molecular mechanisms of neuroinflammation in Alzheimer's disease (AD) and epilepsy. The study finds a direct association between neuroinflammation and the progression of AD and epilepsy. However, more research is needed to develop standardized monitoring guidelines for preventing epilepsy and delaying the progression of AD.
JOURNAL OF ALZHEIMERS DISEASE
(2023)
Correction
Biochemistry & Molecular Biology
Jonaid Ahmad Malik, Zahid Yaseen, Thotapalli Lahari, Sakeel Ahmed, Mohd Farooq Shaikh, Sirajudheen Anwar
MOLECULAR BIOLOGY REPORTS
(2023)
Editorial Material
Pharmacology & Pharmacy
Mohd Farooq Shaikh, Irma Wati Ngadimon, Ayanabha Chakraborti, Jafri Malin Abdullah, Emilio Russo
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Biology
Brandon Wee Siang Phon, Saatheeyavaane Bhuvanendran, Qasim Ayub, Ammu Kutty Radhakrishnan, Muhamad Noor Alfarizal Kamarudin
Summary: This study investigated the suitability of 3D cultures as cell-based models for GBM by leveraging genomic data. Genes related to pathways such as epithelial-to-mesenchymal transition, angiogenesis/migration, hypoxia, stemness, and the Wnt signalling pathway were found to be upregulated in both brain samples from GBM patients and 3D GBM cells. These findings support the use of 3D GBM cultures as reliable preclinical models for studying GBM.
Article
Microbiology
Usman Ahmed, Seng-Kai Ong, Khalid Mohammed Khan, Ruqaiyyah Siddiqui, Naveed Ahmed Khan, Mohd Farooq Shaikh, Bader Saleem Alawfi, Ayaz Anwar
Summary: This study demonstrated the antimicrobial activity of embelin and embelin-doped silver nanoparticles against Acanthamoeba. The compounds showed minimal cytotoxicity and induced apoptosis through the mitochondria-mediated pathway. Gene expression analysis revealed the involvement of several important genes and signaling pathways. Overall, this study provides a comprehensive framework for developing therapeutic agents against microbial infections using embelin and embelin-doped silver nanoparticles.
ARCHIVES OF MICROBIOLOGY
(2023)
Article
Clinical Neurology
Kheng-Seang Lim, Ching -Soong Khoo, Si -Lei Fong, Hui-Jan Tan, Choong Yi Fong, Ahmad Rithauddin Mohamed, Azmi Abdul Rashid, Wan-Chung Law, Mohd Farooq Shaikh, Raihanah Abdul Khalid, Raymond Yen -Leong Tan, Sherrini Bazir Ahmad, Suganthi Chinnasami, Sau-Wei Wong, Azman Ali Raymond, Epilepsy Council Malaysia
Summary: This study aimed to determine the treatment gap in status epilepticus (SE) management in Malaysia. Findings revealed limited availability and underutilization of non-intravenous midazolam in prehospital services, as well as lack of EEG monitoring and treatment options for refractory SE in certain hospitals.
JOURNAL OF CLINICAL NEUROSCIENCE
(2023)
Article
Food Science & Technology
Imrana Jazuli, Goh Bey Hing, Lakshmi Selvaratnam, Deepa Alex, Lee Learn Han, Yatinesh Kumari
Summary: Alzheimer's disease is a significant challenge to healthcare systems and economies worldwide, characterized by progressive memory dysfunction. Neuroinflammation plays a critical role in its progression. Available drugs primarily focus on symptomatic treatment, highlighting the need for safe adjunctive agents with specific targets and mechanisms of action. Swietenia macrophylla has shown potential neuroprotective properties, including anti-inflammatory, antioxidant, anti-acetylcholinesterase, and anti-mitochondrial dysfunction effects.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Editorial Material
Neurosciences
Farhan Mohammad, Mohd. Farooq Shaikh, Yasir Ahmed Syed, Fadel Tissir
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Pei Teng Lum, Mahendran Sekar, Lay Jing Seow, Mohd Farooq Shaikh, Alina Arulsamy, Thaarvena Retinasamy, Siew Hua Gan, Charles Gnanaraj, Norhaizan Mohd Esa, Gobinath Ramachawolran, Vetriselvan Subramaniyan, Suresh V. Chinni, Yuan Seng Wu
Summary: Huntington's disease (HD) is a neurodegenerative disease that affects the daily performances and life quality of patients. Mangiferin, a compound found in the Mangifera indica plant, has been proven to have medicinal benefits against memory and cognitive impairment in neurodegenerative diseases. This study aims to evaluate the neuroprotective effect of mangiferin against 3-nitropropionic acid (3NP) induced HD in rat models.
FRONTIERS IN PHARMACOLOGY
(2023)
Editorial Material
Clinical Neurology
Enes Akyuz, Alberto Lazarowski, Carlos de Cabo, Leonid S. Godlevsky, Mohd. Farooq Shaikh, Zuleyha Doganyigit
FRONTIERS IN NEUROLOGY
(2023)
Article
Biochemistry & Molecular Biology
Kavitha Rajendran, Usman Ahmed, Alexia Chloe Meunier, Mohd Farooq Shaikh, Ruqaiyyah Siddiqui, Ayaz Anwar
Summary: This study evaluated the effectiveness of natural terpene compounds against the deadly pathogen Naegleria fowleri. Thymol showed the highest activity against the amoeba, and the combinations of Forskolin + Thymol and Forskolin + Borneol had a synergistic effect. Importantly, these compounds showed minimal toxicity to human cells.
ACS CHEMICAL NEUROSCIENCE
(2023)
Article
Pharmacology & Pharmacy
Zueleyha Doganyigit, Asli Okan, Enes Akyuz, Seher Yilmaz, Sukru Ates, Serpil Taheri, Zeynep Yilmaz, Mohd. Farooq Shaikh
Summary: The study found that TUDCA and 4-PBA treatment can suppress the process of endoplasmic reticulum stress, reduce oxidative stress and apoptosis, and protect neurons in epileptic seizures.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
