标题
Enhanced Late Na and Ca Currents as Effective Antiarrhythmic Drug Targets
作者
关键词
-
出版物
Frontiers in Pharmacology
Volume 8, Issue -, Pages -
出版商
Frontiers Media SA
发表日期
2017-02-07
DOI
10.3389/fphar.2017.00036
参考文献
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注意：仅列出部分参考文献，下载原文获取全部文献信息。- CaMKII as a target for arrhythmia suppression
- (2017) Julian Mustroph et al. PHARMACOLOGY & THERAPEUTICS
- Roscovitine as the Archetypal Member of a Novel Class of Antiarrhythmics Targeting Late ICa,L
- (2016) Marina Angelini et al. BIOPHYSICAL JOURNAL
- Inhibition of late sodium current attenuates ionic arrhythmia mechanism in ventricular myocytes expressing LaminA-N195K mutation
- (2016) Yogananda S. Markandeya et al. HEART RHYTHM
- Impaired Inactivation of L-Type Ca2+ Current as a Potential Mechanism for Variable Arrhythmogenic Liability of HERG K+ Channel Blocking Drugs
- (2016) Jae Gon Kim et al. PLoS One
- Arrhythmogenesis in Timothy Syndrome is associated with defects in Ca2+-dependent inactivation
- (2016) Ivy E. Dick et al. Nature Communications
- Mechanistic Investigation of the Arrhythmogenic Role of Oxidized CaMKII in the Heart
- (2015) Panagiota T. Foteinou et al. BIOPHYSICAL JOURNAL
- Molecular Basis of Hypokalemia-Induced Ventricular FibrillationCLINICAL PERSPECTIVE
- (2015) Arash Pezhouman et al. CIRCULATION
- Role of Sodium and Calcium Dysregulation in Tachyarrhythmias in Sudden Cardiac Death
- (2015) S. Wagner et al. CIRCULATION RESEARCH
- Misplaced Brain Sodium Channels in Heart Kindle Sudden Death in Epilepsy
- (2015) Alfred L. George Circulation-Arrhythmia and Electrophysiology
- Cardiac late Na+ current: Proarrhythmic effects, roles in long QT syndromes, and pathological relationship to CaMKII and oxidative stress
- (2015) Luiz Belardinelli et al. HEART RHYTHM
- Treatment of Atrial Fibrillation
- (2015) Eric N. Prystowsky et al. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION
- Rational strategy to stop arrhythmias: Early afterdepolarizations and L-type Ca2+current
- (2015) Yogananda S. Markandeya et al. JOURNAL OF GENERAL PHYSIOLOGY
- Targeting the late component of the cardiac L-type Ca2+current to suppress early afterdepolarizations
- (2015) Roshni V. Madhvani et al. JOURNAL OF GENERAL PHYSIOLOGY
- Perspective: A dynamics-based classification of ventricular arrhythmias
- (2015) James N. Weiss et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- From Foe to Friend: Using Animal Toxins to Investigate Ion Channel Function
- (2015) Jeet Kalia et al. JOURNAL OF MOLECULAR BIOLOGY
- Role of CaMKII in cardiac arrhythmias
- (2015) Thomas J. Hund et al. TRENDS IN CARDIOVASCULAR MEDICINE
- Regulation of CaMKII signaling in cardiovascular disease
- (2015) Mariya Y. Mollova et al. Frontiers in Pharmacology
- Antiepileptic activity of preferential inhibitors of persistent sodium current
- (2014) Lyndsey L. Anderson et al. EPILEPSIA
- Calmodulin mutations associated with long QT syndrome prevent inactivation of cardiac L-type Ca2+ currents and promote proarrhythmic behavior in ventricular myocytes
- (2014) Worawan B. Limpitikul et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- CaMKII oxidative activation and the pathogenesis of cardiac disease
- (2014) Elizabeth D. Luczak et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- A novel computational model of mouse myocyte electrophysiology to assess the synergy between Na+loading and CaMKII
- (2014) S. Morotti et al. JOURNAL OF PHYSIOLOGY-LONDON
- L-type Ca2+ channel contributes to alterations in mitochondrial calcium handling in the mdx ventricular myocyte
- (2013) Helena M. Viola et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Early afterdepolarizations in cardiac myocytes: beyond reduced repolarization reserve
- (2013) Zhilin Qu et al. CARDIOVASCULAR RESEARCH
- Inhibition of Late Sodium Current by Mexiletine
- (2013) Yuanfeng Gao et al. Circulation-Arrhythmia and Electrophysiology
- Selective inhibition of late sodium current suppresses ventricular tachycardia and fibrillation in intact rat hearts
- (2013) Arash Pezhouman et al. HEART RHYTHM
- A Mutation in CALM1 Encoding Calmodulin in Familial Idiopathic Ventricular Fibrillation in Childhood and Adolescence
- (2013) Roos F. Marsman et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Modeling Timothy Syndrome with iPS Cells
- (2013) Masayuki Yazawa et al. Journal of Cardiovascular Translational Research
- Enhanced sensitivity of aged fibrotic hearts to angiotensin II- and hypokalemia-induced early afterdepolarization-mediated ventricular arrhythmias
- (2012) Aneesh Bapat et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Enhanced Sarcoplasmic Reticulum Ca 2+ Leak and Increased Na + -Ca 2+ Exchanger Function Underlie Delayed Afterdepolarizations in Patients With Chronic Atrial Fibrillation
- (2012) Niels Voigt et al. CIRCULATION
- Late Sodium Current Inhibition Reverses Electromechanical Dysfunction in Human Hypertrophic Cardiomyopathy
- (2012) Raffaele Coppini et al. CIRCULATION
- Calmodulin-Dependent Protein Kinase II: Linking Heart Failure and Arrhythmias
- (2012) Paari Dominic Swaminathan et al. CIRCULATION RESEARCH
- Glycolytic inhibition causes spontaneous ventricular fibrillation in aged hearts
- (2011) Norishige Morita et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Bi-stable wave propagation and early afterdepolarization–mediated cardiac arrhythmias
- (2011) Marvin G. Chang et al. HEART RHYTHM
- Shaping a new Ca2+conductance to suppress early afterdepolarizations in cardiac myocytes
- (2011) Roshni V. Madhvani et al. JOURNAL OF PHYSIOLOGY-LONDON
- Suppression of Re-Entrant and Multifocal Ventricular Fibrillation by the Late Sodium Current Blocker Ranolazine
- (2011) Norishige Morita et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome
- (2011) Masayuki Yazawa et al. NATURE
- New drugs vs. old concepts: A fresh look at antiarrhythmics
- (2011) Jérôme Thireau et al. PHARMACOLOGY & THERAPEUTICS
- CaMKII in the Cardiovascular System: Sensing Redox States
- (2011) Jeffrey R. Erickson et al. PHYSIOLOGICAL REVIEWS
- Voltage-Gated Ion Channel Dysfunction Precedes Cardiomyopathy Development in the Dystrophic Heart
- (2011) Xaver Koenig et al. PLoS One
- So Little Source, So Much Sink: Requirements for Afterdepolarizations to Propagate in Tissue
- (2010) Yuanfang Xie et al. BIOPHYSICAL JOURNAL
- Guidelines for the management of atrial fibrillation: The Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC)
- (2010) et al. EUROPACE
- Contribution of late sodium current (INa-L) to rate adaptation of ventricular repolarization and reverse use-dependence of QT-prolonging agents
- (2010) Donglin Guo et al. HEART RHYTHM
- Concept of the Vulnerable Parameter: the Sicilian Gambit Revisited
- (2010) Michael R Rosen et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
- Excitation–contraction coupling in human heart failure examined by action potential clamp in rat cardiac myocytes
- (2010) Patricia J. Cooper et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Ranolazine Safely Decreases Ventricular and Atrial Fibrillation in Timothy Syndrome (LQT8)
- (2010) DIPAK P. SHAH et al. PACE-PACING AND CLINICAL ELECTROPHYSIOLOGY
- Increased susceptibility of aged hearts to ventricular fibrillation during oxidative stress
- (2009) Norishige Morita et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Requirement for Ca2+/calmodulin–dependent kinase II in the transition from pressure overload–induced cardiac hypertrophy to heart failure in mice
- (2009) Haiyun Ling et al. JOURNAL OF CLINICAL INVESTIGATION
- Flecainide inhibits arrhythmogenic Ca2+ waves by open state block of ryanodine receptor Ca2+ release channels and reduction of Ca2+ spark mass
- (2009) Fredrick A. Hilliard et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Synchronization of chaotic early afterdepolarizations in the genesis of cardiac arrhythmias
- (2009) D. Sato et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The isoform of CaM kinase II is required for pathological cardiac hypertrophy and remodeling after pressure overload
- (2009) J. Backs et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Dynamic Pathway for Calcium-Independent Activation of CaMKII by Methionine Oxidation
- (2008) Jeffrey R. Erickson et al. CELL
- Oxidative Stress–Induced Afterdepolarizations and Calmodulin Kinase II Signaling
- (2008) Lai-Hua Xie et al. CIRCULATION RESEARCH
- Antiarrhythmic effects of ranolazine in canine pulmonary vein sleeve preparations
- (2008) Serge Sicouri et al. HEART RHYTHM
- The Role of Antiarrhythmic Drug Therapy for the Prevention of Sudden Cardiac Death
- (2008) Ganesh S. Kamath et al. PROGRESS IN CARDIOVASCULAR DISEASES
- Roscovitine, a cyclin-dependent kinase inhibitor, affects several gating mechanisms to inhibit cardiac L-type (Ca(V)1.2) calcium channels
- (2007) V Yarotskyy et al. BRITISH JOURNAL OF PHARMACOLOGY
- Late sodium current in failing heart: Friend or foe?
- (2007) Victor A. Maltsev et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
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