Characterization of the Transcriptomes of Lgr5+ Hair Cell Progenitors and Lgr5- Supporting Cells in the Mouse Cochlea

Bmi1 Regulates the Proliferation of Cochlear Supporting Cells Via the Canonical Wnt Signaling Pathway

(2016) Xiaoling Lu et al.   MOLECULAR NEUROBIOLOGY

Wnt activation followed by Notch inhibition promotes mitotic hair cell regeneration in the postnatal mouse cochlea

(2016) Wenli Ni et al.   Oncotarget

Characterization of Lgr5+ progenitor cell transcriptomes in the apical and basal turns of the mouse cochlea

(2016) Muhammad Waqas et al.   Oncotarget

Regeneration of hair cells in the mammalian vestibular system

(2016) Wenyan Li et al.   Frontiers of Medicine

Role of Wnt and Notch signaling in regulating hair cell regeneration in the cochlea

(2016) Muhammad Waqas et al.   Frontiers of Medicine

Protection from noise-induced hearing loss with Src inhibitors

(2015) Eric C. Bielefeld   DRUG DISCOVERY TODAY

SoxC transcription factors are essential for the development of the inner ear

(2015) Ksenia Gnedeva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zeb2: A multifunctional regulator of nervous system development

(2015) Shane V. Hegarty et al.   PROGRESS IN NEUROBIOLOGY

Making sense of Wnt signaling—linking hair cell regeneration to development

(2015) Lina Jansson et al.   Frontiers in Cellular Neuroscience

Lgr5+ cells regenerate hair cells via proliferation and direct transdifferentiation in damaged neonatal mouse utricle

(2015) Tian Wang et al.   Nature Communications

Cochlear progenitor number is controlled through mesenchymal FGF receptor signaling

(2015) Sung-Ho Huh et al.   eLife

Growth factors have a protective effect on neomycin-induced hair cell loss

(2014) Xiangxin Lou et al.   CELL BIOLOGY INTERNATIONAL

Spontaneous hair cell regeneration in the neonatal mouse cochlea in vivo

(2014) B. C. Cox et al.   DEVELOPMENT

Ligand-dependent Notch signaling strength orchestrates lateral induction and lateral inhibition in the developing inner ear

(2014) J. Petrovic et al.   DEVELOPMENT

Junctionally restricted RhoA activity is necessary for apical constriction during phase 2 inner ear placode invagination

(2014) Xiaorei Sai et al.   DEVELOPMENTAL BIOLOGY

PTK7-Src Signaling at Epithelial Cell Contacts Mediates Spatial Organization of Actomyosin and Planar Cell Polarity

(2014) Anna Andreeva et al.   DEVELOPMENTAL CELL

Hey1 and Hey2 Control the Spatial and Temporal Pattern of Mammalian Auditory Hair Cell Differentiation Downstream of Hedgehog Signaling

(2014) A. Benito-Gonzalez et al.   JOURNAL OF NEUROSCIENCE

Auditory Hair Cell-Specific Deletion of p27Kip1 in Postnatal Mice Promotes Cell-Autonomous Generation of New Hair Cells and Normal Hearing

(2014) B. J. Walters et al.   JOURNAL OF NEUROSCIENCE

Characterization of Transcriptomes of Cochlear Inner and Outer Hair Cells

(2014) H. Liu et al.   JOURNAL OF NEUROSCIENCE

TMIE Is an Essential Component of the Mechanotransduction Machinery of Cochlear Hair Cells

(2014) Bo Zhao et al.   NEURON

The influence of sphingosine-1-phosphate receptor antagonists on gentamicin-induced hair cell loss of the rat cochlea

(2014) Masahiro Nakayama et al.   NEUROSCIENCE LETTERS

HMGA2, the Architectural Transcription Factor High Mobility Group, Is Expressed in the Developing and Mature Mouse Cochlea

(2014) Ibtihel Smeti et al.   PLoS One

Genetic Analysis of Genes Related to Tight Junction Function in the Korean Population with Non-Syndromic Hearing Loss

(2014) Min-A Kim et al.   PLoS One

Lgr5-Positive Supporting Cells Generate New Hair Cells in the Postnatal Cochlea

(2014) Naomi F. Bramhall et al.   Stem Cell Reports

Tympanic border cells are Wnt-responsive and can act as progenitors for postnatal mouse cochlear cells

(2013) T. A. Jan et al.   DEVELOPMENT

Hedgehog signaling regulates prosensory cell properties during the basal-to-apical wave of hair cell differentiation in the mammalian cochlea

(2013) T. Tateya et al.   DEVELOPMENT

Atoh1 directs hair cell differentiation and survival in the late embryonic mouse inner ear

(2013) Kurt T. Chonko et al.   DEVELOPMENTAL BIOLOGY

Postnatal Refinement of Auditory Hair Cell Planar Polarity Deficits Occurs in the Absence of Vangl2

(2013) C. O. Copley et al.   JOURNAL OF NEUROSCIENCE

Usher proteins in inner ear structure and function

(2013) Zubair M. Ahmed et al.   PHYSIOLOGICAL GENOMICS

Role of p63 and the Notch pathway in cochlea development and sensorineural deafness

(2013) A. Terrinoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Generation of hair cells in neonatal mice by β-catenin overexpression in Lgr5-positive cochlear progenitors

(2013) Fuxin Shi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ephrin-A5/EphA4 signalling controls specific afferent targeting to cochlear hair cells

(2013) Jean Defourny et al.   Nature Communications

Mitochondrial Stress Engages E2F1 Apoptotic Signaling to Cause Deafness

(2012) Nuno Raimundo et al.   CELL

Delta-like 1 and lateral inhibition during hair cell formation in the chicken inner ear: evidence against cis-inhibition

(2012) E. Chrysostomou et al.   DEVELOPMENT

Wnt-Responsive Lgr5-Expressing Stem Cells Are Hair Cell Progenitors in the Cochlea

(2012) F. Shi et al.   JOURNAL OF NEUROSCIENCE

Wnt signaling induces proliferation of sensory precursors in the postnatal mouse cochlea

(2012) R. Chai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nonsense Mutations in SMPX, Encoding a Protein Responsive to Physical Force, Result in X-Chromosomal Hearing Loss

(2011) Antje K. Huebner et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Next-Generation Sequencing Identifies Mutations of SMPX, which Encodes the Small Muscle Protein, X-Linked, as a Cause of Progressive Hearing Impairment

(2011) Margit Schraders et al.   AMERICAN JOURNAL OF HUMAN GENETICS

p27Kip1is required to maintain proliferative quiescence in the adult cochlea and pituitary

(2011) Elizabeth C. Oesterle et al.   CELL CYCLE

Temporal Expression Pattern of Fkbp8 in Rodent Cochlea

(2011) Magdalena Zak et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Apoptosis in acquired and genetic hearing impairment: The programmed death of the hair cell

(2011) Ken Op de Beeck et al.   HEARING RESEARCH

Dynamic Expression of Lgr5, a Wnt Target Gene, in the Developing and Mature Mouse Cochlea

(2011) Renjie Chai et al.   JARO-JOURNAL OF THE ASSOCIATION FOR RESEARCH IN OTOLARYNGOLOGY

An RNA Interference-Based Screen of Transcription Factor Genes Identifies Pathways Necessary for Sensory Regeneration in the Avian Inner Ear

(2011) D. M. Alvarado et al.   JOURNAL OF NEUROSCIENCE

Regulated Reprogramming in the Regeneration of Sensory Receptor Cells

(2011) Olivia Bermingham-McDonogh et al.   NEURON

Intrinsic regenerative potential of murine cochlear supporting cells

(2011) Saku T. Sinkkonen et al.   Scientific Reports

Gata2 is required for the development of inner ear semicircular ducts and the surrounding perilymphatic space

(2010) Maarja Haugas et al.   DEVELOPMENTAL DYNAMICS

Up-regulation of hypoxia-inducible factor-1 alpha by cobalt chloride prevents hearing loss in noise-exposed mice

(2010) Jong Woo Chung et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Sensory regeneration in the vertebrate inner ear: Differences at the levels of cells and species

(2010) Mark E. Warchol   HEARING RESEARCH

Expression analysis suggests a potential cytoprotective role of Birc5 in the inner ear

(2010) Negusse Habtemichael et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Chondrocyte-specificSmad4gene conditional knockout results in hearing loss and inner ear malformation in mice

(2009) Shi-Ming Yang et al.   DEVELOPMENTAL DYNAMICS

Expression ofPou3f3/Brn-1and its genomic methylation in developing auditory epithelium

(2009) Hideki Mutai et al.   Developmental Neurobiology

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

(2009) Linda Madisen et al.   NATURE NEUROSCIENCE

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

(2009) Da Wei Huang et al.   Nature Protocols

Expression of Wnt receptors in adult spiral ganglion neurons: frizzled 9 localization at growth cones of regenerating neurites

(2009) S.M. Shah et al.   NEUROSCIENCE

Lgr5 marks cycling, yet long-lived, hair follicle stem cells

(2008) Viljar Jaks et al.   NATURE GENETICS