Article
Pharmacology & Pharmacy
Ruixue Guo, Peipei Wang, Xuejun Zheng, Wen Cui, Jin Shang, Zhanzheng Zhao
Summary: This study demonstrates that the SGLT2 inhibitor dapagliflozin protects podocytes from diabetic nephropathy by regulating the IGF1R/PI3K signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Cell Biology
Lingfei Li, Yanhai Feng, Junhui Zhang, Qiong Zhang, Jun Ren, Cheng Sun, Shujing Li, Xia Lei, Gaoxing Luo, Jiongyu Hu, Yuesheng Huang
Summary: In this study, the researchers investigated the role of MAP4 phosphorylation in causing proteinuria in diabetic nephropathy (DN). They found that the content of p-MAP4 was increased in the urine samples of diabetic patients and in the kidney tissues of diabetic mice. p-MAP4 triggered proteinuria by inducing epithelial-to-mesenchymal transition and apoptosis in podocytes. The study also showed that mice with MAP4 hyperphosphorylation were more susceptible to a certain diabetes treatment and exhibited more severe DN pathology compared to wild-type mice. In vitro experiments further revealed that high glucose triggered the elevation of p-MAP4 and various pathological changes in podocytes, which were rectified by MAP4 dephosphorylation. The findings suggest that p-MAP4 plays a novel role in causing proteinuria in DN and indicate the therapeutic potential of MAP4 in protecting against proteinuria and related diseases.
CELL COMMUNICATION AND SIGNALING
(2022)
Article
Biochemistry & Molecular Biology
Geon-Ho Lee, Jayeon Cheon, Donghee Kim, Hee-Sook Jun
Summary: LPA promotes EMT and renal tubular fibrosis through LPAR1 signaling, downregulating E-cadherin and upregulating vimentin expression. This effect is mediated by regulation of KLF5 expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Lingyan Ren, Renrui Wan, Zheng Chen, Lixia Huo, Ming Zhu, Yong Yang, Qi Chen, Xiaolan Zhang, Xiaoyi Wang
Summary: The study aimed to decipher the mechanism by which triptolide may prevent podocyte epithelial-mesenchymal transition, possibly by activating kindlin-2 and TGF-beta/Smad pathways. Triptolide treatment in diabetic mice was found to alleviate structural injuries and functional variations, increase protein and mRNA levels of key markers, and decrease expression of alpha-SMA through inactivation of kindlin-2 and downregulation of P-SMAD3 in the TGF-beta/Smad signaling pathway.
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Qianqian Yang, Shuqing Yang, Yuehong Liang, Qi Sun, Yi Fang, Lei Jiang, Ping Wen, Junwei Yang
Summary: This study aimed to investigate whether UCP2 promotes autophagy in podocytes and explore the regulation mechanism of UCP2. The results showed that UCP2 expression increased in podocytes under diabetic conditions, and it protected against podocyte injury. However, UCP2 deficiency impaired autophagy and exacerbated podocyte injury and proteinuria in diabetic nephropathy.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Article
Biotechnology & Applied Microbiology
Hanying Ding, Jinxiang Li, Yang Li, Minliang Yang, Sheng Nie, Miaomiao Zhou, Zhanmei Zhou, Xiaobing Yang, Youhua Liu, Fan Fan Hou
Summary: This study identified miR-10a/b as negative regulators of NLRP3 inflammasome in diabetic kidney disease, preventing renal inflammation and reducing albuminuria. Targeting miR-10a/b could be a novel intervention strategy for inhibiting kidney inflammation in DKD.
Article
Cell Biology
Yi-Chun Tsai, Wei-Wen Hung, Wei-An Chang, Ping-Hsun Wu, Ling-Yu Wu, Su-Chu Lee, Mei-Chuan Kuo, Ya-Ling Hsu
Summary: This study investigated the communication within PTECs through exosome transmission in DN, revealing that the miR-1269b-FBLN1 epigenetic regulatory network could be a potential therapeutic strategy to prevent the progression of DN.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Medicine, Research & Experimental
Zongji Zheng, Shuting Zhang, Jiaqi Chen, Meina Zou, Yanlin Yang, Wen Lu, Shijing Ren, Xiangyu Wang, Wenhui Dong, Zikun Zhang, Ling Wang, Meiping Guan, Gladys L. Y. Cheing, Yaoming Xue, Yijie Jia
Summary: The feedback loop formed by HDAC2 and miR-205 plays a crucial role in regulating ECM production in tubular epithelial cells in individuals with DKD, suggesting its significance in the pathogenesis of DKD.
Article
Oncology
Yingying Luo, Danfang Deng, Lamei Lin, Yikun Zhou, Lan Wang, Xinrong Zou, Xiaoqin Wang
Summary: This study found that different isoforms of FGF2 played different roles in EMT in diabetic nephropathy, with LMW FGF2 promoting the process and HMW FGF2 exerting a protective effect.
EXPERIMENTAL CELL RESEARCH
(2022)
Review
Nutrition & Dietetics
Ran Nakamichi, Kaori Hayashi, Hiroshi Itoh
Summary: Podocytes are highly differentiated cells that cover the outside of glomerular capillaries, and damage to podocytes leads to proteinuria and glomerulosclerosis. Diabetes is a main cause of CKD, making it crucial to understand its effects on podocytes for preventing CKD progression.
Article
Food Science & Technology
Yu-Teng Chang, Mu-Chi Chung, Chang-Chi Hsieh, Jeng-Jer Shieh, Ming-Ju Wu
Summary: The study showed that protocatechuic aldehyde (PCA) can alleviate diabetic-induced renal dysfunction, reduce glomerular size, restore normal levels of fibrosis markers, decrease oxidative stress and inflammation in the kidneys of db/db mice. This research provides a foundation for using PCA as an alternative therapy for diabetic nephropathy in the future.
Review
Medicine, Research & Experimental
Xiandeng Li, Ying Zhang, Xiaodong Xing, Mi Li, Yan Liu, Ajing Xu, Jian Zhang
Summary: Diabetic nephropathy is a severe complication of diabetes mellitus, and understanding the underlying mechanisms of podocyte injury is key to developing effective therapeutic interventions. This review summarizes the factors contributing to podocyte injury in DN, including lipotoxicity, hemodynamic abnormalities, oxidative stress, mitochondrial dysfunction, and impaired autophagy. The findings presented in this review provide potential therapeutic targets and strategies for the management of DN associated with podocyte injury.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Pharmacology & Pharmacy
Xi-Zhi Li, Hong Jiang, Liu Xu, Yi-Qi Liu, Jia-Wei Tang, Jia-Sen Shi, Xiu-Juan Yu, Xue Wang, Lei Du, Qian Lu, Cheng-Lin Li, Yao-Wu Liu, Xiao-Xing Yin
Summary: Sarsasapogenin (Sar) prevents podocyte injury in diabetic rats through targeting the GSK3 beta signaling pathway and restoring podocyte autophagy, thus ameliorating experimental DN.
BIOCHEMICAL PHARMACOLOGY
(2021)
Article
Plant Sciences
Zhi Wang, Qiao Wu, Hongzhan Wang, Yang Gao, Kexin Nie, Yueheng Tang, Hao Su, Meilin Hu, Jing Gong, Ke Fang, Hui Dong
Summary: This study found that diosgenin could protect against podocyte injury in the early phase of diabetic nephropathy by regulating SIRT6, and this effect was confirmed in animal experiments and cell experiments.
Article
Medicine, Research & Experimental
Jian Lu, Pei Pei Chen, Jia Xiu Zhang, Xue Qi Li, Gui Hua Wang, Ben Yin Yuan, Si Jia Huang, Xiao Qi Liu, Ting Ting Jiang, Meng Ying Wang, Wen Tao Liu, Xiong Zhong Ruan, Bi Cheng Liu, Kun Ling Ma
Summary: The study showed that GPR43 expression was increased in kidney samples of DN patients, diabetic animal models, and high glucose-stimulated podocytes, with deletion of GPR43 alleviating albuminuria and renal injury in diabetic mice. Antibiotic treatment and fecal microbiota transplantation improved podocyte insulin sensitivity and attenuated glomerular injury in diabetic rats by downregulating GPR43 expression and reducing serum acetate levels.
Article
Engineering, Civil
Tengfei Xu, Guoqing Chen, Kailai Deng, Limin Chen, Xiaolong Li, Song Lou
Article
Spectroscopy
Qiyun Xie, Lihuan Xu, Chengxiang Hu, Limin Chen, Jiajin Zheng, Wei Wang, Handi Yin, Guofeng Cheng, Xiaoqian Ai
Summary: Understanding the phonon-phonon anharmonic effect in HfTe5 is crucial for both scientific interest and potential thermoelectric applications. Raman spectroscopy was used to study the phonon anharmonicity by measuring the temperature dependence of phonon mode softening and broadening in HfTe5 single crystals. Results showed that four phonon anharmonic effects are significant, leading to low thermal conductivity in HfTe5 crystals due to reduced phonon lifetime from enhanced phonon scattering.
JOURNAL OF RAMAN SPECTROSCOPY
(2021)
Article
Nanoscience & Nanotechnology
Douglas K. Pleskow, Lei Zhang, Vladimir Turzhitsky, Mark F. Coughlan, Umar Khan, Xuejun Zhang, Conor J. Sheil, Maria Glyavina, Liming Chen, Shweta Shinagare, Yuri N. Zakharov, Edward Vitkin, Irving Itzkan, Lev T. Perelman, Le Qiu
Summary: The novel coherent confocal light scattering and absorption spectroscopic microscopy enables high-resolution imaging of structures in live cells, down to 10 nm spatial scales, and can sense differences in cancer aggressiveness in live cells and identify cancer grades in tumor tissues without labels.
Article
Pharmacology & Pharmacy
Daniel Rizzolo, Bo Kong, Stephanie Piekos, Liming Chen, Xiaobo Zhong, Jie Lu, Jian Shi, Hao-jie Zhu, Qian Yang, Albert Li, Linhao Li, Hongbing Wang, Anna Siemiatkowska, Celine Park, Leonid Kagan, Grace L. Guo
Summary: Fibroblast growth factors 15 and 19 are important in maintaining bile acid homeostasis, and are currently being tested as potential treatments for certain liver diseases. This study found that long-term elevations of these growth factors can lead to increased expression of drug metabolizing enzymes, affecting drug metabolism and pharmacokinetics. The overexpression of Fgf15 was also found to cause a switch in the expression pattern of these enzymes in male mice, similar to the pattern observed in female mice. This change was associated with differences in growth hormone secretion and STAT5 signaling.
DRUG METABOLISM AND DISPOSITION
(2022)
Review
Cell Biology
Mehrdad Izadirad, Zoufang Huang, Farideh Jafari, Amir Ali Hamidieh, Ahmad Gharehbaghian, Yi-Dong Li, Leila Jafari, Zhe-Sheng Chen
Summary: Despite their small size, extracellular vesicles (EVs) play a significant role in the pathogenesis of acute leukemia, especially as carriers of important molecules like miRNA. Research has shown a growing interest in the potential prognostic value and role of leukemia-derived EVs in clinical settings.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Chunhong Mo, Zhao Wang, Jianying Yang, Yiqiang Ouyang, Qian Mo, Shuting Li, Ping He, Limin Chen, Xinchun Li
Summary: This study presents a facile design and construction of a nanodrug system integrating targeted drug delivery and synergistic chemo-photothermal antitumor activity. The prepared nanocarrier using MoS2 nanosheets modified by alpha(v)beta(3) integrin binding peptide (RGD) and thiolated doxorubicin (DOX) showed favorable stability, biocompatibility, and photothermal conversion efficiency. The nanodrug exhibited targeted delivery to Hela cells and significantly reduced cardiotoxicity compared to free DOX, demonstrating powerful photothermal induced tumor-killing efficacy.
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Lei Zhang, Yidong Li, Chaohua Hu, Yangmin Chen, Zhuo Chen, Zhe-Sheng Chen, Jian-Ye Zhang, Shuo Fang
Summary: This study reveals CDK6-PI3K as a novel target signaling axis to reverse ABCB1-mediated multidrug resistance for the first time in cancers. Deficiency of CDK6 leads to downregulation of ABCB1 expression and reversal of multidrug resistance.
Article
Pharmacology & Pharmacy
Lei Zhang, Biwei Ye, Yunfeng Lin, Yi-Dong Li, Jing-Quan Wang, Zhuo Chen, Feng-Feng Ping, Zhe-Sheng Chen
Summary: In this study, the researchers investigated the effect of the CDK4/6 inhibitor, ribociclib, on multidrug resistance (MDR) mediated by P-glycoprotein (P-gp) in human epidermoid carcinoma cells. They found that ribociclib increased the efficacy of a P-gp substrate drug, colchicine, by down-regulating the expression of P-gp and increasing its ATPase activity. Docking studies suggested that ribociclib interacted with the drug-substrate binding site of P-gp. Additionally, ribociclib inhibited the drug efflux activity of P-gp, leading to increased intracellular accumulation of doxorubicin. These findings suggest that ribociclib may be a potential agent for combined therapy in cancers with P-gp-mediated MDR.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Multidisciplinary Sciences
Douglas K. Pleskow, Mandeep S. Sawhney, Paul K. Upputuri, Tyler M. Berzin, Mark F. Coughlan, Umar Khan, Maria Glyavina, Xuejun Zhang, Liming Chen, Conor J. Sheil, Jonah M. Cohen, Edward Vitkin, Yuri N. Zakharov, Irving Itzkan, Lei Zhang, Le Qiu, Lev T. Perelman
Summary: Bile duct cancer is a common type of liver cancer, often diagnosed in late stages resulting in poor survival rates. A reliable technique for detecting pre-cancerous changes in the bile duct is urgently needed. This study presents an endoscopic light scattering technique that can accurately evaluate the malignant potential of the bile duct. The technique showed high accuracy in detecting malignant transformation in a pilot study, indicating its potential for non-invasive in vivo identification of biliary duct pre-cancer.
NATURE COMMUNICATIONS
(2023)
Article
Integrative & Complementary Medicine
Juntao Li, Yue Wu, Xinxin Yu, Xinyu Zheng, Jiechen Xian, Senjie Li, Wanyin Shi, Yun Tang, Zhe-Sheng Chen, Guixia Liu, Shen Yao, Jian Xu, Xiangwei Zheng
Summary: This study revealed for the first time the pharmacodynamic mechanism of 8-isopentenyl flavonoids in Epimedium sagittatum Maxim. for treating erectile dysfunction (ED), and identified several compounds with significant inhibitory activities and the ability to activate cellular signaling pathways.
Review
Chemistry, Multidisciplinary
Yanyan Wang, Limin Chen, Siyang Li, Luhua Lai
Summary: Biomolecular condensates, formed as membraneless organelles, have diverse biological functions and are associated with diseases. Understanding the roles of intrinsically disordered proteins in their formation and regulation can guide the design of novel drugs.
PROGRESS IN CHEMISTRY
(2022)
Article
Chemistry, Multidisciplinary
Yuhai Sun, Junliang Wu, Yaolin Wang, Jingjing Li, Ni Wang, Jonathan Harding, Shengpeng Mo, Limin Chen, Peirong Chen, Mingli Fu, Daiqi Ye, Jun Huang, Xin Tu
Summary: The reaction pathways of plasma-enhanced catalytic CO2 hydrogenation were investigated in this study. Placing Pd/ZnO in a DBD reactor under plasma environment significantly improved the conversion of CO2 and the yield of CO. In the Plasma + ZnO system, CO2 splitting played an important role in the conversion of CO2.
Meeting Abstract
Medicine, Research & Experimental
Giuseppe Pettinato, Mark F. Coughlan, Xuejun Zhang, Liming Chen, Maria Glyavina, Yuri N. Zakharov, Lei Zhang, Le Qiu, Robert A. Fisher, Lev T. Perelman
XENOTRANSPLANTATION
(2021)
Article
Medicine, Research & Experimental
Wei Chong, Liang Shang, Jin Liu, Zhen Fang, Fengying Du, Hao Wu, Yang Liu, Zhe Wang, Yang Chen, Shengtao Jia, Liming Chen, Leping Li, Hao Chen
Summary: Recent studies have shown that m(6)A modification is significantly associated with TME diversity, and different m(6)A modification patterns in colon cancer are correlated with distinct clinical outcomes and biological pathways.
Review
Biochemistry & Molecular Biology
Liming Chen, Yifan Bao, Suzhen Jiang, Xiao-bo Zhong
