Article
Medicine, Research & Experimental
Jikang Yang, Zhiyuan Xing
Summary: Ligustilide inhibits HCC cell malignancy and antagonizes HCC cell-induced macrophage recruitment and M2 polarization by suppressing YAP and IL-6 release-induced IL-6 receptor/signal transducer and activator of transcription 3 (IL-6R/STAT3) signaling.
EXPERIMENTAL BIOLOGY AND MEDICINE
(2021)
Article
Multidisciplinary Sciences
Galina Gabriely, Duanduan Ma, Shafiuddin Siddiqui, Linqing Sun, Nathaniel P. Skillin, Hadi Abou-El-Hassan, Thais G. Moreira, Dustin Donnelly, Andre P. da Cunha, Mai Fujiwara, Lena R. Walton, Amee Patel, Rajesh Krishnan, Stuart S. Levine, Brian C. Healy, Rafael M. Rezende, Gopal Murugaiyan, Howard L. Weiner
Summary: Myeloid suppressor cells expressing LAP on their surface promote tumor growth by stimulating Tregs and inhibiting effector T cells. Blocking TGF-beta can reduce the tolerogenic ability of these cells, leading to slower cancer progression. Additionally, single-cell RNA-Seq analysis reveals distinct immunosuppressive cell subsets with high levels of MHCII and PD-L1 genes. This study provides new insights into the role of LAP(Hi) MCs in tumor growth and potential therapeutic targets for cancer treatment.
Article
Pharmacology & Pharmacy
Mei Mei, Linfeng Tang, Hao Zhou, Nina Xue, Ming Li
Summary: Metastasis is the leading cause of death in breast cancer, especially in triple-negative breast cancer. Tumor-associated macrophages (TAMs) play a crucial role in tumor progression and metastasis and are important therapeutic targets in cancer treatment. Honokiol inhibits TNBC tumor progression and lung metastasis by regulating the polarization and recruitment of macrophages.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Pharmacology & Pharmacy
Qi Sun, Qi Liu, Xintong Zhou, Xiaomin Wang, Huayao Li, Wenfeng Zhang, Hailian Yuan, Changgang Sun
Summary: In recent years, the focus of tumor therapy has shifted to multi-mode interventions in the tumor microenvironment. Flavonoids have diverse immunomodulatory and anti-cancer activities in the tumor microenvironment. This study provides a comprehensive understanding of how flavonoids regulate tumor-associated macrophages and discusses their potential implications in cancer immunotherapy.
PHARMACOLOGICAL RESEARCH
(2022)
Article
Medicine, Research & Experimental
Takuto Nosaka, Yosuke Murata, Kazuto Takahashi, Tatsushi Naito, Kazuya Ofuji, Hidetaka Matsuda, Masahiro Ohtani, Katsushi Hiramatsu, Yoshiaki Imamura, Takanori Goi, Yasunari Nakamoto
Summary: This study identified the role of 5-LOX in hepatocellular carcinoma (HCC) progression and demonstrated that inhibition of 5-LOX activity can regulate HCC progression, suggesting it as a potential therapeutic target.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Review
Biochemistry & Molecular Biology
Pedram Moeini, Paulina Niedzwiedzka-Rystwej
Summary: Macrophages, crucial cells of the innate immune system, play a significant role in cancer progression and therapy failure by transforming into tumor-associated macrophages (TAMs) within the tumor microenvironment. This review aims to explore the advantages and disadvantages of TAMs in the immune system.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Dentistry, Oral Surgery & Medicine
X. Y. Fang, Y. X. Zhan, X. M. Zhou, L. N. Wu, J. Lin, Y. T. Yi, C. M. Jiang, J. Wang, J. Liu
Summary: Mechanical force-induced CXCL12/CXCR4 axis is involved in promoting orthodontic root resorption (ORR) by attracting Ly6C(hi) inflammatory monocytes and modulating macrophage polarization, leading to an increased M1/M2 ratio in periodontal tissues. Blockage of the CXCL12/CXCR4 axis using AMD3100 may potentially inhibit root resorption.
JOURNAL OF DENTAL RESEARCH
(2022)
Article
Immunology
Hang Ji, Zhihui Liu, Fang Wang, Haogeng Sun, Nan Wang, Yi Liu, Shaoshan Hu, Chao You
Summary: This study aims to construct a Macrophage-Related Gene Prognostic Index (MRGPI) for glioblastoma (GBM) and explore the underlying molecular, metabolic, and immunological features. The MRGPI was found to be an independent risk factor and correlated with macrophage activation. The study provides insights into the prognosis, metabolism, and immune features of GBM, and facilitates personalized application of immune checkpoint inhibitors.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Medicine, Research & Experimental
Degao Chen, Xiaomei Zhang, Zhongjun Li, Bo Zhu
Summary: The article discusses the metabolic regulation between TME and TAMs. Immune molecules from TAMs and TME act as mediators of signal transduction. TAMs are influenced by metabolites produced in the TME.
Review
Immunology
Zicong He, Shuixing Zhang
Summary: TAMs are crucial immune cells in tumors, and their functional transformation from M1 to M2 as tumors progress plays a key role in immunosuppression and tumor promotion processes. Understanding the mechanism of TAM functional transformation in the hypoxic environment is essential for developing novel tumor immunotherapeutic strategies.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biophysics
Chunmei Chen, Wei Zhang, Shi-Yu Lu, Jingjing Wang, Yixin Tan, Sheng Zhao, Yi Ouyang, Luen Xu, Benqing Zhou, Xuntao Yin, Haitao Ran, Hui Liu
Summary: Tumor-associated macrophages (TAMs)-mediated immunotherapy has attracted attention, but the acidic tumor microenvironment limits TAMs' phenotype. This study developed novel LDH-PAA@DOX NSs as deacidification agents to repolarize TAMs and achieve tumor elimination through combined chemodynamic therapy and immunotherapy.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Cell Biology
Athanasios Papadas, Gauri Deb, Alexander Cicala, Adam Officer, Chelsea Hope, Adam Pagenkopf, Evan Flietner, Zachary T. Morrow, Philip Emmerich, Joshua Wiesner, Garrett Arauz, Varun Bansal, Karla Esbona, Christian M. Capitini, Kristina A. Matkowskyj, Dustin A. Deming, Katerina Politi, Scott I. Abrams, Olivier Harismendy, Fotis Asimakopoulos
Summary: The stroma near the tumor edge plays a crucial role in regulating the abundance and activity of cDC1, which in turn affects the T cell inflammatory response in the tumor microenvironment.
Article
Multidisciplinary Sciences
Mark Sorin, Morteza Rezanejad, Elham Karimi, Benoit Fiset, Lysanne Desharnais, Lucas J. M. Perus, Simon Milette, Miranda W. W. Yu, Sarah M. M. Maritan, Samuel Dore, Emilie Pichette, William Enlow, Andreanne Gagne, Yuhong Wei, Michele Orain, Venkata S. K. Manem, Roni Rayes, Peter M. M. Siegel, Sophie Camilleri-Broet, Pierre Olivier Fiset, Patrice Desmeules, Jonathan D. D. Spicer, Daniela F. F. Quail, Philippe Joubert, Logan A. A. Walsh
Summary: Single-cell technologies have provided unprecedented resolution for understanding the complexity of the tumour immune microenvironment. In this study, imaging mass cytometry was used to analyze samples from 416 patients with lung adenocarcinoma, revealing spatial features of the tumour and immunological landscape. By applying deep learning, the researchers successfully predicted post-surgery progression in patients.
Review
Biochemistry & Molecular Biology
Yi Zhao, Benzheng Zhang, Qianqian Zhang, Xiaowei Ma, Helin Feng
Summary: Osteosarcoma is the most common primary bone tumor in children and adolescents, known for its aggressive nature and tendency to metastasize to the lungs. The tumor microenvironment, particularly tumor-associated macrophages, plays a crucial role in promoting tumor growth while inhibiting metastasis in osteosarcoma. Research on the mechanisms of tumor-associated macrophages in osteosarcoma development and immunotherapy for osteosarcoma is of significant interest.
JOURNAL OF ZHEJIANG UNIVERSITY-SCIENCE B
(2021)
Article
Plant Sciences
Dhruvi Shah, Naveen Challagundla, Vaidehi Dave, Ashok Patidar, Bhaskar Saha, Manish Nivsarkar, Varsha B. Trivedi, Reena Agrawal-Rajput
Summary: Berberine can modulate the phenotype of immunosuppressive macrophages in the tumor microenvironment, inhibit tumor growth, and restore anti-tumor immune response of T cells.
Article
Oncology
Lin Jia, Xin-an Lu, Guanghua Liu, Shan Wang, Min Xu, Yang Tian, Shaosen Zhang, Yan Fu, Yongzhang Luo
JOURNAL OF PATHOLOGY
(2017)
Article
Biology
Samina Shaheen, Zhengpeng Wan, Zongyu Li, Alicia Chau, Xinxin Li, Shaosen Zhang, Yang Liu, Junyang Yi, Yingyue Zeng, Jing Wang, Xiangjun Chen, Liling Xu, Wei Chen, Fei Wang, Yun Lu, Wenjie Zheng, Yan Shi, Xiaolin Sun, Zhanguo Li, Chunyang Xiong, Wanli Liu
Article
Cell Biology
Caihong Wang, Shaosen Zhang, Jie Liu, Yang Tian, Boyuan Ma, Siran Xu, Yan Fu, Yongzhang Luo
Article
Cell Biology
Yuanchao Gong, Caihong Wang, Yi Jiang, Shaosen Zhang, Shi Feng, Yan Fu, Yongzhang Luo
Article
Cell Biology
Shaosen Zhang, Caihong Wang, Boyuan Ma, Min Xu, Siran Xu, Jie Liu, Yang Tian, Yan Fu, Yongzhang Luo
Article
Multidisciplinary Sciences
Xiannian Zhang, Linna Peng, Yingying Luo, Shaosen Zhang, Yang Pu, Yamei Chen, Wenjia Guo, Jiacheng Yao, Mingming Shao, Wenyi Fan, Qionghua Cui, Yiyi Xi, Yanxia Sun, Xiangjie Niu, Xuan Zhao, Liping Chen, Yuqian Wang, Yachen Liu, Xinyu Yang, Chengcheng Wang, Ce Zhong, Wen Tan, Jianbin Wang, Chen Wu, Dongxin Lin
Summary: The study analyzed 60 ESCC patient samples using scRNA-seq, TCR-seq and genomics to identify prognostic markers associated with survival and immunosuppressive microenvironments. It revealed the complex tumor ecosystem of ESCC and the interactions between cancer cells and other cells in the tumor microenvironment. The study identified several markers significantly associated with patients' survival, providing insights for precision care of ESCC patients.
NATURE COMMUNICATIONS
(2021)
Article
Biochemistry & Molecular Biology
Jiaze Tang, Anji Ju, Boya Li, Shaosen Zhang, Yuanchao Gong, Boyuan Ma, Yi Jiang, Hongyi Liu, Yan Fu, Yongzhang Luo
Summary: The injection of exogenous recombinant mouse serum albumin (rMSA) reduced protein damages in mice, improving their healthspan and lifespan significantly. The young and undamaged rMSA used in the study showed better results than endogenous serum albumin, leading to potential further improvements in healthspan and lifespan.
Article
Oncology
Ai Lin, Ping Ji, Xiangjie Niu, Xuan Zhao, Yamei Chen, Weiling Liu, Yachen Liu, Wenyi Fan, Yanxia Sun, Chuanwang Miao, Shaosen Zhang, Wen Tan, Dongxin Lin, Eric J. Wagner, Chen Wu
Summary: High-throughput analysis revealed that the recurrent shortening of the BID 3'UTR is a driver of disease progression in esophageal squamous cell carcinoma.
Article
Oncology
Tianyuan Liu, Xuan Zhao, Yuan Lin, Qi Luo, Shaosen Zhang, Yiyi Xi, Yamei Chen, Lin Lin, Wenyi Fan, Jie Yang, Yuling Ma, Alok K. Maity, Yanyi Huang, Jianbin Wang, Jiang Chang, Dongxin Lin, Andrew E. Teschendorff, Chen Wu
Summary: This study develops a computational strategy to identify stem-like preneoplastic cells that may drive cancer progression by dissecting the heterogeneity of differentiation states within a preneoplastic cell population.
Article
Biochemistry & Molecular Biology
Caihong Wang, Shaosen Zhang, Boyuan Ma, Yan Fu, Yongzhang Luo
Summary: This research uncovers a mechanism by which mutant p53 regulates the transcription of RCP to influence lung cancer progression, providing new insights for treating p53 mutant lung cancer.
Article
Oncology
Shaosen Zhang, Caihong Wang, Jiujun Ju, Caixia Wang
Summary: In this study, we uncovered the novel molecular mechanism of extracellular heat shock protein 90 alpha (eHsp90 alpha) in regulating the activity of pyruvate kinase M2 (PKM2) during tumor progression, which benefits the development of new treatments against lung cancer.
FRONTIERS IN ONCOLOGY
(2022)
Article
Oncology
Yamei Chen, Shihao Zhu, Tianyuan Liu, Shaosen Zhang, Junting Lu, Wenyi Fan, Lin Lin, Tao Xiang, Jie Yang, Xuan Zhao, Yiyi Xi, Yuling Ma, Guoyu Cheng, Dongxin Lin, Chen Wu
Summary: In this study, a comprehensive analysis of 79 multistage esophageal lesions from 29 ESCC patients was conducted using single-cell RNA sequencing and spatial transcriptomics. The results showed a gradual loss of ANXA1 expression in epithelial cells during lesion progression, which was attributed to the suppression of its transcription factor KLF4. It was also found that ANXA1 is a ligand for fibroblasts and loss of ANXA1 leads to uncontrolled transformation of normal fibroblasts into cancer-associated fibroblasts (CAFs), facilitated by TGF-b secreted by malignant epithelial cells. This highlights the importance of ANXA1/FPR2 signaling in the crosstalk between epithelial cells and fibroblasts in promoting ESCC.
Article
Biochemistry & Molecular Biology
Boyuan Ma, Anji Ju, Shaosen Zhang, Qi An, Siran Xu, Jie Liu, Li Yu, Yan Fu, Yongzhang Luo
Summary: Hepatic mitochondrial dysfunction contributes to the progression of NAFLD. This study reveals that albumosome, a shell-like structure formed by pre-folding albumin in the cytoplasm, plays a crucial role in maintaining mitochondrial homeostasis and preventing mitochondrial damage. Albumosomes interact with and trap pre-folding CPT2, controlling its excessive sorting to the mitochondria under high-fat-diet-induced stress conditions. Accumulation of albumosomes in hepatocytes during aging protects the liver from mitochondrial damage and fat deposition.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2023)
Article
Biochemistry & Molecular Biology
Jie Yang, Tao Xiang, Shihao Zhu, Yueqiong Lao, Yuqian Wang, Tianyuan Liu, Kai Li, Yuling Ma, Ce Zhong, Shaosen Zhang, Wen Tan, Dongxin Lin, Chen Wu
Summary: APOBEC mutagenesis is prevalent in ESCC and has been found to prolong overall survival of patients through promoting anti-tumor immune infiltration, immune checkpoints expression, and immune related pathway enrichment. The elevated A3A activity exacerbates cytosolic dsDNA accumulation and activates the cGAS-STING pathway. Additionally, A3A is associated with immunotherapy response, indicating its potential clinical utility.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Weiling Liu, Chuanwang Miao, Shaosen Zhang, Yachen Liu, Xiangjie Niu, Yiyi Xi, Wenjia Guo, Jiahui Chu, Ai Lin, Hongjin Liu, Xinyu Yang, Xinjie Chen, Ce Zhong, Yuling Ma, Yuqian Wang, Shihao Zhu, Shuning Liu, Wen Tan, Dongxin Lin, Chen Wu
Summary: This study reveals the important role of overexpressed VAV2 in human cancers, which can impact the efficacy of radiotherapy. VAV2 affects DNA damage repair and signaling pathways, leading to radioresistance in tumors.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2021)