期刊
FRONTIERS IN MOLECULAR NEUROSCIENCE
卷 10, 期 -, 页码 -出版社
FRONTIERS MEDIA SA
DOI: 10.3389/fnmol.2017.00106
关键词
GRP cell; OPC; oligodendrocyte lineage; self-renewal; synergistic effect
资金
- National Key Basic Research Program of China (Ministry of Science and Technology of the People's Republic of China) [2013CB531303, 2012CB910402]
- National Natural Science Foundation of China [81200961, 31372150, 31572224, 31471955]
- Zhejiang Provincial Natural Science Foundation of China [Y2111122, LQ16C090004]
- Medical and Health Research Program of Hangzhou in China [20170533B10]
Emerging evidence indicates that epidermal growth factor (EGF) signaling plays a positive role in myelin development and repair, but little is known about its biological effects on the early generation and differentiation of oligodendrocyte (OL) lineage cells. In this study, we investigated the role of EGF in early OL development with isolated glial restricted precursor (GRP) cells. It was found that EGF collaborated with Platelet Derived Growth Factor-AA (PDGFaa) to promote the survival and self-renewal of GRP cells, but predisposed GRP cells to develop into O4 early-stage oligodendrocyte precursor cells (OPCs) in the absence of or PDGFaa. In OPCs, EGF synergized with PDGFaa to maintain their O4 negative antigenic phenotype. Upon PDGFaa withdrawal, EGF promoted the terminal differentiation of OPCs by reducing apoptosis and increasing the number of mature OLs. Together, these data revealed that EGF is an important mitogen to enhance oligodendroglial development.
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