Identification of a New Potent Inhibitor Targeting KRAS in Non-small Cell Lung Cancer Cells

Non–Small Cell Lung Cancer, Version 5.2017, NCCN Clinical Practice Guidelines in Oncology

(2017) David S. Ettinger et al.   Journal of the National Comprehensive Cancer Network

Drugging RAS: Know the enemy

(2017) Bjoern Papke et al.   SCIENCE

Drugging Undruggable Molecular Cancer Targets

(2016) John S. Lazo et al.   Annual Review of Pharmacology and Toxicology

A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling

(2016) Sai Krishna Athuluri-Divakar et al.   CELL

Drugging Ras GTPase: a comprehensive mechanistic and signaling structural view

(2016) Shaoyong Lu et al.   CHEMICAL SOCIETY REVIEWS

Direct Inhibitors of Ras-Effector Protein Interactions

(2016) Punit Upadhyaya et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

How to Target Activated Ras Proteins: Direct Inhibition vs. Induced Mislocalization

(2016) Ethan J. Brock et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Allele-specific inhibitors inactivate mutant KRAS G12C by a trapping mechanism

(2016) P. Lito et al.   SCIENCE

Direct Modulation of Small GTPase Activity and Function

(2015) Philipp M. Cromm et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Targeting RAS Membrane Association: Back to the Future for Anti-RAS Drug Discovery?

(2015) A. D. Cox et al.   CLINICAL CANCER RESEARCH

Current status of the development of Ras inhibitors

(2015) Fumi Shima et al.   JOURNAL OF BIOCHEMISTRY

Monitoring Ras Interactions with the Nucleotide Exchange Factor Son of Sevenless (Sos) Using Site-specific NMR Reporter Signals and Intrinsic Fluorescence

(2015) Uybach Vo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cancer: The Ras renaissance

(2015) Heidi Ledford   NATURE

Direct inhibition of oncogenic KRAS by hydrocarbon-stapled SOS1 helices

(2015) Elizaveta S. Leshchiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Discovery of a Direct Ras Inhibitor by Screening a Combinatorial Library of Cell-Permeable Bicyclic Peptides

(2015) Thi B. Trinh et al.   ACS Combinatorial Science

Mapping the Conformation Space of Wildtype and Mutant H-Ras with a Memetic, Cellular, and Multiscale Evolutionary Algorithm

(2015) Rudy Clausen et al.   PLoS Computational Biology

A RAS Renaissance: Emerging Targeted Therapies for KRAS-Mutated Non-Small Cell Lung Cancer

(2014) N. Vasan et al.   CLINICAL CANCER RESEARCH

Discovery of Novel Allosteric Effectors Based on the Predicted Allosteric Sites for Escherichia coli D-3-Phosphoglycerate Dehydrogenase

(2014) Qian Wang et al.   PLoS One

Approach for targeting Ras with small molecules that activate SOS-mediated nucleotide exchange

(2014) Michael C. Burns et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

KRAS: feeding pancreatic cancer proliferation

(2014) Kirsten L. Bryant et al.   TRENDS IN BIOCHEMICAL SCIENCES

Lessons from computer simulations of Ras proteins in solution and in membrane

(2013) Priyanka Prakash et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Small molecule inhibition of the KRAS–PDEδ interaction impairs oncogenic KRAS signalling

(2013) Gunther Zimmermann et al.   NATURE

NMR-based functional profiling of RASopathies and oncogenic RAS mutations

(2013) M. J. Smith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ras inhibition via direct Ras binding—is there a path forward?

(2012) Weiru Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

KRAS Mutations in Lung Cancer

(2012) Niki Karachaliou et al.   Clinical Lung Cancer

Targeting the MAPK–RAS–RAF signaling pathway in cancer therapy

(2012) Libero Santarpia et al.   EXPERT OPINION ON THERAPEUTIC TARGETS

Integrated preclinical and clinical development of S-trans, trans-farnesylthiosalicylic acid (FTS, Salirasib) in pancreatic cancer

(2012) Daniel Laheru et al.   INVESTIGATIONAL NEW DRUGS

Small-molecule ligands bind to a distinct pocket in Ras and inhibit SOS-mediated nucleotide exchange activity

(2012) T. Maurer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Clinical Relevance of KRAS in Human Cancers

(2010) Sylwia Jančík et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY