Article
Biochemistry & Molecular Biology
Bei Song, Dongrui Chen, Zixiong Liu, Yuwen Cheng, Zebei Zhang, Weiqing Han, Ruiyan Zhang, Yanchun Gong
Summary: Recent studies have highlighted the role of vascular adventitia inflammation and immune response in hypertension. This study found that SDF-1 exerted opposing effects through CXCR4 and CXCR7 in AngII-induced vascular adventitial remodeling.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Wu-Xun Chen, Nai-Chen Cheng, Yan-Jun Chen, I-Chi Lee
Summary: In this study, silk fibroin-based microneedle patches were fabricated as carriers for adipose stem cell recruitment. The crystallinity of silk fibroin-based microneedles was determined after water annealing treatment. The results showed that the microneedle patches had sufficient strength to penetrate the skin and demonstrated sustained release of the model drug. Dual-layer microneedles loaded with SDF-1 were prepared to enhance drug release for stem cell recruitment.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Medicine, Research & Experimental
Afsaneh Asgari Taei, Sanaz Nasoohi, Gholamreza Hassanzadeh, Mehdi Kadivar, Leila Dargahi, Maryam Farahmandfar
Summary: The study demonstrates that conditioned medium (CM) derived from human embryonic mesenchymal stem cells (hESC-MSC) can significantly improve neurological deficits and infarct volume in rats with experimental stroke. Ischemic stroke is associated with higher levels of neurogenesis and angiogenesis markers, and treatment with CM further enhances these markers in the brain regions. This suggests that the therapeutic benefits of CM from hESC-MSCs are mediated through improved neurogenesis and angiogenesis to accelerate the recovery from cerebral ischemic insult.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Zhi-Han Zhu, Feng Jia, Waqas Ahmed, Gui-Long Zhang, Hong Wang, Chao-Qun Lin, Wang-Hao Chen, Lu-Kui Chen
Summary: In this study, we engineered exosomes (BDNF-hNSC-Exo) by loading brain-derived neurotrophic factor (BDNF) into exosomes derived from neural stem cells (NSCs). These engineered exosomes showed enhanced cell survival and promoted neuronal differentiation, suggesting their potential therapeutic role in ischemic stroke.
NEURAL REGENERATION RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Hye-Jin Hur, Ji Yong Lee, Do-Hun Kim, Myung Soo Cho, Sangsik Lee, Han-Soo Kim, Dong-Wook Kim
Summary: The study showed that administration of NPC-CM promoted functional recovery in rats with pMCAO, by suppressing inflammatory damage, inducing endogenous neurogenesis, and reducing cerebral infarct and inflammation. Proteome analysis of NPC-CM identified proteins associated with nervous system development, neurogenesis, and angiogenesis, highlighting the potency of NPC-CM in stroke therapy. Transciptome analysis confirmed the importance of inflammatory response during stroke recovery and validated key hub genes in the interaction network.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ji Ae Kim, Ye Young Kim, Seung Hak Lee, Chul Jung, Mi Hee Kim, Dae Yul Kim
Summary: The macrophage migration inhibitory factor (MIF) exerts a neuroprotective effect, facilitating neurological recovery and protecting brain tissue from ischemic injury in an in vivo model of ischemic stroke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Neurosciences
Guannan Jiang, Xiang Li, Meirong Liu, Haiying Li, Haitao Shen, Juan Liao, Wanchun You, Qi Fang, Gang Chen
Summary: The study investigates the protective effect of Remote Ischemic Postconditioning (RIPostC) on rats after ischemic stroke. RIPostC was found to improve neurological recovery and brain injury in rats by upregulating the expression levels of CXCR4 and SDF-1 alpha. The neuroprotective effect of RIPostC was diminished when the SDF-1 alpha/CXCR4 signaling axis was inhibited. RIPostC can be used as an intervention strategy for stroke, and the SDF-1 alpha/CXCR4 signaling axis can be a potential target for intervention.
BRAIN RESEARCH BULLETIN
(2023)
Article
Oncology
Crescenzo D'Alterio, Anna Spina, Laura Arenare, Paolo Chiodini, Maria Napolitano, Francesca Galdiero, Luigi Portella, Vittorio Simeon, Simona Signoriello, Francesco Raspagliesi, Domenica Lorusso, Carmela Pisano, Nicoletta Colombo, Gian Franco Zannoni, Nunzia Simona Losito, Rossella De Cecio, Giosue Scognamiglio, Daniela Califano, Daniela Russo, Valentina Tuninetti, Maria Carmela Piccirillo, Piera Gargiulo, Francesco Perrone, Sandro Pignata, Stefania Scala
Summary: Despite advances in research on epithelial ovarian cancer, this study systematically evaluated the CXCR4-CXCL12-CXCR7 axis in tumor and stromal cells, identifying a potential prognostic and therapeutic target in high CXCL12 expression in cancer cells. The study highlights the importance of further investigating the CXCL12 axis to improve treatment efficacy in EOC patients.
Review
Orthopedics
J. Li, H. Chen, D. Zhang, J. Xie, X. Zhou
Summary: Stromal cell-derived factor 1 (SDF-1), also known as CXCL12, plays a crucial role in cartilage development and diseases by affecting chondrocytes through binding to CXCR4. It is not only a subject of research in cartilage development mechanisms, but also a potential therapeutic target for osteoarthritis and rheumatoid arthritis.
OSTEOARTHRITIS AND CARTILAGE
(2021)
Article
Gastroenterology & Hepatology
Alex B. Blair, Jianxin Wang, John Davelaar, Andrew Baker, Keyu Li, Nan Niu, Junke Wang, Yingkuan Shao, Vanessa Funes, Pan Li, Jonathan A. Pachter, Daniel C. Maneval, Felipe Dezem, Jasmine Plummer, Keith Syson Chan, Jun Gong, Andrew E. Hendifar, Stephen J. Pandol, Richard Burkhart, Yuqing Zhang, Lei Zheng, Arsen Osipov
Summary: This study identifies the synergistic effects of targeting both intracellular and extracellular components within the PDAC stroma, and supports the potential of testing anti-CXCR4 antibody in combination with FAKi as a PDAC treatment strategy.
Article
Polymer Science
Yi Wang, Vanessa Penna, Richard J. Williams, Clare L. Parish, David R. Nisbet
Summary: Peptide self-assembly into nanostructured bioactive hydrogels has the potential to repair traumatic brain injuries by maintaining a stable environment and delivering therapeutic proteins. In this study, a recombinant SDF-1 protein was incorporated into a self-assembled peptide hydrogel to create a supportive environment for transplanted cells. The hydrogel successfully delivered viable neural progenitor cells and active SDF-1, resulting in increased neuronal differentiation and improved graft integration.
Review
Biochemistry & Molecular Biology
Takayuki Nagase, Kyohei Kin, Takao Yasuhara
Summary: Ischemic stroke is a significant disease that often leads to long-term disability and mortality. Limited treatments are available, which has prompted research on neurogenesis as a potential therapeutic strategy. Various treatment methods have been found to enhance neurogenesis and facilitate brain repair and functional recovery.
Article
Medicine, Research & Experimental
Hui Wang, Xiaofei Li, Tetsuhiro Kajikawa, Jieun Shin, Jong-Hyung Lim, Ioannis Kourtzelis, Kosuke Nagai, Jonathan M. Korostoff, Sylvia Grossklaus, Ronald Naumann, Triantafyllos Chavakis, George Hajishengallis
Summary: The secreted protein DEL-1 plays a critical role in regulating inflammatory cell recruitment and protecting against inflammatory arthritis. DEL-1 functions both locally in the joints and systemically in lymph nodes to inhibit Tfh responses, making it a promising therapeutic target for inflammatory arthritis treatment.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Cell Biology
Yacong He, Shuang Chen, Bun Tsoi, Shuhua Qi, Bing Gu, Zhenxing Wang, Cheng Peng, Jiangang Shen
Summary: The study found that by inducing the BDNF signaling pathway, AOM can promote adult hippocampal neurogenesis and improve cognitive impairments after stroke. P-CA is identified as the most effective compound in AOM, with the ability to activate the BDNF/TrkB/AKT signaling pathway and promote NSC proliferation.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Fangxi Liu, Xi Cheng, Chuansheng Zhao, Xiaoqian Zhang, Chang Liu, Shanshan Zhong, Zhouyang Liu, Xinyu Lin, Wei Qiu, Xiuchun Zhang
Summary: Using single-cell RNA sequencing, this study investigated the composition and transcriptional features of immune cells in the peri-infarct region after cerebral ischemia. Microglia were found to be the predominant cell type with diverse activation patterns. Infiltrated monocyte-derived macrophages exhibited a gradual transition to activation. Interactions between macrophages and microglia promoted anti-inflammatory and repair-promoting microglia phenotypes and post-stroke neurogenesis.
NEUROSCIENCE BULLETIN
(2023)